FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\ida
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General Information
Symbol
Dmel\ida
Species
D. melanogaster
Name
imaginal discs arrested
Annotation Symbol
CG10850
Feature Type
protein_coding_gene
FlyBase ID
FBgn0041147
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
imaginal discs arrested (ida) encodes a ubiquitin ligase that regulates the mitotic metaphase/anaphase transition. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

APC5, l(3)63Fb

Key Links
Genomic Location
Cytogenetic map
63F6-63F6
Sequence location
Recombination map
3-9
RefSeq locus
NT_037436 REGION:3905344..3907813
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in imaginal disc development
inferred from mutant phenotype
(Bentley et al., 2002)
involved_in positive regulation of mitotic metaphase/anaphase transition
inferred from mutant phenotype
(Bentley et al., 2002)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in anaphase-promoting complex-dependent catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000302880
(GO Reference Genome Project, 2011-)
involved_in positive regulation of mitotic metaphase/anaphase transition
inferred from biological aspect of ancestor with PANTHER:PTN000302880
(GO Reference Genome Project, 2011-)
involved_in protein K11-linked ubiquitination
inferred from biological aspect of ancestor with PANTHER:PTN000302880
(GO Reference Genome Project, 2011-)
involved_in regulation of cell cycle
traceable author statement
(Lee and Orr-Weaver, 2003)
involved_in regulation of proteolysis
traceable author statement
(Lee and Orr-Weaver, 2003)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Slack et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of anaphase-promoting complex
inferred from sequence or structural similarity with UniProtKB:Q9UJX4
(Bentley et al., 2002)
traceable author statement
(Lee and Orr-Weaver, 2003)
inferred from biological aspect of ancestor with PANTHER:PTN000302880
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR037679
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
imaginal discs arrested (ida) encodes a ubiquitin ligase that regulates the mitotic metaphase/anaphase transition. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
ANAPHASE-PROMOTING COMPLEX -
Anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase. Active during mitosis and G1 phases of the cell cycle, it mediates the degradation of cyclins and other key cell cycle regulators triggering the metaphase to anaphase transition and the exit from mitosis. (Adapted from PMID:12208841).
Summary (Interactive Fly)

homolog of APC5, a subunit of the anaphase-promoting complex (APC/cyclosome) - required for proliferation of imaginal disc cells - required for the localisation of Miranda and its associated cargo proteins to the neuroblast basal cortex

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ida for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VZL2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ida-RA
FBtr0073160
NM_139580
2408
777
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
ida-PA
FBpp0073018
88.8
777
9.17
Q9VZL2
NP_647837
AAF47808
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ida using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.61

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism

Comment: rapidly degraded

(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Slack et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ida in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ida
Transgenic constructs containing regulatory region of ida
Aberrations (Deficiencies and Duplications) ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4insc-Mz1407
lethal (with Df(3L)GN19)
lethal | recessive
lethal - all die before end of prepupal stage (with Df(3L)GN19)
lethal - all die before end of prepupal stage | recessive
lethal - all die before end of P-stage | recessive
lethal - all die before end of pupal stage | recessive
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile | germline clone | recessive
Other Phenotypes
Allele
abnormal mitotic cell cycle
abnormal mitotic cell cycle | third instar larval stage
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal neuroanatomy | third instar larval stage
abnormal size | adult stage, with Scer\GAL4ey.PU
abnormal size | third instar larval stage
decreased cell number | germline clone | oogenesis
decreased cell number | third instar larval stage
decreased occurrence of cell division | third instar larval stage
increased mortality, with Scer\GAL4ey.PU
some die during prepupal stage | recessive
some die during prepupal stage | recessive (with Df(3L)GN19)
some die during P-stage | recessive
some die during pupal stage | recessive
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4ey.PU
Phenotype manifest in
Allele
air bubble
embryonic/larval optic lobe | third instar larval stage
eye, with Scer\GAL4ey.PU
eye disc | third instar larval stage, with Scer\GAL4ey.PU
eye disc morphogenetic furrow | third instar larval stage, with Scer\GAL4ey.PU
foregut imaginal ring
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
imaginal disc
larval brain | third instar larval stage
larval hindgut imaginal ring
larval neuroblast | larval stage
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
mesonotum, with Scer\GAL4pnr-MD237
midgut imaginal island
mitotic anaphase
mitotic cell cycle
mitotic prometaphase
salivary gland imaginal ring
testis
trichogen cell, with Scer\GAL4pnr-MD237
unfertilized egg | germline clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\ANAPC5
13 of 14
Yes
Yes
2  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Anapc5
13 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Anapc5
12 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\anapc5
10 of 13
Yes
Yes
Xtro\apba2
1 of 13
No
No
Danio rerio (Zebrafish) (1)
Drer\anapc5
12 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\gfi-3
2 of 14
Yes
Yes
Cele\such-1
2 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP005578
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT1G06590
7 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\APC5
3 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\apc5
7 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:ida. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ANAPC5; anaphase promoting complex subunit 5
    13 of 14
    606948
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        shtd
        suppressible
        ida
        (Tanaka-Matakatsu et al., 2007)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        Pathways
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-9
        Cytogenetic map
        63F6-63F6
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        63F6-63F6
        Limits computationally determined from genome sequence between P{PZ}Sc205634 and P{PZ}l(3)rG166rG166
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        63F-63F
        (Bentley, 2000.10.9)
        Experimentally Determined Recombination Data
        Location

        3-9

        (FlyBase, 2016)

        3-8.4

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (11)
        Genomic Clones (16)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (13)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Homozygous mutants have mitotic defects, die during prepupal development, lack all mature imaginal disc structures and have abnormally small optic lobes.

            (Bentley et al., 2002)

            ida is required for viability during metamorphosis and for proliferation of the adult fated imaginal disc cells.

            (Bentley et al., 2000)

            Mutant animals lack all differentiated imaginal disc structures and have smaller than normal optic lobes. The mutation does not block mitosis, but prevents chromosomes from condensing properly and reaching the metaphase plate.

            (Bentley et al., 2000)

            ida is required for imaginal disc development.

            (Vaskova et al., 2000)

            Discussed during genetic analysis of the Ras64B-Rop region.

            (Harrison et al., 1995)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: ida CG10850

            (FlyBase, 1996-)
            Additional comments

            Source for merge of ida CG10850 was sequence comparison ( date:020313 ).

            (FlyBase, 1996-)
            Nomenclature History
            Source for database identify of

            Source for identity of: ida APC5

            (Lee, 2001.8.28)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (10)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 53 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (genetic) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (59)