Open Close
Reference
Citation
Vagin, V.V., Sigova, A., Li, C., Seitz, H., Gvozdev, V., Zamore, P.D. (2006). A distinct small RNA pathway silences selfish genetic elements in the germline.  Science 313(5785): 320--324.
FlyBase ID
FBrf0194520
Publication Type
Research paper
Abstract

In the Drosophila germline, repeat-associated small interfering RNAs (rasiRNAs) ensure genomic stability by silencing endogenous selfish genetic elements such as retrotransposons and repetitive sequences. Whereas small interfering RNAs (siRNAs) derive from both the sense and antisense strands of their double-stranded RNA precursors, rasiRNAs arise mainly from the antisense strand. rasiRNA production appears not to require Dicer-1, which makes microRNAs (miRNAs), or Dicer-2, which makes siRNAs, and rasiRNAs lack the 2',3' hydroxy termini characteristic of animal siRNA and miRNA. Unlike siRNAs and miRNAs, rasiRNAs function through the Piwi, rather than the Ago, Argonaute protein subfamily. Our data suggest that rasiRNAs protect the fly germline through a silencing mechanism distinct from both the miRNA and RNA interference pathways.

PubMed ID
PubMed Central ID
Related Publication(s)
Review

RasiRNAs battle selfish genetic elements.
Carmi, 2006, Cell 126(2): 223--224 [FBrf0198709]

Note

Molecular biology. A new RNA dimension to genome control.
Carthew, 2006, Science 313(5785): 305--306 [FBrf0192199]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075 1095-9203
    Data From Reference
    Aberrations (1)
    Alleles (13)
    Genes (18)
    Natural transposons (5)
    Transgenic Constructs (1)