FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Gorab
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General Information
Symbol
Dmel\Gorab
Species
D. melanogaster
Name
Golgin, RAB6 interacting
Annotation Symbol
CG33052
Feature Type
protein_coding_gene
FlyBase ID
FBgn0053052
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
Required for centriole duplication likely through its interaction with Sas-6 (PubMed:29892014, PubMed:33704067). During embryogenesis, maternally provided protein is required for centrosome duplication and nuclear division cycles of the syncytial embryos (PubMed:29892014). In femoral chordotonal organs, required for sensory cilia structural integrity and functionality necessary for motor coordination (PubMed:29892014). In male germline, has a role in cytokinesis which seems dependent on its localization to the Golgi (PubMed:29892014). (UniProt, Q8IQQ4)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
74B4-74B5
Sequence location
Recombination map
3-45
RefSeq locus
NT_037436 REGION:17427305..17428836
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables identical protein binding
inferred from physical interaction with UniProtKB:Q8IQQ4
(Fatalska et al., 2021)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VAC8
(Kovacs et al., 2018)
inferred from physical interaction with UniProtKB:O18334
(Fatalska et al., 2021)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in positive regulation of centriole replication
inferred from mutant phenotype
(Fatalska et al., 2021, Kovacs et al., 2018)
involved_in positive regulation of cilium assembly
inferred from mutant phenotype
(Kovacs et al., 2018)
involved_in positive regulation of cytokinesis
inferred from mutant phenotype
(Kovacs et al., 2018)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in non-motile cilium assembly
inferred from biological aspect of ancestor with PANTHER:PTN001087409
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in centriole
inferred from direct assay
(Kovacs et al., 2018)
located_in centrosome
inferred from direct assay
(Fatalska et al., 2021, Kovacs et al., 2018)
located_in Golgi cisterna
inferred from direct assay
(Fatalska et al., 2021)
located_in trans-Golgi network
inferred from direct assay
(Fatalska et al., 2021, Kovacs et al., 2018)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the GORAB family. (Q8IQQ4)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Required for centriole duplication likely through its interaction with Sas-6 (PubMed:29892014, PubMed:33704067). During embryogenesis, maternally provided protein is required for centrosome duplication and nuclear division cycles of the syncytial embryos (PubMed:29892014). In femoral chordotonal organs, required for sensory cilia structural integrity and functionality necessary for motor coordination (PubMed:29892014). In male germline, has a role in cytokinesis which seems dependent on its localization to the Golgi (PubMed:29892014).
(UniProt, Q8IQQ4)
Summary (Interactive Fly)

resembles a group of homodimeric rod-like proteins, the golgins, which function in vesicle tethering - golgins associate through their C-termini with different Golgi domains, and their N-termini both capture vesicles and provide specificity to their tethering - binds to Sas6 as a monomer to mediate centriole duplication

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Gorab for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8IQQ4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gorab-RA
FBtr0075229
NM_176345
1391
338
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Gorab-PA
FBpp0074991
37.7
338
7.02
Q8IQQ4
NP_788523
AAN11712
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Homodimer (via C-terminus); dimerization appears to be required for its trans-Golgi localization but not for its function and centriolar localization (PubMed:33704067). Interacts (via C-terminus) with Rab6; binds Rab6 as a homodimer, this interaction seems to be required for trans-Golgi localization (PubMed:33704067). Interacts (via C-terminus) with Sas-6; binds as a monomer to a Sas-6 homodimer (PubMed:29892014, PubMed:33704067).

(UniProt, Q8IQQ4)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gorab using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.89

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in centriole
inferred from direct assay
(Kovacs et al., 2018)
located_in centrosome
inferred from direct assay
(Fatalska et al., 2021, Kovacs et al., 2018)
located_in Golgi cisterna
inferred from direct assay
(Fatalska et al., 2021)
located_in trans-Golgi network
inferred from direct assay
(Fatalska et al., 2021, Kovacs et al., 2018)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gorab in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gorab
Transgenic constructs containing regulatory region of Gorab
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die during embryonic stage | maternal effect
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile (with Df(3L)BSC432)
female sterile (with Gorab1)
female sterile (with Gorab2)
female sterile | recessive
male fertile
male sterile
Other Phenotypes
Allele
abnormal cytokinesis | spermatogenesis
abnormal locomotor behavior | adult stage | heat sensitive
abnormal mitotic cell cycle | embryonic stage | maternal effect, with Gorab1, Scer\GAL4elav-C155
abnormal mitotic cell cycle | embryonic stage | maternal effect, with GorabUAS.EGFP, Scer\GAL4elav-C155
flightless | heat sensitive
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
uncoordinated | adult stage
uncoordinated | adult stage (with Df(3L)BSC432)
uncoordinated | adult stage (with Gorab1)
uncoordinated | adult stage (with Gorab2)
uncoordinated | adult stage | recessive
Phenotype manifest in
Allele
centriole | adult stage
centriole | decreased number | larval stage
centriole | decreased number | larval stage (with Gorab1)
centriole | decreased number | larval stage (with Gorab2)
centrosome | embryonic stage | maternal effect, with Gorab1, Scer\GAL4elav-C155
centrosome | embryonic stage | maternal effect, with GorabUAS.EGFP, Scer\GAL4elav-C155
centrosome | larval stage
ciliary basal body | adult stage
ciliary rootlet | adult stage
femoral chordotonal organ
meiotic spindle | spermatogenesis
mitotic spindle | embryonic stage | maternal effect, with Gorab1, Scer\GAL4elav-C155
mitotic spindle | embryonic stage | maternal effect, with GorabUAS.EGFP, Scer\GAL4elav-C155
mitotic spindle | larval stage
Nebenkern
wing disc
wing disc | larval stage
wing disc | larval stage (with Gorab1)
wing disc | larval stage (with Gorab2)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\GORAB
9 of 14
Yes
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Gorab
10 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Gorab
9 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\gorab
7 of 13
Yes
Yes
Xtro\castor2
1 of 13
No
Yes
Danio rerio (Zebrafish) (1)
Drer\gorab
8 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP004931
9 of 12
Yes
Yes
Agam\AgaP_AGAP012721
8 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (7)
Atha\AT2G27740
2 of 13
Yes
Yes
Atha\AT2G36410
2 of 13
Yes
Yes
Atha\AT3G09980
2 of 13
Yes
Yes
Atha\AT3G52920
2 of 13
Yes
Yes
Atha\AT5G03660
2 of 13
Yes
Yes
Atha\AT2G36355
1 of 13
No
Yes
Atha\AT3G52900
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Gorab. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
GORAB; golgin, RAB6 interacting
model of  geroderma osteodysplasticum
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
GORAB; golgin, RAB6 interacting
9 of 14
607983
 
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Homodimer (via C-terminus); dimerization appears to be required for its trans-Golgi localization but not for its function and centriolar localization (PubMed:33704067). Interacts (via C-terminus) with Rab6; binds Rab6 as a homodimer, this interaction seems to be required for trans-Golgi localization (PubMed:33704067). Interacts (via C-terminus) with Sas-6; binds as a monomer to a Sas-6 homodimer (PubMed:29892014, PubMed:33704067).
(UniProt, Q8IQQ4 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map
3-45
Cytogenetic map
74B4-74B5
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
74B4-74B5
Limits computationally determined from genome sequence between P{PZ}blot01658 and P{PZ}frc00073&P{PZ}frc02619
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

3-45

(FlyBase, 2016)

3-40.8

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (4)
Genomic Clones (9)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (75)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Kovacs et al., 2018)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments
        Relationship to Other Genes
        Source for database merge of
        Additional comments

        Annotation CG3882 split into CG33051, CG33052 in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)
        Nomenclature History
        Source for database identify of

        Source for identity of: Gorab CG33052

        (Kovacs et al., 2018)
        Nomenclature comments
        Etymology

        Named 'Gorab' after the human counterpart.

        (Kovacs et al., 2018)
        Synonyms and Secondary IDs (5)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 28 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (31)