FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\hfw
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General Information
Symbol
Dmel\hfw
Species
D. melanogaster
Name
halfway
Annotation Symbol
CG3095
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001189
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
Has a role in the ecdysone induced cascade; probably indirect control of 'late' ecdysone genes. (UniProt, Q9W568)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

swi, EG:171E4.2 , singed wings

Key Links
Genomic Location
Cytogenetic map
2B5-2B6
Sequence location
Recombination map
1-0.2
RefSeq locus
NC_004354 REGION:1669570..1673608
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in intracellular signal transduction
inferred from mutant phenotype
(Schwartz et al., 2004)
involved_in pupariation
inferred from mutant phenotype
(Schwartz et al., 2004)
involved_in response to ecdysone
inferred from mutant phenotype
(Schwartz et al., 2004)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Has a role in the ecdysone induced cascade; probably indirect control of 'late' ecdysone genes.
(UniProt, Q9W568)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
hfw: halfway
Recessive lethal; for some alleles, development arrested in third instar, the anterior half initiating puparium formation while the posterior half remains larval. Extent of development influenced by administration of ecdysone and by temperature; pupariation occasionally completed at 18. Some alleles yield a few survivors with characteristic wing abnormalities and occasionally swollen abdomens.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\hfw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9W568)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
hfw-RA
FBtr0070270
NM_130577
2540
611
hfw-RB
FBtr0333115
NM_001272206
3038
611
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
hfw-PA
FBpp0070260
68.5
611
6.43
Q9W568
NP_569933
AAF45654
hfw-PB
FBpp0305326
68.5
611
6.43
Q9W568
NP_001259135
AGB94981
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

611 aa isoforms: hfw-PA, hfw-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hfw using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.47

Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\hfw in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of hfw
Transgenic constructs containing regulatory region of hfw
Aberrations (Deficiencies and Duplications) ( 26 )
Inferred from experimentation ( 26 )
Gene duplicated in
Dp(1;f)1337
(Rayle and Hoar, 1969)
Dp(1;Y)2E-C
(Rayle and Hoar, 1969)
Dp(1;Y)2E
(Aizenzon and Belyaeva, 1982)
Dp(1;Y)dor9T
(Belyaeva et al., 1982)
Dp(1;Y)dor13T
(Belyaeva et al., 1982)
Dp(1;Y)Sz280
(Belyaeva et al., 1987)
Dp(1;Y)y221T
(Belyaeva et al., 1982, Belyaeva et al., 1980)
Dp(1;Y)y240T
(Belyaeva et al., 1980)
Dp(1;Y)y253T
(Aizenzon and Belyaeva, 1982, Belyaeva et al., 1982, Belyaeva et al., 1980)
Dp(1;Y)y267g19.1
(Aizenzon and Belyaeva, 1982, Belyaeva et al., 1980)
Dp(1;Y)y267g24.2
(Protopopov et al., 1991, Aizenzon and Belyaeva, 1982, Belyaeva et al., 1982, Belyaeva et al., 1980)
Gene not duplicated in
Dp(1;f)3
(Rayle and Hoar, 1969)
Dp(1;f)18
(Rayle and Hoar, 1969)
Dp(1;f)101
(Aizenzon and Belyaeva, 1982, Belyaeva et al., 1980, Rayle and Hoar, 1969)
Dp(1;Y)Sz280
(Protopopov et al., 1991, Aizenzon and Belyaeva, 1982, Belyaeva et al., 1982)
Dp(1;Y)y59b
(Aizenzon and Belyaeva, 1982, Belyaeva et al., 1980)
Gene disrupted in
Df(1)RA19
(Aizenzon and Belyaeva, 1982, Belyaeva et al., 1982, Belyaeva et al., 1980)
Df(1)St472
(Aizenzon and Belyaeva, 1982)
Ts(1Lt;YLt)G20
(Belyaeva et al., 1987)
Ts(1Lt;YSt)B131
(Belyaeva et al., 1987)
Gene not disrupted in
Df(1)At127
(Aizenzon and Belyaeva, 1982)
Df(1)br25
(Belyaeva et al., 1987, Belyaeva et al., 1980)
Df(1)br-rv1
(Belyaeva et al., 1987)
Df(1)S39
(Protopopov et al., 1991, Belyaeva et al., 1987, Aizenzon and Belyaeva, 1982, Belyaeva et al., 1982, Belyaeva et al., 1980)
Df(1)St490
(Belyaeva et al., 1987)
Df(1)sta
(Belyaeva et al., 1987, Aizenzon and Belyaeva, 1982, Belyaeva et al., 1980)
In(1)br103
(Belyaeva et al., 1987)
Inferred from location ( 32 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (20)
Hsap\ASPN
1 of 14
Yes
No
Hsap\ECM2
1 of 14
Yes
Yes
Hsap\FLRT2
1 of 14
Yes
Yes
Hsap\IGFALS
1 of 14
Yes
No
Hsap\ISLR2
1 of 14
Yes
No
Hsap\ISLR
1 of 14
Yes
No
Hsap\LGR6
1 of 14
Yes
No
1  
Hsap\LINGO1
1 of 14
Yes
No
Hsap\LINGO2
1 of 14
Yes
No
Hsap\LRRC3B
1 of 14
Yes
No
Hsap\LRRC17
1 of 14
Yes
No
Hsap\LRRC32
1 of 14
Yes
No
Hsap\LRRC38
1 of 14
Yes
Yes
Hsap\LRRC52
1 of 14
Yes
No
Hsap\LRRC66
1 of 14
Yes
No
Hsap\LRRC70
1 of 14
Yes
No
Hsap\LRRN4CL
1 of 14
Yes
Yes
Hsap\SLIT1
1 of 14
Yes
No
Hsap\SLIT2
1 of 14
Yes
No
Hsap\SLIT3
1 of 14
Yes
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
Rnor\Lrrc52
2 of 14
Yes
Yes
Rnor\Chadl
1 of 14
No
No
Rnor\Cpn2
1 of 14
No
No
Rnor\Flrt2
1 of 14
No
Yes
Rnor\Islr2
1 of 14
No
No
Rnor\Islr
1 of 14
No
Yes
Rnor\Lrrc3b
1 of 14
No
No
Rnor\Lrrc3c
1 of 14
No
Yes
Rnor\Lrrc17
1 of 14
No
No
Rnor\Lrrc38
1 of 14
No
No
Rnor\Podnl1
1 of 14
No
Yes
Rnor\Rxfp2
1 of 14
No
No
Rnor\Slit1
1 of 14
No
No
Rnor\Slit2
1 of 14
No
No
Rnor\Slit3
1 of 14
No
No
Mus musculus (laboratory mouse) (19)
Mmus\Chadl
1 of 14
Yes
No
Mmus\Cpn2
1 of 14
Yes
No
Mmus\Flrt2
1 of 14
Yes
Yes
Mmus\Islr2
1 of 14
Yes
No
Mmus\Islr
1 of 14
Yes
Yes
Mmus\Lingo2
1 of 14
Yes
No
Mmus\Lrrc3b
1 of 14
Yes
No
Mmus\Lrrc3c
1 of 14
Yes
No
Mmus\Lrrc17
1 of 14
Yes
Yes
Mmus\Lrrc26
1 of 14
Yes
No
Mmus\Lrrc38
1 of 14
Yes
Yes
Mmus\Lrrc52
1 of 14
Yes
Yes
Mmus\Podnl1
1 of 14
Yes
Yes
Mmus\Rxfp2
1 of 14
Yes
No
Mmus\Slit1
1 of 14
Yes
No
Mmus\Slit2
1 of 14
Yes
No
Mmus\Slit3
1 of 14
Yes
No
Mmus\Tlr5
1 of 14
Yes
No
Mmus\Tril
1 of 14
Yes
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\flrt2
1 of 13
Yes
No
Xtro\islr2
1 of 13
Yes
Yes
Xtro\LOC100493904
1 of 13
Yes
No
Xtro\LOC101730428
1 of 13
Yes
No
Xtro\lrrc3b
1 of 13
Yes
No
Xtro\lrrc38
1 of 13
Yes
Yes
Xtro\lrrc52
1 of 13
Yes
Yes
Xtro\nyx
1 of 13
Yes
No
Xtro\slit1
1 of 13
Yes
No
Xtro\slit3
1 of 13
Yes
No
Danio rerio (Zebrafish) (25)
Drer\mxra5a
2 of 14
Yes
Yes
Drer\si:ch211-237i5.4
2 of 14
Yes
Yes
Drer\bgnb
1 of 14
No
Yes
Drer\flrt1b
1 of 14
No
Yes
Drer\igsf10
1 of 14
No
No
Drer\islr2
1 of 14
No
No
Drer\lgr4
1 of 14
No
No
Drer\lingo4b
1 of 14
No
No
Drer\LOC563710
1 of 14
No
No
Drer\LOC100332583
1 of 14
No
No
Drer\lrrc3ca
1 of 14
No
No
Drer\lrrc3
1 of 14
No
No
Drer\lrrc4ba
1 of 14
No
No
Drer\lrrc38a
1 of 14
No
Yes
Drer\lrrc38b
1 of 14
No
Yes
Drer\lrrn3a
1 of 14
No
No
Drer\si:dkey-1j5.4
1 of 14
No
No
Drer\si:dkey-182i3.11
1 of 14
No
No
Drer\slit1a
1 of 14
No
No
Drer\slit1b
1 of 14
No
No
Drer\slit2
1 of 14
No
No
Drer\slit3
1 of 14
No
No
Drer\tril
1 of 14
No
No
Drer\waif2
1 of 14
No
No
Drer\zgc:153913
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\dma-1
1 of 14
Yes
No
Cele\egg-6
1 of 14
Yes
No
Cele\lron-6
1 of 14
Yes
No
Cele\lron-11
1 of 14
Yes
No
Cele\lron-14
1 of 14
Yes
No
Cele\lron-15
1 of 14
Yes
No
Cele\slt-1
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (13)
Agam\AgaP_AGAP000601
9 of 12
Yes
Yes
Agam\AgaP_AGAP005417
2 of 12
No
No
Agam\AgaP_AGAP002792
1 of 12
No
No
Agam\AgaP_AGAP002793
1 of 12
No
No
Agam\AgaP_AGAP005693
1 of 12
No
No
Agam\AgaP_AGAP009688
1 of 12
No
No
Agam\AgaP_AGAP011292
1 of 12
No
No
Agam\AgaP_AGAP011947
1 of 12
No
No
Agam\AgaP_AGAP012385
1 of 12
No
No
Agam\TOLL1A
1 of 12
No
No
Agam\TOLL6
1 of 12
No
No
Agam\TOLL10
1 of 12
No
No
Agam\TOLL11
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:hfw. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (25)
swi2
3 of 13
18w
1 of 13
CG7702
1 of 13
CG7896
1 of 13
CG16974
1 of 13
CG18480
1 of 13
CG32055
1 of 13
fliI
1 of 13
haf
1 of 13
kek1
1 of 13
kek2
1 of 13
kek3
1 of 13
kek4
1 of 13
kek6
1 of 13
Lapsyn
1 of 13
lbk
1 of 13
Lrt
1 of 13
rdo
1 of 13
sli
1 of 13
Tehao
1 of 13
Tl
1 of 13
Toll-4
1 of 13
Toll-6
1 of 13
Toll-7
1 of 13
Tollo
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-0.2
    Cytogenetic map
    2B5-2B6
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    2B5-2B6
    Limits computationally determined from genome sequence between P{EP}brEP1515 and P{EP}EP1444&P{EP}CG14818EP1190
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-0.2

    (FlyBase, 2016, Comeron et al., 2012)

    1-0.4

    (Aizenzon and Belyaeva, 1982)
    Left of (cM)
    (Aizenzon and Belyaeva, 1982)
    Right of (cM)
    (Aizenzon and Belyaeva, 1982)
    Notes
    Stocks and Reagents
    Stocks (11)
    Genomic Clones (10)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (17)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        Complementation test between the "hfw1" allele described by FBrf0018667 with any "swi" mutant alleles has not been possible, since the "hfw1" stock was lost by the time that "swi" mutant alleles were obtained. "hfw" and "swi" map to the same cytological interval and mutants show similar phenotypes, making it very likely that they are allelic.

        (Schwartz et al., 2004)

        Localisation of hfw, dor and br are clustered in the X chromosomes of taxonomically distant Drosophila species, suggesting an evolutionary significance of such an organisation.

        (Kokoza et al., 1992)

        hfw has been located within a puff on the telomeric chromosome of D.funebris, D.virilis, D.hydei, D.repleta, D.mercatorum and D.paranaensis, within a puff on the distal part of the X chromosome of D.kanekoi and within a puff on the proximal portion of the X chromosome of D.pseudoobscura.pseudoobscura.

        (Kokoza et al., 1991)

        The hfw locus is subject to T(1;2)dorvar7 position effect variegation.

        (Demakova et al., 1988)

        Hormone incubation of mutant salivary glands in vitro and hormone injection of mutants demonstrates the hfw gene product is necessary for induction of late puffs.

        (Belyaeva and Zhimulev, 1982)

        Some swi mutants exhibit puparium formation of the anterior half of the body only, this phenomenon is characteristic of the mutant hfw, localised to the same region. These results suggest the swi mutants belongs to the hfw group.

        (Belyaeva et al., 1980)

        Recessive lethal; for some alleles, development arrested in third instar, the anterior half initiating puparium formation while the posterior half remains larval. Extent of development influenced by administration of ecdysone and by temperature; pupariation occasionally completed at 18oC. Some alleles yield a few survivors with characteristic wing abnormalities and occasionally swollen abdomens.

        Relationship to Other Genes
        Source for database merge of

        Source for merge of: hfw CG3095

        (FlyBase, 1996-)
        Additional comments

        Source for merge of hfw CG3095 was sequence comparison ( date:040402 ).

        (FlyBase, 1996-)
        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (11)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 39 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        References (60)