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Liou, N.F., Lin, S.H., Chen, Y.J., Tsai, K.T., Yang, C.J., Lin, T.Y., Wu, T.H., Lin, H.J., Chen, Y.T., Gohl, D.M., Silies, M., Chou, Y.H. (2018). Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit.  Nat. Commun. 9(1): 2232.
FlyBase ID
FBrf0239187
Publication Type
Research paper
Abstract

Drosophila olfactory local interneurons (LNs) in the antennal lobe are highly diverse and variable. How and when distinct types of LNs emerge, differentiate, and integrate into the olfactory circuit is unknown. Through systematic developmental analyses, we found that LNs are recruited to the adult olfactory circuit in three groups. Group 1 LNs are residual larval LNs. Group 2 are adult-specific LNs that emerge before cognate sensory and projection neurons establish synaptic specificity, and Group 3 LNs emerge after synaptic specificity is established. Group 1 larval LNs are selectively reintegrated into the adult circuit through pruning and re-extension of processes to distinct regions of the antennal lobe, while others die during metamorphosis. Precise temporal control of this pruning and cell death shapes the global organization of the adult antennal lobe. Our findings provide a road map to understand how LNs develop and contribute to constructing the olfactory circuit.

PubMed ID
PubMed Central ID
PMC5993751 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Publisher Correction: Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit.
Liou et al., 2018, Nat. Commun. 9(1): 4729 [FBrf0240595]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference
    Alleles (40)
    Genes (26)
    Insertions (29)
    Transgenic Constructs (11)