FlyBase Gene Report: Dmel\Ankle2

General Information

Symbol

Dmel\Ankle2

Species

D. melanogaster

Name

Ankle2

Annotation Symbol

CG8465

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028343

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

Ankle2 (Ankle2) encodes an important protein for proper development of the third instar larval CNS. Ankle2 loss causes a small brain phenotype, defects in proliferation and excessive apoptosis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

l(1)G0222, l(1)G0316

Key Links

Genomic Location

Cytogenetic map

16B5-16B6

Sequence location

X:17,571,854..17,579,229 [-]

Recombination map

1-57

RefSeq locus

NC_004354 REGION:17571854..17579229

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein phosphatase 2A binding

inferred from biological aspect of ancestor with PANTHER:PTN000469495

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in cell morphogenesis

inferred from mutant phenotype

(D'Ambrosio and Vale, 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in negative regulation of phosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000469495

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in positive regulation of protein dephosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000469495

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(D'Ambrosio and Vale, 2010)

inferred from direct assay

(assigned by UniProt )

(Link et al., 2019)

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in endoplasmic reticulum

inferred from direct assay

(assigned by UniProt )

(Link et al., 2019)

inferred from direct assay

(D'Ambrosio and Vale, 2010)

located_in nuclear envelope

inferred from direct assay

(assigned by UniProt )

(Link et al., 2019)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in endoplasmic reticulum

inferred from biological aspect of ancestor with PANTHER:PTN000469495

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the ANKLE2 family. (Q8MQX9)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Involved in brain development probably by regulating asymmetric division of neuroblasts (PubMed:31735666, PubMed:30550790, PubMed:25259927). Regulates neuroblast asymmetric cell division by controlling asymmetric protein localization of Mira, Baz, Par-6 and aPKC, and spindle alignment (PubMed:31735666). Also, regulates the localization of kinase Ball during mitosis, specifically maintaining Ball in the nucleus during interphase (PubMed:31735666). Required for proper ER and nuclear envelope morphology in neuroblasts (PubMed:31735666).

(UniProt, Q8MQX9)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ankle2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8MQX9)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ankle2-RD

FBtr0301413

NM_132993

3870

1174

Ankle2-RE

FBtr0301414

NM_167569

3876

1174

Ankle2-RF

FBtr0301415

NM_167570

3569

1110

Ankle2-RG

FBtr0340625

NM_001298446

3855

1169

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ankle2-PD

FBpp0290627

129.1

1174

8.09

NP_573221

AAF48735

Ankle2-PE

FBpp0290628

129.1

1174

8.09

NP_728082

AAF48736

Ankle2-PF

FBpp0290629

123.0

1110

8.35

NP_728083

AAF48737

Ankle2-PG

FBpp0309489

128.5

1169

8.01

NP_001285375

AHN59845

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1174 aa isoforms: Ankle2-PD, Ankle2-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q8MQX9

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ankle2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(D'Ambrosio and Vale, 2010)

inferred from direct assay

(assigned by UniProt )

(Link et al., 2019)

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in endoplasmic reticulum

inferred from direct assay

(assigned by UniProt )

(Link et al., 2019)

inferred from direct assay

(D'Ambrosio and Vale, 2010)

located_in nuclear envelope

inferred from direct assay

(assigned by UniProt )

(Link et al., 2019)

Expression Deduced from Reporters

Reporter: PBac{602.P.SVS-1}Ankle2^CPTI000326

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ankle2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ankle2

View exonic expression by tissue for Dmel\Ankle2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028343

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32732/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028343

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028343

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028343

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8465

Flygut - An atlas of the Drosophila adult midgut

FBgn0028343

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ankle2

Transgenic constructs containing regulatory region of Ankle2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene duplicated in

Dp(1;3)DC331

(Popodi et al., 2010-, Venken et al., 2010)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Ankle2^GD13933

lethal | larval stage

Ankle2^G0316

lethal | prepupal stage

Ankle2^G0316

lethal | pupal stage

Ankle2^G0316

lethal | recessive

lethal - all die before end of larval stage

lethal - all die before end of larval stage (with Ankle2^CRIMIC)

Ankle2^IGFP

lethal - all die before end of larval stage (with Ankle2^IGFP)

Ankle2^CRIMIC

lethal - all die before end of pupal stage (with Ankle2^A)

lethal - all die before end of pupal stage (with Ankle2^CRIMIC)

Ankle2^A

lethal - all die before end of pupal stage (with Ankle2^IGFP)

Ankle2^A

lethal - all die before end of pupal stage | temperature conditional

Ankle2^A

viable

Ankle2^e03639

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ankle2^GD13933

viable, with Scer\GAL4^Mef2.PR

Ankle2^GD13933

viable, with Scer\GAL4^pnr-MD237

Ankle2^GD13933

viable, with Scer\GAL4^tin.CΔ4

Ankle2^GD13933

Sterility

Allele

fertile

Ankle2^e03639

Other Phenotypes

Allele

abnormal feeding behavior | third instar larval stage

Ankle2^A

abnormal mitotic cell cycle

Ankle2^A

abnormal neuroanatomy | larval stage

Ankle2^GD13933

abnormal neuroanatomy | somatic clone

Ankle2^A

abnormal neuroanatomy | third instar larval stage

abnormal size | third instar larval stage

decreased occurrence of cell division | larval stage | somatic clone

Ankle2^A

increased cell death | third instar larval stage

Ankle2^A

some die during larval stage

Ankle2^G0222

visible, with Scer\GAL4^pnr-MD237

Ankle2^GD13933

Phenotype manifest in

Allele

centrosome | increased number | third instar larval stage

Ankle2^A

embryonic/larval brain | larval stage | somatic clone

Ankle2^A

embryonic/larval brain | third instar larval stage

endoplasmic reticulum | third instar larval stage

Ankle2^A

ganglion mother cell | larval stage

Ankle2^GD13933

larval neuroblast | larval stage

Ankle2^GD13933

larval neuroblast | third instar larval stage

Ankle2^A

larval neuroblast | third instar larval stage (with Ankle2^A)

Ankle2^CRIMIC

larval neuroblast | third instar larval stage (with Ankle2^CRIMIC)

Ankle2^A

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Ankle2^GD13933

mitotic spindle | third instar larval stage

Ankle2^A

nuclear envelope | third instar larval stage

Ankle2^A

sensory organ cell | somatic clone

Ankle2^A

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ANKLE2

9 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ankle2

9 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Ankle2

7 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\ankle2

6 of 12

Yes

Danio rerio (Zebrafish) (2)

Drer\ankle2

9 of 15

Yes

Drer\LOC569920

3 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\lem-4

9 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Ankle2^A

model of microcephaly

CEA

(Yamamoto et al., 2014)

model of primary autosomal recessive microcephaly 16

CEA

(Link et al., 2019)

CEA with Hsap\ANKLE2^{L573V.UAS.Tag:FLAG}

(Link et al., 2019)

CEA with Hsap\ANKLE2^{Q782X.UAS.Tag:FLAG}

(Link et al., 2019)

CEA with Hsap\ANKLE2^{A109P.UAS.Tag:FLAG}

(Link et al., 2019)

CEA with Hsap\ANKLE2^{G201W.UAS.Tag:FLAG}

(Link et al., 2019)

Ankle2^CRIMIC

model of primary autosomal recessive microcephaly 16

CEA

(Link et al., 2019)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ANKLE2; ankyrin repeat and LEM domain containing 2

model of primary autosomal recessive microcephaly 16

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Ankle2^A

exacerbates microcephaly

modeled by ZIKV\NS4A^{UAS.Tag:StrepII}

(Shah et al., 2018)

model of primary autosomal recessive microcephaly 16

is ameliorated by ball²

(Link et al., 2019)

is ameliorated by ball^E107

(Link et al., 2019)

is ameliorated by l(2)gl^ts3

(Link et al., 2019)

Ankle2^UAS.cLa

ameliorates microcephaly

modeled by ZIKV\NS4A^{UAS.Tag:StrepII}

(Shah et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ANKLE2; ankyrin repeat and LEM domain containing 2

9 of 15

616062

MICROCEPHALY 16, PRIMARY, AUTOSOMAL RECESSIVE; MCPH16

primary autosomal recessive microcephaly 16

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Ankle2

Hsap\ANKLE2

(Link et al., 2019, Yamamoto et al., 2014)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ankle2 - Lkb1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Ankle2 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Ankle2 - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Ankle2 - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ankle2

suppressible

ball

(Link et al., 2019)

Ankle2

suppressible

l(2)gl

(Link et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0028343

MIST (protein-protein) - An integrated Molecular Interaction Database

Ankle2

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0028343

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Initiation of Nuclear Envelope Reformation

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-57

Cytogenetic map

16B5-16B6

Sequence location

X:17,571,854..17,579,229 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

16B5-16B6

Limits computationally determined from genome sequence between P{EP}baz^EP1446 and P{EP}EP1464

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

16B6-16B11

(determined by in situ hybridisation) 16B1--4 (determined by in situ hybridisation)

(Peter et al., 2002, Schäfer et al., 1999.8.12)

Experimentally Determined Recombination Data

Location

1-57

(FlyBase, 2016)

1-57.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18178

w¹¹¹⁸ PBac{RB}Ankle2^e03639

11969

w^67c23 P{lacW}Ankle2^G0316/FM7c

62774

w¹¹¹⁸ PBac{IT.GAL4}Ankle2^0312-G4

91531

y¹ w^*; PBac{UAS-Ankle2.L}VK00037

77437

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06569}attP40

86070

w¹¹¹⁸ PBac{WH}Ankle2^f02349; l(3)*^*/TM6B, Tb¹

91635

y¹ w^* Ankle2^A P{neoFRT}19A/FM7c, P{GAL4-Kr.C}DC1, P{UAS-GFP.S65T}DC5, sn⁺

91530

y¹ w^*; PBac{Ankle2-GFPR}VK00037/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7; TM2/TM6B, Tb¹

Kyoto

115023

w¹¹¹⁸ PBac{602.P.SVS-1}Ankle2^CPTI000326

VDRC

v100655

P{KK106212}VIE-260B

v24107

w¹¹¹⁸; P{GD13933}v24107

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (45)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD02148

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028343

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028343

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32732

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Ankle2 l(1)G0222

(Yamamoto et al., 2014)

Source for database merge of

Source for merge of: l(1)G0222 CG8465 l(1)G0316

(Peter et al., 2002)

Source for merge of: l(1)G0222 anon-WO03040301.175 anon-WO03040301.177 anon-WO03040301.179

(FlyBase, 1996-)

Additional comments

Source for merge of l(1)G0222 anon-WO03040301.175 anon-WO03040301.177 anon-WO03040301.179 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Gene is named "Ankle2" based on orthology to the H. sapiens ANKLE2 gene.

(Yamamoto et al., 2014)

Changed full name from "Ankyrin repeat and LEM domain containing 2" to "Ankle2" because, unlike the human ortholog, the D. melanogaster gene product lacks a LEM domain.

(FlyBase, 2009-)

Identification

External Crossreferences and Linkouts ( 53 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32732

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8MQX9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8MQX9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8MQX9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028343

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028343

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32732/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028343

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028343

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028343

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8465

Flygut - An atlas of the Drosophila adult midgut

FBgn0028343

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0028343

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32732

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007850

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG8465

MARRVEL_MODEL - MARRVEL (model organism gene)

32732

modMine - A data warehouse for the modENCODE project

FBgn0028343

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0028343

DRSC - Results frm RNAi screens

FBgn0028343

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028343

FlyMine - An integrated database for Drosophila genomics

FBgn0028343

MIST (protein-protein) - An integrated Molecular Interaction Database

Ankle2

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Initiation of Nuclear Envelope Reformation

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

Ankle-2

(Harnish et al., 2021)

Ankle2

(Link and Bellen, 2020, Link et al., 2019, Myat et al., 2019, Shah et al., 2018, Clandinin and Owens, 2016-)

CG8465

(Hosono et al., 2015, D'Ambrosio and Vale, 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Bourbon et al., 2002)

anon-WO03040301.175

anon-WO03040301.177

anon-WO03040301.179

dAnkle2

(Yamamoto et al., 2014)

l(1)G0222

(Naveed et al., 2018, Deivasigamani et al., 2014, Yamamoto et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Popodi et al., 2010-, Venken et al., 2010, Tan et al., 2009)

l(1)G0316

(Schäfer et al., 1999.8.12)

Name Synonyms

ANKLE2 ortholog

Ankle2

Ankyrin repeat and LEM domain containing 2

l(1)G0222

(Kong et al., 2010)

lethal (1) G0222

Secondary FlyBase IDs