FlyBase Gene Report: Dmel\Prx4

General Information

Symbol

Dmel\Prx4

Species

D. melanogaster

Name

Peroxiredoxin 4

Annotation Symbol

CG1274

Feature Type

protein_coding_gene

FlyBase ID

FBgn0040308

Gene Model Status

Current

Stock Availability

5 publicly available

Enzyme Name (EC)

thioredoxin-dependent peroxiredoxin (1.11.1.24)

Gene Summary

Peroxiredoxin 4 (Prx4) encodes an atypical 2-Cys peroxiredoxin that regulates hydrogen peroxide levels and participates in the formation of disulfide bonds during oxidative protein folding. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

Jafrac2, dPrx4, thioredoxin peroxidase 2, DPx4156, Jafrac

Key Links

Genomic Location

Cytogenetic map

63A3-63A3

Sequence location

3L:3,042,359..3,044,174 [+]

Recombination map

3-5

RefSeq locus

NT_037436 REGION:3042359..3044174

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables peroxiredoxin activity

inferred from direct assay

(McGinnis et al., 2021)

enables protein binding

inferred from physical interaction with FLYBASE:Diap1; FB:FBgn0260635

(Tenev et al., 2002)

enables thioredoxin-dependent peroxiredoxin activity

inferred from direct assay

(Radyuk et al., 2001)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables antioxidant activity

inferred from electronic annotation with InterPro:IPR000866

(InterPro Project Members, 2004-)

enables oxidoreductase activity

inferred from electronic annotation with InterPro:IPR000866

(InterPro Project Members, 2004-)

enables peroxiredoxin activity

inferred from electronic annotation with InterPro:IPR019479

(InterPro Project Members, 2004-)

enables thioredoxin peroxidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000073874

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in apoptotic signaling pathway

inferred from mutant phenotype

(Tenev et al., 2002)

inferred from genetic interaction with FLYBASE:Diap1; FB:FBgn0260635

(Tenev et al., 2002)

involved_in cellular response to cold

inferred from direct assay

(Radyuk et al., 2013)

involved_in defense response to bacterium

inferred from direct assay

(Radyuk et al., 2013)

involved_in hydrogen peroxide catabolic process

inferred from direct assay

(Radyuk et al., 2001)

involved_in positive regulation of receptor signaling pathway via JAK-STAT

inferred from genetic interaction with FLYBASE:hop; FB:FBgn0004864

(Radyuk et al., 2013)

inferred from genetic interaction with FLYBASE:Stat92E; FB:FBgn0016917

(Radyuk et al., 2013)

inferred from genetic interaction with FLYBASE:dome; FB:FBgn0043903

(Radyuk et al., 2013)

involved_in response to oxidative stress

inferred from mutant phenotype

(Radyuk et al., 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cell redox homeostasis

inferred from biological aspect of ancestor with PANTHER:PTN000073874

(GO Reference Genome Project, 2011-)

involved_in hydrogen peroxide catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000073874

(GO Reference Genome Project, 2011-)

involved_in response to oxidative stress

inferred from biological aspect of ancestor with PANTHER:PTN000073874

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Tenev et al., 2002)

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in endoplasmic reticulum

inferred from direct assay

(Radyuk et al., 2013, Tenev et al., 2002)

located_in extracellular region

inferred from direct assay

(Radyuk et al., 2001)

located_in extracellular space

inferred from direct assay

(Radyuk et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000073874

(GO Reference Genome Project, 2011-)

is_active_in endoplasmic reticulum

inferred from biological aspect of ancestor with PANTHER:PTN000841180

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RHG PROTEINS

PEROXIREDOXINS

Pathway (FlyBase)

POSITIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

thioredoxin-dependent peroxiredoxin activity

a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]- disulfide + H2O (1.11.1.24)

RHEA 62620: peroxiredoxin activity
RHEA 10008: thioredoxin peroxidase activity
RHEA 63528:

Summaries

Gene Snapshot

Gene Group (FlyBase)

RHG PROTEINS -: RHG proteins possess a 12 amino acid RHG motif. This motif, also known as the IAP-binding motif (IBM), interacts with the BIR domain of Inhibitor of apoptosis proteins (IAPs) and relieving IAP-mediated caspase inhibition. Over-expression of individual RHG proteins is sufficient to induce apoptosis. (Adapted from FBrf0225510).
PEROXIREDOXINS -: Peroxiredoxins are a family of thiol-dependent antioxidant proteins that catalyze the reduction of hydrogen peroxide, peroxynitrite and a wide range of organic hydroperoxides (ROOH) to the corresponding alcohol (ROH) and water. These proteins function as peroxidases only when coupled to a sulfhydryl-reducing system such as thioredoxin or glutathione. Catalytic activity is dependent on the oxidation of a conserved cysteine residue at the active site. (Adapted from FBrf0139661, PMID:12517450.)

Pathway (FlyBase)

POSITIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY -: Positive regulators of JAK-STAT signaling up-regulate the pathway, enhancing transcriptional control by Stat92E.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Prx4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V3Q4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Prx4-RA

FBtr0072982

NM_080263

1047

242

Prx4-RB

FBtr0072983

NM_167971

1178

242

Prx4-RC

FBtr0332112

NM_001274421

1007

242

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Prx4-PA

FBpp0072852

26.7

242

6.79

FBpp0072853

26.7

242

6.79

FBpp0304422

26.7

242

6.79

Q9V3Q4

NP_001261350

AGB94045

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

242 aa isoforms: Prx4-PA, Prx4-PB, Prx4-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9V3Q4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Prx4 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.97

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

garland cell primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

posterior spiracle primordium

Comment: reported as posterior spiracle specific anlage

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism

(Radyuk et al., 2001)

third instar larval stage

organism

(Radyuk et al., 2001)

pupal stage

organism

(Radyuk et al., 2001)

day 1 of adulthood | male -- day 2 of adulthood | male

organism

(Radyuk et al., 2001)

Additional Descriptive Data

Prx4 transcript is expressed most intensely in embryos and young adults, and less instensely in third instar larvae and pupae.

(Radyuk et al., 2001)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Tenev et al., 2002)

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in endoplasmic reticulum

inferred from direct assay

(Radyuk et al., 2013, Tenev et al., 2002)

located_in extracellular region

inferred from direct assay

(Radyuk et al., 2001)

located_in extracellular space

inferred from direct assay

(Radyuk et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Prx4 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Prx4

View exonic expression by tissue for Dmel\Prx4

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040308

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

53577/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040308

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040308

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040308

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1274

Flygut - An atlas of the Drosophila adult midgut

FBgn0040308

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Prx4

Stages(s) 1-3
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Prx4

Transgenic constructs containing regulatory region of Prx4

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6092

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | heat sensitive, with Scer\GAL4^da.G32

Prx4^UAS.cRa

viable

Prx4^f01922

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Prx4^GD5909

viable, with Scer\GAL4^Mef2.PR

Prx4^GD5909

viable, with Scer\GAL4^pnr-MD237

Prx4^GD5909

viable, with Scer\GAL4^tin.CΔ4

Prx4^GD5909

Sterility

Allele

fertile

Prx4^f01922

Other Phenotypes

Allele

abnormal oxidative stress response, with Scer\GAL4^da.G32

abnormal oxidative stress response | recessive

Prx4^f01922

chemical sensitive, with Scer\GAL4^da.G32

chemical sensitive | recessive

Prx4^f01922

flightless, with Scer\GAL4^Mef2.PR

Prx4^GD5909

increased cell death

Prx4^AKP.Ub.GMR

increased cell death, with Scer\GAL4^da.G32

Prx4^UAS.cRa

short lived, with Scer\GAL4^da.G32

Prx4^UAS.cRa

Phenotype manifest in

Allele

adult fat body, with Scer\GAL4^da.G32

Prx4^UAS.cRa

adult somatic muscle cell, with Scer\GAL4^da.G32

Prx4^UAS.cRa

eye

Prx4^AKP.Ub.GMR

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (6)

Hsap\PRDX4

14 of 14

Yes

7 of 14

7 of 14

7 of 14

3 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Prdx4

14 of 14

Yes

7 of 14

7 of 14

7 of 14

5 of 14

3 of 14

Mus musculus (laboratory mouse) (6)

Mmus\Prdx4

14 of 14

Yes

7 of 14

7 of 14

6 of 14

3 of 14

3 of 14

Xenopus tropicalis (Western clawed frog) (8)

Xtro\prdx4

7 of 13

Yes

Xtro\limk2

5 of 13

Xtro\prdx2

5 of 13

Xtro\prdx1

3 of 13

Yes

Xtro\arhgef9

1 of 13

Xtro\lemd1

1 of 13

Yes

Xtro\prdx3

1 of 13

Xtro\prdx6

1 of 13

Danio rerio (Zebrafish) (5)

Drer\prdx4

14 of 14

Yes

7 of 14

7 of 14

7 of 14

3 of 14

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\prdx-2

8 of 14

Yes

Cele\prdx-3

7 of 14

Cele\prdx-6

3 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\TPX3

12 of 12

Yes

6 of 12

6 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (6)

Atha\2-Cys Prx B

11 of 13

Yes

Atha\AT3G11630

11 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\TSA1

12 of 13

Yes

Scer\TSA2

12 of 13

Yes

Scer\PRX1

3 of 13

Scer\DOT5

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\tpx1

9 of 12

Yes

Spom\but1

1 of 12

Escherichia coli (enterobacterium) (2)

Ecol\ahpC

10 of 11

Yes

Ecol\bcp

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Prx4. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

11 of 13

11 of 13

10 of 13

4 of 13

4 of 13

4 of 13

4 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PRDX4; peroxiredoxin 4

14 of 14

300927

PRDX1; peroxiredoxin 1

7 of 14

176763

METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblC TYPE; MAHCC

methylmalonic aciduria and homocystinuria type cblC

PRDX2; peroxiredoxin 2

7 of 14

600538

PRDX3; peroxiredoxin 3

7 of 14

PEROXIREDOXIN 3; PRDX3

autosomal recessive spinocerebellar ataxia 32

PRDX6; peroxiredoxin 6

3 of 14

602316

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

Prx4 - mir-1

luminiscence technology

(Easow et al., 2007)

protein-protein

Physical Interaction

Assay

References

Prx4 - Coprox

experimental knowledge based

(Guruharsha et al., 2011)

Prx4 - Diap2

experimental knowledge based

(Guruharsha et al., 2011)

Prx4 - Mpcp2

experimental knowledge based

(Guruharsha et al., 2011)

Prx4 - Pez

experimental knowledge based

(Guruharsha et al., 2011)

Prx4 - Ser12

experimental knowledge based

(Guruharsha et al., 2011)

Prx4 - mtDNA-helicase

experimental knowledge based

(Guruharsha et al., 2011)

Prx4 - pr

experimental knowledge based

(Guruharsha et al., 2011)

Prx4 - su(Hw)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Prx4

suppressible

Diap1

(Tenev et al., 2002)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

72801

DroID - A comprehensive database of gene and protein interactions.

FBgn0040308

MIST (protein-protein) - An integrated Molecular Interaction Database

53577

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Apoptosis - fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-5

Cytogenetic map

63A3-63A3

Sequence location

3L:3,042,359..3,044,174 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

63A3-63A3

Limits computationally determined from genome sequence between P{PZ}l(3)06803⁰⁶⁸⁰³ and P{PZ}kst⁰¹³¹⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

62F-62F

(Santaren, 1999.7.8)

63B3-63B5

(Radyuk, 2000.11.16)

62F-62F

(determined by in situ hybridisation)

(Rodriguez et al., 2000)

Experimentally Determined Recombination Data

Location

3-5

(FlyBase, 2016)

3-6.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18489

w¹¹¹⁸; PBac{WH}Prx4^f01922

56043

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04351}attP40

1274R-4

v104006

v43252

w¹¹¹⁸; P{GD5909}v43252/CyO

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH25379

Other clones

DPiM_GH25379

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0040308

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0040308

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Radyuk et al., 2013)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Jafrac2 is an IAP antagonist.

(Tenev et al., 2002)

Jafrac2 may promote cell death by liberating Nc from th-mediated inhibition.

(Tenev et al., 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: Jafrac2 CG1274

(Bayraktaroglu, 2000.8.7)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Jafrac2 Prx4156

(Orr, 2001.3.5)

Source for identity of: Prx4 Jafrac2

(McGinnis et al., 2021)

Nomenclature comments

Etymology

The gene is named "Jafrac2" after the initials of people in the Santaren research group who first published on the gene.

(Santaren, 2001.10.24)

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

1274

(Ravi et al., 2009)

CG1274

(Murari et al., 2022, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Easow et al., 2007, Li et al., 2003, Orr, 2001.3.5)

DPx-4156

(Radyuk et al., 2001)

DPx4156

(Detienne et al., 2018, Heifetz and Rivlin, 2010, Orr et al., 2001)

JafRac2

(Tuxworth et al., 2011)

Jafrac

(Saucedo et al., 2021, Pridie et al., 2020, Gao et al., 2014)

Jafrac-2

(Kuranaga and Miura, 2007)

Prx4

(Salminen et al., 2024, Scharenbrock et al., 2024, Nozawa et al., 2023, Stapper and Jahn, 2018, Radyuk et al., 2013)

Prx4156

dPRDX4

(Murari et al., 2022)

dPrx4

(Odnokoz et al., 2023, McGinnis et al., 2021, Bradshaw, 2019, Detienne et al., 2018, Radyuk et al., 2013)

jafrac2

(Xu et al., 2009)

thioredoxin peroxidase 2 isoform A

(Edgar et al., 2012)

Name Synonyms

Jafrac2

(Detienne et al., 2018, Heifetz and Rivlin, 2010)

Peroxiredoxin 4

Peroxiredoxin 4156

(Orr et al., 2001)

Thioredoxin peroxidase 2

(Steller et al., 2014.7.9, Heifetz and Rivlin, 2010)

jafrac2

(Bergmann et al., 2003)

peroxiredoxin 4

(Radyuk et al., 2013)

thioredoxin peroxidase

(Zhang et al., 2004)

thioredoxin peroxidase 2

(Ramond et al., 2020, Detienne et al., 2018, Cammarato et al., 2011, Santaren, 1999.7.8)

Secondary FlyBase IDs

FBgn0035389

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 50 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

53577

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V3Q4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9V3Q4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V3Q4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040308

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

53577/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040308

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040308

FlyMine - An integrated database for Drosophila genomics

FBgn0040308

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1274

MARRVEL_MODEL - MARRVEL (model organism gene)

53577

Linkouts

BioGRID - A database of protein and genetic interactions.

72801

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0040308

DroID - A comprehensive database of gene and protein interactions.

FBgn0040308

DRSC - Results frm RNAi screens

FBgn0040308

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040308

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0040308

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1274

Flygut - An atlas of the Drosophila adult midgut

FBgn0040308

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0040308

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001071

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Apoptosis - fly

MIST (protein-protein) - An integrated Molecular Interaction Database

53577

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

References (96)

The following external sites may use different assemblies or annotations than FlyBase.

1.97

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