FB2025_05 , released December 11, 2025
Gene: Dmel\Arl8
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General Information
Symbol
Dmel\Arl8
Species
D. melanogaster
Name
ADP ribosylation factor-like 8
Annotation Symbol
CG7891
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037551
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion (PubMed:16537643, PubMed:29940804, PubMed:30115618). Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes (PubMed:29940804). In larval motor neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30115618, PubMed:30174114). Acts downstream of Rab2 during presynaptic precursor vesicle biogenesis (PubMed:33822845). Essential role in chromosome segregation (PubMed:15331635). (UniProt, Q9VHV5)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Gie, GTPase indispensable for equal segregation of chromosomes

Key Links
Genomic Location
Cytogenetic map
84E13-84E13
Sequence location
Recombination map
3-48
RefSeq locus
NT_033777 REGION:8126605..8129835
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (26 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:O76878
(Rosa-Ferreira et al., 2018)
inferred from physical interaction with UniProtKB:A1ZAJ2
(Vukoja et al., 2018)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables alpha-tubulin binding
inferred from sequence or structural similarity with UniProtKB:Q9NVJ2
(Okai et al., 2004)
enables beta-tubulin binding
inferred from sequence or structural similarity with UniProtKB:Q9NVJ2
(Okai et al., 2004)
enables GDP binding
inferred from sequence or structural similarity with UniProtKB:Q9NVJ2
(Okai et al., 2004)
enables GTP binding
inferred from sequence or structural similarity with UniProtKB:Q9NVJ2
(Okai et al., 2004)
inferred from electronic annotation with InterPro:IPR005225, InterPro:IPR006689, InterPro:IPR044154
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from electronic annotation with InterPro:IPR006689, InterPro:IPR044154
(InterPro Project Members, 2004-)
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in anterograde axonal transport
inferred from mutant phenotype
(Vukoja et al., 2018)
involved_in autophagosome-lysosome fusion
inferred from mutant phenotype
(Boda et al., 2019)
involved_in axonal transport
inferred from mutant phenotype
(Rosa-Ferreira et al., 2018)
involved_in late endosome to lysosome transport
inferred from mutant phenotype
(Rosa-Ferreira et al., 2018)
involved_in lysosome localization
inferred from mutant phenotype
(Boda et al., 2019)
involved_in neurotransmitter secretion
inferred from mutant phenotype
(Vukoja et al., 2018)
involved_in presynapse assembly
inferred from mutant phenotype
(Vukoja et al., 2018)
involved_in response to hypoxia
inferred from mutant phenotype
(Jha et al., 2016)
involved_in sister chromatid segregation
inferred from mutant phenotype
(Okai et al., 2004)
inferred from mutant phenotype
(Secombe and Parkhurst, 2004)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in anterograde axonal transport
inferred from biological aspect of ancestor with PANTHER:PTN000918485
(GO Reference Genome Project, 2011-)
involved_in protein transport
inferred from electronic annotation with InterPro:IPR044154
(InterPro Project Members, 2004-)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Rosa-Ferreira et al., 2018, Vukoja et al., 2018)
located_in cytoplasmic side of lysosomal membrane
inferred from direct assay
(Hofmann and Munro, 2006)
located_in lysosomal membrane
inferred from direct assay
(Rosa-Ferreira et al., 2018, Vukoja et al., 2018)
located_in lysosome
inferred from direct assay
(Boda et al., 2019, Hofmann and Munro, 2006)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Rosa-Ferreira et al., 2018)
located_in S bouton
inferred from direct assay
(Rosa-Ferreira et al., 2018)
located_in synapse
inferred from direct assay
(Vukoja et al., 2018)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from sequence or structural similarity with UniProtKB:Q9NVJ2
(Okai et al., 2004)
is_active_in lysosomal membrane
inferred from biological aspect of ancestor with PANTHER:PTN000195171
(GO Reference Genome Project, 2011-)
located_in midbody
inferred from sequence or structural similarity with UniProtKB:Q9NVJ2
(Okai et al., 2004)
located_in spindle midzone
inferred from sequence or structural similarity with UniProtKB:Q9NVJ2
(Okai et al., 2004)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Arf family. (Q9VHV5)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Group (FlyBase)
ARF GTPASES -
The ADP-Ribosylation Factor (Arf) family are members of the Ras superfamily of small GTPases. Arfs are involved in the regulation of vesicular trafficking mediating processes such as cargo-sorting, vesicle assembly and membrane fusion. (Adapted from PMID:15731001).
Protein Function (UniProtKB)
Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion (PubMed:16537643, PubMed:29940804, PubMed:30115618). Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes (PubMed:29940804). In larval motor neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30115618, PubMed:30174114). Acts downstream of Rab2 during presynaptic precursor vesicle biogenesis (PubMed:33822845). Essential role in chromosome segregation (PubMed:15331635).
(UniProt, Q9VHV5)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Arl8 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VHV5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Arl8-RA
FBtr0081794
NM_141512
916
186
Arl8-RB
FBtr0339723
NM_001300296
1241
186
Arl8-RC
FBtr0339724
NM_001300297
1901
186
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Arl8-PA
FBpp0081290
21.3
186
7.29
Q9VHV5
NP_649769
AAF54194
Arl8-PB
FBpp0308779
21.3
186
7.29
Q9VHV5
NP_001287225
AHN57224
Arl8-PC
FBpp0308780
21.3
186
7.29
Q9VHV5
NP_001287226
AHN57225
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

186 aa isoforms: Arl8-PA, Arl8-PB, Arl8-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with tubulin (PubMed:15331635). Interacts (in GTP-bound form) with Rilpl (PubMed:30115618). Interacts with unc-104 (PubMed:30174114).

(UniProt, Q9VHV5)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arl8 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.88

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Rosa-Ferreira et al., 2018, Vukoja et al., 2018)
located_in cytoplasmic side of lysosomal membrane
inferred from direct assay
(Hofmann and Munro, 2006)
located_in lysosomal membrane
inferred from direct assay
(Rosa-Ferreira et al., 2018, Vukoja et al., 2018)
located_in lysosome
inferred from direct assay
(Boda et al., 2019, Hofmann and Munro, 2006)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Rosa-Ferreira et al., 2018)
located_in S bouton
inferred from direct assay
(Rosa-Ferreira et al., 2018)
located_in synapse
inferred from direct assay
(Vukoja et al., 2018)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Arl8 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Arl8
Transgenic constructs containing regulatory region of Arl8
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)D7
(Rosa-Ferreira et al., 2018)
Inferred from location ( 9 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage
lethal - all die before end of pupal stage
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal size | larval stage
abnormal size | third instar larval stage (with Df(3R)BSC222)
abnormal stress response, with Scer\GAL4da.G32
decreased rate of adult locomotory behavior, with Scer\GAL4Ddc.PL
flightless, with Arl8e00336, Scer\GAL4Act5C.PU
flightless, with Arl8e00336, Scer\GAL4C164
flightless, with Arl8e00336, Scer\GAL4nSyb.PU
flightless, with Arl8UAS.GFP, Scer\GAL4Act5C.PU
flightless, with Arl8UAS.GFP, Scer\GAL4C164
flightless, with Arl8UAS.GFP, Scer\GAL4nSyb.PU
increased rate of adult locomotory behavior | progressive, with Scer\GAL4Ddc.PL
long lived, with Scer\GAL4Ddc.PL
paralytic | third instar larval stage
short lived, with Scer\GAL4Ddc.PL
some die during pupal stage, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
autolysosome | third instar larval stage
autophagosome | increased number | third instar larval stage
axon | larval stage
axon | larval stage (with Df(3R)BSC222)
dense core granule | decreased number | larval stage (with Df(3R)BSC222)
embryonic/larval garland cell | third instar larval stage, with Scer\GAL4pros.PMG
embryonic/larval garland cell | third instar larval stage (with Df(3R)BSC222)
fat cell | third instar larval stage
larval peripheral nervous system | larval stage (with Df(3R)BSC222)
larval somatic muscle cell | larval stage
late endosome | third instar larval stage, with Scer\GAL4pros.PMG
late endosome | third instar larval stage (with Df(3R)BSC222)
NMJ bouton | larval stage
synapse | larval stage
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (35)
Hsap\ARL8A
12 of 14
Yes
Yes
1  
Hsap\ARL8B
12 of 14
Yes
Yes
Hsap\ARF1
2 of 14
No
No
Hsap\ARF3
2 of 14
No
No
1  
Hsap\ARF4
2 of 14
No
No
Hsap\ARF5
2 of 14
No
No
1  
Hsap\ARF6
2 of 14
No
No
1  
Hsap\ARL1
2 of 14
No
No
Hsap\ARL5A
2 of 14
No
No
1  
Hsap\ARL5B
2 of 14
No
No
Hsap\ARL6
2 of 14
No
No
1  
Hsap\ARL15
2 of 14
No
No
Hsap\ARFRP1
1 of 14
No
No
Hsap\ARL2
1 of 14
No
No
Hsap\ARL3
1 of 14
No
No
Hsap\ARL4A
1 of 14
No
No
Hsap\ARL4C
1 of 14
No
No
1  
Hsap\ARL5C
1 of 14
No
No
Hsap\ARL11
1 of 14
No
No
Hsap\ARL13A
1 of 14
No
No
Hsap\ARL13B
1 of 14
No
No
Hsap\ARL14
1 of 14
No
No
Hsap\RAB4B
1 of 14
No
No
Hsap\RAB7A
1 of 14
No
No
5  
Hsap\RAB33B
1 of 14
No
No
Hsap\RAB44
1 of 14
No
No
Hsap\RAN
1 of 14
No
No
Hsap\RRAGA
1 of 14
No
No
Hsap\RRAGB
1 of 14
No
No
Hsap\RRAGC
1 of 14
No
No
1  
Hsap\RRAGD
1 of 14
No
No
1  
Hsap\SAR1A
1 of 14
No
No
Hsap\SAR1B
1 of 14
No
No
Hsap\SRPRB
1 of 14
No
No
Hsap\TRIM23
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (23)
Rnor\Arl8a
12 of 14
Yes
Yes
Rnor\Arl8b
11 of 14
No
Yes
Rnor\Arf1
2 of 14
No
No
Rnor\Arf2
2 of 14
No
No
Rnor\Arf3
2 of 14
No
No
Rnor\Arf6
2 of 14
No
No
Rnor\Arl1
2 of 14
No
No
Rnor\Arl5a
2 of 14
No
No
Rnor\Arl5b
2 of 14
No
No
Rnor\Arl6
2 of 14
No
No
Rnor\Arl15
2 of 14
No
No
Rnor\Arf4
1 of 14
No
No
Rnor\Arf5
1 of 14
No
No
Rnor\Arfrp1
1 of 14
No
No
Rnor\Arl2
1 of 14
No
No
Rnor\Arl3
1 of 14
No
No
Rnor\Arl4d
1 of 14
No
No
Rnor\Arl5c
1 of 14
No
No
Rnor\Arl11
1 of 14
No
No
Rnor\Arl13a
1 of 14
No
Yes
Rnor\Arl13b
1 of 14
No
No
Rnor\Arl14
1 of 14
No
No
Rnor\Srprb
1 of 14
No
No
Mus musculus (laboratory mouse) (24)
Mmus\Arl8b
12 of 14
Yes
Yes
Mmus\Arl8a
11 of 14
No
Yes
Mmus\Arf1
2 of 14
No
No
Mmus\Arf2
2 of 14
No
No
Mmus\Arf3
2 of 14
No
No
Mmus\Arf6
2 of 14
No
No
Mmus\Arl1
2 of 14
No
No
Mmus\Arl5a
2 of 14
No
No
Mmus\Arl5b
2 of 14
No
No
Mmus\Arl6
2 of 14
No
No
Mmus\Arl15
2 of 14
No
No
Mmus\Arf4
1 of 14
No
No
Mmus\Arf5
1 of 14
No
No
Mmus\Arfrp1
1 of 14
No
No
Mmus\Arl2
1 of 14
No
No
Mmus\Arl3
1 of 14
No
No
Mmus\Arl4d
1 of 14
No
No
Mmus\Arl5c
1 of 14
No
No
Mmus\Arl10
1 of 14
No
Yes
Mmus\Arl11
1 of 14
No
No
Mmus\Arl13a
1 of 14
No
No
Mmus\Arl13b
1 of 14
No
No
Mmus\Arl14
1 of 14
No
No
Mmus\Srprb
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (23)
Xtro\arl8a
10 of 13
Yes
Yes
Xtro\arl8b
10 of 13
Yes
Yes
Xtro\arl10b
4 of 13
No
Yes
Xtro\arf5
2 of 13
No
No
Xtro\arf6
2 of 13
No
No
Xtro\arl1
2 of 13
No
No
Xtro\arl5a
2 of 13
No
No
Xtro\arl5b
2 of 13
No
No
Xtro\arl5c
2 of 13
No
No
Xtro\ppp1r14c
2 of 13
No
No
Xtro\arf11l.2
1 of 13
No
No
Xtro\arl2
1 of 13
No
No
Xtro\arl4c
1 of 13
No
No
Xtro\arl10
1 of 13
No
Yes
Xtro\arl11
1 of 13
No
No
Xtro\arl13a
1 of 13
No
Yes
Xtro\arl13b
1 of 13
No
Yes
Xtro\rab34
1 of 13
No
No
Xtro\ran
1 of 13
No
No
Xtro\rragc
1 of 13
No
No
Xtro\sar1a
1 of 13
No
No
Xtro\sar1b
1 of 13
No
No
Xtro\srprb
1 of 13
No
No
Danio rerio (Zebrafish) (34)
Drer\arl8ba
13 of 14
Yes
Yes
Drer\arl8bb
12 of 14
No
Yes
Drer\arl8a
11 of 14
No
Yes
Drer\arf1
2 of 14
No
No
Drer\arf2a
2 of 14
No
No
Drer\arf3a
2 of 14
No
No
Drer\arf3b
2 of 14
No
No
Drer\arf4b
2 of 14
No
No
Drer\arf5
2 of 14
No
No
Drer\arf6a
2 of 14
No
No
Drer\arf6b
2 of 14
No
No
Drer\arl1
2 of 14
No
No
Drer\arl6
2 of 14
No
No
Drer\arl15a
2 of 14
No
No
Drer\arl15b
2 of 14
No
No
Drer\si:ch1073-165f9.2
2 of 14
No
No
Drer\zgc:77650
2 of 14
No
No
Drer\arf4a
1 of 14
No
No
Drer\arfrp1
1 of 14
No
No
Drer\arl2
1 of 14
No
No
Drer\arl3a
1 of 14
No
No
Drer\arl3b
1 of 14
No
No
Drer\arl3l1
1 of 14
No
No
Drer\arl3l2
1 of 14
No
No
Drer\arl4d
1 of 14
No
No
Drer\arl5a
1 of 14
No
No
Drer\arl5c
1 of 14
No
No
Drer\arl8
1 of 14
No
No
Drer\arl11
1 of 14
No
No
Drer\arl13a
1 of 14
No
No
Drer\arl13b
1 of 14
No
No
Drer\arl14
1 of 14
No
No
Drer\srprb
1 of 14
No
No
Drer\zgc:110286
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (20)
Cele\arl-8
12 of 14
Yes
Yes
Cele\arf-1
2 of 14
No
No
Cele\arf-5
2 of 14
No
No
Cele\arf-6
2 of 14
No
No
Cele\arl-1
2 of 14
No
No
Cele\arl-5
2 of 14
No
No
Cele\arl-6
2 of 14
No
No
Cele\warf-1
2 of 14
No
No
Cele\arl-3
1 of 14
No
No
Cele\arl-13
1 of 14
No
Yes
Cele\C56E6.2
1 of 14
No
No
Cele\evl-20
1 of 14
No
No
Cele\R186.3
1 of 14
No
No
Cele\rab-7
1 of 14
No
No
Cele\rab-33
1 of 14
No
No
Cele\raga-1
1 of 14
No
No
Cele\ragc-1
1 of 14
No
No
Cele\ran-1
1 of 14
No
No
Cele\sar-1
1 of 14
No
No
Cele\Y54E10BR.2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (14)
Agam\AgaP_AGAP004227
12 of 12
Yes
Yes
Agam\AgaP_AGAP002931
2 of 12
No
No
Agam\AgaP_AGAP006890
2 of 12
No
No
Agam\AgaP_AGAP011254
2 of 12
No
No
Agam\AgaP_AGAP011730
2 of 12
No
No
Agam\AgaP_AGAP012014
2 of 12
No
No
Agam\AgaP_AGAP002991
1 of 12
No
No
Agam\AgaP_AGAP003905
1 of 12
No
No
Agam\AgaP_AGAP004098
1 of 12
No
No
Agam\AgaP_AGAP004496
1 of 12
No
No
Agam\AgaP_AGAP004586
1 of 12
No
No
Agam\AgaP_AGAP005267
1 of 12
No
No
Agam\AgaP_AGAP006688
1 of 12
No
No
Agam\AgaP_AGAP007634
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (32)
Atha\ARLA1A
12 of 13
Yes
Yes
Atha\ARLA1C
12 of 13
Yes
Yes
Atha\ARLA1D
12 of 13
Yes
Yes
Atha\ARLA1B
10 of 13
No
Yes
Atha\ARF1
2 of 13
No
No
Atha\ARFA1D
2 of 13
No
No
Atha\ARFA1E
2 of 13
No
No
Atha\ARFA1F
2 of 13
No
No
Atha\ARFB1A
2 of 13
No
No
Atha\ARFB1B
2 of 13
No
No
Atha\ARFC1
2 of 13
No
No
Atha\ARF1A1C
1 of 13
No
No
Atha\ARF3
1 of 13
No
No
Atha\ARFA1B
1 of 13
No
No
Atha\ARFB1C
1 of 13
No
No
Atha\ARFD1A
1 of 13
No
No
Atha\ARFD1B
1 of 13
No
No
Atha\AT1G02620
1 of 13
No
No
Atha\AT2G18770
1 of 13
No
No
Atha\AT3G62560
1 of 13
No
No
Atha\AT5G05670
1 of 13
No
No
Atha\RAB7A
1 of 13
No
No
Atha\RAB7B
1 of 13
No
No
Atha\RAB18
1 of 13
No
No
Atha\RABC2A
1 of 13
No
No
Atha\RABG3c
1 of 13
No
No
Atha\RABG3d
1 of 13
No
No
Atha\RABG3E
1 of 13
No
No
Atha\SAR1B
1 of 13
No
No
Atha\SAR2
1 of 13
No
No
Atha\SARA1A
1 of 13
No
No
Atha\TTN5
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (12)
Scer\ARF1
2 of 13
Yes
No
Scer\ARF2
2 of 13
Yes
No
Scer\ARF3
2 of 13
Yes
No
Scer\ARL1
2 of 13
Yes
No
Scer\ARL3
1 of 13
No
No
Scer\GSP1
1 of 13
No
No
Scer\GSP2
1 of 13
No
No
Scer\GTR1
1 of 13
No
No
Scer\GTR2
1 of 13
No
No
Scer\SAR1
1 of 13
No
No
Scer\SRP102
1 of 13
No
No
Scer\VPS21
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\arf1
2 of 12
Yes
No
Spom\arf6
2 of 12
Yes
No
Spom\alp41
1 of 12
No
No
Spom\srp102
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Arl8. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (18)
Arf1
2 of 13
Arf4
2 of 13
Arf6
2 of 13
Arfrp1
2 of 13
Arl1
2 of 13
Arl2
2 of 13
Arl5
2 of 13
dnd
2 of 13
Sar1
2 of 13
Arl4
1 of 13
Arl6
1 of 13
CG11356
1 of 13
CG13692
1 of 13
CG17819
1 of 13
RabX6
1 of 13
RagA-B
1 of 13
RagC-D
1 of 13
SrpRβ
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Arl8Q75L.UAS
    ameliorates  Parkinson's disease 1
    modeled by Hsap\SNCAA53T.UAS
    (Szinyákovics et al., 2023)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ARL8A; ARF like GTPase 8A
    12 of 14
    616597
         
        ARL8B; ARF like GTPase 8B
        12 of 14
        616596
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Arl8 - Arf1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Arf4
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - CCT3
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - CCT6
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - CG1416
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Chc
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Cyp12d1-p
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Gale
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Hel25E
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - KdelR
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Ldh
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Mcad
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Mec2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Ost1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Past1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Rab1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Rab2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Rab5
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - RhoL
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Rilpl
            two hybrid, pull down, Identification by mass spectrometry
            (Rosa-Ferreira et al., 2018)
            Arl8 - Rpt1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Rtnl1
            two hybrid
            (Hu et al., 2017.6.13)
            Arl8 - SERCA
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - ScsβA
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - ScsβG
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - SsRβ
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Tapδ
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - Tspo
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - UQCR-C2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - spidey
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - strat
            experimental knowledge based
            (Guruharsha et al., 2011)
            Arl8 - wal
            experimental knowledge based
            (Guruharsha et al., 2011)
            Summary of Genetic Interactions
            Interaction Browsers
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Subunit Structure (UniProtKB)
            Interacts with tubulin (PubMed:15331635). Interacts (in GTP-bound form) with Rilpl (PubMed:30115618). Interacts with unc-104 (PubMed:30174114).
            (UniProt, Q9VHV5 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-48
            Cytogenetic map
            84E13-84E13
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            84E13-84E13
            Limits computationally determined from genome sequence between P{EP}EP3060EP3060 and P{PZ}grn05930
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            3-48

            (FlyBase, 2016)

            3-44.8

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (5)
            Genomic Clones (15)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (34)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Hofmann and Munro, 2006)
            Commercially Available Antibodies
             
            Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
            Cell Line Information
            Publicly Available Cell Lines
             
            Other Stable Cell Lines
             
              Other Comments

              Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.

              (Jha et al., 2016)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: CG7891 BcDNA:LD29185

              (FlyBase, 1996-)
              Additional comments

              Source for merge of CG7891 BcDNA:LD29185 was a shared cDNA ( date:020730 ).

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of

              Source for identity of: Gie CG7891

              (Okai et al., 2004)

              Source for identity of: Arl8 Gie

              (Pasqualato et al., 2002)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (9)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 44 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (71)