FlyBase Gene Report: Dmel\PIP5K59B

General Information

Symbol

Dmel\PIP5K59B

Species

D. melanogaster

Name

Phosphatidylinositol 4-phosphate 5-kinase 59B

Annotation Symbol

CG3682

Feature Type

protein_coding_gene

FlyBase ID

FBgn0034789

Gene Model Status

Current

Stock Availability

16 publicly available

Enzyme Name (EC)

1-phosphatidylinositol-4-phosphate 5-kinase (2.7.1.68)

Gene Summary

Phosphatidylinositol 4-phosphate 5-kinase at 59B (PIP5K59B) encodes a lipid kinase enzyme that mediates the synthesis of the lipid phosphatidylinositol 4,5 bisphosphate (PIP2) during phospholipase C signalling. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dPIP5K, PIP5K, PIP5K 59B, PI4P5K

Key Links

Genomic Location

Cytogenetic map

59B4-59B4

Sequence location

2R:22,874,769..22,881,436 [+]

Recombination map

2-101

RefSeq locus

NT_033778 REGION:22874769..22881436

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables 1-phosphatidylinositol-4-phosphate 5-kinase activity

inferred from sequence or structural similarity with UniProtKB:Q99755

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000557041

(GO Reference Genome Project, 2011-)

enables phosphatidylinositol kinase activity

inferred from electronic annotation with InterPro:IPR002498

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in cellular response to light stimulus

inferred from mutant phenotype

(Chakrabarti et al., 2015)

involved_in phototransduction, visible light

inferred from mutant phenotype

(Chakrabarti et al., 2015)

involved_in positive regulation of phosphatidylinositol biosynthetic process

inferred from mutant phenotype

(Chakrabarti et al., 2015)

involved_in regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Khuong et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in phosphatidylinositol metabolic process

inferred from electronic annotation with InterPro:IPR002498

(InterPro Project Members, 2004-)

involved_in phosphatidylinositol phosphate biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000557041

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in rhabdomere microvillus membrane

inferred from direct assay

(Chakrabarti et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000557041

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PHOSPHATIDYLINOSITOL 5 KINASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

1-phosphatidylinositol-4-phosphate 5-kinase activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) (2.7.1.68)

RHEA 14425:

Summaries

Gene Snapshot

Gene Group (FlyBase)

PHOSPHATIDYLINOSITOL 5 KINASES -: D :Phosphatidylinositol 5 kinases catalyze the phosphorylation of phosphatidylinositol (PI), or specific mono or bisphosphate derivatives of PI, at position 5 on the inositol ring to generate PI5P, PI(3,5)P[[2]], PI(4,5)P[[2]] or PI(3,4,5)P[[3]]. The resulting phosphoinositides can then act as signalling molecules to mediate/regulate a range of cellular and physiological processes, including cell polarity, cell migration, autophagy, growth, development, and ageing. (Adapted from FBrf0227909.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\PIP5K59B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A6M3Q9L5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Alternative translation stop created by use of multiphasic reading frames within coding region.

Gene model reviewed during 6.27

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

PIP5K59B-RA

FBtr0071900

NM_137885

3395

729

PIP5K59B-RE

FBtr0290095

NM_166567

3458

750

PIP5K59B-RF

FBtr0304921

NM_001259542

3544

777

PIP5K59B-RH

FBtr0304923

NM_001259543

3481

756

PIP5K59B-RI

FBtr0339762

NM_001043101

3556

781

PIP5K59B-RJ

FBtr0480545

NM_001382080

4407

891

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

PIP5K59B-PA

FBpp0071811

80.2

729

8.90

FBpp0288534

82.7

750

9.13

FBpp0293460

85.6

777

9.13

FBpp0293462

83.1

756

8.90

FBpp0308809

86.1

781

9.12

FBpp0428316

99.0

891

10.14

QJC18736

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PIP5K59B using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

PIP5K59B_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.78

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 14

larval central nervous system

(Murray et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Chakrabarti et al., 2015)

eye

(Chakrabarti et al., 2015)

Additional Descriptive Data

PIP5K59B is expressed predominantly in the head in adults and is enriched in the eye.

(Chakrabarti et al., 2015)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in rhabdomere microvillus membrane

inferred from direct assay

(Chakrabarti et al., 2015)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\PIP5K59B in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\PIP5K59B

View exonic expression by tissue for Dmel\PIP5K59B

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37633/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0034789

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034789

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0034789

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3682

Flygut - An atlas of the Drosophila adult midgut

FBgn0034789

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 20 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of PIP5K59B

Transgenic constructs containing regulatory region of PIP5K59B

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

PIP5K59B^GD11044

viable, with Scer\GAL4^Mef2.PR

PIP5K59B^GD11044

viable, with Scer\GAL4^pnr-MD237

PIP5K59B^GD11044

viable, with Scer\GAL4^tin.CΔ4

PIP5K59B^GD11044

Other Phenotypes

Allele

abnormal neurophysiology | adult stage

PIP5K59B¹⁸

abnormal neurophysiology | adult stage, with Scer\GAL4^GMR.PF

PIP5K59B^{RNAi.UAS.L.cKa}

abnormal neurophysiology | adult stage, with Scer\GAL4^ninaE.PT

PIP5K59B^{RNAi.UAS.L.cKa}

abnormal neurophysiology | adult stage | dominant, with Scer\GAL4^ninaE.PT

PIP5K59B^{RNAi.UAS.L.cKa}

abnormal neurophysiology | somatic clone

PIP5K59B¹⁸

decreased size | adult stage, with PIP5K59B¹⁸, Scer\GAL4^ninaE.PT

PIP5K59B^UAS.L

decreased size | adult stage, with PIP5K59B^UAS.L, Scer\GAL4^ninaE.PT

PIP5K59B¹⁸

visible | adult stage, with PIP5K59B¹⁸, Scer\GAL4^ninaE.PT

PIP5K59B^UAS.L

visible | adult stage, with PIP5K59B^UAS.L, Scer\GAL4^ninaE.PT

PIP5K59B¹⁸

visible | adult stage | light conditional | progressive, with Scer\GAL4^ninaE.PT

Phenotype manifest in

Allele

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^nSyb.PS

PIP5K59B^GD11044

eye, with PIP5K59B¹⁸, Scer\GAL4^ninaE.PT

PIP5K59B^UAS.L

eye, with PIP5K59B^UAS.L, Scer\GAL4^ninaE.PT

PIP5K59B¹⁸

eye photoreceptor cell | somatic clone

PIP5K59B¹⁸

ommatidium | light conditional, with Scer\GAL4^ninaE.PT

primordial germ cell | embryonic stage | maternal effect, with Scer\GAL4^Tub.PU

PIP5K59B^HMC05328

retina

PIP5K59B¹⁸

retina, with Scer\GAL4^GMR.PF

PIP5K59B^{RNAi.UAS.L.cKa}

retina, with Scer\GAL4^ninaE.PT

PIP5K59B^{RNAi.UAS.L.cKa}

rhabdomere | decreased number | light conditional, with Scer\GAL4^ninaE.PT

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (12)

Hsap\PIP5K1A

13 of 14

Yes

Hsap\PIP5K1B

11 of 14

Yes

Hsap\PIP5K1C

11 of 14

Yes

Hsap\PIPSL

8 of 14

Yes

Hsap\PIP5KL1

4 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

Yes

Hsap\RSPH10B

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (9)

Rnor\Pip5k1a

13 of 14

Yes

Rnor\Pip5k1b

11 of 14

Yes

Rnor\Pip5k1c

11 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

Yes

Rnor\Pikfyve

1 of 14

Rnor\Psmd4

1 of 14

Mus musculus (laboratory mouse) (9)

Mmus\Pip5k1a

13 of 14

Yes

Mmus\Pip5k1b

11 of 14

Yes

Mmus\Pip5k1c

11 of 14

Yes

Mmus\Pip4k2b

3 of 14

Mmus\Pip4k2c

3 of 14

Mmus\Pip5kl1

3 of 14

Yes

Mmus\Pip4k2a

2 of 14

Mmus\Pikfyve

1 of 14

Mmus\Psmd4

1 of 14

Xenopus tropicalis (Western clawed frog) (12)

Xtro\pip5k1c

7 of 13

Yes

Xtro\pip5k1b

5 of 13

Yes

Xtro\pip5k1a

3 of 13

Yes

Xtro\pip5kl1

3 of 13

Xtro\pip4k2c

2 of 13

Xtro\akap12

1 of 13

Yes

Xtro\leprot

1 of 13

Xtro\pbxip1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (15)

Drer\pip5k1ab

13 of 14

Yes

Drer\pip5k1ba

11 of 14

Drer\pip5k1bb

11 of 14

Yes

Drer\pip5k1ca

11 of 14

Yes

Drer\pip5k1aa

10 of 14

Yes

Drer\pip5k1cb

10 of 14

Yes

Drer\pip5kl1

4 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

Yes

Drer\pikfyve

1 of 14

Drer\psmd4a

1 of 14

Drer\psmd4b

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\ppk-1

13 of 14

Yes

Cele\ppk-2

3 of 14

Cele\ppk-3

2 of 14

Cele\rpn-10

1 of 14

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP009170

3 of 12

Yes

Agam\AgaP_AGAP005216

2 of 12

Agam\AgaP_AGAP009169

2 of 12

Yes

Agam\AgaP_AGAP005559

1 of 12

Arabidopsis thaliana (thale-cress) (16)

Atha\AT1G10900

9 of 13

Yes

Atha\AT1G60890

9 of 13

Yes

Atha\PIP5K1

9 of 13

Yes

Atha\PIP5K2

9 of 13

Yes

Atha\PIP5K3

9 of 13

Yes

Atha\PIP5K4

9 of 13

Yes

Atha\PIP5K5

9 of 13

Yes

Atha\PIP5K6

9 of 13

Yes

Atha\PIP5K9

9 of 13

Yes

Atha\PIPK10

7 of 13

Yes

Atha\PIPK11

6 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\MSS4

7 of 13

Yes

Scer\FAB1

2 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\its3

9 of 12

Yes

Spom\fab1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:PIP5K59B. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

11 of 13

5 of 13

2 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

model of lethal congenital contracture syndrome 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

13 of 14

603275

PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta

11 of 14

602745

PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

11 of 14

606102

LETHAL CONGENITAL CONTRACTURE SYNDROME 3; LCCS3

lethal congenital contracture syndrome 3

PIPSL; PIP5K1A and PSMD4 like (pseudogene)

8 of 14

PIP5KL1; phosphatidylinositol-4-phosphate 5-kinase like 1

4 of 14

612865

PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

3 of 14

603140

PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta

3 of 14

603261

PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

3 of 14

617104

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

PIP5K59B - Tre1

anti tag coimmunoprecipitation, anti tag western blot

(Kim et al., 2021)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Gαq

suppressible

PIP5K59B

(Kumari et al., 2022)

pbl

enhanceable

PIP5K59B

(Gregory et al., 2007)

pnut

suppressible

PIP5K59B

(Kumari et al., 2022)

rdgB

enhanceable

PIP5K59B

(Chakrabarti et al., 2015)

rdgB

suppressible

PIP5K59B

(Kumari et al., 2022)

WASp

enhanceable

PIP5K59B

(Kim et al., 2021)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0034789

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of PIPs at the plasma membrane

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-101

Cytogenetic map

59B4-59B4

Sequence location

2R:22,874,769..22,881,436 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

59B4-59B4

Limits computationally determined from genome sequence between P{PZ}blw⁰³⁹⁷² and P{EP}EP627

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-101

(FlyBase, 2016)

2-106.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (31)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0034789

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0034789

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Chakrabarti et al., 2015)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Annotations CG17281, CG3682 merged as CG3682 in release 3 of the genome annotation, April 2002.

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: PIP5K59B CG3682

(Morrison et al., 2000)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG17281

CG3682

(National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Trivedi et al., 2020, Liu et al., 2018, Jouette et al., 2017, Cockcroft and Raghu, 2016, Balakrishnan et al., 2015, Chakrabarti et al., 2015, Rosa-Ferreira et al., 2015, White-Grindley et al., 2014, Murray et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Cremona and De Camilli, 2001, Morrison et al., 2000)

PI4P5K

(Khuong et al., 2013, Khuong et al., 2010)

PIP5K

(Krishnan et al., 2025, Smylla et al., 2021)

PIP5K 59B

(Gregory et al., 2007, Morrison et al., 2000)

PIP5K59B

(Corthals et al., 2023, Lu et al., 2022, Ostalé et al., 2021, Meltzer et al., 2019, Gene Disruption Project members, 2018-, Jouette et al., 2017, Transgenic RNAi Project members, 2017-, Balakrishnan et al., 2015, Ashwal-Fluss et al., 2014, White-Grindley et al., 2014, Murray et al., 2012)

PIPK59B

(Parkhitko et al., 2021)

dPIP5K

(Kumari et al., 2022, Ugrankar et al., 2019, Balakrishnan et al., 2018, Liu et al., 2018, Cockcroft and Raghu, 2016, Chakrabarti et al., 2015)

dPIP5K59B

(Liu et al., 2018)

dpip5k

(Kim et al., 2021, Suratekar et al., 2018)

Name Synonyms

PIP5K59B

Phosphatidylinositol 4-phosphate 5-kinase 59B

Phosphatidylinositol 4-phosphate 5-kinase at 59B

Secondary FlyBase IDs

FBgn0034790

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 64 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37633

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A6M3Q9L5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A6M3Q9L5

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37633/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0034789

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0034789

FlyMine - An integrated database for Drosophila genomics

FBgn0034789

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3682

MARRVEL_MODEL - MARRVEL (model organism gene)

37633

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0034789

DroID - A comprehensive database of gene and protein interactions.

FBgn0034789

DRSC - Results frm RNAi screens

FBgn0034789

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

PIP5K59B_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034789

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0034789

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3682

Flygut - An atlas of the Drosophila adult midgut

FBgn0034789

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0034789

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009489

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of PIPs at the plasma membrane

References (62)

The following external sites may use different assemblies or annotations than FlyBase.

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