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Citation
Radimerski, T., Montagne, J., Hemmings-Mieszczak, M., Thomas, G. (2002). Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling.  Genes Dev. 16(20): 2627--2632.
FlyBase ID
FBrf0152009
Publication Type
Research paper
Abstract

Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in one of two tumor suppressor genes, TSC1 and TSC2. Here, we show that absence of Drosophila Tsc1/2 leads to constitutive dS6K activation and inhibition of dPKB, the latter effect being relieved by loss of dS6K. In contrast, the dPTEN tumor suppressor, a negative effector of PI3K, has little effect on dS6K, but negatively regulates dPKB. More importantly, we demonstrate that reducing dS6K signaling rescues early larval lethality associated with loss of dTsc1/2 function, arguing that the S6K pathway is a promising target for the treatment of TSC.

PubMed ID
PubMed Central ID
PMC187466 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Alleles (11)
    Genes (9)
    Cell Lines (1)
    Transgenic Constructs (6)