FlyBase Allele Report: Dmel\lace[k05305]

General Information

Symbol

Dmel\lace^k05305

Species

D. melanogaster

Name

FlyBase ID

FBal0011566

Feature type

allele

Associated gene

Dmel\lace

Associated Insertion(s)

P{lacW}lace^k05305

Carried in Construct

Also Known As

l(2)k05305

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Roote, 1995.5.4)

Progenitor genotype

Associated Insertion(s)

P{lacW}lace^k05305

Cytology

Description

P-element insertion 8-10 bp upstream of the lace transcription start site.

(Goyal et al., 2019)

P{lacW} insertion 8 to 10bp upstream of the 5' end of the transcription unit.

(Adachi-Yamada et al., 1999)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:15,499,116..15,499,123 [+]

(Hull et al., 2024, Oswald et al., 2015, Yonamine et al., 2011, Carvalho et al., 2010, Adachi-Yamada et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Spradling et al., 1999, Roote, 1995.5.4, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of hereditary sensory and autonomic neuropathy type 1

CEA with lace^U2

(Goyal et al., 2019)

CEA with lace²

(Goyal et al., 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates retinal disease

modeled by norpA^P41

(Acharya et al., 2003)

exacerbates primary autosomal dominant microcephaly 18

modeled by bchs⁵⁸

(Hebbar et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Carvalho et al., 2010)

abnormal flight (with lace²)

(Herr et al., 2003)

abnormal neuroanatomy | adult stage (with lace²)

(Goyal et al., 2019)

abnormal neuroanatomy | adult stage (with lace^U2)

(Goyal et al., 2019)

abnormal neuroanatomy | larval stage

(West et al., 2018)

abnormal neuroanatomy | larval stage (with Df(2L)Exel7063)

(Huang et al., 2018)

abnormal neuroanatomy | larval stage (with lace²)

(Goyal et al., 2019, Huang et al., 2018, West et al., 2018)

abnormal neuroanatomy | larval stage (with lace⁷)

(West et al., 2018)

abnormal neurophysiology | larval stage

(West et al., 2018)

abnormal starvation stress response | adult stage (with lace²)

(Walls et al., 2013)

decreased cell size | adult stage (with lace²)

(Walls et al., 2013)

increased size | larval stage | recessive

(West et al., 2018)

lethal | recessive

(Goyal et al., 2019, Herr et al., 2003, Ashburner et al., 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

lethal - all die before end of larval stage | nutrition conditional

(Carvalho et al., 2010)

lethal - all die before end of P-stage

(West et al., 2018)

lethal - all die before end of P-stage (with lace^k00706)

(West et al., 2018)

partially lethal (with lace¹)

(West et al., 2018)

partially lethal (with lace²)

(West et al., 2018)

partially lethal (with lace⁸)

(West et al., 2018)

partially lethal - majority die (with lace²)

(Goyal et al., 2019)

partially lethal - majority die (with lace⁸)

(Goyal et al., 2019)

partially lethal - majority die (with lace^U2)

(Goyal et al., 2019)

short lived | recessive

(Herr et al., 2003)

some die during larval stage

(West et al., 2018)

some die during larval stage (with lace^k00706)

(West et al., 2018)

some die during P-stage

(West et al., 2018)

some die during P-stage (with lace^k00706)

(West et al., 2018)

some die during third instar larval stage | nutrition conditional

(Carvalho et al., 2010)

visible | recessive

(Adachi-Yamada et al., 1999)

Phenotype Manifest In

adult fat body (with lace²)

(Walls et al., 2013)

alpha/beta Kenyon cell | larval stage (with lace²)

(Goyal et al., 2019)

antenna

(Adachi-Yamada et al., 1999)

axon | adult stage (with lace²)

(Goyal et al., 2019)

chaeta

(Herr et al., 2003)

cone cell

(Adachi-Yamada et al., 1999)

crossvein | ectopic

(Adachi-Yamada et al., 1999)

embryonic/larval neuromuscular junction (with Df(2L)Exel7063)

(Huang et al., 2018)

embryonic/larval neuromuscular junction (with lace²)

(Huang et al., 2018)

embryonic/larval neuromuscular junction | larval stage

(West et al., 2018)

eye

(Herr et al., 2003)

eye-antennal disc

(Adachi-Yamada et al., 1999)

growth cone (with lace²)

(Goyal et al., 2019)

interommatidial bristle

(Adachi-Yamada et al., 1999)

Kenyon cell (with lace²)

(Goyal et al., 2019)

leg

(Adachi-Yamada et al., 1999)

leg disc

(Adachi-Yamada et al., 1999)

lipid droplet | adult stage (with lace²)

(Walls et al., 2013)

lobe system of adult mushroom body (with lace²)

(Goyal et al., 2019)

lobe system of adult mushroom body (with lace^U2)

(Goyal et al., 2019)

lobe system of larval mushroom body (with lace²)

(Goyal et al., 2019)

macrochaeta

(Adachi-Yamada et al., 1999)

microchaeta

(Adachi-Yamada et al., 1999)

mitochondrion

(West et al., 2018)

NMJ bouton, with Scer\GAL4^Mhc.PU, lace^UAS.Tag:HA

(West et al., 2018)

NMJ bouton | decreased number | larval stage

(West et al., 2018)

NMJ bouton | decreased number | larval stage (with lace²)

(West et al., 2018)

NMJ bouton | decreased number | larval stage (with lace⁷)

(West et al., 2018)

ommatidium

(Herr et al., 2003, Adachi-Yamada et al., 1999)

primary pigment cell

(Adachi-Yamada et al., 1999)

secondary pigment cell

(Adachi-Yamada et al., 1999)

terminal bouton | larval stage (with Df(2L)Exel7063)

(Huang et al., 2018)

terminal bouton | larval stage (with lace²)

(Huang et al., 2018)

tertiary pigment cell

(Adachi-Yamada et al., 1999)

wing

(Herr et al., 2003, Adachi-Yamada et al., 1999)

wing disc

(Adachi-Yamada et al., 1999)

Detailed Description

Statement

Reference

Unlike wild-type and lace[2] heterozygous controls, lace^k05305/lace² and lace^k05305/lace^U2 transheterozygous adults show a mushroom body "lost-lobe" phenotype in about half of cases; the overall dendrite organization in lace^k05305/lace² seems unaffected, as indicated by microtubule polarity (nod) and compartment identity (Apc2, DenMark, etc). Single cell analysis reveals a failure of lace^k05305/lace² mushroom body neurons to extend their axon branches dorsally, instead developing parallel horizontal branches. In lace^k05305/lace² larvae and pupae the vertical α/α' Kenyon cell lobe is already missing. Despite the missing lobe in larvae, the α/β axons and α'/β' axons still segregate into distinct horizontal lobes; there is non-segregation of the α' and β' growth cones, despite of unperturbed peduncle development; γ Kenyon cells do not seem to be affected.

(Goyal et al., 2019)

lace²/lace^k05305 and lace^k05305/Df(3L)BSC671 larvae have significantly reduced bouton number and significantly increased bouton size at the neuromuscular junction of muscle 4, compared to controls, with no effect on the number of satellite boutons.

(Huang et al., 2018)

lace^k05305/lace² transheterozygous mutant adults present significantly decreased survival to starvation, decreased body weight, decreased adiposity in abdominal sections and decreased sizes of fat body cells and lipid droplets, but similar feeding behavior, as assessed by starvation-induced appetite, postprandial meal volume, average meal frequency and volume, and caloric intake, as compared to controls.

(Walls et al., 2013)

When raised on a standard diet, lace^k05305 mutants survive to adulthood, although in reduced numbers. However, when these mutants are raised on lipid-depleted medium+cholesterol, 90% arrest as third instar larvae. This arrest is likely to be caused by the lack of dietary sphingolipid in lipid-depleted media. More than 80% of arrested lace^k05305 mutant larvae remain viable for at least 10 days by which time their heterozygote siblings have pupariated. When raised on lipid-depleted medium with cholesterol, homozygous lace^k05305 mutant larvae die 3 days earlier than their heterozygous siblings.

(Carvalho et al., 2010)

Heterozygotes have normal photoreceptor organisation.

(Acharya et al., 2003)

lace^k05305/lace² adults have an average flight score of 1.41 +/- 0.063 compared to 1.62 +/- 0.14 in wild-type flies in a standard flight performance assay. The average number of dorsal longitudinal flight muscles per hemithorax is 5.94 +/- 0.030 in the mutant flies, compared to 6.00 +/- 0.00 in wild-type flies. Homozygotes show 91% lethality. Those adults that do survive have a lifespan of less than one week and have pronounced morphological defects; wings are notched and often fail to inflate, bristles are missing and the eyes are often rough with irregular ommatidia. Surviving adults have an average of 4.82 +/- 0.53 dorsal longitudinal flight muscles per hemithorax, compared to 6.00 +/- 0.00 in wild-type flies.

(Herr et al., 2003)

lace^k05305/lace² shows reduced viability. lace^k05305/lace² flies often show incision of the wing margin, and there is an ectopic crossvein. The hexagonal array of the ommatidia is disrupted, especially along the equatorial plane. The deep pseudopupil pattern is normal. In the notum, the microchaetae lack pigment and are occasionally missing, while the number of macrochaetae is variable. In the leg and antenna, bifurcation of the distal portion is rarely seen. The lethality and various adult mutant phenotypes of lace^k05305/lace² flies can be rescued by feeding with sphingosine. The adult mutant phenotypes cannot be rescued by exogenous sphingomyelin or ceramide. The wing, leg and eye-antennal discs of lace^k05305/lace² animals contain a considerably high number of dead cells. Severe malformation of the primordial wing blade is seen in the wing disc. The developing pupal eye shows loss of cells among cone cells, primary pigment cells, secondary pigment cells, tertiary pigment cells and interommatidial bristles.

(Adachi-Yamada et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

lace^U2/lace^k05305 has abnormal neuroanatomy | adult stage phenotype, enhanceable by Spt-I[+]/Spt-I^l(2)49Fb-4

(Goyal et al., 2019)

lace^U2/lace^k05305 has abnormal neuroanatomy | adult stage phenotype, enhanceable by Spt-I[+]/Spt-I^B2

(Goyal et al., 2019)

lace²/lace^k05305 has abnormal neuroanatomy | adult stage phenotype, enhanceable by Scer\GAL4^Dscam1.4.5/Dscam1^{TM1.UAS.RFP(Unk)}

(Goyal et al., 2019)

lace²/lace^k05305 has abnormal starvation stress response | adult stage phenotype, enhanceable by Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹

(Walls et al., 2013)

Suppressed by

Statement

Reference

lace²/lace^k05305 has abnormal neuroanatomy | adult stage phenotype, suppressible | partially by Scer\GAL4^Dscam1.4.5/Dscam1^{RNAi.UAS.17.1}

(Goyal et al., 2019)

lace^k05305 has abnormal neuroanatomy | larval stage phenotype, suppressible by hiw^ND9/hiw^ND9

(West et al., 2018)

lace^k05305 has lethal | recessive phenotype, suppressible by Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹

(Herr et al., 2003)

lace²/lace^k05305 has visible phenotype, suppressible by Dsor1^Su1

(Adachi-Yamada et al., 1999)

lace²/lace^k05305 has visible phenotype, suppressible by rl^Sem

(Adachi-Yamada et al., 1999)

Enhancer of

Statement

Reference

lace[+]/lace^k05305 is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Df(2L)cl7/bchs⁵⁸

(Hebbar et al., 2015)

lace[+]/lace^k05305 is an enhancer of decreased cell number | third instar larval stage phenotype of Df(2L)cl7/bchs⁵⁸

(Hebbar et al., 2015)

lace²/lace^k05305 is an enhancer of abnormal starvation stress response | adult stage phenotype of Sply⁰⁵⁰⁹¹

(Walls et al., 2013)

Suppressor of

Statement

Reference

lace^k05305/lace^k05305 is a suppressor of abnormal neuroanatomy | recessive | larval stage phenotype of hiw^ND9

(West et al., 2018)

lace[+]/lace^k05305 is a suppressor of increased cell death phenotype of Sply⁰⁵⁰⁹¹

(Herr et al., 2003)

lace[+]/lace^k05305 is a suppressor of lethal | recessive phenotype of Sply⁰⁵⁰⁹¹

(Herr et al., 2003)

lace[+]/lace^k05305 is a suppressor of flightless | recessive phenotype of Sply⁰⁵⁰⁹¹

(Herr et al., 2003)

lace[+]/lace^k05305 is a suppressor of semi-sterile | recessive phenotype of Sply⁰⁵⁰⁹¹

(Herr et al., 2003)

NOT Suppressor of

Statement

Reference

lace²/lace^k05305 is a non-suppressor of abnormal feeding behavior | adult stage phenotype of Sply⁰⁵⁰⁹¹

(Walls et al., 2013)

Other

Statement

Reference

hiw^ND9, lace^k05305 has abnormal neuroanatomy | dominant | larval stage phenotype

(West et al., 2018)

hiw^ND9, lace^k05305 has abnormal neuroanatomy | larval stage phenotype

(West et al., 2018)

hiw^ND9, lace^k05305 has increased size | larval stage phenotype

(West et al., 2018)

Bsg⁶⁹²⁵, lace^k05305 has increased size | larval stage phenotype

(West et al., 2018)

Scer\GAL4^elav.PU, Spt-I^C129W.UAS, lace[+]/lace^k05305 has abnormal neuroanatomy | larval stage phenotype

(Oswald et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

lace^U2/lace^k05305 has lobe system of adult mushroom body phenotype, enhanceable by Spt-I[+]/Spt-I^l(2)49Fb-4

(Goyal et al., 2019)

lace^U2/lace^k05305 has lobe system of adult mushroom body phenotype, enhanceable by Spt-I[+]/Spt-I^B2

(Goyal et al., 2019)

lace^U2/lace^k05305 has lobe system of adult mushroom body phenotype, enhanceable by Scer\GAL4^Dscam1.4.5/Dscam1^{TM1.UAS.RFP(Unk)}

(Goyal et al., 2019)

NOT Enhanced by

Statement

Reference

lace²/lace^k05305 has adult fat body phenotype, non-enhanceable by Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹

(Walls et al., 2013)

lace²/lace^k05305 has lipid droplet | adult stage phenotype, non-enhanceable by Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹

(Walls et al., 2013)

Suppressed by

Statement

Reference

lace^U2/lace^k05305 has lobe system of adult mushroom body phenotype, suppressible | partially by Scer\GAL4^Dscam1.4.5/Dscam1^{RNAi.UAS.17.1}

(Goyal et al., 2019)

lace^k05305 has NMJ bouton | larval stage | decreased number phenotype, suppressible by hiw^ND9/hiw^ND9

(West et al., 2018)

lace^k05305 has chaeta phenotype, suppressible by Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹

(Herr et al., 2003)

lace^k05305 has eye phenotype, suppressible by Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹

(Herr et al., 2003)

lace^k05305 has ommatidium phenotype, suppressible by Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹

(Herr et al., 2003)

lace^k05305 has wing phenotype, suppressible by Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹

(Herr et al., 2003)

lace²/lace^k05305 has microchaeta phenotype, suppressible by rl^Sem

(Adachi-Yamada et al., 1999)

lace²/lace^k05305 has wing disc phenotype, suppressible by hep^r75

(Adachi-Yamada et al., 1999)

lace²/lace^k05305 has wing phenotype, suppressible by Dsor1^Su1

(Adachi-Yamada et al., 1999)

lace²/lace^k05305 has crossvein phenotype, suppressible by Dsor1^Su1

(Adachi-Yamada et al., 1999)

lace²/lace^k05305 has ommatidium phenotype, suppressible by Dsor1^Su1

(Adachi-Yamada et al., 1999)

lace²/lace^k05305 has microchaeta phenotype, suppressible by Dsor1^Su1

(Adachi-Yamada et al., 1999)

lace²/lace^k05305 has macrochaeta phenotype, suppressible by Dsor1^Su1

(Adachi-Yamada et al., 1999)

lace²/lace^k05305 has wing phenotype, suppressible by rl^Sem

(Adachi-Yamada et al., 1999)

Enhancer of

Statement

Reference

lace[+]/lace^k05305 is an enhancer of larval RP2 motor neuron | third instar larval stage | decreased number phenotype of Df(2L)cl7/bchs⁵⁸

(Hebbar et al., 2015)

lace[+]/lace^k05305 is an enhancer of larval DA1 motor neuron | third instar larval stage | decreased number phenotype of Df(2L)cl7/bchs⁵⁸

(Hebbar et al., 2015)

Suppressor of

Statement

Reference

lace^k05305/lace^k05305 is a suppressor of NMJ bouton | increased number | larval stage phenotype of hiw^ND9

(West et al., 2018)

lace[+]/lace^k05305 is a suppressor of autophagosome | third instar larval stage | decreased number phenotype of Df(2L)cl7/bchs⁵⁸

(Hebbar et al., 2015)

lace[+]/lace^k05305 is a suppressor of eye phenotype of Dref^UAS.cSa

(Ida et al., 2009)

lace[+]/lace^k05305 is a suppressor of photoreceptor neuron phenotype of Scer\GAL4^GMR.PF, shi^1.UAS

(Acharya et al., 2003)

lace[+]/lace^k05305 is a suppressor of rhabdomere phenotype of Arr2³

(Acharya et al., 2003)

lace[+]/lace^k05305 is a suppressor of rhabdomere phenotype of norpA^P41

(Acharya et al., 2003)

lace[+]/lace^k05305 is a suppressor of dorsal longitudinal indirect flight muscle cell phenotype of Sply⁰⁵⁰⁹¹

(Herr et al., 2003)

Other

Statement

Reference

hiw^ND9, lace^k05305 has NMJ bouton | larval stage | decreased number phenotype

(West et al., 2018)

hiw^ND9, lace^k05305 has embryonic/larval neuromuscular junction phenotype

(West et al., 2018)

Bsg⁶⁹²⁵, lace^k05305 has NMJ bouton | larval stage | decreased number phenotype

(West et al., 2018)

Scer\GAL4^elav.PU, Spt-I^C129W.UAS, lace[+]/lace^k05305 has embryonic/larval neuromuscular junction phenotype

(Oswald et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The mushroom body "lost lobe" phenotype penetrance observed in lace^k05305/lace² transheterozygous adults is significantly increased and decreased by the Scer\GAL4^Dscam1.4.5-driven expression of Dscam1^{TM1.UAS.RFP(Unk)} and Dscam1^{miRNA.UAS.17.1}, respectively.

lace^k05305/lace² transheterozygous adults that also express Vap33^UAS.cPa under the control of Scer\GAL4^Tab2-201Y do not show a mushroom body "lost lobe" phenotype.

(Goyal et al., 2019)

Introduction of heterozygous lace^k05305 in the presence of Spt-I^{C129W.Scer\UAS} and the pan-neuronal driver Scer\GAL4^elav.PU induces a 50% reduction of bouton numbers compared with wild-type.

(Oswald et al., 2015)

lace^k05305/lace², Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹ adults exhibit a more severe decrease in survival in response to starvation as compared to either lace^k05305/lace² or Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹ mutants.

The decreased body weight, decreased adiposity in abdominal sections and decreased sizes of fat body cells and lipid droplets, observed in lace^k05305/lace² transheterozygous mutant adults are not altered by Sply⁰⁵⁰⁹¹ homozygosity.

The decreased feeding behavior observed in Sply⁰⁵⁰⁹¹ homozygous mutant adults, as assessed by their decreased starvation-induced appetite, decreased postprandial meal volume, decreased average meal frequency and volume, and decreased daily food intake, is not suppressed by lace^k05305/lace² transheterozygosity.

(Walls et al., 2013)

One copy of lace^k05305 partially suppresses the degeneration of rhabdomeres seen in Arr2³ flies; the rhabdomeres are mostly intact in the rescued flies, but some cellular degeneration (characterised by vacuoles and dark multivesicular bodies) is still seen. The degeneration of photoreceptor cells seen in flies expressing shi^1.Scer\UAS under the control of Scer\GAL4^GMR.PF is substantially suppressed by lace^k05305/+. One copy of lace^k05305 suppresses the retinal degeneration seen in norpA³⁹ flies.

(Acharya et al., 2003)

Sply⁰⁵⁰⁹¹/Sply⁰⁵⁰⁹¹ lace^k05305/+ adults have an average flight score of 1.41 +/- 0.063 compared to 2.60 +/- 0.032 in wild-type flies in a standard flight performance assay. The average number of dorsal longitudinal flight muscles per hemithorax is 5.13 +/- 0.26 in the mutant flies, compared to 6.00 +/- 0.00 in wild-type flies. Sply⁰⁵⁰⁹¹ lace^k05305 double homozygotes show 61% lethality. The eye, bristle and wing defects of lace^k05305 surviving adults are suppressed in Sply⁰⁵⁰⁹¹ lace^k05305 double homozygotes.

(Herr et al., 2003)

rl^Sem suppresses the wing margin incision and loss of microchaetae phenotypes of lace^k05305/lace² flies.

(Adachi-Yamada et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

lace^k02303

(BDGP Project Members, 1994-1999)

Rescued by

lace²/lace^k05305 is rescued by Scer\GAL4^Dscam1.4.5/lace^{WT.UAS.Tag:HA}

(Goyal et al., 2019)

lace²/lace^k05305 is rescued by Scer\GAL4^repo.PL/lace^{WT.UAS.Tag:HA}

(Goyal et al., 2019)

lace^k05305 is rescued by lace^UAS.Tag:HA/Scer\GAL4^Tub.PU

(West et al., 2018)

lace^k05305 is rescued by lace^UAS.Tag:HA/Scer\GAL4^repo.PU

(West et al., 2018)

lace²/lace^k05305 is rescued by lace^UAS.Tag:HA/Scer\GAL4^69B

(Adachi-Yamada et al., 1999)

Partially rescued by

lace²/lace^k05305 is partially rescued by Scer\GAL4^Tab2-201Y/lace^{WT.UAS.Tag:HA}

(Goyal et al., 2019)

lace^k05305 is partially rescued by lace^UAS.Tag:HA/Scer\GAL4^Mhc.PU

(West et al., 2018)

Not rescued by

lace^k05305 is not rescued by Scer\GAL4^elav.PU/lace^UAS.Tag:HA

(West et al., 2018)

Comments

Incision of the wing margin in lace^k05305/lace² flies is rescued by lace^{Scer\UAS.T:Ivir\HA1} expressed under the control of Scer\GAL4^69B.

(Adachi-Yamada et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

12176

y¹ w^67c23; P{lacW}lace^k05305/CyO

Kyoto

111432

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}lace^k05305 P{neoFRT}40A/CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(Roote, 1995.5.4)

Comments

The phenotype is caused by the P{lacW} insertion.

(Adachi-Yamada et al., 1999)

Complements: CycE^k02602.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Lace^k05305

(Hull et al., 2024)

Lace^k5305

(Hull et al., 2024)

k05305

(Ashburner et al., 1999)

l(2)k05305

(Carvalho et al., 2010, Acharya et al., 2003, Adachi-Yamada et al., 1999, Spradling et al., 1999)

lace^53/5

(Roote, 1995.5.4)

lace^P

(Oswald et al., 2015)

lace^k05305

(Huang et al., 2018, Walls et al., 2018, West et al., 2018, Hebbar et al., 2015, Walls et al., 2013, Ida et al., 2009, Geng and MacDonald, 2007)

lace^k05

(Goyal et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (22)

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