FlyBase Gene Report: Dmel\jeb

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Gene: Dmel\jeb

General Information

Symbol

Dmel\jeb

Species

D. melanogaster

Name

jelly belly

Annotation Symbol

CG30040

Feature Type

protein_coding_gene

FlyBase ID

FBgn0086677

Gene Model Status

Stock Availability

10 publicly available

Gene Summary

jelly belly (jeb) encodes a secreted, low-density lipoprotein (LDL) repeat containing protein that functions as signalling ligand for the product of Alk. Binding of the ligand to its receptor activates intracellular Ras/ERK and PI3K signalling pathways. The roles of the product of jeb include embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(2)k05644

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:12,085,194..12,119,340 [-]

Recombination map

2-66

RefSeq locus

NT_033778 REGION:12085194..12119340

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables receptor ligand activity

inferred from direct assay

(Yang et al., 2007)

enables transmembrane receptor protein tyrosine kinase activator activity

inferred from direct assay

(Lee et al., 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables transmembrane receptor protein tyrosine kinase activator activity

inferred from biological aspect of ancestor with PANTHER:PTN000473686

(GO Reference Genome Project, 2011-)

Biological Process (10 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from mutant phenotype

(Bazigou et al., 2007)

involved_in cell surface receptor protein tyrosine kinase signaling pathway

inferred from direct assay

(Yang et al., 2007)

involved_in compound eye photoreceptor development

inferred from mutant phenotype

(Bazigou et al., 2007)

involved_in muscle cell fate specification

inferred from mutant phenotype

(Lee et al., 2003)

involved_in negative regulation of neuromuscular synaptic transmission

inferred from mutant phenotype

(Rohrbough et al., 2013)

involved_in positive regulation of MAPK cascade

inferred from mutant phenotype

(Rohrbough et al., 2013)

inferred from direct assay

(Lee et al., 2003)

involved_in salivary gland morphogenesis

inferred from mutant phenotype

(Vining et al., 2005)

involved_in synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Rohrbough et al., 2013)

involved_in visceral muscle development

inferred from mutant phenotype

(Englund et al., 2003, Lee et al., 2003, Weiss et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mesoderm migration involved in gastrulation

traceable author statement

(Taylor, 2002)

involved_in positive regulation of MAPK cascade

inferred from biological aspect of ancestor with PANTHER:PTN000473686

(GO Reference Genome Project, 2011-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

located_in cell surface

inferred from direct assay

(Tong et al., 2011)

located_in extracellular region

inferred from direct assay

(Rohrbough et al., 2013)

located_in synaptic vesicle

inferred from direct assay

(Rohrbough et al., 2013)

located_in terminal bouton

inferred from direct assay

(Friedman et al., 2013)

located_in type Ib terminal bouton

inferred from direct assay

(Rohrbough et al., 2013)

located_in type Is terminal bouton

inferred from direct assay

(Rohrbough et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in extracellular region

traceable author statement

(Taylor, 2002)

is_active_in terminal bouton

inferred from biological aspect of ancestor with PANTHER:PTN000473686

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED RECEPTOR LIGANDS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

jelly belly (jeb) encodes a secreted, low-density lipoprotein (LDL) repeat containing protein that functions as signalling ligand for the product of Alk. Binding of the ligand to its receptor activates intracellular Ras/ERK and PI3K signalling pathways. The roles of the product of jeb include embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

UNCLASSIFIED RECEPTOR LIGANDS -: This group comprises receptor ligands that do not classify under other groups in FlyBase.

Summary (Interactive Fly)

a secreted ligand that contains an LDL receptor repeat - required for visceral mesoderm development

Interactive Fly

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\jeb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q95NU8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0088021

4455

560

FBtr0333065

10378

560

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0087128

61.5

560

6.32

FBpp0305279

61.5

560

6.32

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

560 aa isoforms: jeb-PA, jeb-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q95NU8

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jeb using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

jeb_1
jeb_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.77

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 8 -- 10

somatic trunk mesoderm | segmentally repeated | ventral

(Weiss et al., 2001)

embryonic stage 11 -- 12

somatic trunk mesoderm

(Weiss et al., 2001)

embryonic stage 16

neuron | subset of larval ventral nerve cord

(Weiss et al., 2001)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 17

(Weiss et al., 2001)

Additional Descriptive Data

jeb transcript is embryonically expressed in the ventral somatic mesoderm, adjacent to dorsal visceral mesoderm precursors. Somatic mesoderm expression is detected beginning at embryonic stage 8, and can no longer be detected at stage 12. At embryonic stage 10 jeb expressing cell clusters are interdigitated with bap-expressing cell clusters. At embryonic stage 11, jeb-expressing cells form continuous stripes that are adjacent and ventral to bap-expressing cells. At embryonic stage 16, jeb is expressed in a subset of neurons in the ventral nerve cord.

(Weiss et al., 2001)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11

fusion competent cell

• cell surface

(Stute et al., 2004)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10

visceral trunk mesoderm | dorsal

• cytoplasm | punctate

Comment: jeb is taken up by, but not expressed in, this tissue

(Weiss et al., 2001)

embryonic stage 11

visceral trunk mesoderm | restricted

• cell surface

(Stute et al., 2004)

muscle founder cell

• cell surface

(Stute et al., 2004)

embryonic stage 17

larval longitudinal connective

(Weiss et al., 2001)

• axon

(Weiss et al., 2001)

embryonic/larval neuromuscular junction

Comment: primarily presynaptic localization

(Rohrbough and Broadie, 2010)

Comment: synapse

(Rohrbough and Broadie, 2010)

larval central nervous system

(Okamoto and Nishimura, 2015)

(Okamoto and Nishimura, 2015)

third instar larval stage -- adult stage

outer photoreceptor cell

(Bazigou et al., 2007)

inner photoreceptor cell

(Bazigou et al., 2007)

wandering third instar larval stage

embryonic/larval neuromuscular junction

• terminal bouton

(Rohrbough et al., 2013)

• cell surface

(Tong et al., 2011)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

jeb is prdominantly expressed in the CNS and not in salivary gland, fat body, Malpighian tubule, or imaginal discs. High levels of jeb signal are detected in neurons and in the neurite-like structures that surround dorsomedial neurosecretory cells.

(Okamoto and Nishimura, 2015)

jeb protein labels the cell surface of lamina cells in pupa.

(Tong et al., 2011)

jeb is expressed at larval glutamergic neuromusclular junction synapses where it is primarily presynaptic and exhibits a localized punctate bouton expression pattern. It is strongly concentrated in smaller bouton subtypes, Is, II, and III and is heterogeneously and weakly expressed in type Ib boutons (with Alk). Extracellular jeb is localized at all bouton subtypes, predominantly closely associated with the presynaptic membrane. Concentrated jeb puncta are also observed a short distance from synaptic boutons. In mature embryos, jeb exhibited dense and extensive punctate localization along longitudinal neuropil axon tracts, and was also present in neuronal somata and segmental nerve trunks.

(Rohrbough and Broadie, 2010)

jeb protein is expressed in photoreceptor cells R1-8 from the third instar larval stage through adulthood. Expression is strong at 24 and 40 hours APF, decreasing at 50 hours APF. Strong pupal expression is observed in the R1-6 axons in the lamina, and R7-8 axons in the medulla at the 24 and 40 hours APF timepoints. The expression pattern in the developing visual system is complementay to that of Alk.

(Bazigou et al., 2007)

Secreted jeb protein is taken up by Alk-expressing cells in the visceral mesoderm.

(Stute et al., 2004)

jeb protein is secreted from cells in the somatic mesoderm and taken up by cells in the visceral mesoderm. Later in development, jeb is localized to a subset of axons in the ventral nerve cord, including the longitudinal connectives, and axons projecting to the periperal nervous system.

(Weiss et al., 2001)

Marker for

(Tong et al., 2011)

Subcellular Localization

CV Term

Evidence

References

located_in cell surface

inferred from direct assay

(Tong et al., 2011)

located_in extracellular region

inferred from direct assay

(Rohrbough et al., 2013)

located_in synaptic vesicle

inferred from direct assay

(Rohrbough et al., 2013)

located_in terminal bouton

inferred from direct assay

(Friedman et al., 2013)

located_in type Ib terminal bouton

inferred from direct assay

(Rohrbough et al., 2013)

located_in type Is terminal bouton

inferred from direct assay

(Rohrbough et al., 2013)

Expression Deduced from Reporters

Reporter: P{jeb-lacZ.B}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11

(Weiss et al., 2001)

embryonic somatic muscle cell | ventral

(Weiss et al., 2001)

embryonic stage 8 -- 10

somatic trunk mesoderm | segmentally repeated | ventral

(Weiss et al., 2001)

embryonic stage 11 -- 12

somatic trunk mesoderm

(Weiss et al., 2001)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\jeb in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\jeb

View exonic expression by tissue for Dmel\jeb

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36295/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086677

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086677

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086677

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30040

Flygut - An atlas of the Drosophila adult midgut

FBgn0086677

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of jeb

Transgenic constructs containing regulatory region of jeb

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene not disrupted in

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gene disrupted in

(Bazigou et al., 2007, Deal-Herr and Cook, 2003.8.29)

(Christensen and Cook, 2006.8.30)

(Christensen et al., 2008.12.28)

(Cook and Cook, 2010.5.7)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die during embryonic stage | recessive

jeb^SH0422

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

jeb^GD5472

viable, with Scer\GAL4^elav-C155

jeb^UAS.cVa

viable, with Scer\GAL4^Mef2.PR

jeb^GD5472

viable, with Scer\GAL4^pnr-MD237

jeb^GD5472

Other Phenotypes

Allele

abnormal cell migration | embryonic stage 13

jeb^-c1

abnormal developmental rate, with Scer\GAL4^NP0423

abnormal eclosion rhythm, with Scer\GAL4^NP423

jeb^KK111857

abnormal learning | adult stage, with Scer\GAL4^Alk.38, Scer\GAL80^ts.αTub84B

jeb^UAS.cVa

abnormal learning | adult stage, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B

jeb^UAS.cVa

abnormal learning | adult stage, with Scer\GAL4^Ras64B.PW, Scer\GAL80^ts.αTub84B

jeb^UAS.cVa

abnormal locomotor rhythm

jeb^k05644

abnormal neuroanatomy | somatic clone

jeb^SH0422

abnormal neuroanatomy | somatic clone | third instar larval stage

jeb^k05644

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^how-24B

jeb^UAS.cWa

abnormal neurophysiology

jeb^k05644

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^futsch-C380

jeb^UAS.cWa

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^how-24B

jeb^UAS.cWa

abnormal size | pupal stage, with Scer\GAL4^386Y

jeb^UAS.cVa

abnormal size | pupal stage, with Scer\GAL4^Alk.38

jeb^UAS.cVa

abnormal size | pupal stage, with Scer\GAL4^elav-C155

jeb^UAS.cVa

abnormal size | pupal stage, with Scer\GAL4^Ras64B.PW

jeb^UAS.cVa

decreased body size | P-stage, with Scer\GAL4^elav-C155

jeb^UAS.cVa

decreased body size | pupal stage, with Scer\GAL4^elav-C155

jeb^UAS.cVa

increased body size | P-stage, with Scer\GAL4^NP0423

jeb^HMC04318

increased cell death | embryonic stage 13

jeb^-c1

increased cell number | larval stage, with Scer\GAL4^elav-C155

jeb^UAS.cVa

some die during embryonic stage | recessive

jeb^SH0422

Phenotype manifest in

Allele

axon & photoreceptor cell R1 | somatic clone

jeb^SH0422

axon & photoreceptor cell R2 | somatic clone

jeb^SH0422

axon & photoreceptor cell R3 | somatic clone

jeb^SH0422

axon & photoreceptor cell R4 | somatic clone

jeb^SH0422

axon & photoreceptor cell R5 | somatic clone

jeb^SH0422

axon & photoreceptor cell R6 | somatic clone

jeb^SH0422

axon & photoreceptor cell R8 | somatic clone

jeb^SH0422

circular trunk visceral muscle primordium

circular trunk visceral muscle primordium, with Scer\GAL4^bap.3

jeb^UAS.cVa

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^how-24B

jeb^UAS.cWa

embryonic visceral muscle cell

fusion competent cell & visceral mesoderm, with Scer\GAL4^twi.PG

jeb^UAS.cWa

fusion competent cell & visceral muscle primordium

jeb^weli

gonadal sheath proper primordium | embryonic stage 13 (with Df(2R)BSC699)

jeb^weli

larval brain | larval stage, with Scer\GAL4^elav-C155

jeb^UAS.cVa

larval digestive system

jeb^k05644

larval neuron | increased number | larval stage, with Scer\GAL4^elav-C155

jeb^UAS.cVa

longitudinal trunk visceral muscle primordium | embryonic stage 13

jeb^-c1

muscle founder cell & circular visceral muscle primordium

jeb^weli

muscle founder cell & visceral mesoderm, with Scer\GAL4^twi.PG

jeb^UAS.cWa

muscle founder cell & visceral muscle primordium

muscle founder cell & visceral muscle primordium | ectopic, with Scer\GAL4^twi.2PE

jeb^UAS.cWa

neuromuscular junction

jeb^k05644

optic cartridge | somatic clone

jeb^SH0422

presumptive embryonic salivary gland

pupa, with Scer\GAL4^elav-C155

jeb^UAS.cVa

terminal bouton | somatic clone | third instar larval stage

jeb^k05644

visceral trunk mesoderm

visceral trunk mesoderm, with Scer\GAL4^bap.3

jeb^UAS.cWa

visceral trunk mesoderm | embryonic stage 13 (with Df(2R)BSC699)

jeb^weli

visceral trunk mesoderm | embryonic stage (with Df(2R)BSC199)

jeb^weli

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (2)

4 of 14

Yes

Yes

2 of 14

No

Yes

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:jeb. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

ameliorates cancer

modeled by Alk^UAS.cLa

(Wolfstetter et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

enzyme linked immunosorbent assay, anti bait coimmunoprecipitation, western blot, affinity technology, tag visualisation, fluorescence microscopy, inferred by author

(Englund et al., 2003, Lee et al., 2003)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Lee et al., 2003)

suppressible

(Wolfstetter et al., 2017)

suppressible

(Lee et al., 2003)

suppressible

(Wolfstetter et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Walker et al., 2013)

enhanceable

(Gouzi et al., 2011)

enhanceable

(Pan and O'Connor, 2021)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0086677

MIST (genetic) - An integrated Molecular Interaction Database

36295

MIST (protein-protein) - An integrated Molecular Interaction Database

36295

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-66

Cytogenetic map

Sequence location

2R:12,085,194..12,119,340 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

48E1-48E2

Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

48E1-48E2

(Oh et al., 2003)

48E9-48E9

(Weiss, 2001.9.27)

48E9-48E9

(determined by in situ hybridisation)

(Weiss et al., 2001)

48E1-48E2

(determined by in situ hybridisation)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-66

(FlyBase, 2016)

2-67.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

91543

w^*; jeb^-c1/SM6b, P{eve-lacZ8.0}SB1

36200

y¹ w^*; Mi{MIC}jeb^MI03124/SM6a

10576

w^67c23; P{lacW}jeb^k05644/CyO, P{sevRas1.V12}FK1

82517

y¹ sc^* v¹ sev²¹; P{WKO.3-G6}attP40

67553

y¹ sc^* v¹ sev²¹; P{TOE.GS00159}attP40

56022

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04318}attP40

603859

y¹ w^*; P{org-1.SM-RFP}Jon25Bi^18a P{tinC-GFP}cn^13b jeb^S4111 P{HLH54F.LVM-RFP}16c/CyO, P{GAL4-twi.G}2.2, P{UAS-2xEGFP}AH2.2

111183

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}jeb^k05644 /CyO y⁺

v103047

P{KK111857}VIE-260B

v30800

w¹¹¹⁸; P{GD5472}v30800

Genomic Clones (35)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH16255

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0086677

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0086677

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Stute et al., 2004, Weiss et al., 2001)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

jeb is required in R1-R6 cells to target their axons to the appropriate sets of target neurons in the lamina.

(Bazigou et al., 2007)

ChEST reveals this is a target of Mef2.

(Junion et al., 2005)

1 allele of l(2)SH0422 recovered in a P-insertion screen.

(Oh et al., 2003)

jeb protein is produced by somatic muscle precursors and is taken up by visceral muscle precursors.

(Weiss et al., 2001)

jeb is required for visceral mesoderm migration and differentiation.

(Weiss et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: jeb l(2)k05644

(Weiss, 2002.1.2)

Source for merge of: jeb l(2)SH0422

(Bazigou et al., 2007)

Additional comments

Annotations CG13180, CG13182 merged as CG30040 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for identity of jelly-belly CG13180 CG13182 was sequence comparison ( date:011117 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: jelly-belly CG13180 CG13182

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG13180

(Bowler et al., 2006)

CG13182

CG30040

(Guven-Ozkan et al., 2016, Ni et al., 2010.12.1, Hazelett et al., 2009, Keleman et al., 2009.8.5)

jeb

(GenetiVision Corporation, 2026-, Bischoff et al., 2025, Nelson et al., 2025, Wolfstetter et al., 2025, Reim, 2024.4.19, Corthals et al., 2023, Anllo and DiNardo, 2022, Beaver et al., 2022, Pfeifer et al., 2022, Hertenstein et al., 2021, Kannangara et al., 2021, Mendoza-Garcia et al., 2021, Pan and O'Connor, 2021, Uçkun et al., 2021, Bakshi and Joshi, 2020, Mira and Morante, 2020, Meltzer et al., 2019, Zhou et al., 2019, Ariss et al., 2018, Croset et al., 2018, Mortensen et al., 2018, Read, 2018, Mendoza-García et al., 2017, Transgenic RNAi Project members, 2017-, Wolfstetter et al., 2017, Guven-Ozkan et al., 2016, Aradska et al., 2015, Diao et al., 2015, Hugosson et al., 2014, Pecot et al., 2014, Popichenko et al., 2013, Rohrbough et al., 2013, Walker et al., 2013, Nfonsam et al., 2012, Reim et al., 2012, Hadjieconomou et al., 2011, Cook and Cook, 2010.5.7, Hazelett et al., 2009, Liu et al., 2009, Wolfstetter et al., 2009, Christensen et al., 2008.12.28, Bazigou et al., 2007, Bazigou et al., 2007, Sandmann et al., 2007, Yang et al., 2007, Bartolome and Charlesworth, 2006, Christensen and Cook, 2006.8.30, Varshney and Palmer, 2006)

l(2)SH0422

l(2)k05644

(Spradling et al., 1999)

Name Synonyms

Jelly Belly

(Mendoza-García et al., 2017, Dani et al., 2012, Shirinian et al., 2007, Varshney and Palmer, 2006)

Jelly belly

(Nässel et al., 2015, Koyama et al., 2013, Sopko and Perrimon, 2013, Homem and Knoblich, 2012, Tong et al., 2011, Rohrbough and Broadie, 2010, Bazigou et al., 2007, Yang et al., 2007)

jelly belly

(Destalminil-Letourneau et al., 2021, Reim et al., 2012, Hazelett et al., 2009, Wolfstetter et al., 2009, Weiss, 2001.9.27, Weiss et al., 2001)

jelly-belly

jellybelly

(Vining and Andrew, 2004)

lethal (2) SH0422

Secondary FlyBase IDs

FBgn0033681
FBgn0065792
FBgn0022161
FBgn0040761
FBgn0050040

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36295

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q95NU8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q95NU8

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q95NU8

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36295/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086677

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086677

FlyMine - An integrated database for Drosophila genomics

FBgn0086677

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG30040

MARRVEL_MODEL - MARRVEL (model organism gene)

36295

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0086677

DroID - A comprehensive database of gene and protein interactions.

FBgn0086677

DRSC - Results frm RNAi screens

FBgn0086677

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

jeb_1
jeb_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086677

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0086677

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30040

Flygut - An atlas of the Drosophila adult midgut

FBgn0086677

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032166

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

36295

MIST (protein-protein) - An integrated Molecular Interaction Database

36295

References (136)