FlyBase Gene Report: Dmel\Nrk

General Information

Symbol

Dmel\Nrk

Species

D. melanogaster

Name

Neurospecific receptor kinase

Annotation Symbol

CG4007

Feature Type

protein_coding_gene

FlyBase ID

FBgn0020391

Gene Model Status

Current

Stock Availability

14 publicly available

Enzyme Name (EC)

receptor protein-tyrosine kinase (2.7.10.1)

Gene Summary

Neurospecific receptor kinase (Nrk) encodes a receptor tyrosine kinase that is expressed in the developing nervous system and regulates axon pathfinding and rhabdomere elongation. It interacts genetically with Dys and Dg. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dnrk, DmHD-434, nrtk_dros

Key Links

Genomic Location

Cytogenetic map

49F4-49F4

Sequence location

2R:13,160,063..13,163,484 [+]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13160063..13163484

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein tyrosine kinase activity

inferred from direct assay

(Oishi et al., 1997)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266

(InterPro Project Members, 2004-)

enables protein tyrosine kinase activity

inferred from electronic annotation with InterPro:IPR020635

(InterPro Project Members, 2004-)

enables transmembrane receptor protein tyrosine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity

(Oishi et al., 1997)

enables Wnt-protein binding

inferred from biological aspect of ancestor with PANTHER:PTN004704195

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in muscle cell cellular homeostasis

inferred from mutant phenotype

(Kucherenko et al., 2011)

inferred from genetic interaction with FLYBASE:Dg; FB:FBgn0034072

(Kucherenko et al., 2011)

inferred from genetic interaction with FLYBASE:Dys; FB:FBgn0260003

(Kucherenko et al., 2011)

involved_in photoreceptor cell axon guidance

inferred from mutant phenotype

(Marrone et al., 2011)

involved_in rhabdomere development

inferred from mutant phenotype

(Marrone et al., 2011)

involved_in signal transduction

inferred from direct assay

(Oishi et al., 1997)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in cell surface receptor protein tyrosine kinase signaling pathway

inferred from electronic annotation with InterPro:IPR016247

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence or structural similarity

(Oishi et al., 1997)

part_of receptor complex

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RECEPTOR TYROSINE KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (Q9V6K3)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

transmembrane receptor protein tyrosine kinase activity

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) (2.7.10.1)

protein tyrosine kinase activity

RHEA 10596:

Summaries

Gene Snapshot

Gene Group (FlyBase)

RECEPTOR TYROSINE KINASES -: Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).

Protein Function (UniProtKB)

Tyrosine-protein kinase receptor that functions during early stages of neuronal development.

(UniProt, Q9V6K3)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Nrk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V6K3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

7ME4

Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nrk-RA

FBtr0087728

NM_057907

3235

724

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Nrk-PA

FBpp0086841

81.8

724

6.62

Q9V6K3

NP_477255

AAF58420

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

714 (aa)

(Oishi et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

7ME4

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9V6K3

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nrk using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nrk_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Oishi et al., 1997)

embryonic stage 10 -- 17

neurogenic region

(Oishi et al., 1997)

presumptive embryonic/larval central nervous system

(Oishi et al., 1997)

embryonic stage 17

peripheral nervous system

(Oishi et al., 1997)

Additional Descriptive Data

The 3.5 kb Nrk transcript is expressed at 4-22 hours of embryogenesis, with the highest embryonic expression at 4-10 hours. Expression continues to be detected in larvae, reaches its highest levels in pupae and is low in adult flies. Using in situ hybridization, embryonic expression is first detected at stage 10, in ventral regions of the germ band. Expression continues to be detected in the developing nervous system through the rest of embryonic development.

(Oishi et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nrk in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Nrk

View exonic expression by tissue for Dmel\Nrk

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36445/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020391

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020391

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020391

Flygut - An atlas of the Drosophila adult midgut

FBgn0020391

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Nrk

Transgenic constructs containing regulatory region of Nrk

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel8057

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Nrk^k14301

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal locomotor behavior | dominant | temperature conditional

Nrk^k14301

abnormal neuroanatomy | third instar larval stage

Nrk^k14301

short lived, with Scer\GAL4^Mef2.PR

Nrk^GD14403

Phenotype manifest in

Allele

axon | third instar larval stage

Nrk^k14301

indirect flight muscle cell, with Scer\GAL4^Toll-6-D42

Nrk^RNAi.UAS.cUa

lamina plexus | third instar larval stage

Nrk^k14301

rhabdomere | adult stage, with Scer\GAL4^GMR.PU

Nrk^GD14403

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (96)

Hsap\MUSK

12 of 14

Yes

Hsap\ROR1

5 of 14

Hsap\ROR2

5 of 14

Hsap\NTRK1

2 of 14

Yes

Hsap\NTRK2

2 of 14

Yes

Hsap\NTRK3

2 of 14

Yes

Hsap\PTK7

2 of 14

Hsap\AATK

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\LMTK3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\YES1

1 of 14

Hsap\ZAP70

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (60)

Rnor\Musk

12 of 14

Yes

Rnor\Ror1

5 of 14

Rnor\Ror2

4 of 14

Rnor\Ntrk1

2 of 14

Yes

Rnor\Ntrk2

2 of 14

Yes

Rnor\Ntrk3

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zap70

1 of 14

Mus musculus (laboratory mouse) (61)

Mmus\Musk

12 of 14

Yes

Mmus\Ror1

5 of 14

Mmus\Ror2

5 of 14

Mmus\Ntrk1

2 of 14

Yes

Mmus\Ntrk2

2 of 14

Yes

Mmus\Ntrk3

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zap70

1 of 14

Xenopus tropicalis (Western clawed frog) (71)

Xtro\musk

9 of 13

Yes

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100494464

1 of 13

Yes

Xtro\LOC100494929

1 of 13

Xtro\LOC100495443

1 of 13

Xtro\LOC100495885

1 of 13

Yes

Xtro\LOC100495931

1 of 13

Xtro\LOC100496572

1 of 13

Xtro\LOC101730305

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\trim27

1 of 13

Yes

Xtro\tyro3

1 of 13

Yes

Xtro\uqcrfs1

1 of 13

Xtro\vps16

1 of 13

Xtro\XB5729271

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (67)

Drer\musk

10 of 14

Yes

Drer\ror1

4 of 14

Drer\ror2

4 of 14

Drer\ntrk2a

2 of 14

Yes

Drer\ntrk3a

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ntrk2b

1 of 14

Yes

Drer\ntrk3b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\yrk

1 of 14

Drer\zap70

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (61)

Cele\cam-1

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (31)

Agam\AgaP_AGAP006988

12 of 12

Yes

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (92)

Atha\STY46

2 of 13

Yes

Atha\VIK

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G15530

1 of 13

Yes

Atha\AT1G19390

1 of 13

Yes

Atha\AT1G25390

1 of 13

Yes

Atha\AT1G66910

1 of 13

Yes

Atha\AT1G66920

1 of 13

Yes

Atha\AT1G70740

1 of 13

Atha\AT2G23450

1 of 13

Yes

Atha\AT2G28960

1 of 13

Atha\AT2G43700

1 of 13

Yes

Atha\AT3G08870

1 of 13

Yes

Atha\AT3G45330

1 of 13

Yes

Atha\AT3G45410

1 of 13

Atha\AT3G45420

1 of 13

Yes

Atha\AT3G45430

1 of 13

Yes

Atha\AT3G45440

1 of 13

Yes

Atha\AT3G53380

1 of 13

Yes

Atha\AT3G53810

1 of 13

Atha\AT3G56050

1 of 13

Yes

Atha\AT3G59750

1 of 13

Yes

Atha\AT4G01330

1 of 13

Yes

Atha\AT4G11900

1 of 13

Yes

Atha\AT4G14780

1 of 13

Atha\AT4G28350

1 of 13

Yes

Atha\AT4G29050

1 of 13

Yes

Atha\AT4G31110

1 of 13

Yes

Atha\AT4G31170

1 of 13

Atha\AT5G02070

1 of 13

Atha\AT5G03140

1 of 13

Yes

Atha\AT5G10530

1 of 13

Atha\AT5G24080

1 of 13

Yes

Atha\AT5G38210

1 of 13

Yes

Atha\AT5G38240

1 of 13

Yes

Atha\AT5G56790

1 of 13

Yes

Atha\AT5G59270

1 of 13

Yes

Atha\AT5G60270

1 of 13

Yes

Atha\AT5G60280

1 of 13

Atha\AT5G60310

1 of 13

Yes

Atha\AT5G60320

1 of 13

Atha\AT5G65600

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\CRK11

1 of 13

Atha\CRK12

1 of 13

Atha\CRK13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\CRK22

1 of 13

Yes

Atha\CRK23

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\CRK36

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\LECRKA4.2

1 of 13

Yes

Atha\LECRKA4.3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\TPK1

1 of 13

Yes

Scer\TPK3

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Nrk. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (33)

Ror

8 of 13

Alk

4 of 13

btl

4 of 13

Cad96Ca

4 of 13

CG3277

4 of 13

Egfr

4 of 13

Eph

4 of 13

htl

4 of 13

Ret

4 of 13

sev

4 of 13

Ddr

3 of 13

dnt

3 of 13

drl

3 of 13

InR

3 of 13

Pvr

3 of 13

Tie

3 of 13

Abl

2 of 13

Ack

2 of 13

Btk

2 of 13

Csk

2 of 13

Drl-2

2 of 13

Fak

2 of 13

FER

2 of 13

otk

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Sdr

1 of 13

tor

1 of 13

tutl

1 of 13

Wsck

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

MUSK; muscle associated receptor tyrosine kinase

model of fetal akinesia deformation sequence syndrome 1

IEA

(FlyBase, 2019-)

model of congenital myasthenic syndrome 9

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Nrk^k14301

exacerbates muscular dystrophy

modeled by Dg^O86

(Kucherenko et al., 2011)

modeled by Dg³²³

(Kucherenko et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MUSK; muscle associated receptor tyrosine kinase

12 of 14

601296

ROR1; receptor tyrosine kinase like orphan receptor 1

5 of 14

602336

DEAFNESS, AUTOSOMAL RECESSIVE 108; DFNB108

autosomal recessive nonsyndromic deafness 108

ROR2; receptor tyrosine kinase like orphan receptor 2

5 of 14

602337

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dys

suppressible

Nrk

(Kucherenko et al., 2008)

fzr

suppressible

Nrk

(Neuert et al., 2017)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0020391

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V6K3

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

49F4-49F4

Sequence location

2R:13,160,063..13,163,484 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49F4-49F4

Limits computationally determined from genome sequence between P{lacW}Psc^k07834&P{lacW}Su(z)2^k06344 and P{EP}EP873^EP873

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

49F-49F

(determined by in situ hybridisation)

(Oishi et al., 1997)

49F7-49F8

(determined by in situ hybridisation)

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-71.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

600139

w^*; Nrk^KO

28454

y¹ w^*; P{EP}Nrk^G2759 ND-MWFE^G2759

77053

y¹ sc^* v¹ sev²¹; P{TKO.GS00841}attP40

56936

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04375}attP2

55184

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03875}attP40

80503

y¹ sc^* v¹ sev²¹; P{TOE.GS01918}attP40/CyO

NIG-Fly

4007R-2

P{NIG.4007R}2

4007R-3

P{NIG.4007R}3

2RG-0891

y² VhaAC39-1^cho-1 v¹; P{U6-Nrk.NIG.sgRNA}attP40/CyO

VDRC

v103804

P{KK100208}VIE-260B

v36282

w¹¹¹⁸; P{GD14403}v36282

v341629

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00721}attP40/CyO-GFP

More stocks available...

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE55360

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0020391

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0020391

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities, spindle abnormalities, chromosome abnormalities are chromosome alignment defects are seen.

(Bettencourt-Dias et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Identification and characterisation of a new member of the Trk/Ror family RTKs, Nrk, which is expressed specifically in the developing nervous system during embryogenesis.

(Oishi et al., 1997)

Relationship to Other Genes

Source for database merge of

Additional comments

Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.

(Oates, 1997.11.10)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG4007

(National Institute of Genetics Fly Stocks, 2022-, Neuert et al., 2017, Vogel et al., 2013, Kirienko and Fay, 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Morrison et al., 2000, Whitfield, 2000.6.22)

DNRK

(Rehn et al., 1998)

DmHD-434

(Oates et al., 1998, Oates, 1997.11.10)

Dnrk

(Minami, 1997.2.25, Oishi et al., 1997)

HD-434

Nrk

(Bischoff et al., 2025, Sutton et al., 2024, Pan and O'Connor, 2021, Shi et al., 2021, Watanabe and Riddle, 2021, Nye et al., 2020, Port et al., 2020, Mele and Johnson, 2019, Neuert et al., 2017, Transgenic RNAi Project members, 2017-, Dean et al., 2013, Sopko and Perrimon, 2013, Japanese National Institute of Genetics, 2012.5.21, Kucherenko et al., 2011, Marrone et al., 2011, Kucherenko et al., 2008, Sanchez, 2006, Pickeral et al., 2000)

ROR2

(Banyai and Patthy, 2004)

anon-WO2004063362.79

l(2)k14301

nrk

(Mattila et al., 2008)

nrtk_dros

(Saldanha et al., 1998, Saldanha et al., 1998)

Name Synonyms

Drosophila neurospecific receptor kinase

(Oishi et al., 1997)

Neuronal receptor kinase

(Kucherenko et al., 2011)

Neurospecific receptor kinase

(Dean et al., 2013, Marrone et al., 2011)

Neurotrophic receptor kinase

(Mele and Johnson, 2019)

Neurotropic receptor kinase

(Sopko and Perrimon, 2013)

neurospecific receptor tyrosine kinase

(Minami, 1997.2.25)

Secondary FlyBase IDs

FBgn0021861
FBgn0022790
FBgn0082206

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36445

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V6K3

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V6K3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V6K3

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36445/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0020391

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0020391

FlyMine - An integrated database for Drosophila genomics

FBgn0020391

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4007

MARRVEL_MODEL - MARRVEL (model organism gene)

36445

PDB - An information portal to biological macromolecular structures

7ME4

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0020391

DroID - A comprehensive database of gene and protein interactions.

FBgn0020391

DRSC - Results frm RNAi screens

FBgn0020391

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nrk_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0020391

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0020391

Flygut - An atlas of the Drosophila adult midgut

FBgn0020391

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V6K3

References (77)

The following external sites may use different assemblies or annotations than FlyBase.

-0.49

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