FlyBase Gene Report: Dmel\fus

General Information

Symbol

Dmel\fus

Species

D. melanogaster

Name

fusilli

Annotation Symbol

CG8205

Feature Type

protein_coding_gene

FlyBase ID

FBgn0023441

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

mRNA splicing factor that regulates alternative splicing od specific genes. Has a maternal role in embryonic dorsal-ventral patterning; such role is probably indirect and due to its function as mRNA splicing factor regulator. (UniProt, Q9BJZ5)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

E(cact^E10)7, Enhancer of cactus^E10, number 7

Key Links

Genomic Location

Cytogenetic map

52B3-52B5

Sequence location

2R:15,657,318..15,676,669 [-]

Recombination map

2-75

RefSeq locus

NT_033778 REGION:15657318..15676669

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables mRNA binding

inferred from direct assay

(Warzecha et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables mRNA binding

inferred from sequence or structural similarity

(Lasko, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN001018050

(GO Reference Genome Project, 2011-)

enables nucleic acid binding

inferred from electronic annotation with InterPro:IPR035979

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR035979, InterPro:IPR036397

(InterPro Project Members, 2004-)

enables RNA binding

inferred from electronic annotation with InterPro:IPR000504

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in regulation of RNA splicing

inferred from direct assay

(Warzecha et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of RNA splicing

inferred from biological aspect of ancestor with PANTHER:PTN000360053

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in nucleoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000360053

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:P35637

(Gene Ontology Curators, 2002-)

part_of ribonucleoprotein complex

inferred from biological aspect of ancestor with PANTHER:PTN000359854

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the ESRP family. (Q9BJZ5)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

(UniProt, Q9BJZ5)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\fus for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9BJZ5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts may not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

fus-RA

FBtr0087348

NM_166106

2790

557

fus-RB

FBtr0087347

NM_166109

4375

633

fus-RC

FBtr0087345

NM_166105

3671

891

fus-RD

FBtr0087344

NM_079952

5256

967

fus-RE

FBtr0087346

NM_166107

5512

967

fus-RF

FBtr0087343

NM_166108

5243

967

fus-RG

FBtr0302330

NM_001169690

3834

860

fus-RH

FBtr0306648

NM_001259418

2630

526

Additional Transcript Data and Comments

Reported size (kB)

5.247 (longest cDNA)

(Wakabayashi-Ito et al., 2001)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

fus-PA

FBpp0086481

59.2

557

8.20

NP_725480

AAF58117

fus-PB

FBpp0086480

66.5

633

8.82

NP_725483

AAM70984

fus-PC

FBpp0086478

95.5

891

6.87

NP_725479

AAM70980

fus-PD

FBpp0086477

102.7

967

7.09

FBpp0086479

102.7

967

7.09

FBpp0086476

102.7

967

7.09

FBpp0291536

92.4

860

6.83

FBpp0297603

56.2

526

8.26

A0A0B4K880

NP_001246347

AFH08101

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

967 aa isoforms: fus-PD, fus-PE, fus-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

967 (aa)

(Wakabayashi-Ito et al., 2001)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fus using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.93

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9

proctodeum

(Wakabayashi-Ito et al., 2001)

stomodeum

(Wakabayashi-Ito et al., 2001)

embryonic stage 9 -- 10

dorsal ectoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11

mesoderm | segmentally repeated

(Wakabayashi-Ito et al., 2001)

embryonic stage 11 -- 12

corpus allatum primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

fat body/gonad primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

embryonic stage 13

embryonic foregut

(Wakabayashi-Ito et al., 2001)

embryonic/larval posterior spiracle

(Wakabayashi-Ito et al., 2001)

embryonic/larval fat body

(Wakabayashi-Ito et al., 2001)

ectoderm | segmentally repeated

(Wakabayashi-Ito et al., 2001)

embryonic stage 13 -- 16

embryonic foregut

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic/larval corpus allatum

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

embryonic/larval lymph gland

(Fisher et al., 2012)

adult stage & oogenesis

nurse cell

(Wakabayashi-Ito et al., 2001)

follicle cell

(Wakabayashi-Ito et al., 2001)

Additional Descriptive Data

The follicle cells in which fus is expressed may correspond to the centripetally migrating follicle cells.

(Wakabayashi-Ito et al., 2001)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\fus in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\fus

View exonic expression by tissue for Dmel\fus

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0023441

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44095/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0023441

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0023441

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0023441

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8205

Flygut - An atlas of the Drosophila adult midgut

FBgn0023441

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\fus

Stages(s) 1-3
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 35 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of fus

Transgenic constructs containing regulatory region of fus

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2R)Exel7137

(Ryder, 2004.4.26)

Df(2R)Jp4

(Wakabayashi-Ito et al., 2001)

Df(2R)WMG

(Wakabayashi-Ito et al., 2001)

Gene not disrupted in

Df(2R)Jp5

(Wakabayashi-Ito et al., 2001)

Df(2R)XTE-11

(Wakabayashi-Ito et al., 2001)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage | recessive

partially lethal - majority die, with Scer\GAL4^pnr-MD237

fus^GD13841

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

fus^GD13841

viable, with Scer\GAL4^Mef2.PR

fus^GD13841

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

fus^GD13841

some die during embryonic stage | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

fus^GD13841

visible, with Scer\GAL4^pnr-MD237

fus^GD13841

Phenotype manifest in

Allele

mesonotum, with Scer\GAL4^pnr-MD237

fus^GD13841

wing blade posterior compartment, with Scer\GAL4^en-e16E

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

Hsap\ESRP2

12 of 14

Yes

Hsap\ESRP1

11 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RBM19

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (11)

Rnor\Esrp2

12 of 14

Yes

Rnor\Esrp1

11 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Mus musculus (laboratory mouse) (10)

Mmus\Esrp2

12 of 14

Yes

Mmus\Esrp1

11 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\esrp1

8 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (11)

Drer\esrp2

12 of 14

Yes

Drer\esrp1

10 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\sym-2

10 of 14

Yes

Cele\hrpf-2

3 of 14

Cele\hrpf-1

1 of 14

Cele\rbm-12

1 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP011722

10 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (8)

Atha\AT3G20890

4 of 13

Yes

Atha\AT5G66010

4 of 13

Yes

Atha\AT1G45100

1 of 13

Atha\AT2G35410

1 of 13

Atha\AT3G48835

1 of 13

Yes

Atha\AT4G09040

1 of 13

Atha\AT5G41690

1 of 13

Atha\PHIP1

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\GBP2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:fus. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

glo

6 of 13

CG7879

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ESRP1; epithelial splicing regulatory protein 1

model of autosomal recessive nonsyndromic deafness 109

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ESRP2; epithelial splicing regulatory protein 2

12 of 14

612960

ESRP1; epithelial splicing regulatory protein 1

11 of 14

612959

DEAFNESS, AUTOSOMAL RECESSIVE 109; DFNB109

autosomal recessive nonsyndromic deafness 109

GRSF1; G-rich RNA sequence binding factor 1

4 of 14

604851

HNRNPF; heterogeneous nuclear ribonucleoprotein F

4 of 14

601037

HNRNPH3; heterogeneous nuclear ribonucleoprotein H3

4 of 14

602324

HNRNPH1; heterogeneous nuclear ribonucleoprotein H1

3 of 14

601035

NEURODEVELOPMENTAL DISORDER WITH CRANIOFACIAL DYSMORPHISM AND SKELETAL DEFECTS; NEDCDS

HNRNPH2; heterogeneous nuclear ribonucleoprotein H2

3 of 14

300610

INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, BAIN TYPE; MRXSB

syndromic X-linked intellectual developmental disorder bain type

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

fus - stau

anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization

(Laver et al., 2013)

protein-protein

Physical Interaction

Assay

References

fus - CG44251

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

fus|cact

enhanceable

Egfr

(Wakabayashi-Ito et al., 2001)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cact

enhanceable

fus

(Wakabayashi-Ito et al., 2001, Wakabayashi-Ito and Anderson, 1998, Ito et al., 1997)

cact

enhanceable

fus|Egfr

(Wakabayashi-Ito et al., 2001)

suppressible

fus

(Krupp et al., 2005)

enhanceable

fus

(Krupp et al., 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68827

DroID - A comprehensive database of gene and protein interactions.

FBgn0023441

MIST (genetic) - An integrated Molecular Interaction Database

44095

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-75

Cytogenetic map

52B3-52B5

Sequence location

2R:15,657,318..15,676,669 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

52B3-52B5

Limits computationally determined from genome sequence between P{lacW}Vha36^k07207 and P{lacW}l(2)k05713^k05713

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

52B1-52B3

(Wakabayashi-Ito, 2000.11.16, Wakabayashi-Ito and Anderson, 1998)

Experimentally Determined Recombination Data

Location

2-75

(FlyBase, 2016)

2-79.0

(Comeron et al., 2012)

Left of (cM)

P{lacW}k02201

(Wakabayashi-Ito et al., 2001)

(Ito, 1996.4.29)

Right of (cM)

(Wakabayashi-Ito et al., 2001)

(Ito, 1996.4.29)

Notes

fus¹ used in recombination mapping.

(Wakabayashi-Ito et al., 2001)

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

26485

w¹¹¹⁸; Mi{ET1}fus^MB09495/SM6a

27457

y¹ w^*; P{EP}fus^G2369

35935

y¹ w^*; Mi{MIC}fus^MI01038

30645

y¹ w^*; Mi{MIC}fus^MI00168/CyO

30911

Adc^b-1 pr¹ cn¹ fus¹/CyO

30912

cn¹ P{lacW}fus² bw¹ speck¹/CyO

55921

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04208}attP40

NIG-Fly

2RG-0676

y² VhaAC39-1^cho-1 v¹; P{U6-fus.NIG.sgRNA}attP40/CyO

VDRC

v330263

P{VSH330263}attP40

v107575

P{KK108164}VIE-260B

Genomic Clones (28)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (83)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0023441

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0023441

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Na et al., 2016)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

fus is required for full activity of the Egfr pathway in follicle cells.

(Wakabayashi-Ito et al., 2001)

Identified in a screen for enhancers of cact^E10/+.

(Ito et al., 1997)

Relationship to Other Genes

Source for database merge of

Source for merge of: fus E(cact^E10)7

(Wakabayashi-Ito, 2001.8.27)

Source for merge of: fus CG8205

(FlyBase, 1996-)

Additional comments

Source for merge of fus CG8205 was sequence comparison ( date:010307 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG8205

(National Institute of Genetics Fly Stocks, 2022-, Meadows, 2017.1.11, Na et al., 2016, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Raisin et al., 2003)

E(cact^E10)7

(Ito, 1996.4.29, Ito et al., 1996)

FUS

(Braems et al., 2021, Gogia et al., 2021, Ishiguro et al., 2021, Keegan and Hughes, 2021, Yamaguchi et al., 2021, Gois et al., 2020)

Fus

(Castro et al., 2020)

cg8205

(Lasko, 2000)

fus

(Sutton et al., 2024, Voutyraki et al., 2023, Kumar et al., 2021, Sapiro et al., 2020, Wang et al., 2018, Hu et al., 2017.6.13, Na et al., 2016, Ashwal-Fluss et al., 2014, Luck et al., 2014, Foley et al., 2010, Janic et al., 2010, Urasaki et al., 2008, Haag-Liautard et al., 2007, Robida et al., 2007, Burgler and Macdonald, 2005)

Name Synonyms

Enhancer of cactusE10, number 7

(Ito, 1996.4.29, Ito et al., 1996)

Fusilli

(Warzecha et al., 2009)

fusilli

(Yang and Carstens, 2017, Laver et al., 2013, Nairz et al., 2006, Ito et al., 1997)

Secondary FlyBase IDs

FBgn0015696
FBgn0034034

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 88 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44095

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9BJZ5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9BJZ5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9BJZ5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0023441

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44095/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0023441

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0023441

FlyMine - An integrated database for Drosophila genomics

FBgn0023441

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8205

MARRVEL_MODEL - MARRVEL (model organism gene)

44095

Linkouts

BioGRID - A database of protein and genetic interactions.

68827

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0023441

DroID - A comprehensive database of gene and protein interactions.

FBgn0023441

DRSC - Results frm RNAi screens

FBgn0023441

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0023441

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0023441

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8205

Flygut - An atlas of the Drosophila adult midgut

FBgn0023441

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0023441

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009268

MIST (genetic) - An integrated Molecular Interaction Database

44095

References (70)

The following external sites may use different assemblies or annotations than FlyBase.

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