FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\dgrn
Open Close
General Information
Symbol
Dmel\dgrn
Species
D. melanogaster
Name
degringolade
Annotation Symbol
CG10981
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037384
Gene Model Status
Current
Stock Availability
10 publicly available
Enzyme Name (EC)
Gene Summary
degringolade (dgrn) encodes a SUMO-Targeted ubiquitin ligase. During development it is required for Notch signaling and patterning. It contributes to transcriptional regulation, DNA repair, and cytoskeleton dynamics. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

STUbL

Key Links
Genomic Location
Cytogenetic map
83C4-83C4
Sequence location
Recombination map
3-47.5
RefSeq locus
NT_033777 REGION:5824615..5826576
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (21 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables RNA polymerase II-specific DNA-binding transcription factor binding
inferred from physical interaction with FLYBASE:hry; FB:FBgn0001168
(Abed et al., 2011)
enables SUMO binding
inferred from physical interaction with FLYBASE:Sumo; FB:FBgn0264922
(Abed et al., 2011)
enables ubiquitin protein ligase activity
inferred from direct assay
(Abed et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ubiquitin protein ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN001495439
(GO Reference Genome Project, 2011-)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
Biological Process (12 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in innate immune response
inferred from mutant phenotype
(Koltun et al., 2017)
involved_in neurogenesis
inferred from genetic interaction with FLYBASE:E(spl)m8-HLH; FB:FBgn0000591
(Barry et al., 2011)
involved_in positive regulation of antimicrobial peptide production
inferred from mutant phenotype
(Koltun et al., 2017)
involved_in positive regulation of DNA-templated transcription
inferred from direct assay
(Abed et al., 2011)
involved_in positive regulation of peptidoglycan recognition protein signaling pathway
inferred from genetic interaction with FLYBASE:PGRP-LC; FB:FBgn0035976
(Koltun et al., 2017)
involved_in positive regulation of Toll signaling pathway
inferred from genetic interaction with FLYBASE:cact; FB:FBgn0000250,FLYBASE:Tl; FB:FBgn0262473
(Koltun et al., 2017)
involved_in protein ubiquitination
inferred from direct assay
(Abed et al., 2011)
involved_in regulation of embryonic development
inferred from mutant phenotype
(Barry et al., 2011)
involved_in regulation of establishment of protein localization
inferred from direct assay
(Abed et al., 2011)
involved_in sex determination
inferred from mutant phenotype
(Barry et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001495439
(GO Reference Genome Project, 2011-)
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN001495439
(GO Reference Genome Project, 2011-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Barry et al., 2011)
located_in nuclear periphery
inferred from direct assay
(Ryu et al., 2015)
located_in nucleus
inferred from direct assay
(Barry et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
colocalizes_with PML body
inferred from biological aspect of ancestor with PANTHER:PTN001495439
(GO Reference Genome Project, 2011-)
part_of SUMO-targeted ubiquitin ligase complex
inferred by curator from GO:0032183,GO:0061630
(Abed et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
ubiquitin protein ligase activity
Summaries
Gene Snapshot
degringolade (dgrn) encodes a SUMO-Targeted ubiquitin ligase. During development it is required for Notch signaling and patterning. It contributes to transcriptional regulation, DNA repair, and cytoskeleton dynamics. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES -
This group comprises RING domain ubiquitin ligases that do not classify under other groups in FlyBase.
Pathway (FlyBase)
POSITIVE REGULATORS OF TOLL-NF-kappaB SIGNALING PATHWAY -
In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. Positive regulators of Toll-NF-κB Signaling lead to the increased nuclear accumulation of the NF-κB proteins and regulated expression of target genes. (Adapted from FBrf0091014 and FBrf0223077).
POSITIVE REGULATORS OF IMD SIGNALING PATHWAY -
Positive regulators of the immune deficiency (Imd) pathway result in the increased activity of the NFκB-like transcription factor Rel in the nucleus. (Adapted from FBrf0224587 and FBrf0238555.)
Summary (Interactive Fly)

SUMO-targeted ubiquitin ligase that acts as a negative regulator of the repressor Hairy and its corepressor Groucho during embryonic segmentation and neurogenesis - acts as a regulator in sex determination by interfering with the repressive activities of Deadpan and Groucho

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\dgrn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VNJ0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.53

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dgrn-RA
FBtr0078638
NM_141339
1632
319
dgrn-RB
FBtr0078639
NM_169112
1611
312
dgrn-RD
FBtr0344116
NM_001300259
1635
205
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
dgrn-PA
FBpp0078287
35.2
319
5.01
Q9VNJ0
NP_649596
AAF51944
dgrn-PB
FBpp0078288
34.4
312
5.12
Q8I0J6
NP_731017
AAN14328
dgrn-PD
FBpp0310533
23.4
205
7.95
A0A0B4LHT4
NP_001287188
AHN57187
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dgrn using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.96

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 9 -- 10
germline cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
germline cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
germline cell
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Barry et al., 2011)
adult stage | female
ovary
(Barry et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Barry et al., 2011)
Additional Descriptive Data

dgrn protein is observed in the cytoplasm in early embryos. It is also observed in the nucleus at specific stages, including nuclear cycles 5, 9, 12, and 14A. Following cellularization, expression is predominantly cytoplasmic but some nuclear accumulation is seen, for example in neuroblasts.

(Barry et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Barry et al., 2011)
located_in nuclear periphery
inferred from direct assay
(Ryu et al., 2015)
located_in nucleus
inferred from direct assay
(Barry et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dgrn in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dgrn
Transgenic constructs containing regulatory region of dgrn
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (62)
Hsap\RNF4
9 of 14
Yes
Yes
Hsap\BRCA1
2 of 14
No
Yes
Hsap\AMFR
1 of 14
No
No
Hsap\BFAR
1 of 14
No
No
Hsap\CBLC
1 of 14
No
No
1  
Hsap\COP1
1 of 14
No
Yes
Hsap\HLTF
1 of 14
No
No
Hsap\LNX2
1 of 14
No
No
Hsap\LONRF1
1 of 14
No
No
Hsap\LONRF2
1 of 14
No
No
Hsap\LONRF3
1 of 14
No
No
Hsap\LRSAM1
1 of 14
No
Yes
1  
Hsap\MID1
1 of 14
No
No
Hsap\MID2
1 of 14
No
No
Hsap\PEX10
1 of 14
No
No
1  
Hsap\RFWD3
1 of 14
No
No
Hsap\RNF2
1 of 14
No
No
Hsap\RNF5
1 of 14
No
No
1  
Hsap\RNF8
1 of 14
No
Yes
Hsap\RNF20
1 of 14
No
No
Hsap\RNF38
1 of 14
No
No
Hsap\RNF40
1 of 14
No
No
1  
Hsap\RNF44
1 of 14
No
No
Hsap\RNF113A
1 of 14
No
No
2  
Hsap\RNF114
1 of 14
No
Yes
Hsap\RNF125
1 of 14
No
No
Hsap\RNF128
1 of 14
No
No
Hsap\RNF130
1 of 14
No
No
Hsap\RNF138
1 of 14
No
Yes
1  
Hsap\RNF145
1 of 14
No
No
Hsap\RNF149
1 of 14
No
No
Hsap\RNF150
1 of 14
No
No
1  
Hsap\RNF151
1 of 14
No
No
Hsap\RNF165
1 of 14
No
No
Hsap\RNF166
1 of 14
No
Yes
Hsap\RNF167
1 of 14
No
No
Hsap\RNF168
1 of 14
No
No
Hsap\RNF170
1 of 14
No
Yes
Hsap\RNF180
1 of 14
No
Yes
Hsap\RNF185
1 of 14
No
No
2  
Hsap\RNF215
1 of 14
No
No
Hsap\RNFT1
1 of 14
No
No
Hsap\RNFT2
1 of 14
No
No
Hsap\SYVN1
1 of 14
No
No
4  
Hsap\TOPORS
1 of 14
No
No
Hsap\TRAF6
1 of 14
No
No
Hsap\TRIM3
1 of 14
No
No
Hsap\TRIM6
1 of 14
No
Yes
Hsap\TRIM7
1 of 14
No
Yes
Hsap\TRIM17
1 of 14
No
Yes
Hsap\TRIM21
1 of 14
No
Yes
Hsap\TRIM26
1 of 14
No
Yes
Hsap\TRIM31
1 of 14
No
Yes
Hsap\TRIM35
1 of 14
No
Yes
Hsap\TRIM39
1 of 14
No
Yes
Hsap\TRIM50
1 of 14
No
Yes
Hsap\TRIM58
1 of 14
No
Yes
Hsap\TRIM60
1 of 14
No
Yes
Hsap\TRIM68
1 of 14
No
No
Hsap\TRIM69
1 of 14
No
Yes
Hsap\TRIM75P
1 of 14
No
Yes
Hsap\ZNRF4
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (26)
Rnor\Rnf4
10 of 14
Yes
Yes
Rnor\Brca1
2 of 14
No
Yes
Rnor\Cop1
1 of 14
No
Yes
Rnor\Lnx2
1 of 14
No
No
Rnor\Lonrf1
1 of 14
No
No
Rnor\Lonrf2
1 of 14
No
No
Rnor\Lonrf3
1 of 14
No
No
Rnor\Pex10
1 of 14
No
No
Rnor\Rnf20
1 of 14
No
No
Rnor\Rnf103
1 of 14
No
Yes
Rnor\Rnf114
1 of 14
No
Yes
Rnor\Rnf115
1 of 14
No
No
Rnor\Rnf125
1 of 14
No
Yes
Rnor\Rnf166
1 of 14
No
Yes
Rnor\Rnf170
1 of 14
No
Yes
Rnor\Rnf181
1 of 14
No
No
Rnor\Rnf220
1 of 14
No
No
Rnor\Rnft1
1 of 14
No
No
Rnor\Syvn1
1 of 14
No
No
Rnor\Topors
1 of 14
No
No
Rnor\Traf6
1 of 14
No
No
Rnor\Trim17
1 of 14
No
Yes
Rnor\Trim21
1 of 14
No
Yes
Rnor\Trim26
1 of 14
No
Yes
Rnor\Trim35
1 of 14
No
Yes
Rnor\Trim80
1 of 14
No
Yes
Mus musculus (laboratory mouse) (25)
Mmus\Rnf4
9 of 14
Yes
Yes
Mmus\Brca1
2 of 14
No
Yes
Mmus\Cop1
1 of 14
No
Yes
Mmus\Lnx2
1 of 14
No
No
Mmus\Lonrf1
1 of 14
No
No
Mmus\Lonrf2
1 of 14
No
No
Mmus\Lonrf3
1 of 14
No
No
Mmus\Pex10
1 of 14
No
No
Mmus\Rfwd3
1 of 14
No
No
Mmus\Rnf20
1 of 14
No
No
Mmus\Rnf103
1 of 14
No
Yes
Mmus\Rnf114
1 of 14
No
Yes
Mmus\Rnf115
1 of 14
No
No
Mmus\Rnf125
1 of 14
No
Yes
Mmus\Rnf166
1 of 14
No
Yes
Mmus\Rnf170
1 of 14
No
Yes
Mmus\Rnf181
1 of 14
No
No
Mmus\Rnf185
1 of 14
No
No
Mmus\Syvn1
1 of 14
No
No
Mmus\Topors
1 of 14
No
No
Mmus\Trim17
1 of 14
No
Yes
Mmus\Trim21
1 of 14
No
Yes
Mmus\Trim26
1 of 14
No
No
Mmus\Trim35
1 of 14
No
Yes
Mmus\Trim80
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (36)
Xtro\rnf4
8 of 13
Yes
Yes
Xtro\brca1
1 of 13
No
Yes
Xtro\cdpf1
1 of 13
No
No
Xtro\chmp3
1 of 13
No
No
Xtro\cox15
1 of 13
No
No
Xtro\dtx3
1 of 13
No
Yes
Xtro\lnx2
1 of 13
No
No
Xtro\LOC100485004
1 of 13
No
No
Xtro\LOC100485658
1 of 13
No
Yes
Xtro\LOC100489639
1 of 13
No
No
Xtro\LOC100494722
1 of 13
No
No
Xtro\LOC100495443
1 of 13
No
No
Xtro\LOC105947078
1 of 13
No
No
Xtro\lonrf2
1 of 13
No
No
Xtro\lonrf3
1 of 13
No
No
Xtro\pcgf3
1 of 13
No
No
Xtro\pex10
1 of 13
No
No
Xtro\rnf20
1 of 13
No
No
Xtro\rnf32
1 of 13
No
Yes
Xtro\rnf40
1 of 13
No
No
Xtro\rnf43
1 of 13
No
No
Xtro\rnf44
1 of 13
No
No
Xtro\rnf112.1
1 of 13
No
No
Xtro\rnf150
1 of 13
No
No
Xtro\rnf151
1 of 13
No
No
Xtro\rnf170
1 of 13
No
Yes
Xtro\rnft1
1 of 13
No
No
Xtro\syvn1
1 of 13
No
No
Xtro\topors
1 of 13
No
No
Xtro\traf6
1 of 13
No
No
Xtro\trim69.1
1 of 13
No
No
Xtro\trim69.2
1 of 13
No
No
Xtro\XB5729975
1 of 13
No
No
Xtro\XB5759442
1 of 13
No
No
Xtro\XB5786944
1 of 13
No
No
Xtro\xnf7
1 of 13
No
No
Danio rerio (Zebrafish) (40)
Drer\rnf4
9 of 14
Yes
Yes
Drer\amfra
1 of 14
No
No
Drer\amfrb
1 of 14
No
No
Drer\btr04
1 of 14
No
Yes
Drer\btr12
1 of 14
No
No
Drer\btr16
1 of 14
No
Yes
Drer\btr21
1 of 14
No
Yes
Drer\btr24
1 of 14
No
No
Drer\btr25
1 of 14
No
Yes
Drer\cop1
1 of 14
No
Yes
Drer\ftr41
1 of 14
No
No
Drer\ftr43
1 of 14
No
No
Drer\ftr50
1 of 14
No
No
Drer\ftr58
1 of 14
No
Yes
Drer\ftr81
1 of 14
No
Yes
Drer\hltf
1 of 14
No
No
Drer\irgf4
1 of 14
No
Yes
Drer\lnx2b
1 of 14
No
No
Drer\lonrf1
1 of 14
No
No
Drer\lonrf1l
1 of 14
No
No
Drer\pex10
1 of 14
No
No
Drer\pja2
1 of 14
No
No
Drer\rfwd3
1 of 14
No
No
Drer\rnf2
1 of 14
No
No
Drer\rnf8
1 of 14
No
Yes
Drer\rnf151
1 of 14
No
No
Drer\rnf166
1 of 14
No
Yes
Drer\rnf168
1 of 14
No
Yes
Drer\rnf213a
1 of 14
No
Yes
Drer\rnft1
1 of 14
No
No
Drer\rnft2
1 of 14
No
No
Drer\shprh
1 of 14
No
No
Drer\si:ch1073-440b2.1
1 of 14
No
No
Drer\si:dkey-183n20.15
1 of 14
No
Yes
Drer\toporsa
1 of 14
No
No
Drer\traf6
1 of 14
No
No
Drer\trim35-14
1 of 14
No
Yes
Drer\trim35-40
1 of 14
No
Yes
Drer\trim69
1 of 14
No
Yes
Drer\zgc:173581
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\C26B9.6
1 of 14
Yes
No
Cele\C55A6.1
1 of 14
Yes
No
Cele\nhl-1
1 of 14
Yes
No
Cele\prx-12
1 of 14
Yes
No
Cele\rnf-5
1 of 14
Yes
No
Cele\sli-1
1 of 14
Yes
No
Cele\T02C1.2
1 of 14
Yes
Yes
Cele\toe-4
1 of 14
Yes
No
Cele\Y4C6A.3
1 of 14
Yes
No
Cele\Y38F1A.2
1 of 14
Yes
Yes
Cele\Y47G6A.31
1 of 14
Yes
No
Cele\ZC13.1
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (21)
Agam\AgaP_AGAP007458
6 of 12
Yes
No
Agam\AgaP_AGAP000928
1 of 12
No
No
Agam\AgaP_AGAP002028
1 of 12
No
No
Agam\AgaP_AGAP002073
1 of 12
No
No
Agam\AgaP_AGAP003004
1 of 12
No
No
Agam\AgaP_AGAP003179
1 of 12
No
No
Agam\AgaP_AGAP003558
1 of 12
No
Yes
Agam\AgaP_AGAP003666
1 of 12
No
No
Agam\AgaP_AGAP004640
1 of 12
No
No
Agam\AgaP_AGAP005449
1 of 12
No
No
Agam\AgaP_AGAP005643
1 of 12
No
No
Agam\AgaP_AGAP006041
1 of 12
No
No
Agam\AgaP_AGAP006367
1 of 12
No
No
Agam\AgaP_AGAP006900
1 of 12
No
No
Agam\AgaP_AGAP007335
1 of 12
No
No
Agam\AgaP_AGAP009902
1 of 12
No
No
Agam\AgaP_AGAP010697
1 of 12
No
No
Agam\AgaP_AGAP013215
1 of 12
No
Yes
Agam\AgaP_AGAP013233
1 of 12
No
No
Agam\AgaP_AGAP013357
1 of 12
No
No
Agam\AgaP_AGAP013371
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (85)
Atha\AT3G07200
8 of 13
Yes
Yes
Atha\AT5G48655
8 of 13
Yes
Yes
Atha\AT1G04360
1 of 13
No
No
Atha\AT1G11100
1 of 13
No
No
Atha\AT1G18660
1 of 13
No
No
Atha\AT1G18760
1 of 13
No
No
Atha\AT1G18770
1 of 13
No
No
Atha\AT1G18780
1 of 13
No
No
Atha\AT1G19310
1 of 13
No
No
Atha\AT1G20823
1 of 13
No
No
Atha\AT1G21960
1 of 13
No
No
Atha\AT1G23980
1 of 13
No
No
Atha\AT1G26800
1 of 13
No
No
Atha\AT1G36950
1 of 13
No
Yes
Atha\AT1G49230
1 of 13
No
No
Atha\AT1G49850
1 of 13
No
No
Atha\AT1G53010
1 of 13
No
No
Atha\AT1G69085
1 of 13
No
No
Atha\AT1G72200
1 of 13
No
No
Atha\AT1G74620
1 of 13
No
Yes
Atha\AT1G74990
1 of 13
No
No
Atha\AT2G20030
1 of 13
No
No
Atha\AT2G23780
1 of 13
No
No
Atha\AT2G27940
1 of 13
No
No
Atha\AT2G29840
1 of 13
No
No
Atha\AT2G35910
1 of 13
No
No
Atha\AT2G38970
1 of 13
No
No
Atha\AT2G39100
1 of 13
No
No
Atha\AT2G42030
1 of 13
No
No
Atha\AT2G44410
1 of 13
No
No
Atha\AT2G44578
1 of 13
No
Yes
Atha\AT2G46495
1 of 13
No
Yes
Atha\AT3G05250
1 of 13
No
No
Atha\AT3G07120
1 of 13
No
Yes
Atha\AT3G13228
1 of 13
No
No
Atha\AT3G18773
1 of 13
No
No
Atha\AT3G20010
1 of 13
No
No
Atha\AT3G20395
1 of 13
No
Yes
Atha\AT3G26730
1 of 13
No
No
Atha\AT3G27330
1 of 13
No
No
Atha\AT3G54780
1 of 13
No
Yes
Atha\AT3G58030
1 of 13
No
No
Atha\AT3G58720
1 of 13
No
No
Atha\AT3G61180
1 of 13
No
Yes
Atha\AT4G03965
1 of 13
No
Yes
Atha\AT4G09100
1 of 13
No
No
Atha\AT4G12140
1 of 13
No
No
Atha\AT4G13490
1 of 13
No
Yes
Atha\AT4G26400
1 of 13
No
No
Atha\AT5G03450
1 of 13
No
No
Atha\AT5G05130
1 of 13
No
No
Atha\AT5G08139
1 of 13
No
No
Atha\AT5G10650
1 of 13
No
No
Atha\AT5G17600
1 of 13
No
No
Atha\AT5G37250
1 of 13
No
No
Atha\AT5G41350
1 of 13
No
No
Atha\AT5G41450
1 of 13
No
No
Atha\AT5G43420
1 of 13
No
No
Atha\AT5G43530
1 of 13
No
No
Atha\AT5G52140
1 of 13
No
No
Atha\AT5G53910
1 of 13
No
Yes
Atha\AT5G54990
1 of 13
No
Yes
Atha\ATL3
1 of 13
No
No
Atha\ATL8
1 of 13
No
No
Atha\ATL9
1 of 13
No
No
Atha\BB
1 of 13
No
No
Atha\BRCA1
1 of 13
No
Yes
Atha\COP1
1 of 13
No
No
Atha\EDA16
1 of 13
No
No
Atha\Hrd1A
1 of 13
No
No
Atha\HUB1
1 of 13
No
No
Atha\MBR2
1 of 13
No
No
Atha\PEX10
1 of 13
No
No
Atha\PEX12
1 of 13
No
No
Atha\PUB8
1 of 13
No
Yes
Atha\RAD5
1 of 13
No
No
Atha\RGLG3
1 of 13
No
Yes
Atha\RHA3A
1 of 13
No
No
Atha\RMA1
1 of 13
No
No
Atha\RMA2
1 of 13
No
No
Atha\RMA3
1 of 13
No
No
Atha\SDIR1
1 of 13
No
No
Atha\VIM2
1 of 13
No
Yes
Atha\VIM4
1 of 13
No
Yes
Atha\XBAT35
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\IRC20
1 of 13
Yes
No
Scer\MAG2
1 of 13
Yes
No
Scer\PSH1
1 of 13
Yes
Yes
Scer\RAD5
1 of 13
Yes
No
Scer\RAD18
1 of 13
Yes
Yes
Scer\SLX8
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (7)
Spom\rfp2
5 of 12
Yes
Yes
Spom\slx8
2 of 12
No
No
Spom\SPCC548.05c
2 of 12
No
No
Spom\brl2
1 of 12
No
No
Spom\pas4
1 of 12
No
No
Spom\rfp1
1 of 12
No
Yes
Spom\SPBC2A9.04c
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:dgrn. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (25)
CG43058
7 of 13
elfless
6 of 13
CG44271
4 of 13
CG13481
2 of 13
CG14983
2 of 13
CG17329
2 of 13
CG31807
2 of 13
CG33552
2 of 13
Bre1
1 of 13
Cbl
1 of 13
CG8141
1 of 13
CG10916
1 of 13
CG13605
1 of 13
CG32369
1 of 13
CG32847
1 of 13
CG34308
1 of 13
mura
1 of 13
mus302
1 of 13
nopo
1 of 13
Rnf146
1 of 13
Sce
1 of 13
sip3
1 of 13
sordd1
1 of 13
sordd2
1 of 13
Traf6
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RNF4; ring finger protein 4
    9 of 14
    602850
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        dgrn - CG10681
        two hybrid
        (Hu et al., 2017.6.13)
        dgrn - CG7824
        two hybrid
        (Hu et al., 2017.6.13)
        dgrn - CG8851
        two hybrid
        (Hu et al., 2017.6.13)
        dgrn - E(spl)m3-HLH
        pull down, autoradiography
        (Barry et al., 2011)
        dgrn - E(spl)m5-HLH
        pull down, autoradiography
        (Barry et al., 2011)
        dgrn - E(spl)m7-HLH
        pull down, autoradiography
        (Barry et al., 2011)
        dgrn - E(spl)m8-HLH
        pull down, autoradiography
        (Barry et al., 2011)
        dgrn - E(spl)mβ-HLH
        pull down, autoradiography
        (Barry et al., 2011)
        dgrn - E(spl)mγ-HLH
        pull down, autoradiography
        (Barry et al., 2011)
        dgrn - E(spl)mδ-HLH
        pull down, autoradiography
        (Barry et al., 2011)
        dgrn - Gsc
        two hybrid
        (Hu et al., 2017.6.13)
        dgrn - Hey
        pull down, autoradiography
        (Barry et al., 2011)
        dgrn - Odj
        two hybrid
        (Hu et al., 2017.6.13)
        dgrn - Rad60
        coimmunoprecipitation, anti tag western blot
        (Ryu et al., 2015)
        dgrn - SMC5
        coimmunoprecipitation, western blot
        (Ryu et al., 2015)
        dgrn - SMC6
        coimmunoprecipitation, western blot
        (Ryu et al., 2015)
        dgrn - Sas-6
        two hybrid
        (Hu et al., 2017.6.13)
        dgrn - Sumo
        pull down, anti tag western blot
        (Abed et al., 2011)
        dgrn - Tm1
        two hybrid
        (Hu et al., 2017.6.13)
        dgrn - dpn
        pull down, autoradiography
        (Barry et al., 2011)
        dgrn - gdrd
        two hybrid
        (Hu et al., 2017.6.13)
        dgrn - hry
        pull down, anti tag western blot, autoradiography, two hybrid, enzymatic study
        (Abed et al., 2011, Barry et al., 2011)
        dgrn - lwr
        two hybrid
        (Hu et al., 2017.6.13)
        dgrn - side
        pull down, autoradiography
        (Barry et al., 2011)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        cindr
        enhanceable
        dgrn
        (Ketosugbo et al., 2017)
        gro
        suppressible
        dgrn
        (Abed et al., 2011)
        hry
        suppressible
        dgrn
        (Abed et al., 2011)
        N
        suppressible
        dgrn
        (Barry et al., 2011)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-47.5
        Cytogenetic map
        83C4-83C4
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        83C4-83C4
        Limits computationally determined from genome sequence between P{lacW}casj1C2 and P{PZ}lab01241
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-47.5

        (FlyBase, 2016)

        3-44.1

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (10)
        Genomic Clones (20)
        cDNA Clones (35)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Barry et al., 2011)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments
            Relationship to Other Genes
            Source for database merge of
            Additional comments
            Nomenclature History
            Source for database identify of

            Source for identity of: dgrn CG10981

            (Abed et al., 2011)
            Nomenclature comments
            Etymology

            The gene is named "degringolade", meaning 'to deteriorate rapidly'.

            (Barry et al., 2011)
            Synonyms and Secondary IDs (6)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 50 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (45)