FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Vinc
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General Information
Symbol
Dmel\Vinc
Species
D. melanogaster
Name
Vinculin
Annotation Symbol
CG3299
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004397
Gene Model Status
Current
Stock Availability
24 publicly available
Gene Summary
Vinculin (Vinc) encodes a key mechanoeffector of cell-cell and cell-extracellular matrix adhesion. It binds to the products of rhea and α-Cat, when they are stretched by force, and links them to actin. Vinc mutant flies are viable and fertile although mild defects have been documented in muscle attachment and heart function. [Date last reviewed: 2018-09-06] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Vin, EG:103B4.1 , CT11081

Key Links
Genomic Location
Cytogenetic map
2E2-2E3
Sequence location
Recombination map
1-0.8
RefSeq locus
NC_004354 REGION:2214347..2222567
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables actin binding
inferred from electronic annotation with InterPro:IPR017997
(InterPro Project Members, 2004-)
enables actin filament binding
inferred from electronic annotation with InterPro:IPR006077, InterPro:IPR036723
(InterPro Project Members, 2004-)
enables alpha-catenin binding
inferred from biological aspect of ancestor with PANTHER:PTN005285701
(GO Reference Genome Project, 2011-)
enables beta-catenin binding
inferred from biological aspect of ancestor with PANTHER:PTN005285701
(GO Reference Genome Project, 2011-)
enables structural molecule activity
inferred from electronic annotation with InterPro:IPR000633
(InterPro Project Members, 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in cell adhesion
inferred from biological aspect of ancestor with PANTHER:PTN005285701
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR000633, InterPro:IPR006077, InterPro:IPR036723
(InterPro Project Members, 2004-)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(Jurado et al., 2016)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
located_in actin cytoskeleton
inferred from electronic annotation with InterPro:IPR000633
(InterPro Project Members, 2004-)
is_active_in adherens junction
inferred from biological aspect of ancestor with PANTHER:PTN005285701
(GO Reference Genome Project, 2011-)
is_active_in cell-cell contact zone
inferred from biological aspect of ancestor with PANTHER:PTN005285701
(GO Reference Genome Project, 2011-)
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN005285701
(GO Reference Genome Project, 2011-)
is_active_in cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN005285701
(GO Reference Genome Project, 2011-)
is_active_in focal adhesion
inferred from biological aspect of ancestor with PANTHER:PTN005285701
(GO Reference Genome Project, 2011-)
located_in focal adhesion
traceable author statement
(Hynes and Zhao, 2000)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN005285701
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the vinculin/alpha-catenin family. (O46037)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Vinculin (Vinc) encodes a key mechanoeffector of cell-cell and cell-extracellular matrix adhesion. It binds to the products of rhea and α-Cat, when they are stretched by force, and links them to actin. Vinc mutant flies are viable and fertile although mild defects have been documented in muscle attachment and heart function. [Date last reviewed: 2018-09-06]
Protein Function (UniProtKB)
Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane.
(UniProt, O46037)
Summary (Interactive Fly)

component of adherens and focal adhesion junctions - regulates cytoskeletal anchoring at the plasma membrane - regulates cell adhesion - mechanotransduction - triggers the formation of cytoplasmic adhesion complexes - interacts with α-Catenin - recruited to amniosersoa apical cell membranes during dorsal closure - regulates of cardiac function during aging

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Vinc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O46037)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Vinc-RA
FBtr0070420
NM_057472
3766
961
Vinc-RB
FBtr0342770
NM_001297884
3744
961
Vinc-RC
FBtr0342771
NM_001297885
3838
961
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Vinc-PA
FBpp0070404
106.3
961
6.66
O46037
NP_476820
AAF45752
Vinc-PB
FBpp0309622
106.3
961
6.66
O46037
NP_001284813
AHN59284
Vinc-PC
FBpp0309623
106.3
961
6.66
O46037
NP_001284814
AHN59285
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

961 aa isoforms: Vinc-PA, Vinc-PB, Vinc-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Exhibits self-association properties.

(UniProt, O46037)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vinc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.65

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic foregut
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(Jurado et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Vinc in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 39 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Vinc
Transgenic constructs containing regulatory region of Vinc
Aberrations (Deficiencies and Duplications) ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4Mef2.PU
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Act5C.PU
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4Mef2.PU
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal cell number | adult stage, with Scer\GAL4klu-G410
abnormal cell number | adult stage, with Scer\GAL4NP7397
abnormal cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
abnormal cell polarity | embryonic stage, with Scer\GAL4Hand.PU
increased cell number | embryonic stage, with Scer\GAL4Hand.PU
increased cell number | embryonic stage, with Scer\GAL4tin.CΔ4
increased cell size | adult stage, with Scer\GAL4NP7397
increased occurrence of cell division | adult stage, with Scer\GAL4klu-G410
increased occurrence of cell division | adult stage, with Scer\GAL4NP7397
long lived, with Scer\GAL4tin.CΔ4
some die during embryonic stage, with Scer\GAL4Mef2.PU
Phenotype manifest in
Allele
adult gut, with Scer\GAL4klu-G410
adult gut, with Scer\GAL4NP7397
adult gut | somatic clone, with Scer\GAL4Tub.PU
adult heart, with Scer\GAL4tin.CΔ4
cardiac myofibril, with Scer\GAL4tin.CΔ4
embryonic cardioblast | increased number, with Scer\GAL4Hand.PU
embryonic cardioblast | increased number, with Scer\GAL4tin.CΔ4
embryonic somatic muscle cell, with Scer\GAL4Mef2.PU
enteroblast | increased number, with Scer\GAL4klu-G410
follicle cell | somatic clone, with Scer\GAL4Act5C.PU
intestinal stem cell | decreased number | somatic clone, with Scer\GAL4Tub.PU
muscle attachment site
wing cell | pupal stage | somatic clone, with Scer\GAL4Act5C.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\VCL
12 of 14
Yes
Yes
Hsap\CTNNA1
2 of 14
No
No
1  
Hsap\CTNNA2
2 of 14
No
No
Hsap\CTNNA3
2 of 14
No
No
Hsap\CTNNAL1
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Vcl
13 of 14
Yes
Yes
Rnor\Ctnna1
2 of 14
No
No
Rnor\Ctnnal1
2 of 14
No
No
Rnor\Ctnna2
1 of 14
No
No
Rnor\Ctnna3
1 of 14
No
No
Mus musculus (laboratory mouse) (6)
Mmus\Vcl
12 of 14
Yes
Yes
Mmus\Ctnna1
2 of 14
No
No
1  
Mmus\Ctnna2
2 of 14
No
No
2  
Mmus\Ctnna3
2 of 14
No
No
Mmus\Ctnnal1
2 of 14
No
No
Mmus\Vinac1
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\vcl
6 of 13
Yes
Yes
Xtro\ctnna2
1 of 13
No
No
Xtro\tnrc6a
1 of 13
No
No
Danio rerio (Zebrafish) (5)
Drer\vclb
13 of 14
Yes
Yes
Drer\vcla
12 of 14
No
Yes
Drer\ctnna2
2 of 14
No
No
Drer\ctnnal1
2 of 14
No
No
Drer\ctnna1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\deb-1
13 of 14
Yes
Yes
Cele\ctn-1
1 of 14
No
No
Cele\hmp-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (4)
Agam\AgaP_AGAP007532
12 of 12
Yes
Yes
Agam\AgaP_AGAP003424
2 of 12
No
No
Agam\AgaP_AGAP011097
2 of 12
No
No
Agam\AgaP_AGAP010736
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\NARA5
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Vinc. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (2)
α-Catr
3 of 13
α-Cat
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
VCL; vinculin
model of  dilated cardiomyopathy 1W
IEA
(FlyBase, 2019-)
model of  hypertrophic cardiomyopathy 15
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
VCL; vinculin
12 of 14
193065
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Vinc
suppressible
mys
(Maartens et al., 2016)
Vinc
enhanceable
Pax
(Maartens et al., 2016)
Vinc
suppressible
rhea
(Maartens et al., 2016)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
cno
enhanceable
Vinc
(Sheppard et al., 2023)
Mhc
suppressible
Vinc
(Kaushik et al., 2015)
rhea
suppressible
Vinc
(Camp et al., 2024)
α-Cat
enhanceable
Vinc
(Sheppard et al., 2023)
External Data
Subunit Structure (UniProtKB)
Exhibits self-association properties.
(UniProt, O46037 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map
1-0.8
Cytogenetic map
2E2-2E3
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
2E2-2E3
Limits computationally determined from genome sequence between P{EP}ActnEP1193&P{EP}CG4322EP1631 and P{EP}EP1460&P{EP}CG2924EP1596
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
2E-2F
(Alatortsev, 1996.3.13)
2E3-2E3
(determined by in situ hybridisation)
(Alatortsev, 1998.1.31)
Experimentally Determined Recombination Data
Location

1-0.8

(FlyBase, 2016)

1-0.2

(Comeron et al., 2012)

1-

(Alatortsev, 1996.3.13)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (24)
Genomic Clones (11)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (35)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
 

polyclonal

(Heiden et al., 2021)
Commercially Available Antibodies
 
Cell Line Information
Publicly Available Cell Lines
 
    Other Stable Cell Lines
     
      Other Comments

      S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

      (Stroschein-Stevenson et al., 2006)

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      (Kiger et al., 2003)

      dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

      (Rogers et al., 2003)

      Mutant analysis reveals Vinc is not an essential gene.

      (Alatortsev, 1997)

      Multiple regions of homology in the Vinc and α-Cat sequences suggest the proteins may have overlapping functions.

      (Alatortsev, 1997)

      Western blots of different developmental stages demonstrate there are two form of Vinc gene product: a ubiquitous form and a form primarily limited to ovaries and embryos.

      (Kravit and Cheney, 1991)
      Relationship to Other Genes
      Source for database merge of
      Additional comments
      Nomenclature History
      Source for database identify of

      Source for identity of: Vinc CG3299

      (Deng, 1999.11)
      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (12)
      Reported As
      Symbol Synonym
      CG3299
      (Çiçek et al., 2016, Balakrishnan et al., 2015, Rosa-Ferreira et al., 2015, Christis and Munro, 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Sepp et al., 2008, Rogers et al., 2003, Benos, 2000.12.13, Goldstein and Gunawardena, 2000)
      CT11081
      (Wheeler and Hynes, 2001, Hynes and Zhao, 2000)
      Dmvincp
      (Alatortsev, 1997)
      EG:103B4.1
      (Benos et al., 2001, Benos, 2000.12.13)
      VINC
      (Lence et al., 2016)
      Vin
      (Dibya et al., 2009, Junion et al., 2007)
      Vin2EF
      Vinc
      (Jacobs et al., 2025, Chen et al., 2024, Burghardt et al., 2023, Corthals et al., 2023, Dondi et al., 2021, López-Gay et al., 2020, Parra and Johnston, 2020, Alégot et al., 2019, Kong et al., 2019, Raza et al., 2019, Thuveson et al., 2019, Gene Disruption Project members, 2018-, Park et al., 2018, Wang et al., 2018, Hu et al., 2017.6.13, Transgenic RNAi Project members, 2017-, Jurado et al., 2016, Maartens et al., 2016, Sarov et al., 2016, Ramdas et al., 2015, DeSalvo et al., 2014, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Wasbrough et al., 2010, Kwon et al., 2008, Yakoby et al., 2008, Stroschein-Stevenson et al., 2006)
      Vinculin
      (Perez-Vale and Peifer, 2020)
      vinc
      (Ikawa et al., 2023, Ku et al., 2023, Akhmanova et al., 2022, López-Gay et al., 2020, Hassan et al., 2019, Sarpal et al., 2019, Pinheiro et al., 2017, Moreira et al., 2013, Levi et al., 2006, Andolfatto and Wall, 2003)
      Name Synonyms
      Vinculin
      (Mira-Osuna and Borgne, 2024, Koehler and Huber, 2023, Lv et al., 2022, Heiden et al., 2021, Fujisawa et al., 2020, Kong and Großhans, 2020, Das Gupta and Narasimha, 2019, Kale et al., 2018, Park et al., 2018, Hara, 2017, Transgenic RNAi Project members, 2017-, Jurado et al., 2016, Klapholz et al., 2015, Maartens and Brown, 2015, Pichaud, 2014, Bharadwaj et al., 2013, Guillot and Lecuit, 2013, Kroeger et al., 2012, Labeau-Dimenna et al., 2012, Cammarato et al., 2011, Serio et al., 2010, Desai et al., 2008, Sepp et al., 2008, Rogers et al., 2003)
      Vinculin at 2EF
      vinculin
      (Gou et al., 2023, Gou et al., 2020, Ko and Martin, 2020, Green et al., 2018, Bulgakova et al., 2017, Zhu et al., 2017, Hara et al., 2016, Maartens et al., 2016, Rosa-Ferreira et al., 2015, Ribeiro et al., 2014, Moreira et al., 2013, Bulgakova et al., 2012, Jani and Schock, 2007, Lo, 2006, Kiesler et al., 2005, Rogers et al., 2003, Petit et al., 2002, Brown, 2000, Taylor, 2000, Alatortsev, 1996.3.13)
      Secondary FlyBase IDs
      • FBgn0015840
      • FBgn0024918
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 67 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      FlyMine - An integrated database for Drosophila genomics
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      References (155)