FlyBase Gene Report: Dmel\Uaf1

General Information

Symbol

Dmel\Uaf1

Species

D. melanogaster

Name

USP1-associated factor 1

Annotation Symbol

CG9062

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033607

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

Regulatory component of the Usp12-46 deubiquitylase complex (PubMed:37798281). activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity). The complex deubiquitylates the wg/wingless-signaling receptor arr/arrow, which stabilizes the receptor and increases its concentration at the cell surface; this enhances the sensitivity of cells to wg/wingless-signal stimulation (PubMed:37798281). This increases the amplitude and spatial range of the signaling response to the wg/wingless morphogen gradient, facilitating the precise concentration-dependent regulation of its target genes (PubMed:37798281). Together with Wdr20 and Usp12-46 required for wg/wingless-mediated signaling in the wing imaginal disc and for wg/wingless-dependent regulation of intestinal stem cell proliferation (PubMed:37798281). (UniProt, Q1LZ08)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

47E5-47E6

Sequence location

2R:11,280,484..11,283,971 [-]

Recombination map

2-64

RefSeq locus

NT_033778 REGION:11280484..11283971

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables deubiquitinase activator activity

traceable author statement

(Spencer et al., 2023)

enables ubiquitin binding

inferred from biological aspect of ancestor with PANTHER:PTN000458477

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with SGD:S000003648

(Gene Ontology Curators, 2002-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in negative regulation of ubiquitin-dependent protein catabolic process

inferred from direct assay

(Spencer et al., 2023)

involved_in positive regulation of canonical Wnt signaling pathway

inferred from mutant phenotype

(Spencer et al., 2023)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in double-strand break repair via homologous recombination

inferred from biological aspect of ancestor with PANTHER:PTN000458477

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of peptidase complex

inferred from physical interaction with FLYBASE:Usp12-46; FB:FBgn0039025,FLYBASE:Wdr20; FB:FBgn0039451

(Spencer et al., 2023)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:Q8TAF3

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

USP46 DEUBIQUITINASE COMPLEX

Pathway (FlyBase)

POSITIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY

Protein Family (UniProt)

Belongs to the WD repeat WDR48 family. (Q1LZ08)

Protein Signatures (InterPro)

Summaries

Pathway (FlyBase)

POSITIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -: Positive regulators of Wnt-TCF (canonical Wnt) signaling up-regulate the pathway, resulting in the enhancement of transcriptional regulation mediated by β-catenin (arm).

Gene Group (FlyBase)

USP46 DEUBIQUITINASE COMPLEX -: The USP46 deubiquitinase complex is a conserved complex which removes ubiquitin from post-translationally modified proteins. (Adapted from FBrf0257735, PMID:37798301.)

Protein Function (UniProtKB)

(UniProt, Q1LZ08)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Uaf1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q1LZ08)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Uaf1-RB

FBtr0088181

NM_165814

3035

668

Uaf1-RC

FBtr0332422

NM_001273957

2849

680

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Uaf1-PB

FBpp0087277

75.3

668

7.14

FBpp0304695

76.6

680

7.14

A0A0B4KET0

NP_001260886

AGB93419

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Catalytic component of the Usp12-46 deubiquitylase complex consisting of Usp12-46, Wdr20 and Uaf1; regulatory subunit that, together wtih Wdr20, stabilizes Usp12-46 (PubMed:37798281). The Usp12-46 deubiquitylase complex associates with arr/arrow; the interaction leads to deubiquitination and stabilization of arr/arrow (PubMed:37798281).

(UniProt, Q1LZ08)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Uaf1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG9062_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.08

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of peptidase complex

inferred from physical interaction with FLYBASE:Usp12-46; FB:FBgn0039025,FLYBASE:Wdr20; FB:FBgn0039451

(Spencer et al., 2023)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Uaf1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Uaf1

View exonic expression by tissue for Dmel\Uaf1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033607

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36199/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033607

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033607

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033607

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9062

Flygut - An atlas of the Drosophila adult midgut

FBgn0033607

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Uaf1

Transgenic constructs containing regulatory region of Uaf1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel6060

(Ryder, 2004.4.26)

Inferred from location ( 12 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Uaf1^GD1703

viable

Uaf1^CB02056

viable, with Scer\GAL4^Mef2.PR

Uaf1^GD1703

viable, with Scer\GAL4^pnr-MD237

Uaf1^GD1703

viable, with Scer\GAL4^tin.CΔ4

Uaf1^GD1703

viable (with Uaf1³)

Uaf1⁸

viable (with Uaf1⁸)

Uaf1³

Other Phenotypes

Allele

increased cell number | adult stage (with Uaf1³)

increased cell number | adult stage (with Uaf1⁴)

Uaf1³

increased cell number | adult stage (with Uaf1⁸)

Uaf1³

increased cell number | adult stage | cell non-autonomous | somatic clone

increased occurrence of cell division | cell non-autonomous | somatic clone

Uaf1⁴

short lived (with Uaf1³)

Uaf1⁸

short lived (with Uaf1⁸)

Uaf1³

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Uaf1^GD1703

Phenotype manifest in

Allele

adult posterior midgut epithelium | cell non-autonomous | somatic clone

Uaf1⁴

enteroblast | adult stage | increased number (with Uaf1³)

enteroblast | adult stage | increased number (with Uaf1⁴)

Uaf1³

enteroblast | adult stage | increased number (with Uaf1⁸)

Uaf1³

intestinal stem cell of posterior adult midgut epithelium | cell non-autonomous | increased number | somatic clone

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (50)

Hsap\WDR48

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (23)

Rnor\Wdr48

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (22)

Mmus\Wdr48

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (29)

Xtro\wdr48

11 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100491248

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (27)

Drer\wdr48b

14 of 14

Yes

Drer\wdr48a

12 of 14

Yes

Drer\LOC100534785

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (20)

Cele\wdr-48

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\Y45F10D.7

1 of 14

Anopheles gambiae (African malaria mosquito) (28)

Agam\AgaP_AGAP001361

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (44)

Atha\LRS1

13 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT4G04940

1 of 13

Atha\AT4G34380

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\DUF1

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (6)

Spom\bun107

10 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Uaf1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (28)

adp

1 of 13

ago

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

gro

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

wds

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

WDR48; WD repeat domain 48

14 of 14

612167

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Uaf1 - CG14931

experimental knowledge based

(Guruharsha et al., 2011)

Uaf1 - arr

anti tag coimmunoprecipitation, anti tag western blot

(Spencer et al., 2023)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, Q1LZ08 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0033607

MIST (protein-protein) - An integrated Molecular Interaction Database

36199

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Fanconi anemia pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Ub-specific processing proteases

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q1LZ08

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-64

Cytogenetic map

47E5-47E6

Sequence location

2R:11,280,484..11,283,971 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

47E5-47E6

Limits computationally determined from genome sequence between P{PZ}rM547 and P{lacW}Fpps^k06103&P{lacW}Fpps^k03514

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-64

(FlyBase, 2016)

2-64.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

86042

w¹¹¹⁸; PBac{WH}Uaf1^f00047/CyO

FlyORF

F002988

M{UAS-Uaf1.ORF.3xHA.GW}ZH-86Fb

Kyoto

104735

w^*; P{GawB}Uaf1^NP4664 / CyO

VDRC

v3810

w¹¹¹⁸; P{GD1703}v3810

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (75)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE72568

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033607

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033607

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Uaf1 CG9062

(Spencer et al., 2023)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG9062

(Spencer et al., 2023, Earl et al., 2020, Hou et al., 2020, Moshkin et al., 2013, Sen et al., 2013, Sen et al., 2013, Christis and Munro, 2012, Buszczak et al., 2007)

Uaf1

(Spencer et al., 2023)

Name Synonyms

USP1-associated factor 1

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36199

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q1LZ08

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q1LZ08

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KET0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q1LZ08

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033607

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36199/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033607

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033607

FlyMine - An integrated database for Drosophila genomics

FBgn0033607

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9062

MARRVEL_MODEL - MARRVEL (model organism gene)

36199

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033607

DroID - A comprehensive database of gene and protein interactions.

FBgn0033607

DRSC - Results frm RNAi screens

FBgn0033607

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG9062_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033607

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033607

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9062

Flygut - An atlas of the Drosophila adult midgut

FBgn0033607

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0033607

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008107

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Fanconi anemia pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

36199

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Ub-specific processing proteases

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q1LZ08

References (34)

The following external sites may use different assemblies or annotations than FlyBase.

1.08

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