FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Golgin97
Open Close
General Information
Symbol
Dmel\Golgin97
Species
D. melanogaster
Name
Golgin 97
Annotation Symbol
CG4840
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086757
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Golgin 97 (Golgin97) encodes a a Golgi protein required for the centrosome cycle. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

cbs, centrosomin's beautiful sister, dGolgin-97, dem

Key Links
Genomic Location
Cytogenetic map
50A9-50A9
Sequence location
Recombination map
2-68
RefSeq locus
NT_033778 REGION:13450586..13453393
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables small GTPase binding
(Sinka et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in centrosome cycle
inferred from mutant phenotype
(Eisman et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in Golgi vesicle transport
inferred by curator from GO:0000138,GO:0031267
(Sinka et al., 2008)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
located_in chromatin
inferred from direct assay
(Eisman et al., 2006)
located_in cytoplasm
inferred from direct assay
(Eisman et al., 2006)
located_in Golgi apparatus
inferred from direct assay
(Torres et al., 2014)
located_in Golgi trans cisterna
inferred from direct assay
(Sinka et al., 2008)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Eisman et al., 2006)
located_in spindle
inferred from direct assay
(Eisman et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in Golgi apparatus
inferred from biological aspect of ancestor with PANTHER:PTN001504455
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Golgin 97 (Golgin97) encodes a a Golgi protein required for the centrosome cycle. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
GOLGINS -
Golgins are long, parallel coiled-coil homodimers important in regulating vesicle mediated transport and Golgi architecture. They are anchored to specific sites on the Golgi complex surface either by a C-terminal transmembrane domain or interacting with Arf/Arf-like GTPases via a GRIP/GRAB domain. Golgins are thought to act as tethering factors, interacting with vesicles by binding Rab GTPases and guiding them to the correct Golgi cisternae. (Adapted from PMID:21436057).
Summary (Interactive Fly)

a trans-Golgi protein that links Golgi inheritance to the cell cycle

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Golgin97 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7K4K7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Golgin97-RA
FBtr0087666
NM_137031
2257
611
Golgin97-RB
FBtr0309886
NM_001259368
2233
603
Golgin97-RC
FBtr0309887
NM_001259369
2227
601
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Golgin97-PA
FBpp0086786
70.8
611
4.97
Q7K4K7
NP_610875
AAF58374
Golgin97-PB
FBpp0301620
69.9
603
4.93
A0A0B4K775
NP_001246297
AFH08051
Golgin97-PC
FBpp0301621
69.7
601
4.93
A0A0B4K864
NP_001246298
AFH08052
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Golgin97 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.88

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in chromatin
inferred from direct assay
(Eisman et al., 2006)
located_in cytoplasm
inferred from direct assay
(Eisman et al., 2006)
located_in Golgi apparatus
inferred from direct assay
(Torres et al., 2014)
located_in Golgi trans cisterna
inferred from direct assay
(Sinka et al., 2008)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Eisman et al., 2006)
located_in spindle
inferred from direct assay
(Eisman et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Golgin97 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Golgin97
Transgenic constructs containing regulatory region of Golgin97
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\GOLGA1
12 of 14
Yes
Yes
Hsap\CCDC186
1 of 14
No
No
Hsap\LAMA1
1 of 14
No
No
Hsap\LAMA2
1 of 14
No
No
1  
Hsap\LAMA3
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Golga1
11 of 14
Yes
Yes
Rnor\Golga4
1 of 14
No
No
Rnor\Lama1
1 of 14
No
No
Rnor\Lama2
1 of 14
No
No
Rnor\Lama5
1 of 14
No
No
Mus musculus (laboratory mouse) (6)
Mmus\Golga1
11 of 14
Yes
Yes
Mmus\Ccdc186
1 of 14
No
No
Mmus\Golga4
1 of 14
No
No
Mmus\Lama1
1 of 14
No
No
Mmus\Lama2
1 of 14
No
No
Mmus\Lama3
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\golga1
10 of 13
Yes
Yes
Xtro\lama1
1 of 13
No
No
Xtro\lamb2
1 of 13
No
No
Xtro\XB5969698
1 of 13
No
No
Danio rerio (Zebrafish) (5)
Drer\golga1
12 of 14
Yes
Yes
Drer\ccdc186
1 of 14
No
No
Drer\lama5
1 of 14
No
No
Drer\lamb4
1 of 14
No
No
Drer\lzts1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\epi-1
1 of 14
Yes
No
Cele\lam-3
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP001765
12 of 12
Yes
Yes
Agam\AgaP_AGAP000283
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Golgin97. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
GCC88
2 of 13
Golgin104
1 of 13
LanA
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GOLGA1; golgin A1
    12 of 14
    602502
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-68
        Cytogenetic map
        50A9-50A9
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        50A9-50A9
        Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-68

        (FlyBase, 2016)

        2-72.3

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes

        cbs is very tightly linked to cnn.

        (Megraw et al., 1999)
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (22)
        cDNA Clones (14)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Sinka et al., 2008)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            cbs protein undergoes a dramatic relocalization during mitosis from the cytoplasm to an association with chromosomes from late prometaphase to early telophase.

            (Eisman et al., 2006)

            cbs appears to participate in microtubule organising centre function.

            (Megraw et al., 1999)

            Transcription start sites of cnn and cbs are separated by a mere 134bp. Overall orientation not stated: cnn- cbs+

            (Megraw, 1999.3.3)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: cbs CG4840

            (Eisman et al., 2006)
            Additional comments
            Nomenclature History
            Source for database identify of

            Source for identity of: Golgin97 cbs

            (FlyBase, 2009-)
            Nomenclature comments

            Changed gene symbol 'cbs' to 'Golgin97' (a synonym) to eliminate the case-insensitive duplication with the 'Cbs' gene symbol, which is the widely used abbreviation for the gene encoding cystathionine beta-synthase across species.

            (FlyBase, 2009-)
            Etymology
            Synonyms and Secondary IDs (11)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 42 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (47)