FlyBase Allele Report: Dmel\PEK[GD5584]

General Information

Symbol

Dmel\PEK^GD5584

Species

D. melanogaster

Name

FlyBase ID

FBal0207969

Feature type

allele

Associated gene

Dmel\PEK

Associated Insertion(s)

Carried in Construct

P{GD5584}

Also Known As

perk RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD5584}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD5584

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by park²⁵

(Celardo et al., 2016)

modeled by Pink1^B9

(Celardo et al., 2016)

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Popovic et al., 2023)

ameliorates prion disease

modeled by Hsap\PRNP^V129.UAS

(Fernandez-Funez et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

long lived, with Scer\GAL4^bun-GSG5961

(Wang et al., 2015)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of PEK^GD5584 under the control of Scer\GAL4^109(2)80 does not significantly affect the total branch length of the dendritic arbor in class IV ddaC neurons in third instar larvae.

(Tsuyama et al., 2017)

Expression of PEK^GD5584 under the control of Scer\GAL4^bun-GSG5961, using RU486 food supplementation to induce the expression, extends adult lifespan relative to controls.

(Wang et al., 2015)

Adults expressing PEK^GD5584 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

5584

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/PEK^GD5584 is a non-enhancer of decreased cell number | larval stage | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Suppressor of

Statement

Reference

PEK^GD5584, Scer\GAL4^nub.PU is a suppressor of increased cell death | larval stage phenotype of Gp93^NIG.5520R, Scer\GAL4^nub.PU

(Xu et al., 2025)

PEK^GD5584, Scer\GAL4^109(2)80 is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

Scer\GAL4^elav.PU/PEK^GD5584 is a suppressor of abnormal neuroanatomy | adult stage phenotype of park²⁵

(Celardo et al., 2016)

Scer\GAL4^elav.PU/PEK^GD5584 is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Pink1^B9

(Celardo et al., 2016)

PEK^GD5584, Scer\GAL4^NP5130 is a suppressor of increased occurrence of cell division phenotype of Scer\GAL4^NP5130, hep^UAS.cBa

(Wang et al., 2015)

PEK^GD5584, Scer\GAL4^NP5130 is a suppressor of increased occurrence of cell division phenotype of N^RNAi.P.UAS, Scer\GAL4^NP5130

(Wang et al., 2015)

PEK^GD5584, Scer\GAL4^NP5130 is a suppressor of increased occurrence of cell division | adult stage phenotype of Ero1L^GD3577, Scer\GAL4^NP5130

(Wang et al., 2015)

PEK^GD5584, Scer\GAL4^da.G32 is a suppressor | partially of abnormal developmental rate | larval stage phenotype of PPP1R15^GD5953, Scer\GAL4^da.G32

(Malzer et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Act.PU/PEK^GD5584 is a non-suppressor of decreased cell number | somatic clone | larval stage phenotype of scrib¹

(Zheng et al., 2023)

Other

Statement

Reference

PEK^GD5584, PPP1R15^GD5953, Scer\GAL4^da.G32 has partially lethal phenotype

(Malzer et al., 2013)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/PEK^GD5584 is a non-enhancer of eye-antennal disc | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Suppressor of

Statement

Reference

PEK^GD5584, Scer\GAL4^nub.PU is a suppressor of wing disc | larval stage phenotype of Gp93^NIG.5520R, Scer\GAL4^nub.PU

(Xu et al., 2025)

PEK^GD5584, Scer\GAL4^109(2)80 is a suppressor | partially of abdominal dorsal multidendritic neuron ddaC | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

PEK^GD5584, Scer\GAL4^109(2)80 is a suppressor | partially of dendrite | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

Scer\GAL4^elav.PU/PEK^GD5584 is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of park²⁵

(Celardo et al., 2016)

Scer\GAL4^elav.PU/PEK^GD5584 is a suppressor | partially of dopaminergic PPL1 neuron | adult stage phenotype of Pink1^B9

(Celardo et al., 2016)

PEK^GD5584, Scer\GAL4^NP5130 is a suppressor of adult gut phenotype of Scer\GAL4^NP5130, hep^UAS.cBa

(Wang et al., 2015)

PEK^GD5584, Scer\GAL4^NP5130 is a suppressor of adult gut phenotype of N^RNAi.P.UAS, Scer\GAL4^NP5130

(Wang et al., 2015)

PEK^GD5584, Scer\GAL4^NP5130 is a suppressor of intestinal stem cell | adult stage phenotype of Ero1L^GD3577, Scer\GAL4^NP5130

(Wang et al., 2015)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Act.PU/PEK^GD5584 is a non-suppressor of eye-antennal disc | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

The shortening of the dendritic arbor in class IV ddaC neurons in third instar larvae expressing prel^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^109(2)80 is strongly mitigated by co-expression of any of PEK^GD5584.

(Tsuyama et al., 2017)

Expression of PEK^GD5584 under the control of Scer\GAL4^elav.PU significantly rescues the loss of dopaminergic neurons characteristic for either Pink1^B9 or park²⁵/park²⁵ mutant adults.

(Celardo et al., 2016)

The increased cell proliferation in the adult gut expressing hep^Scer\UAS.cBa or Ero1L^GD3577 or N^{dsRNA.P.Scer\UAS} under the control of Scer\GAL4^esg-NP5130 (using tub-gal80[ts] to limit the time of expression) is suppressed by co-expression of PEK^GD5584.

(Wang et al., 2015)

Co-expression of PEK^GD5584 modestly rescues the developmental delay phenotype of animals expressing Gadd34^GD5953 under the control of Scer\GAL4^da.G32. However, these animals often die during eclosion from the pupal case, and surviving adults show severe mobility defects and have strongly reduced longevity.

(Malzer et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v16427

w¹¹¹⁸; P{GD5584}v16427

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

5584

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

PEK^GD5584

PERK^RNAi

(Wang et al., 2015)

Perk[GD]

(Tsuyama et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

Open Close