FlyBase Gene Report: Dmel\hang

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\hang

General Information

Symbol

Dmel\hang

Species

D. melanogaster

Name

hangover

Annotation Symbol

CG32575

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026575

Gene Model Status

Stock Availability

13 publicly available

Gene Summary

hangover (hang) encodes a nuclear zinc finger protein that is expressed in adult fly brain neurons. Lack of hang produces a reduction of Fas2 expression. Its roles include life span, bouton growth at the neuromuscular junction and regulation of cellular stress in response to ethanol, heat and paraquat. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

BcDNA:LD22118

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:16,422,831..16,438,454 [+]

Recombination map

1-53

RefSeq locus

NC_004354 REGION:16422831..16438454

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables mRNA binding

inferred from direct assay

(Ruppert et al., 2017)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN004702832

(GO Reference Genome Project, 2011-)

enables nucleic acid binding

non-traceable author statement

(Scholz et al., 2005)

inferred from electronic annotation with InterPro:IPR003604

(InterPro Project Members, 2004-)

enables sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004702832

(GO Reference Genome Project, 2011-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR003604, InterPro:IPR012934

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

acts_upstream_of behavioral response to ethanol

inferred from mutant phenotype

(Ruppert et al., 2017)

involved_in behavioral response to ethanol

inferred from mutant phenotype

(Scholz et al., 2005)

involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from mutant phenotype

(Ruppert et al., 2017)

involved_in response to ethanol

inferred from mutant phenotype

(Scholz et al., 2005)

involved_in response to heat

inferred from mutant phenotype

(Scholz et al., 2005)

involved_in response to oxidative stress

inferred from mutant phenotype

(Scholz et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN004702832

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Ruppert et al., 2017, Scholz et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN004702832

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from electronic annotation with InterPro:IPR012934

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

hangover (hang) encodes a nuclear zinc finger protein that is expressed in adult fly brain neurons. Lack of hang produces a reduction of Fas2 expression. Its roles include life span, bouton growth at the neuromuscular junction and regulation of cellular stress in response to ethanol, heat and paraquat. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Protein Function (UniProtKB)

Required for normal development of ethanol tolerance. Relies on two distinct molecular pathways: a cellular stress pathway defined by hang, and a parallel pathway requiring octopamine.

(UniProt, Q9VXG1)

Summary (Interactive Fly)

a nuclear RNA binding protein that regulates dunce transcript levels, bouton growth at the neuromuscular junction, and cellular stress in response to ethanol, heat and paraquat

Interactive Fly

Gene Model and Products

Number of Transcripts

3

Number of Unique Polypeptides

3

Please see the JBrowse view of Dmel\hang for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VXG1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Supported by strand-specific RNA-Seq data.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0074276

7876

1901

FBtr0290069

8763

2223

FBtr0343571

7971

1959

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0074052

208.2

1901

4.98

FBpp0288508

242.3

2223

5.65

FBpp0310171

213.8

1959

5.02

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hang using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

hang_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.78

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

• pole plasm

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

primordial germ cell

(Fisher et al., 2012)

embryonic stage 7 -- 8

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

embryonic neuroblast of ventral nerve cord primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

procephalic neuroblast

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

wandering third instar larval stage

wing pouch | restricted

(Molnar et al., 2012)

wing hinge primordium | restricted

(Molnar et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult brain | restricted

• nucleus | punctate

(Ruppert et al., 2017)

Additional Descriptive Data

hang-XP is expressed in the nucleus, but is excluded from the nucleoli.

(Ruppert et al., 2017)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Ruppert et al., 2017, Scholz et al., 2005)

Expression Deduced from Reporters

Reporter: P{GawB}cb01

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 14

(Ward et al., 2002)

third instar larval stage

(Ward et al., 2002)

larval central nervous system

(Ward et al., 2002)

(Ward et al., 2002)

adult stage | male

testis | intense

(Ward et al., 2002)

oogenesis & adult stage | female

terminal filament

(Ward et al., 2002)

germarium region 1

(Ward et al., 2002)

posterior aeropyle

(Ward et al., 2002)

oogenesis stage S8 -- S13 & adult stage | female

(Ward et al., 2002)

oogenesis stage S1 -- S14 & adult stage | female

follicle cell | subset

(Ward et al., 2002)

oogenesis stage S14 & adult stage | female

dorsal appendage forming follicle cell

(Ward et al., 2002)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\hang in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\hang

View exonic expression by tissue for Dmel\hang

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026575

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32613/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026575

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026575

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026575

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32575

Flygut - An atlas of the Drosophila adult midgut

FBgn0026575

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\hang

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of hang

Transgenic constructs containing regulatory region of hang

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially duplicated in

Dp(1;1)FDDP-0024486

(Cook, 2014.8.18)

Inferred from location ( 21 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^29BD

hang^GS1135

lethal, with Scer\GAL4^c355

hang^GS1135

lethal, with Scer\GAL4^hs.2sev

hang^GS1135

lethal, with Scer\GAL4^Pde4.RA

hang^UAS.cSa

partially lethal - majority die, with Scer\GAL4^dpp.blk1

hang^GS1135

partially lethal - majority die | adult stage, with Scer\GAL4^pnr-MD237

hang^GD11309

hang^AE10

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

hang^GD12787

Sterility

Allele

female semi-sterile, with Scer\GAL4^nanos.PG

hang^KK106334

female sterile, with Scer\GAL4^nanos.PG

hang^GD12787

Other Phenotypes

Allele

abnormal behavior | adult stage

hang^AE10

chemical resistant | adult stage, with Scer\GAL4^Pde4.RA

hang^UAS.cSa

chemical sensitive

hang^AE10

chemical sensitive | adult stage

hang^AE10

chemical sensitive | adult stage, with Scer\GAL4^Pde4.RA

hang^UAS.cSa

decreased fecundity | female, with Scer\GAL4^{VP16.nanos.UTR}

hang^AE10

visible, with Scer\GAL4^dpp.blk1

hang^GS1135

visible, with Scer\GAL4^pnr-MD237

Phenotype manifest in

Allele

egg | absent, with Scer\GAL4^{VP16.nanos.UTR}

egg chamber | decreased number, with Scer\GAL4^{VP16.nanos.UTR}

trichogen cell, with Scer\GAL4^pnr-MD237

wing, with Scer\GAL4^dpp.blk1

hang^GS1135

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (18)

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (8)

Rnor\LOC100365363

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

No

Mus musculus (laboratory mouse) (17)

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

Yes

Xenopus tropicalis (Western clawed frog) (9)

Xtro\LOC100485704

1 of 13

Yes

No

Xtro\LOC101731232

1 of 13

Yes

No

Xtro\LOC116411608

1 of 13

Yes

No

Xtro\LOC116411645

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

Danio rerio (Zebrafish) (8)

Drer\LOC100333012

1 of 14

Yes

No

Drer\si:ch211-202h22.10

1 of 14

Yes

Yes

Drer\si:ch211-216l23.1

1 of 14

Yes

No

Drer\si:dkey-14k9.3

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (11)

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

Anopheles gambiae (African malaria mosquito) (29)

Agam\AgaP_AGAP004259

1 of 12

Yes

No

Agam\AgaP_AGAP004285

1 of 12

Yes

No

Agam\AgaP_AGAP005269

1 of 12

Yes

No

Agam\AgaP_AGAP006129

1 of 12

Yes

Yes

Agam\AgaP_AGAP006544

1 of 12

Yes

Yes

Agam\AgaP_AGAP007513

1 of 12

Yes

No

Agam\AgaP_AGAP007514

1 of 12

Yes

No

Agam\AgaP_AGAP007516

1 of 12

Yes

No

Agam\AgaP_AGAP007518

1 of 12

Yes

Yes

Agam\AgaP_AGAP007804

1 of 12

Yes

Yes

Agam\AgaP_AGAP008134

1 of 12

Yes

Yes

Agam\AgaP_AGAP009069

1 of 12

Yes

Yes

Agam\AgaP_AGAP009096

1 of 12

Yes

No

Agam\AgaP_AGAP011403

1 of 12

Yes

Yes

Agam\AgaP_AGAP011404

1 of 12

Yes

Yes

Agam\AgaP_AGAP011405

1 of 12

Yes

No

Agam\AgaP_AGAP011408

1 of 12

Yes

Yes

Agam\AgaP_AGAP011409

1 of 12

Yes

Yes

Agam\AgaP_AGAP011410

1 of 12

Yes

No

Agam\AgaP_AGAP011411

1 of 12

Yes

Yes

Agam\AgaP_AGAP011721

1 of 12

Yes

No

Agam\AgaP_AGAP012027

1 of 12

Yes

Yes

Agam\AgaP_AGAP012741

1 of 12

Yes

No

Agam\AgaP_AGAP012742

1 of 12

Yes

Yes

Agam\AgaP_AGAP012753

1 of 12

Yes

Yes

Agam\AgaP_AGAP012768

1 of 12

Yes

No

Agam\AgaP_AGAP012816

1 of 12

Yes

Yes

Agam\AgaP_AGAP012918

1 of 12

Yes

Yes

Agam\AgaP_AGAP012919

1 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:hang. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (27)

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

alcohol, response to, stress-response genes

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

model of alcohol use disorder

CEA

(Scholz et al., 2005)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

model of alcohol use disorder

is exacerbated by Tbh^nM18

(Scholz et al., 2005)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot, molecular sieving

(Lenz et al., 2025)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot, molecular sieving

(Lenz et al., 2025)

anti tag coimmunoprecipitation, western blot, molecular sieving, Identification by mass spectrometry

(Lenz et al., 2025)

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry, molecular sieving

(Lenz et al., 2025)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

RNA-protein

Physical Interaction

Assay

References

pull down, quantitative reverse transcription pcr

(Ruppert et al., 2017)

pull down, quantitative reverse transcription pcr

(Ruppert et al., 2017)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Ruppert et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Ruppert et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58953

DroID - A comprehensive database of gene and protein interactions.

FBgn0026575

MIST (protein-protein) - An integrated Molecular Interaction Database

32613

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

X

Recombination map

1-53

Cytogenetic map

Sequence location

X:16,422,831..16,438,454 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14C4-14C4

Limits computationally determined from genome sequence between P{EP}EP1547^EP1547 and P{EP}CG4928^EP1341

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-53

(FlyBase, 2016)

1-54.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

83667

y¹ w^*; PBac{hang-GFP.FPTB}VK00037

83914

y¹ v¹; P{SAM.dCas9.GS05497}attP40/CyO

22571

y¹ w^67c23 P{EPgy2}hang^EY22604

92205

y¹ w^*; TI{CRIMIC.TG4.0}hang^{CR02226-TG4.0}

35674

y¹ sc^* v¹ sev²¹; P{TRiP.GLV21039}attP2

41870

y¹ sc^* v¹ sev²¹; P{TRiP.GL01300}attP40

57791

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04985}attP40

11347

P{EP}hang^G10658

4411R-1

v100952

P{KK106334}VIE-260B

v23000

w¹¹¹⁸; P{GD12787}v23000

v341507

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00578}attP40/CyO-GFP

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (107)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP15743

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026575

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026575

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

hang is required for ethanol tolerance development.

(Scholz et al., 2005)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Identification: in a behavioral screen.

(Scholz and Heberlein, 2004)

hang encodes for a zinc-finger protein required for the normal tolerance development in Drosophila. The hang gene defines a stress pathway required for ethanol tolerance in Drosophila.

(Scholz and Heberlein, 2004)

hang flies are defective in responses to several environmental stressors, such as heat and the free radical-generating agent paraquat, and display a reduced life span.

(Scholz and Heberlein, 2004)

Relationship to Other Genes

Source for database merge of

Source for merge of: BcDNA:LD22118 CG4411

(Bayraktaroglu, 2000.11.2)

Source for merge of: BcDNA:LD22118 BcDNA:GM07804

(FlyBase, 1996-)

Source for merge of: BcDNA:LD22118 CG4416

(FlyBase, 1996-)

Additional comments

Annotations CG4411, CG4416 merged as CG32575 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of BcDNA:LD22118 CG4416 was a shared cDNA ( date:010720 ).

(FlyBase, 1996-)

Source for merge of BcDNA:LD22118 BcDNA:GM07804 was a shared cDNA ( date:020730 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: hang CG32575

(Scholz, 2004.2.23)

Nomenclature comments

Etymology

The gene is named "hangover" as mutant flies have a reduced ability to develop tolerance to ethanol.

(Scholz et al., 2005)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

BcDNA:GM07804

BcDNA:LD22118

(Schulz et al., 2004, Giot et al., 2003)

CG32575

(Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Grieder et al., 2007, Larschan et al., 2007, Larschan et al., 2007, Peng et al., 2007)

CG4411

(Ward et al., 2002)

CG4416

(Boutros et al., 2004)

HANG

(Bajpe et al., 2008)

Hang

(Erokhin et al., 2021)

LD22118

(Toba et al., 1999)

Name Synonyms

hangover

(Scholz, 2025, Peterson and Ahmad, 2024, Kaun et al., 2012, Morozova et al., 2012, Bhandari et al., 2009, Li et al., 2008, Lindsay et al., 2008, Schwenkert et al., 2008, Scholz and Heberlein, 2004, Schwenkert et al., 2003)

Secondary FlyBase IDs

FBgn0030750
FBgn0030751
FBgn0052575
FBgn0062484

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32613

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VXG1

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VXG1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VXG1

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026575

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32613/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026575

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026575

FlyMine - An integrated database for Drosophila genomics

FBgn0026575

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32575

MARRVEL_MODEL - MARRVEL (model organism gene)

32613

Linkouts

BioGRID - A database of protein and genetic interactions.

58953

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026575

DroID - A comprehensive database of gene and protein interactions.

FBgn0026575

DRSC - Results frm RNAi screens

FBgn0026575

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

hang_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026575

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026575

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32575

Flygut - An atlas of the Drosophila adult midgut

FBgn0026575

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

32613

References (86)