FlyBase Gene Report: Dmel\Ddr

General Information

Symbol

Dmel\Ddr

Species

D. melanogaster

Name

Discoidin domain receptor

Annotation Symbol

CG33531

Feature Type

protein_coding_gene

FlyBase ID

FBgn0053531

Gene Model Status

Current

Stock Availability

20 publicly available

Gene Summary

expressed in larval peripheral nerves - loss of function resulted in severely reduced ensheathment of axons and reduced axon caliber - a strong dominant genetic interaction was found between Ddr and the type XV/XVIII collagen Multiplexin (Mp), suggesting Ddr functions as a collagen receptor to drive axon wrapping, in adult nerves, loss of Ddr decreased long-term survival of sensory neurons and significantly reduced axon caliber without overtly affecting ensheathment - glial gene required for axon ensheathment (Interactive Fly, Ddr )

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

26C1-26C2

Sequence location

2L:6,253,123..6,323,466 [+]

Recombination map

2-19

RefSeq locus

NT_033779 REGION:6253123..6323466

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719

(InterPro Project Members, 2004-)

enables collagen binding

inferred from biological aspect of ancestor with PANTHER:PTN002400507

(GO Reference Genome Project, 2011-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245

(InterPro Project Members, 2004-)

enables protein tyrosine kinase collagen receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002400507

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cell surface receptor protein tyrosine kinase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

involved_in positive regulation of neuron projection development

inferred from biological aspect of ancestor with PANTHER:PTN008618212

(GO Reference Genome Project, 2011-)

involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN008618212

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

part_of receptor complex

inferred from biological aspect of ancestor with PANTHER:PTN001230349

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RECEPTOR TYROSINE KINASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

RECEPTOR TYROSINE KINASES -: Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ddr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q59DZ7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ddr-RD

FBtr0340169

NM_001169424

1690

380

Ddr-RF

FBtr0344770

NM_001298737

4770

1054

Ddr-RG

FBtr0344771

NM_001014474

4360

1054

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ddr-PD

FBpp0309154

42.1

380

8.26

FBpp0311099

116.5

1054

6.91

FBpp0311100

116.5

1054

6.91

Q59DZ7

NP_001014474

AAX52658

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1054 aa isoforms: Ddr-PF, Ddr-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ddr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ddr_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.64

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ddr in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ddr

View exonic expression by tissue for Dmel\Ddr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3346209/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0053531

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053531

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0053531

Flygut - An atlas of the Drosophila adult midgut

FBgn0053531

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ddr

Transgenic constructs containing regulatory region of Ddr

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)Exel6016

(Ryder, 2004.4.26)

Df(2L)Exel9038

(Ryder, 2004.4.26)

Inferred from location ( 16 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Ddr^GD15146

viable

Ddr^EU173

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Ddr^GD13382

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal sleep | adult stage | female

Ddr^MB11489

visible, with Scer\GAL4^pnr-MD237

Ddr^GD15146

Phenotype manifest in

Allele

mesonotum, with Scer\GAL4^pnr-MD237

Ddr^GD15146

trichogen cell, with Scer\GAL4^pnr-MD237

Ddr^GD15146

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (94)

Hsap\DDR2

12 of 14

Yes

Hsap\DDR1

11 of 14

Yes

Hsap\AATK

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\YES1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (49)

Rnor\Ddr2

12 of 14

Yes

Rnor\Ddr1

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Src

1 of 14

Rnor\Txk

1 of 14

Rnor\Zap70

1 of 14

Mus musculus (laboratory mouse) (54)

Mmus\Ddr1

11 of 14

Yes

Mmus\Ddr2

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (49)

Xtro\ddr1

10 of 13

Yes

Xtro\ddr2l

10 of 13

Yes

Xtro\ddr2

7 of 13

Yes

5 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ntrk1

1 of 13

Yes

Xtro\pcnp

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\uqcrfs1

1 of 13

Danio rerio (Zebrafish) (79)

Drer\ddr2a

12 of 14

Yes

Drer\ddr1

11 of 14

Yes

Drer\ddr2b

11 of 14

Yes

Drer\ddr2l

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\edil3b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\met

1 of 14

Drer\mfge8a

1 of 14

Yes

Drer\mfge8b

1 of 14

Yes

Drer\mst1rb

1 of 14

Drer\musk

1 of 14

Drer\nrp2a

1 of 14

Yes

Drer\ntrk1

1 of 14

Yes

Drer\ntrk2a

1 of 14

Drer\ntrk2b

1 of 14

Yes

Drer\ntrk3a

1 of 14

Drer\ntrk3b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\ddr-2

11 of 14

Yes

Cele\ddr-1

6 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (29)

Agam\AgaP_AGAP008742

7 of 12

Yes

Agam\AgaP_AGAP008743

2 of 12

Yes

Agam\AgaP_AGAP008744

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (19)

Atha\AT1G01540

1 of 13

Yes

Atha\AT1G76360

1 of 13

Yes

Atha\AT2G28940

1 of 13

Yes

Atha\AT3G56050

1 of 13

Yes

Atha\AT4G01330

1 of 13

Yes

Atha\AT4G18950

1 of 13

Yes

Atha\AT4G31170

1 of 13

Yes

Atha\AT5G42440

1 of 13

Yes

Atha\AT5G65530

1 of 13

Yes

Atha\CRK12

1 of 13

Yes

Atha\FER

1 of 13

Yes

Atha\HT1

1 of 13

Yes

Atha\NP1

1 of 13

Yes

Atha\NP2

1 of 13

Yes

Atha\RBK1

1 of 13

Yes

Atha\SUB

1 of 13

Yes

Atha\VIK

1 of 13

Yes

Atha\WEE1

1 of 13

Yes

Atha\WRKY19

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\BCK1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ddr. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (33)

smal

10 of 13

Alk

3 of 13

btl

3 of 13

Cad96Ca

3 of 13

drl

3 of 13

Eph

3 of 13

htl

3 of 13

InR

3 of 13

Nrk

3 of 13

Ret

3 of 13

Ror

3 of 13

sev

3 of 13

CG3277

2 of 13

dnt

2 of 13

Egfr

2 of 13

Pvr

2 of 13

Tie

2 of 13

Abl

1 of 13

Btk

1 of 13

CG10702

1 of 13

Csk

1 of 13

Drl-2

1 of 13

Fak

1 of 13

FER

1 of 13

otk2

1 of 13

otk

1 of 13

Sdr

1 of 13

Src42A

1 of 13

Src64B

1 of 13

svr

1 of 13

tor

1 of 13

tutl

1 of 13

Wsck

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

DDR2; discoidin domain receptor tyrosine kinase 2

model of spondylometaepiphyseal dysplasia, short limb-hand type

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Ddr^GD7334

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DDR2; discoidin domain receptor tyrosine kinase 2

12 of 14

191311

spondylometaepiphyseal dysplasia, short limb-hand type

DDR1; discoidin domain receptor tyrosine kinase 1

11 of 14

600408

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

77927

DroID - A comprehensive database of gene and protein interactions.

FBgn0053531

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-19

Cytogenetic map

26C1-26C2

Sequence location

2L:6,253,123..6,323,466 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

26C1-26C2

Limits computationally determined from genome sequence between P{EP}chic^EP713&P{EP}chic^EP1095 and P{lacW}Gef26^k13720

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-19

(FlyBase, 2016)

2-20.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

601314

w¹¹¹⁸; P{VT003173-p65.AD}attP40

74976

w¹¹¹⁸; P{VT003173-GAL4.DBD}attP2

29214

w¹¹¹⁸; Mi{ET1}Ddr^MB11489

55906

y¹ v¹; P{TRiP.HMC04190}attP2

63446

w¹¹¹⁸; PBac{IT.GAL4}Ddr^0614-G4

Korea

14910

P{VT003173-GAL4}attP2

Kyoto

103728

w^*; P{GawB}Ddr^NP0725 / CyO

VDRC

v51719

w¹¹¹⁸; P{GD7334}v51719

v52126

w¹¹¹⁸; P{GD7334}v52126

v23316

w¹¹¹⁸; P{GD13382}v23316

v29720

w¹¹¹⁸; P{GD15146}v29720

v342725

P{hsFLP}1, y1 w1118; P{HD_CFD01429}attP40/CyO-GFP

More stocks available...

Genomic Clones (78)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (10)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP05449

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0053531

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0053531

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, chromosome abnormalities are seen.

(Bettencourt-Dias et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG9488 CG13985 CG11573 CG9490

(Edwards, 2003.2.11)

Additional comments

Annotations CG9488, CG13985, CG11573 and CG9490 merged as CG33531 (which corresponds to Ddr) in release 4.1 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Nomenclature History

Source for database identify of

Source for identity of: Ddr CG9488 CG13985 CG11573 CG9490

(Edwards, 2003.2.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG11573

(Anholt and Mackay, 2001)

CG13985

(Jayanandanan et al., 2011, Tuxworth et al., 2011, Giot et al., 2003)

CG33531

(National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Ni et al., 2010.12.1, Holloway et al., 2008)

CG9488

(Bettencourt-Dias et al., 2004, Anholt and Mackay, 2001)

CG9490

(Wheeler et al., 2004, Giot et al., 2003, Lee et al., 2002, Anholt and Mackay, 2001)

CT33540

(Morrison et al., 2000)

DDR

(Morrison et al., 2000)

ddr

(Sharma et al., 2020)

Name Synonyms

Discoidin domain receptor

(Mele and Johnson, 2019, Sopko and Perrimon, 2013, Edwards, 2003.2.11)

Secondary FlyBase IDs

FBgn0031796
FBgn0031793
FBgn0031794
FBgn0031795
FBgn0031797

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

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Result

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External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3346209

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q59DZ7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q59DZ7

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3346209/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0053531

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0053531

FlyMine - An integrated database for Drosophila genomics

FBgn0053531

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33531

MARRVEL_MODEL - MARRVEL (model organism gene)

3346209

Linkouts

BioGRID - A database of protein and genetic interactions.

77927

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0053531

DroID - A comprehensive database of gene and protein interactions.

FBgn0053531

DRSC - Results frm RNAi screens

FBgn0053531

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ddr_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053531

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0053531

Flygut - An atlas of the Drosophila adult midgut

FBgn0053531

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0053531

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (78)

The following external sites may use different assemblies or annotations than FlyBase.

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