FlyBase Gene Report: Dmel\Alh

General Information

Symbol

Dmel\Alh

Species

D. melanogaster

Name

Alhambra

Annotation Symbol

CG1070

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261238

Gene Model Status

Current

Stock Availability

46 publicly available

Gene Summary

Alhambra (Alh) encodes a zinc finger/leucine zipper nuclear protein. It is required in the nervous system for maintaining eve expression and normal growth. It is also involved in muscle development and male courtship behavior. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Red Book
Interactive Fly

Also Known As

AF10, dAF10, l(3)j8C8, sticking, stk

Key Links

Genomic Location

Cytogenetic map

84B6-84C3

Sequence location

3R:7,094,596..7,124,185 [-]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:7094596..7124185

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables DNA-binding transcription factor activity

inferred from mutant phenotype

(Bahri et al., 2001)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables histone reader activity

inferred from biological aspect of ancestor with PANTHER:PTN001012887

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in haltere development

inferred from genetic interaction with FLYBASE:Ubx; FB:FBgn0003944

(Pallavi et al., 2006)

involved_in instar larval development

inferred from mutant phenotype

(Bahri et al., 2001)

involved_in larval somatic muscle development

inferred from expression pattern

(Dobi et al., 2014)

inferred from mutant phenotype

(Dobi et al., 2014)

involved_in molting cycle, chitin-based cuticle

inferred from mutant phenotype

(Bahri et al., 2001)

involved_in regulation of DNA-templated transcription

inferred from mutant phenotype

(Bahri et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in chromatin remodeling

inferred from biological aspect of ancestor with PANTHER:PTN001012887

(GO Reference Genome Project, 2011-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN001012887

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Perrin et al., 2003, Bahri et al., 2001)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001012887

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

stk: sticking

Undefined prepupariation effective lethal phase; stk/T(2;3)Ta1 fails to complete eclosion.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Alh for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4KGP1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216885.

Gene model reviewed during 6.02

Alternative translation stop created by use of multiphasic reading frames within coding region.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Alh-RA

FBtr0081612

NM_079526

5006

1376

Alh-RB

FBtr0081614

NM_169172

3883

824

Alh-RD

FBtr0081613

NM_169171

4823

1323

Alh-RF

FBtr0113200

NM_001104228

4906

1165

Alh-RH

FBtr0300494

NM_001170065

5420

1165

Alh-RI

FBtr0300495

NM_001170066

5327

1134

Alh-RJ

FBtr0330367

NM_001104227

5420

1448

Alh-RK

FBtr0334672

NM_001275399

5033

1385

Alh-RL

FBtr0334673

NM_001275400

4850

1332

Alh-RM

FBtr0334674

NM_169170

5196

1084

Alh-RN

FBtr0334675

NM_001275401

5100

1052

Alh-RO

FBtr0334676

NM_001275402

5324

1133

Alh-RP

FBtr0334677

NM_001275403

6029

1717

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Alh-PA

FBpp0081129

138.9

1376

9.03

FBpp0081131

84.3

824

9.48

FBpp0081130

132.9

1323

8.82

FBpp0112112

119.6

1165

10.04

FBpp0289721

118.3

1165

9.54

FBpp0289722

115.3

1134

9.70

FBpp0303393

149.2

1448

10.04

FBpp0306733

140.0

1385

9.28

FBpp0306734

134.0

1332

9.09

FBpp0306735

110.1

1084

9.87

FBpp0306736

107.1

1052

9.95

FBpp0306737

115.2

1133

9.64

FBpp0306738

174.2

1717

9.50

A0A0B4KGP1

NP_001262332

AGB95715

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Alh using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.59

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4

organism | 20-70% egg length

(Linder et al., 2001)

embryonic stage 4 -- 5

organism | pair rule expression pattern

Comment: stripes coincide with, but are wider than, eve stripes

(Bahri et al., 2001)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

foregut anlage in statu nascendi

(Fisher et al., 2012)

organism | pair rule expression pattern

(Fisher et al., 2012)

trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 6 -- 8

organism | pair rule expression pattern

(Linder et al., 2001)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut anlage

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 12 -- 17

presumptive embryonic/larval central nervous system

(Bahri et al., 2001)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- third instar larval stage

organism

Comment: peak at 18 hr AEL

(Linder et al., 2001)

adult stage | male

organism | faint

(Linder et al., 2001)

adult stage | female

organism

(Linder et al., 2001)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 14 -- 17

• nucleus

(Bahri et al., 2001)

neuron of presumptive embryonic/larval central nervous system

• nucleus

(Bahri et al., 2001)

larval RP2 motor neuron

• nucleus

(Bahri et al., 2001)

larval DA1 motor neuron

• nucleus

(Bahri et al., 2001)

pCC neuron

• nucleus

(Bahri et al., 2001)

third instar larval stage

ring gland

• nucleus

Comment: excluded from nucleolus

(Bahri et al., 2001)

larval ventral nerve cord

• nucleus

(Bahri et al., 2001)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Perrin et al., 2003, Bahri et al., 2001)

Expression Deduced from Reporters

Reporter: P{GawB}Alh^NP6628

Stage

Tissue/Position (including subcellular localization)

Reference

pharate adult stage P8 -- adult stage

antennal trichoid sensillum at4

(Hueston et al., 2016)

Reporter: P{GawB}Alh^NP7010

Stage

Tissue/Position (including subcellular localization)

Reference

pharate adult stage P8 -- adult stage

antennal trichoid sensillum at4

(Hueston et al., 2016)

Reporter: P{GawB}Alh^NP7441

Stage

Tissue/Position (including subcellular localization)

Reference

pharate adult stage P8 -- adult stage

antennal trichoid sensillum at4

(Hueston et al., 2016)

Reporter: PBac{768.FSVS-0}Alh^CPTI003598

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

Comment: punctate expression throughout adult brain, higher in adult brain cortex

(Knowles-Barley, 2011.8.24)

adult brain

Comment: punctate expression throughout adult brain, higher in adult brain cortex

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Alh in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Alh

View exonic expression by tissue for Dmel\Alh

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261238

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40850/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261238

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037471

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261238

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1070

Flygut - An atlas of the Drosophila adult midgut

FBgn0261238

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 67 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 21 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Alh

Transgenic constructs containing regulatory region of Alh

Aberrations (Deficiencies and Duplications) ( 21 )

Inferred from experimentation ( 21 )

Gene partially disrupted in

Df(3R)dsx2M

(Clark et al., 2007, Perrin and Dura, 2004)

Df(3R)Mlp84B^P8

(Clark et al., 2007)

Df(3R)Mlp84B^y-30

(Perrin and Dura, 2004)

Df(3R)Mlp84B^y-37

(Perrin and Dura, 2004)

Df(3R)Scx2

(Clark et al., 2007)

Gene not disrupted in

Df(3R)D6

(Cavener et al., 1986)

Df(3R)dsx2M

(Cavener et al., 1986)

Df(3R)dsx10M

(Cavener et al., 1986)

Df(3R)dsx29

(Cavener et al., 1986)

Df(3R)F76

(Cavener et al., 1986)

Df(3R)Scr

(Kaufman et al., 1990, Cavener et al., 1986)

Df(3R)Tpl10

(Cavener et al., 1986)

Df(3R)WIN3

(Cavener et al., 1986)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^elav-C155

Alh^S.UAS

lethal (with Alh^j8C8)

Alh^RV95

lethal (with Alh^RV95)

Alh^j8C8

lethal (with Df(3R)Antp1)

Alh¹³⁵³

lethal (with Df(3R)Antp6)

Alh¹³⁵³

lethal (with Df(3R)Antp17)

Alh¹³⁵³

lethal (with Df(3R)Scx2)

lethal (with Df(3R)Scx4)

Alh¹³⁵³

lethal | recessive

viable

viable, with Scer\GAL4^Mef2.PR

Alh^GD1362

viable (with Alh^dsx2M)

viable (with Alh^EP3618)

viable (with Alh^j8C8)

viable (with Alh^RV95)

viable (with Df(3R)dsx2M)

Alh^EP3618

viable (with Df(3R)Mlp84B^y-30)

viable (with Df(3R)Mlp84B^y-37)

viable (with Df(3R)Scx2)

Alh^EP3618

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal cell number | adult stage | somatic clone, with Scer\FLP1^ey.PN

abnormal developmental rate | recessive

Alh^RV95

abnormal neuroanatomy | adult stage | somatic clone, with Scer\FLP1^ey.PN

abnormal song

Alh⁰¹⁰

non-enhancer of variegation, with P{hsp26-pt-T}39C-4

Alh¹

non-enhancer of variegation, with P{hsp26-pt-T}39C-5

Alh¹

non-suppressor of variegation, with P{hsp26-pt-T}39C-4

Alh¹

non-suppressor of variegation, with P{hsp26-pt-T}39C-5

Alh¹

Phenotype manifest in

Allele

adult olfactory receptor neuron Ir84a | somatic clone, with Scer\FLP1^ey.PN

adult olfactory receptor neuron Or47b | ectopic | somatic clone, with Scer\FLP1^ey.PN

adult olfactory receptor neuron Or65 | somatic clone, with Scer\FLP1^ey.PN

adult olfactory receptor neuron Or88a | somatic clone, with Scer\FLP1^ey.PN

antennal lobe glomerulus DL3 | somatic clone, with Scer\FLP1^ey.PN

antennal lobe glomerulus DP1l | somatic clone, with Scer\FLP1^ey.PN

antennal lobe glomerulus VA1d | somatic clone, with Scer\FLP1^ey.PN

antennal lobe glomerulus VA1v | somatic clone, with Scer\FLP1^ey.PN

antennal lobe glomerulus VM4 | somatic clone, with Scer\FLP1^ey.PN

antennal segment 3 sense organ | somatic clone, with Scer\FLP1^ey.PN

larva

Alh^RV95

larval nervous system

Alh^RV95

larval RP2 motor neuron

Alh^k44324

larval somatic muscle cell

Alh^r13

larval somatic muscle cell (with Df(3R)BSC633)

Alh^r13

wing

Alh^W47

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (12)

Hsap\MLLT6

7 of 14

Yes

Hsap\MLLT10

7 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (11)

Rnor\Mllt10

7 of 14

Yes

Rnor\Mllt6

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (11)

Mmus\Mllt6

7 of 14

Yes

Mmus\Mllt10

7 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (10)

Xtro\mllt6

6 of 13

Yes

Xtro\mllt10

6 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (12)

Drer\mllt10

7 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\zfp-1

7 of 14

Yes

Cele\lin-49

3 of 14

Cele\phf-14

2 of 14

Cele\phf-15

1 of 14

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP001451

9 of 12

Yes

Agam\AgaP_AGAP006776

2 of 12

Agam\AgaP_AGAP007617

2 of 12

Agam\AgaP_AGAP000754

1 of 12

Arabidopsis thaliana (thale-cress) (7)

Atha\AT3G14740

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\NTO1

1 of 13

Yes

Scer\SNT2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Alh. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

Br140

5 of 13

rno

5 of 13

CG15439

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

MLLT10; MLLT10 histone lysine methyltransferase DOT1L cofactor

model of acute myeloid leukemia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MLLT6; MLLT6, PHD finger containing

7 of 14

600328

MLLT10; MLLT10 histone lysine methyltransferase DOT1L cofactor

7 of 14

602409

LEUKEMIA, ACUTE MYELOID; AML

acute myeloid leukemia

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Alh

pull down, autoradiography

(Perrin et al., 2003)

Alh - Ada2b

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Alh - Bro

two hybrid array

(Shokri et al., 2019)

Alh - CG15269

two hybrid array

(Shokri et al., 2019)

Alh - Hinfp

two hybrid array

(Shokri et al., 2019)

Alh - Hr78

two hybrid array

(Shokri et al., 2019)

Alh - Su(var)205

fluorescence polarization spectroscopy, predetermined participant

(Mendez et al., 2011)

Alh - gro

two hybrid array

(Shokri et al., 2019)

Alh - vnd

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ubx

enhanceable

Alh

(Pallavi et al., 2006)

suppressible

Alh

(Perrin et al., 2003)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66047

DroID - A comprehensive database of gene and protein interactions.

FBgn0261238

MIST (protein-protein) - An integrated Molecular Interaction Database

40850

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

gene_with_stop_codon_read_through

(Jungreis, 2011.11.18)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84B6-84C3

Sequence location

3R:7,094,596..7,124,185 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84B6-84C3

Limits computationally determined from genome sequence between P{lacW}l(3)L2100^L2100 and P{EP}EP3060^EP3060

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

84B-84B

(determined by in situ hybridisation)

(Weber et al., 2005)

84C1-84C2

(Linder, 2000.6.22, Perrin, 1999.12.20, BDGP Project Members, 1994-1999)

84C1-84C2

(determined by in situ hybridisation)

(Spradling et al., 1999)

84C1-84C8

(determined by in situ hybridisation)

(Cavener et al., 1986)

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.2

(Comeron et al., 2012)

3-[47.5]

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (46)

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (55)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261238

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261238

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Bahri et al., 2001)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Area matching Drosophila EST AA392258.

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: Alh l(3)j8C8

(Perrin and Dura, 2004)

Source for merge of: Alh stk

(Clark, 2009.5.14)

Source for merge of: Alh anon-WO0118547.226

(FlyBase, 1996-)

Additional comments

Source for identity of Alhambra CG1070 was sequence comparison ( date:000601 ).

(FlyBase, 1996-)

Source for merge of Alh anon-WO0118547.226 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Alhambra CG1070

(FlyBase, 1996-)

Nomenclature comments

Etymology

The gene is named "Alhambra" based on the red eye colour phenotype seen in w^ph-p.lac+3/w¹¹¹⁸ ; Alh¹/+ flies (the Alhambra is a beautiful Moorish palace in Granada, Spain. Its name comes from the Arabic word "hamra", which means red).

(Perrin et al., 2003)

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

AF10

(Meyer-Nava et al., 2020, Mendez et al., 2011, Linder, 2000.6.22)

CG1070

(Meadows, 2017.1.11, Azad et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Bienz, 2006)

Dalf

(Bahri et al., 2001)

anon-WO0118547.226

dAF10

(Mohan et al., 2010, Li et al., 2002, Linder et al., 2001)

l(3)84Be

l(3)g2

l(3)g5

l(3)j13A6

l(3)j8C8

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(3)j8c8

(Clark et al., 2007)

l(3)r13

l(3j8C8

(Provost et al., 2006)

stk

(Clark, 2009.5.14)

Name Synonyms

ALHAMBRA

(Boucher et al., 2001)

Alhambra

(Wang et al., 2016, Toshima et al., 2014, Pöyhönen et al., 2012, Mohan et al., 2010, Swaminathan et al., 2010, Clark, 2009.5.14, Moran and Kyriacou, 2009, Clark et al., 2007, Bienz, 2006, Perrin, 1999.12.20, FlyBase, 1996-)

alhambra

(Mudiganti et al., 2010, Clark et al., 2007)

sticking

(Clark, 2009.5.14)

Secondary FlyBase IDs

FBgn0037471
FBgn0011412
FBgn0011439
FBgn0062159
FBgn0003528

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 127 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40850

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4KGP1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4KGP1

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261238

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40850/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261238

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261238

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1070

MARRVEL_MODEL - MARRVEL (model organism gene)

40850

Linkouts

BioGRID - A database of protein and genetic interactions.

66047

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261238

DroID - A comprehensive database of gene and protein interactions.

FBgn0261238

DRSC - Results frm RNAi screens

FBgn0261238

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037471

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261238

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1070

Flygut - An atlas of the Drosophila adult midgut

FBgn0261238

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013701

MIST (protein-protein) - An integrated Molecular Interaction Database

40850

References (109)

The following external sites may use different assemblies or annotations than FlyBase.

-0.59

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