FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Cyt-b5
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General Information
Symbol
Dmel\Cyt-b5
Species
D. melanogaster
Name
Cytochrome b5
Annotation Symbol
CG2140
Feature Type
protein_coding_gene
FlyBase ID
FBgn0264294
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
Cytochrome b5 (Cyt-b5) encodes a microsomal cytochrome b5 which is a small hemoprotein that participates in electron transfer in multiple biochemical reactions and pathways, including the metabolism of endogenous and xenobiotic compounds. [Date last reviewed: 2021-01-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dpld, dappled, l(2)01857

Key Links
Genomic Location
Cytogenetic map
43D3-43D3
Sequence location
Recombination map
2-56
RefSeq locus
NT_033778 REGION:7533506..7535936
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables heme binding
inferred from electronic annotation with InterPro:IPR018506
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000451724
(GO Reference Genome Project, 2011-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in response to oxidative stress
inferred from mutant phenotype
(Chen et al., 2017)
involved_in xenobiotic metabolic process
inferred from mutant phenotype
(Kleinhesselink et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in membrane
inferred from biological aspect of ancestor with PANTHER:PTN000451724
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cytochrome b5 family. (Q9V4N3)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cytochrome b5 (Cyt-b5) encodes a microsomal cytochrome b5 which is a small hemoprotein that participates in electron transfer in multiple biochemical reactions and pathways, including the metabolism of endogenous and xenobiotic compounds. [Date last reviewed: 2021-01-21]
Protein Function (UniProtKB)
Cytochrome b5 is a membrane-bound hemoprotein which functions as an electron carrier for several membrane-bound oxygenases.
(UniProt, Q9V4N3)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Cyt-b5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V4N3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cyt-b5-RA
FBtr0088906
NM_165540
692
123
Cyt-b5-RB
FBtr0088905
NM_136450
830
134
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cyt-b5-PA
FBpp0087980
13.9
123
8.21
NP_724575
AAG22305
Cyt-b5-PB
FBpp0087979
15.2
134
4.71
Q9V4N3
NP_610294
AAF59233
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyt-b5 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.25

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4
epithelial cell
(Lecuyer et al., 2007)
epithelium
(Lecuyer et al., 2007)
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | pair rule expression pattern
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | pair rule expression pattern
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
organism | pair rule expression pattern
(Fisher et al., 2012)
organism | segmentally repeated
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
organism | segmentally repeated
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic anal pad
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval corpus allatum
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval oenocyte
(Fisher et al., 2012)
embryonic/larval salivary gland
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cyt-b5 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cyt-b5
Transgenic constructs containing regulatory region of Cyt-b5
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (11)
Hsap\CYB5A
12 of 14
Yes
Yes
1  
Hsap\CYB5B
10 of 14
No
Yes
1  
Hsap\CYB5R4
2 of 14
No
No
Hsap\FA2H
2 of 14
No
No
1  
Hsap\CYB5D1
1 of 14
No
No
Hsap\FADS1
1 of 14
No
No
Hsap\FADS2B
1 of 14
No
No
Hsap\FADS2
1 of 14
No
No
Hsap\FADS3
1 of 14
No
No
Hsap\HERC2
1 of 14
No
No
Hsap\SUOX
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (9)
Rnor\Cyb5a
11 of 14
Yes
Yes
Rnor\Cyb5b
9 of 14
No
Yes
Rnor\Cyb5r4
2 of 14
No
No
Rnor\Cyb5d1
1 of 14
No
No
Rnor\Fa2h
1 of 14
No
No
Rnor\Fads1
1 of 14
No
No
Rnor\Fads2b
1 of 14
No
No
Rnor\Fads2
1 of 14
No
No
Rnor\Suox
1 of 14
No
No
Mus musculus (laboratory mouse) (8)
Mmus\Cyb5a
11 of 14
Yes
Yes
Mmus\Cyb5b
8 of 14
No
Yes
Mmus\Cyb5r4
2 of 14
No
No
Mmus\Fa2h
2 of 14
No
No
Mmus\Cyb5d1
1 of 14
No
No
Mmus\Fads1
1 of 14
No
No
Mmus\Fads2b
1 of 14
No
No
Mmus\Fads2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\cyb5a
8 of 13
Yes
Yes
Xtro\cyb5b
7 of 13
No
Yes
Xtro\cyb5d1
1 of 13
No
No
Xtro\cyb5r4
1 of 13
No
No
Xtro\fads2
1 of 13
No
No
Xtro\sgtb
1 of 13
No
No
Xtro\suox
1 of 13
No
No
Danio rerio (Zebrafish) (6)
Drer\cyb5a
10 of 14
Yes
Yes
Drer\cyb5b
10 of 14
Yes
Yes
Drer\cyb5r4
2 of 14
No
No
Drer\cyb5d1
1 of 14
No
No
Drer\fa2h
1 of 14
No
No
Drer\fads2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\cytb-5.1
13 of 14
Yes
Yes
Cele\cytb-5.2
6 of 14
No
No
Cele\F58B4.2
4 of 14
No
Yes
Cele\D2023.1
1 of 14
No
Yes
Cele\fath-1
1 of 14
No
No
Cele\suox-1
1 of 14
No
No
Cele\Y52B11A.3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP007121
12 of 12
Yes
Yes
Agam\AgaP_AGAP002113
6 of 12
No
Yes
Agam\AgaP_AGAP006060
3 of 12
No
No
Agam\AgaP_AGAP008363
3 of 12
No
No
Agam\AgaP_AGAP011314
2 of 12
No
No
Agam\AgaP_AGAP010016
1 of 12
No
No
Agam\AgaP_AGAP010877
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (11)
Atha\CB5-E
11 of 13
Yes
Yes
Atha\CB5-D
10 of 13
No
Yes
Atha\CB5-B
9 of 13
No
Yes
Atha\CB5-A
8 of 13
No
Yes
Atha\CB5-C
8 of 13
No
Yes
Atha\CB5LP
4 of 13
No
Yes
Atha\NIA1
2 of 13
No
No
Atha\NIA2
2 of 13
No
No
Atha\RLF
2 of 13
No
No
Atha\SLD1
1 of 13
No
No
Atha\SLD2
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\CYB5
9 of 13
Yes
Yes
Scer\CYB2
2 of 13
No
No
Scer\IRC21
2 of 13
No
No
Scer\OLE1
2 of 13
No
No
Scer\SCS7
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\oca8
10 of 12
Yes
Yes
Spom\SPBC29A10.16c
6 of 12
No
Yes
Spom\SPAC1F12.10c
2 of 12
No
No
Spom\SPCC330.03c
2 of 12
No
No
Spom\SPCC1281.06c
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Cyt-b5. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
CG3566
10 of 13
CG6870
6 of 13
firewood
5 of 13
CG11257
2 of 13
CG15429
1 of 13
shop
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    CYB5A; cytochrome b5 type A
    model of  methemoglobinemia and ambiguous genitalia
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CYB5A; cytochrome b5 type A
    12 of 14
    613218
     
    CYB5B; cytochrome b5 type B
    10 of 14
    611964
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Cyt-b5 - Pi3K21B
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Summary of Genetic Interactions
        Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
        External Data
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-56
        Cytogenetic map
        43D3-43D3
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        43D3-43D3
        Limits computationally determined from genome sequence between P{EP}CG1600EP398 and P{PZ}scra03427&P{EP}EP2179
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        43D1-43D4
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        43C-43C
        (determined by in situ hybridisation)
        (Rodriguez et al., 1996)
        43C-43C
        (Wu et al., 1996)
        43E4-43E3
        43D3--7
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-56

        (FlyBase, 2016)

        2-56.7

        (Comeron et al., 2012)

        2-

        (Wu et al., 1996)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (13)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (79)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

              (Harvie et al., 1998)

              Mutant alleles show formation of melanotic pseudotumors.

              (Wu et al., 1996)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: Cyt-b5 BcDNA:GH02503

              (FlyBase, 1996-)

              Source for merge of: Cyt-b5 BcDNA:RE66521

              (Misra, 2000.8.25, FlyBase, 1996-)

              Source for merge of: Cyt-b5 dpld l(2)k00107

              (Kleinhesselink et al., 2011)
              Additional comments

              Previous genome annotation had assigned the 'dappled' ('dpld') complementation group to CG1624 (now CG42396, 'wech') based on the position of the k08815 insertion, which does not complement one of the original 'dpld' insertional alleles, k14202. However, analysis of flanking sequence of both the original 'dpld' insertional alleles, k14202 and k09716, indicates they map to the 5' UTR of CG2140/'Cyt-b5'. Re-analysis of the flanking sequences of k08815 indicates that this insertion is accompanied by a large deletion, thereby explaining the discrepancy and the original error. Thus, the 'dappled' complementation group is correctly identified as CG2140/'Cyt-b5'.

              (Kleinhesselink et al., 2011)

              The "dpld, dappled" complementation group does not correspond to CG1624.

              (Loer et al., 2008)

              Source for merge of Cyt-b5 BcDNA:RE66521 was a shared cDNA ( date:030728 ).

              (Misra, 2000.8.25, FlyBase, 1996-)

              "l(2)k00107" probably corresponds to "Cyt-b5"; the P{lacW} insertion in the "l(2)k00107k00107" allele maps 36bp upstream of the 5' end of the CT6982 transcript of "Cyt-b5".

              (Misra, 2000.8.25)

              Source for merge of Cyt-b5 BcDNA:GH02503 was a shared cDNA ( date:030728 ).

              (FlyBase, 1996-)

              FlyBase curator comment: the "dpld" complementation group was previously associated with the CG1624 annotation in FlyBase, due to flanking sequence from the "k08815" line mapping within the CG1624 transcription unit and the fact that the "k08815" line fails to complement the "dappled" alleles "dpld[k09716]" and "dpld[k14202]" (both of these alleles and the "k08815" line show the melanotic tumour phenotype for which the "dappled" complementation group was named). However, FBrf0204992 indicates that CG1624 does not correspond to the "dpld" complementation group. The information corresponding to the CG1624 annotation has thus been split out from the information corresponding to the "dappled" complementation group in FlyBase. The CG1624 annotation has been renamed CG42396 to prevent confusion. Due to the previous error in FlyBase, the symbol "dpld" and the name "dappled" have been used in the literature for both the complementation group that shows the "dappled" melanotic tumour phenotype and also for the CG1624 annotation. The source for the previous confusion is probably the "k08815" line. FBrf0214429 shows that the gene mutated in the "dappled" alleles dpld[k09716] and dpld[k14202] is the Cyt-b5 gene. The paper also shows that the "k08815" line contains a deficiency (Df(2R)k08815) as well as the P{lacW}wechk08815 insertion within the CG1624 transcription unit. This deficiency removes the Cyt-b5 gene, thus explaining why the "k08815" line fails to complement the "dappled" alleles.

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (13)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 52 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
              References (72)