FlyBase Gene Report: Dmel\GstE14

General Information

Symbol

Dmel\GstE14

Species

D. melanogaster

Name

Glutathione S transferase E14

Annotation Symbol

CG4688

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033817

Gene Model Status

Current

Stock Availability

6 publicly available

Enzyme Name (EC)

glutathione transferase (2.5.1.18)

steroid Delta-isomerase (5.3.3.1)

Gene Summary

Glutathione S transferase E14 (GstE14) encodes an essential protein for ecdysone biosynthesis. It is thought to play a crucial role in regulating cholesterol intake and/or transport in the steroidogenic cells. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

nobo

Key Links

Genomic Location

Cytogenetic map

49F12-49F12

Sequence location

2R:13,239,729..13,241,013 [+]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13239729..13241013

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables glutathione transferase activity

inferred from direct assay

(Koiwai et al., 2020, Saisawang et al., 2012)

enables steroid Delta-isomerase activity

inferred from direct assay

(Škerlová et al., 2020)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables glutathione transferase activity

inferred from biological aspect of ancestor with PANTHER:PTN001679864

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in cholesterol homeostasis

inferred from mutant phenotype

(Chanut-Delalande et al., 2014, Enya et al., 2014)

involved_in ecdysteroid biosynthetic process

inferred from mutant phenotype

(Enya et al., 2014)

involved_in glutathione metabolic process

inferred from direct assay

(Koiwai et al., 2020, Saisawang et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in glutathione metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN001679864

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from sequence or structural similarity with RGD:70952

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

SOLUBLE GLUTATHIONE S-TRANSFERASES

INTRAMOLECULAR OXIDOREDUCTASES TRANSPOSING C-C DOUBLE BONDS

Protein Family (UniProt)

Belongs to the GST superfamily. Epsilon family. (Q7JYX0)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

glutathione transferase activity

RX + glutathione = an S-substituted glutathione + a halide anion + H(+) (2.5.1.18)

RHEA 16437: steroid Delta-isomerase activity

a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid (5.3.3.1)

RHEA 14709:

Summaries

Gene Snapshot

Gene Group (FlyBase)

SOLUBLE GLUTATHIONE S-TRANSFERASES -: Glutathione transferases (glutathione S-transferases, GST) catalyze nucleophilic attack by reduced glutathione on nonpolar compounds that contain an electrophilic carbon, nitrogen, or sulfur atom. At least 14 classes of soluble GSTs have been identified in prokaryotes and eukaryotes: Theta, Omega, Sigma and Zeta exist in all eukaryotes. D. melanogaster has two additional classes, Delta and Epsilon. In D. mel, the class is indicated by the letter after the Gst prefix. (Adapted from FBrf0217315 and PMID:15822171).
INTRAMOLECULAR OXIDOREDUCTASES TRANSPOSING C-C DOUBLE BONDS -: Intramolecular oxidoreductases transposing C-C double bonds catalyze the oxidation of one part of a molecule and the concurrent reduction of another part of the same molecule, and one or more carbon-carbon double bonds in the molecule are rearranged. (Adapted from FBrf0238665.)

Protein Function (UniProtKB)

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25300303, PubMed:25344753). May be involved in detoxification (PubMed:22082028).

(UniProt, Q7JYX0)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\GstE14 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7JYX0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

GstE14-RA

FBtr0087744

NM_137011

1008

232

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

GstE14-PA

FBpp0086857

26.6

232

5.33

Q7JYX0

NP_610855

AAF58397

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7JYX0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GstE14 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

GstE14_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.76

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11

amnioserosa

(Enya et al., 2014)

embryonic stage 16

prothoracic gland

(Enya et al., 2014)

wandering third instar larval stage

prothoracic gland

(Enya et al., 2014)

oogenesis stage S8

follicle cell

(Enya et al., 2014)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

ring gland

(Enya et al., 2014)

adult stage | female

ovary

(Enya et al., 2014)

Additional Descriptive Data

GstE14 transcripts are detected by rt-pcr in the ring gland and in the ovary but not in other tissues tested. In an embryonic developmental profile, maximal levels are observed in embryonic stages 5-10 (2-6 hours after egg laying). In embryos, transcripts are detected by in situ hybridization in the blastoderm with a ventral bias. As cellularization proceeds, expression is observed nearly ubiquitously in the epidermal cells. Epression is observed in the amnioseros at stage 11 and in PG (prothoracic gland) cells at stage 16. GstE14 transcripts are also found in PG cells in wandering third instar larvae and in follicle cells of stage 8 egg chambers

(Enya et al., 2014)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\GstE14 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\GstE14

View exonic expression by tissue for Dmel\GstE14

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36467/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033817

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033817

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033817

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4688

Flygut - An atlas of the Drosophila adult midgut

FBgn0033817

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of GstE14

Transgenic constructs containing regulatory region of GstE14

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel7124

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage, with Scer\GAL4^phtm.PO

lethal - all die during embryonic stage | recessive

GstE14^KO

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

GstE14^GD10522

viable, with Scer\GAL4^Mef2.PR

GstE14^GD10522

viable, with Scer\GAL4^pnr-MD237

GstE14^GD10522

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (18)

Hsap\GSTT2B

6 of 14

Yes

5 of 14

5 of 14

5 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\MARS1

1 of 14

Hsap\VARS1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (24)

Rnor\Gstt1

6 of 14

Yes

Rnor\Gstt3

6 of 14

Yes

Rnor\Gstt4

6 of 14

Yes

5 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Mars1

1 of 14

Rnor\Vars1

1 of 14

Mus musculus (laboratory mouse) (19)

Mmus\Gstt1

5 of 14

Yes

Mmus\Gstt2

5 of 14

Yes

Mmus\Gstt3

5 of 14

Yes

Mmus\Gstt4

5 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\gstt1-like.2

4 of 13

Yes

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (14)

Drer\gstt1b

6 of 14

Yes

5 of 14

4 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (44)

Cele\gst-24

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (35)

Agam\GSTU4

12 of 12

Yes

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

4 of 12

4 of 12

4 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (55)

Atha\ATGSTF13

8 of 13

Yes

Atha\GSTF2

8 of 13

Yes

Atha\GSTF3

8 of 13

Yes

Atha\GSTF5

8 of 13

Yes

Atha\GSTF6

8 of 13

Yes

Atha\GSTF7

8 of 13

Yes

Atha\GSTF12

8 of 13

Yes

7 of 13

7 of 13

7 of 13

7 of 13

7 of 13

Yes

7 of 13

5 of 13

5 of 13

5 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (6)

Scer\URE2

5 of 13

Yes

Scer\GTT2

4 of 13

Scer\CAM1

2 of 13

Scer\GTT1

1 of 13

Yes

Scer\TEF4

1 of 13

Scer\YGR201C

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\gst1

6 of 12

Yes

Spom\gst2

6 of 12

Yes

Spom\gst3

2 of 12

Yes

Spom\SPAC29A4.02c

1 of 12

Spom\SPCC1183.02

1 of 12

Escherichia coli (enterobacterium) (9)

Ecol\yfcG

5 of 11

Yes

Ecol\yghU

5 of 11

Yes

4 of 11

4 of 11

2 of 11

1 of 11

Yes

Ecol\gstA

1 of 11

Ecol\yibF

1 of 11

Ecol\yncG

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:GstE14. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (40)

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

8 of 13

5 of 13

5 of 13

5 of 13

5 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GSTT2B; glutathione S-transferase theta 2B

6 of 14

GSTT1; glutathione S-transferase theta 1

5 of 14

600436

GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)

5 of 14

600437

GSTT4; glutathione S-transferase theta 4

5 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

GstE14

x-ray crystallography, molecular sieving, molecular weight estimation by staining

(Koiwai et al., 2020, Škerlová et al., 2020)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0033817

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

49F12-49F12

Sequence location

2R:13,239,729..13,241,013 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49F12-49F12

Limits computationally determined from genome sequence between P{EP}Dp^EP358 and P{lacW}drk^k13809&P{EP}mip120^EP606

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-71.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

54836

y¹ v¹; P{TRiP.HMJ21555}attP40

NIG-Fly

4688R-2

P{NIG.4688R}2

HMJ21555

y¹ v¹; P{TRiP.HMJ21555}attP40/CyO

2RG-1000

y² VhaAC39-1^cho-1 v¹; P{U6-GstE14.NIG.sgRNA}attP40/CyO

VDRC

v101884

P{KK110122}VIE-260B

v44832

w¹¹¹⁸; P{GD10522}v44832

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH27559

Other clones

DPiM_RH27559

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033817

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

214223.33

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033817

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Enya et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: GstE14 CG4688

(Saisawang et al., 2012)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG4688

(National Institute of Genetics Fly Stocks, 2022-, Koiwai et al., 2020, Japanese National Institute of Genetics, 2012.5.21, Saisawang et al., 2012, Napoletano et al., 2011, Nagoshi et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Li et al., 2008, Low et al., 2007)

DmGSTE14

(Škerlová et al., 2020)

DmNobo

(Koiwai et al., 2020)

GSTE14

(Petiot et al., 2024, Schwartz et al., 2024, Mannervik et al., 2021, Saisawang and Ketterman, 2014)

GstE14

(Li et al., 2024, Salminen et al., 2024, Gonis et al., 2022, Sebastian et al., 2022, Baker et al., 2021, Brown et al., 2020, Mortensen et al., 2018, Zanet et al., 2016, Bischof and FlyORF project members, 2014.6.20, Chanut-Delalande et al., 2014)

Nobo

(Yuan et al., 2024, Kamiyama and Niwa, 2022)

gste14

(Saisawang et al., 2012)

nobo

(Christesen et al., 2017, Enya et al., 2017, Fujikawa et al., 2015, Enya et al., 2014)

Name Synonyms

Glutathione S transferase E14

Noppera-bo

(Niwa and Niwa, 2016)

noppera-bo

(Enya et al., 2014)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 60 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36467

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7JYX0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7JYX0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7JYX0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36467/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033817

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033817

FlyMine - An integrated database for Drosophila genomics

FBgn0033817

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4688

MARRVEL_MODEL - MARRVEL (model organism gene)

36467

PDB - An information portal to biological macromolecular structures

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033817

DroID - A comprehensive database of gene and protein interactions.

FBgn0033817

DRSC - Results frm RNAi screens

FBgn0033817

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

GstE14_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033817

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033817

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4688

Flygut - An atlas of the Drosophila adult midgut

FBgn0033817

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

References (62)

The following external sites may use different assemblies or annotations than FlyBase.

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