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Citation
Brand, A.H., Dormand, E.L. (1995). The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system.  Curr. Opin. Neurobiol. 5(5): 572--578.
FlyBase ID
FBrf0084801
Publication Type
Review
Abstract

The GAL4 system is a method for directed gene expression that allows genes to be expressed ectopically in numerous cell- or tissue-specific patterns. The technique is being exploited to study the Drosophila melanogaster nervous system at all stages of development, from the embryo to the adult. The GAL4 system is being used to target the expression of novel marker genes in living animals to label cells, or subcellular structures. Directed expression of toxin genes can be used as a method for targeted cell ablation to study the role of cell-cell interactions in development. Ectopic expression helps to elucidate the function of different genes in cell fate determination and differentiation, and is helping to define the regions of the brain involved in sexual behaviour.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Opin. Neurobiol.
    Title
    Current Opinion in Neurobiology
    Publication Year
    1991-
    ISBN/ISSN
    0959-4388
    Data From Reference