Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
5' UTR contains an ORF as described in Malzer et al (FBrf0221464); potential peptide 49 aa in length; initial methionine is conserved; an intact uORF represses Gadd34 translation except under conditions of ER stress (tunicamycin).
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PPP1R15 using the Feature Mapper tool.
PPP1R15 transcripts are abundant in the yolk sac at stage 5 suggesting a maternal contribution. During gastrulation, they are found in invaginating endoderm and the surrounding ectoderm. Strong signal is later observed in epidermis, brain, Malpighian tubule, and the primordia of the midgut and hindgut. At later stages of embryogenesis, signal is mainly observed in the CNS.
GBrowse - Visual display of RNA-Seq signalsView Dmel\PPP1R15 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
FlyBase Curator comment: Queried author Kampinga who said "The drosophila GADD34 we mention in our JBC paper is CG3825".
Named 'Gadd34' after its human ortholog.