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FB2026_01
,
released March 12, 2026
Argk, Arginine kinase, AK, ARK, AK-1
Please see the JBrowse view of Dmel\Argk1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Argk1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
Argk1 expression is enriched in border follicle cells relative to other cells in the egg chamber.
Argk1 enzyme activity is present throughout development but there are sharp, transient peaks during the prepupal period and at eclosion. The greatest increase in activity is seen in imaginal discs in the prepupal period. This peak is not seen at the restrictive temperature in the ts-ecdysoneless mutant ecd1 but reappears after larvae are shifted back to a nonrestrictive temperature or fed 20-hydroxyecdysone.
Comment: Expression throughout all neuropil areas in adult brain, higher in some areas.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Argk1 in JBrowse
3-28
3-21.4
1-
3-25.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Investigation of the Argk isoenzyme system in flight muscle.
Immunological distances were measured by microcomplement fixation for 20 species of Drosophila Argk. The unit evolutionary period for Drosophila Argk is estimated to be 59 million years. The value predicted for vertebrate creatine kinase was 30 million years. The difference may be because a single gene encodes Drosophila Argk whereas three genes encode various forms of vertebrate creatine kinase.
Argk encodes two isozymes that have parallel gene-dosage responses, immunological similarities and cosegregation of electrophoretic mobility differences.
Structural gene for arginine kinase (ARGK) based on gene dosage studies. Cellular and mitochondrial forms behave as if both are products of the gene. (FBrf0042737).
high in body-wall and digestive-tract musculature;
Source for merge of: CG5173 CG4929
Source for merge of: Argk CG4929
Annotations CG4929, CG5173 merged as CG32031 in release 3 of the genome annotation.
Source for merge of Argk CG4929 was a shared cDNA ( date:010720 ).
Source for identity of: Argk1 Argk
