FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Ars2
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General Information
Symbol
Dmel\Ars2
Species
D. melanogaster
Name
Arsenic resistance protein 2
Annotation Symbol
CG7843
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033062
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Arsenic resistance protein 2 (Ars2) encodes a protein that binds the cap binding complex and plays roles in small RNA biogenesis. It facilitates miRNA processing from primary miRNAs to pre-miRNAs. In addition, it interacts with the product of Dcr-2, modulates its activity and is required for siRNA-mediated silencing and antiviral defense. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
42A9-42A9
Sequence location
Recombination map
2-55
RefSeq locus
NT_033778 REGION:6080828..6085625
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:A1ZAW0
(Sabin et al., 2009)
inferred from physical interaction with UniProtKB:Q9V3L6
(Sabin et al., 2009)
inferred from physical interaction with UniProtKB:Q9V9V7
(Sabin et al., 2009)
enables protein-macromolecule adaptor activity
inferred from direct assay
(Lee et al., 2025)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein-macromolecule adaptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000323018
(GO Reference Genome Project, 2011-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in defense response to Gram-negative bacterium
inferred from mutant phenotype
(Berkey et al., 2009)
acts_upstream_of negative regulation of viral genome replication
inferred from mutant phenotype
(Sabin et al., 2009)
involved_in nuclear RNA surveillance
inferred from mutant phenotype
(Lee et al., 2025)
involved_in primary miRNA processing
inferred from mutant phenotype
(Sabin et al., 2009)
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing
inferred from mutant phenotype
(Sabin et al., 2009)
involved_in siRNA processing
inferred from mutant phenotype
(Sabin et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mRNA splicing, via spliceosome
inferred by curator from GO:0071011,GO:0071013
(Herold et al., 2009)
involved_in primary miRNA processing
inferred from biological aspect of ancestor with PANTHER:PTN000323018
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
is_active_in nucleus
inferred from direct assay
(Lee et al., 2025)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nuclear body
inferred from biological aspect of ancestor with PANTHER:PTN000323018
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ARS2 family. (Q9V9K7)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Arsenic resistance protein 2 (Ars2) encodes a protein that binds the cap binding complex and plays roles in small RNA biogenesis. It facilitates miRNA processing from primary miRNAs to pre-miRNAs. In addition, it interacts with the product of Dcr-2, modulates its activity and is required for siRNA-mediated silencing and antiviral defense. [Date last reviewed: 2019-03-21]
Protein Function (UniProtKB)
Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha.
(UniProt, Q9V9K7)
Summary (Interactive Fly)

RNA-binding protein - siRNA- and miRNA-mediated silencing - susceptibility to RNA viruses - anti-viral immunity

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Ars2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V9K7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ars2-RA
FBtr0086018
NM_136359
3419
943
Ars2-RC
FBtr0086021
NM_165458
3198
943
Ars2-RD
FBtr0086020
NM_165459
3549
943
Ars2-RE
FBtr0310665
NM_001273790
3026
935
Ars2-RF
FBtr0310666
NM_001273791
3248
208
Ars2-RG
FBtr0310667
NM_165460
3038
939
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ars2-PA
FBpp0085354
107.2
943
5.21
Q9V9K7
NP_610203
AAF57281
Ars2-PC
FBpp0085357
107.2
943
5.21
Q9V9K7
NP_724453
AAM68343
Ars2-PD
FBpp0085356
107.2
943
5.21
Q9V9K7
NP_724454
AAM68344
Ars2-PE
FBpp0302785
106.3
935
5.24
A0A0B4KEI5
NP_001260719
AGB93253
Ars2-PF
FBpp0302786
23.7
208
7.16
A0A0B4KF41
NP_001260720
AGB93254
Ars2-PG
FBpp0302787
106.8
939
5.29
NP_724455
AAM68345
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

943 aa isoforms: Ars2-PA, Ars2-PC, Ars2-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with cbp20, Dcr-2 and pasha.

(UniProt, Q9V9K7)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ars2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.81

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
is_active_in nucleus
inferred from direct assay
(Lee et al., 2025)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ars2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ars2
Transgenic constructs containing regulatory region of Ars2
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel7085
(Ryder, 2004.4.26)
Inferred from location ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act.PU
lethal, with Scer\GAL4da.G32
lethal, with Scer\GAL4insc-Mz1407
lethal (with Ars2c00735)
lethal (with Ars2e01128)
lethal | recessive
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female fertile, with Scer\GAL4nanos.PG
female semi-fertile, with Ars2GL00079, Scer\GAL4VP16.mat.αTub67C
female semi-fertile, with Ars2R12fsX, Scer\GAL4VP16.mat.αTub67C
fertile
Other Phenotypes
Allele
abnormal developmental rate | maternal effect, with Scer\GAL4nanos.PG
abnormal immune response | heat sensitive, with Scer\GAL4hs.PB
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
flightless, with Scer\GAL4Mef2.PR
some die during embryonic stage | maternal effect, with Ars2GL00079, Scer\GAL4VP16.mat.αTub67C
some die during embryonic stage | maternal effect, with Ars2R12fsX, Scer\GAL4VP16.mat.αTub67C
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
centrosome | increased number | oogenesis, with Scer\GAL4nanos.PG
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
mesonotum, with Scer\GAL4pnr-MD237
myofibril, with Scer\GAL4Mef2.PR
sarcomere, with Scer\GAL4Mef2.PR
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\SRRT
14 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Srrt
10 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Srrt
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\srrt
10 of 13
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\srrt
13 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\E01A2.2
13 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\SRRT_ANOGA
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\SE
9 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC725.08
7 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ars2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 4 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SRRT; serrate, RNA effector molecule
    14 of 14
    614469
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        Interacts with cbp20, Dcr-2 and pasha.
        (UniProt, Q9V9K7 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-55
        Cytogenetic map
        42A9-42A9
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        42A9-42A9
        Limits computationally determined from genome sequence between P{lacW}l(2)k09848k09848&P{EP}EP407 and P{lacW}geminink14019&P{PZ}Adf101349
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-55

        (FlyBase, 2016)

        2-55.8

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (14)
        Genomic Clones (21)
        cDNA Clones (77)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Morgunova et al., 2025, Sabath et al., 2013, Sabin et al., 2009)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              CG7843 is required for siRNA- and endogenous siRNA-mediated silencing and is required upstream of RISC.

              (Sabin et al., 2009)

              CG7843 is required for miRNA-mediated silencing, upstream of pre-miRNA production. It may have a role in stabilising primary miRNA transcripts.

              (Sabin et al., 2009)

              Area matching Drosophila EST AA536378.

              (Davies, 2001.3.15)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: CG7843 anon-WO0118547.166

              (FlyBase, 1996-)
              Additional comments

              Source for merge of CG7843 anon-WO0118547.166 was sequence comparison ( date:041117 ).

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of

              Source for identity of: Ars2 CG7843

              (Sabin et al., 2009)
              Nomenclature comments
              Etymology

              Named "Ars2" after its homolog in mammalia.

              (Sabin et al., 2009)
              Synonyms and Secondary IDs (5)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 66 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (91)