Human Disease Model Report: HIV infection

General Information

Name

HIV infection

FlyBase ID

FBhh0001307

Disease Ontology Term

human immunodeficiency virus infectious disease

Parent Disease

OMIM

Overview

Drosophila models utilizing transgenic introduction of HIV-1 genes have contributed to understanding the function and roles of these genes. Examples include the HIV-1 genes HIV-1\Tat, which is required for viral gene expression and for viral replication; HIV-1\Vpu, one of several accessory proteins that enhance the expression of viral genes, the infectivity of the virus and the production of virions; HIV-1\nef, which impacts regulation of apoptosis; and HIV-1\Rev, the HIV-1 reverse transcriptase gene.

[updated May 2021 by FlyBase; FBrf0222196]

Disease Summary Information

Disease Summary: HIV infection

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Infection with Human immunodeficiency virus 1 or Human immunodeficiency virus 2 causes a viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers. HIV viruses are transmitted by transfer of blood, semen, vaginal fluid, or breast milk; typically transmitted by sexual contact; can be transmitted by contaminated needles. [Disease Ontology, DOID:526; 2021.01.19]

(FlyBase Curators, 2013-)

Genetics

Cellular phenotype and pathology

The virus infects helper T cells (CD4+ T cells), which are directly or indirectly destroyed, macrophages, and dendritic cells. [Disease Ontology, DOID:526; 2021.01.19]

(FlyBase Curators, 2013-)

Molecular information

HIV-1 is an enveloped retrovirus that uses its own reverse transcriptase to replicate its genomic single-stranded RNA through a DNA intermediate. During its life cycle, this viral DNA can become permanently integrated into the host cell DNA where its genes are expressed (FBrf0217134 and references cited therein).

(FlyBase Curators, 2013-)

External links

Disease synonyms

HIV-1 infection

human immunodeficiency virus infection

Related Diseases

Related human health report(s)

infection by viral pathogens

Ortholog Information

Human gene(s) in FlyBase

Other mammalian ortholog(s) used

D. melanogaster Gene Information (0)

Other Genes Used: Viral, Bacterial, Synthetic (4)

Summary of Physical Interactions (1 groups)

HIV-1\Vpu

protein-protein

Interacting group

Assay

References

HIV-1\Vpu - slmb

anti bait coimmunoprecipitation, anti tag western blot, two hybrid

(Marchal et al., 2012)

Alleles Reported to Model Human Disease (Disease Ontology) (3 alleles)

HIV-1\Tat

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

HIV-1\Tat^hs.PB

model of human immunodeficiency virus infectious disease

CEA

(Battaglia et al., 2001)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

HIV-1\Vpu

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

HIV-1\Vpu^UAS.cLa

model of human immunodeficiency virus infectious disease

CEA

(Marchal et al., 2012, Leulier et al., 2003)

model of fungal infectious disease

CEA

(Leulier et al., 2003)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

HIV-1\Vpu^UAS.cLa

model of human immunodeficiency virus infectious disease

is ameliorated by BacA\p35^UAS.cHa

(Marchal et al., 2012)

is ameliorated by Diap1^UAS.cHa

(Marchal et al., 2012)

is ameliorated by slpr^KK100726

(Marchal et al., 2012)

is ameliorated by Diap1^UY1835

(Marchal et al., 2012)

is ameliorated by Tak1^KK108611

(Marchal et al., 2012)

is ameliorated by Traf6^GD7146

(Marchal et al., 2012)

is ameliorated by bsk^NIG.5680R

(Marchal et al., 2012)

is ameliorated by hep^NIG.4353R

(Marchal et al., 2012)

is exacerbated by slmb^UAS.cGa

(Marchal et al., 2012)

HIV-1\nef

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

HIV-1\nef^UAS.cLa

model of human immunodeficiency virus infectious disease

CEA

(Lee et al., 2005)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

HIV-1\nef^UAS.cLa

model of human immunodeficiency virus infectious disease

is ameliorated by hep¹

(Lee et al., 2005)

is ameliorated by bsk¹

(Lee et al., 2005)

is exacerbated by bsk^UAS.cBa

(Lee et al., 2005)

is exacerbated by hep^UAS.cBa

(Lee et al., 2005)

Alleles Representing Disease-Implicated Variants

Genetic Tools, Stocks and Reagents

Sources of Stocks

Contact lab of origin for a reagent not available from a public stock center.

Bloomington Stock Center Disease Page

Related mammalian, viral, bacterial, or synthetic transgenes

Allele

Transgene

Publicly Available Stocks

HIV-1\Rev^UAS.EGFP

P{UASp-HIV-1\Rev.EGFP}

y¹ w^*; P{UASp-HIV-1\Rev.EGFP}attP2

HIV-1\Rev^UAS.sgGFP

P{UAS-Rev::GFPsg}

y¹ w^*; P{UAS-Rev::GFPsg}B2

HIV-1\Vpu^{2.6.UAS.Tag:HA}

Selected Drosophila transgenes

Allele

Transgene

Publicly Available Stocks

RNAi constructs available

Allele

Transgene

Publicly Available Stocks

Selected Drosophila classical alleles

Allele

Allele class

Mutagen

Publicly Available Stocks

References (20)

Report Sections

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