Jafrac, DPx-4783, DPx4783, dPrx1, Peroxiredoxin 1
Gene model reviewed during 5.49
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer (By similarity). Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity). Interacts with SESN1 and SESN2 (By similarity).
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
Conjugated to URM1, a ubiquitin-like protein.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Jafrac1 using the Feature Mapper tool.
Jafrac1 transcript is maternally deposited. Maternal transcript quickly degrades, except in germline cells, where it is protected from degradation through embryonic stage 9. At later embryonic stages, Jafrac1 transcript is expressed in crystal cells.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Jafrac1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Jafrac1 Prx4783
Source for merge of: Jafrac1 CG1633
Jafrac1 is not required for the formation, specification, motility, or survival of primordial germline cells.
The gene is named "Jafrac1" after the initials of people in the Santaren research group who first published on the gene.