FlyBase Gene Report: Dmel\Orc3

General Information

Symbol

Dmel\Orc3

Species

D. melanogaster

Name

Origin recognition complex subunit 3

Annotation Symbol

CG4088

Feature Type

protein_coding_gene

FlyBase ID

FBgn0005654

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Summary

Origin recognition complex subunit 3 (Orc3) encodes a subunit of the origin recognition complex. It is involved in DNA replication initiation and border follicle cell migration regulation. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

lat, latheo, ORC, l(2)49Fd, vr6

Key Links

Genomic Location

Cytogenetic map

49F7-49F8

Sequence location

2R:13,202,728..13,206,547 [-]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13202728..13206547

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9U3V9

(Kurshakova et al., 2021, Kopytova et al., 2016)

inferred from physical interaction with UniProtKB:Q9VTL1

(Kopytova et al., 2016)

inferred from physical interaction with UniProtKB:Q9VYX1

(Kopytova et al., 2016)

enables ribonucleoprotein complex binding

inferred from direct assay

(Kopytova et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR020795

(InterPro Project Members, 2004-)

non-traceable author statement

(Sokolowski, 2001)

enables DNA replication origin binding

inferred from biological aspect of ancestor with PANTHER:PTN000297471

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in DNA replication initiation

inferred from direct assay

(Chesnokov et al., 1999)

involved_in positive regulation of border follicle cell migration

inferred from mutant phenotype

(Wang et al., 2006)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

involved_in DNA replication initiation

inferred from biological aspect of ancestor with PANTHER:PTN000297471

(GO Reference Genome Project, 2011-)

involved_in DNA replication

inferred from electronic annotation with InterPro:IPR020795

(InterPro Project Members, 2004-)

non-traceable author statement

(Sokolowski, 2001)

involved_in larval feeding behavior

non-traceable author statement

(Sokolowski, 2001)

involved_in learning or memory

non-traceable author statement

(Sokolowski, 2001)

involved_in learning

non-traceable author statement

(Sokolowski, 2001)

involved_in olfactory learning

traceable author statement

(Roman and Davis, 2001)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

part_of nuclear origin of replication recognition complex

inferred from direct assay

(Chesnokov et al., 1999)

part_of nuclear pore

inferred from direct assay

(Kopytova et al., 2016)

located_in nucleus

inferred from direct assay

(Kopytova et al., 2016)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of DNA replication preinitiation complex

inferred from biological aspect of ancestor with PANTHER:PTN000297471

(GO Reference Genome Project, 2011-)

part_of nuclear origin of replication recognition complex

inferred from electronic annotation with InterPro:IPR020795

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000297471

(GO Reference Genome Project, 2011-)

part_of nuclear pre-replicative complex

inferred from biological aspect of ancestor with PANTHER:PTN000297471

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ORIGIN RECOGNITION COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ORIGIN RECOGNITION COMPLEX -: The Origin Recognition Complex (ORC) is a multi-subunit complex that binds replication origin during replication initiation. Many ORC subunits belong to the AAA+ superfamily of ATPases. (Adapted from FBrf0227879).

Summary (Interactive Fly)

ORC3 homolog - regulates DNA replication - also, a presynaptic protein with a role in the Ca2+-dependent synaptic modulation mechanisms necessary for behavioral plasticity

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Orc3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7K2L1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Orc3-RA

FBtr0087768

NM_057556

3315

721

Orc3-RB

FBtr0087769

NM_165971

2423

721

Additional Transcript Data and Comments

Reported size (kB)

2.3 (northern blot)

(Chesnokov et al., 1999)

3.9, 2.6 (northern blot)

(Pinto et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Orc3-PA

FBpp0086881

82.3

721

7.40

FBpp0086882

82.3

721

7.40

Q7K2L1

NP_725260

AAM68599

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

721 aa isoforms: Orc3-PA, Orc3-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

721 (aa); 79 (kD observed)

(Chesnokov et al., 1999, Pinto et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Orc3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lat_1
lat_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.19

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Pinto et al., 1999)

oogenesis stage S9 -- S10

centripetal follicle cell

(Manning et al., 2017)

egg chamber | restricted

(Manning et al., 2017)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage & larval stage

(Chesnokov et al., 1999)

Additional Descriptive Data

lat message is detected in the adult brain.

(Pinto et al., 1999)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

neuromuscular junction

(Rohrbough et al., 1999)

bouton

(Rohrbough et al., 1999)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

(Pinto et al., 1999)

adult stage

adult brain

(Pinto et al., 1999)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of nuclear origin of replication recognition complex

inferred from direct assay

(Chesnokov et al., 1999)

part_of nuclear pore

inferred from direct assay

(Kopytova et al., 2016)

located_in nucleus

inferred from direct assay

(Kopytova et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Orc3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Orc3

View exonic expression by tissue for Dmel\Orc3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36454/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0005654

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0005654

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0005654

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4088

Flygut - An atlas of the Drosophila adult midgut

FBgn0005654

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 37 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Orc3

Transgenic constructs containing regulatory region of Orc3

Aberrations (Deficiencies and Duplications) ( 32 )

Inferred from experimentation ( 32 )

Gene partially disrupted in

Df(2R)CRIMIC-CR70843

(Gene Disruption Project members, 2018-)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal (with Df(2R)Exel8057)

Orc3¹

lethal | recessive

lethal - all die before end of pupal stage | recessive

viable

Orc3^P1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Orc3^GD1272

viable, with Scer\GAL4^Mef2.PR

Orc3^GD1272

viable, with Scer\GAL4^tin.CΔ4

Orc3^GD1272

Other Phenotypes

Allele

abnormal behavior | recessive

abnormal learning

Orc3^P1

abnormal learning | recessive

abnormal locomotor behavior | recessive

abnormal memory

abnormal neuroanatomy | larval stage | recessive

abnormal neurophysiology | larval stage | recessive

abnormal size | third instar larval stage

abnormal size | third instar larval stage (with Orc3^lE344)

Orc3^vr6.35

abnormal size | third instar larval stage (with Orc3^vr6.35)

Orc3^lE344

decreased occurrence of cell division | third instar larval stage

decreased occurrence of cell division | third instar larval stage (with Orc3^lE344)

Orc3^vr6.6

decreased occurrence of cell division | third instar larval stage (with Orc3^vr6.6)

Orc3^lE344

non-suppressor of variegation | dominant, with In(1)w^m4

some die during pupal stage | recessive

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

wild-type

Orc3^+t17.1

Phenotype manifest in

Allele

adult mushroom body

Orc3^P1

axon terminus

border follicle cell | somatic clone

Orc3^23G9

bouton

imaginal disc

larval central nervous system

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\ORC3

13 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Orc3

13 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Orc3

13 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\orc3

10 of 13

Yes

Xtro\mrc1

1 of 13

Danio rerio (Zebrafish) (1)

Drer\orc3

12 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP010406

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\ORC3

10 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\ORC3

6 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\orc3

11 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Orc3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

CG33964

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Orc3^KK100894

exacerbates brain cancer

modeled by Ras85D^V12.cUa.UAS, scrib⁶⁷³

(Manzanero-Ortiz et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ORC3; origin recognition complex subunit 3

13 of 14

604972

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Orc3 - CG9890

anti bait coimmunoprecipitation, western blot

(Fursova et al., 2018)

Orc3 - Cdc6

pull down, electron microscopy, molecular weight estimation by staining

(Schmidt and Bleichert, 2020, Bleichert et al., 2018)

Orc3 - Orc1

x-ray crystallography, pull down, molecular weight estimation by staining, electron microscopy

(Schmidt and Bleichert, 2020, Bleichert et al., 2018, Bleichert et al., 2015, Bleichert et al., 2013)

Orc3 - Orc2

x-ray crystallography, pull down, molecular weight estimation by staining, anti bait coimmunoprecipitation, western blot, electron microscopy, cross-linking study, Identification by mass spectrometry

(Schmidt and Bleichert, 2020, Bleichert et al., 2018, Kopytova et al., 2016, Bleichert et al., 2015, Bleichert et al., 2013, Pinto et al., 1999)

Orc3 - Orc4

pull down, autoradiography, molecular weight estimation by staining, x-ray crystallography, anti bait coimmunoprecipitation, western blot, electron microscopy

(Schmidt and Bleichert, 2020, Bleichert et al., 2018, Kopytova et al., 2016, Bleichert et al., 2015, Bleichert et al., 2013)

Orc3 - Orc5

x-ray crystallography, electron microscopy, anti bait coimmunoprecipitation, western blot, cross-linking study, Identification by mass spectrometry

(Schmidt and Bleichert, 2020, Bleichert et al., 2018, Kopytova et al., 2016, Bleichert et al., 2015)

Orc3 - Orc6

cross-linking study, anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry, electron microscopy, x-ray crystallography, fluorescence polarization spectroscopy, predetermined participant, pull down, molecular weight estimation by staining, autoradiography

(Balasov et al., 2020, Schmidt and Bleichert, 2020, Bleichert et al., 2018, Kopytova et al., 2016, Bleichert et al., 2015, Bleichert et al., 2013)

Orc3 - PCID2

anti tag coimmunoprecipitation, anti tag western blot

(Kopytova et al., 2016)

Orc3 - Su(var)205

pull down, autoradiography

(Pak et al., 1997)

Orc3 - cav

pull down, autoradiography

(Badugu et al., 2003)

Orc3 - e(y)2

anti bait coimmunoprecipitation, peptide massfingerprinting, anti tag coimmunoprecipitation, anti tag western blot, western blot

(Kopytova et al., 2016)

Orc3 - sbr

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot

(Kopytova et al., 2016)

Orc3 - su(Hw)

anti bait coimmunoprecipitation, western blot

(Vorobyeva et al., 2013)

Orc3 - xmas

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Kurshakova et al., 2021, Kopytova et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62217

DroID - A comprehensive database of gene and protein interactions.

FBgn0005654

MIST (protein-protein) - An integrated Molecular Interaction Database

36454

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2007)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

49F7-49F8

Sequence location

2R:13,202,728..13,206,547 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49F7-49F8

Limits computationally determined from genome sequence between P{EP}CG33182^EP728&P{lacW}Aats-val^k14804 and P{EP}Dp^EP358

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

49F-49F

(determined by in situ hybridisation)

(Pinto et al., 1999)

49F7-49F8

(determined by in situ hybridisation)

(Chesnokov et al., 1999)

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-71.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (26)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0005654

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0005654

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Vorobyeva et al., 2013, Chesnokov et al., 1999, Pinto et al., 1999)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The lat gene product functions in DNA replication during cell proliferation.

(Pinto et al., 1999)

Cessation of cell proliferation in third instar larvae defines the phenotypic defect of null mutations in the lat gene.

(Pinto et al., 1999)

The lat gene product is specifically localised to the synaptic boutons.

(Rohrbough et al., 1999)

The lat gene product plays a central role in regulating Ca²⁺- and activity-dependent synaptic plasticity.

(Rohrbough et al., 1999)

Basal synaptic transmission amplitude at the lat mutant NMJ is elevated 3 to 4 fold, and Ca²⁺ dependence of transmission is significantly reduced. Multiple forms of synaptic facilitation and posttetanic potentiation are strongly depressed or absent at the mutant synapse.

(Rohrbough et al., 1999)

Genetic dissection of the learning and memory gene lat.

(Boynton and Tully, 1992)

lat is involved in the middle term component of memory formation (MTM).

(Tully et al., 1990)

Relationship to Other Genes

Source for database merge of

Source for merge of: lat Orc3

(Pinto et al., 1999)

Additional comments

One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by lat (CG4088) and CG34315 (CG34315).

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Source for identity of: Orc3 lat

(FlyBase, 2009-)

Nomenclature comments

Renamed from 'lat' to 'Orc3' to be consistent with the nomenclature for the other 5 genes encoding subunits of the 'origin recognition complex' in D. melanogaster and the established nomenclature for these conserved genes across species. 'lat'/'latheo' are retained as synonyms for the gene.

(FlyBase, 2009-)

Etymology

'latheo' is Greek for "to cause a person not to know".

(DiAntonio, 1999)

Named after a Greek word, meaning "forgetful", related to the name of one of the rivers of Hades, Lethe, whose waters caused all those who drank from them to forget their former life.

(Greenspan, 1995)

"latheo" is Greek: "to cause a person not to know" (Benet's Reader's Encyclopedia 1987).

(Boynton and Tully, 1992)

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG4088

(National Institute of Genetics Fly Stocks, 2022-, Neuert et al., 2017, Çiçek et al., 2016, Hosono et al., 2015, Schertel et al., 2013, Müller et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, FlyBase Genome Annotators, 2007)

DmORC3

(Chesnokov et al., 1999, Pak et al., 1997)

DmOrc3

(Clarey et al., 2006)

LAT

(Dubnau et al., 2003)

Lat

(Odierna et al., 2020, Schwartz et al., 2016)

ORC

(Bielinsky et al., 2001, Wakimoto, 1998, Huang and Kellum, 1997)

ORC3

(Richards et al., 2022, Meyer-Nava et al., 2020, Fursova et al., 2018, Maksimenko et al., 2018, Vorobyeva et al., 2013, Park and Asano, 2008, Badugu et al., 2005, Badugu et al., 2003, Li et al., 2002, Chesnokov, 1999.3.30, Wallrath, 1998)

Orc3

(Kurshakova et al., 2024, Kurshakova et al., 2021, Balasov et al., 2020, Parker et al., 2019, Gene Disruption Project members, 2018-, Manning et al., 2017, Kopytova et al., 2016, Bleichert et al., 2015, Liang et al., 2014, Bleichert et al., 2013, Maqbool et al., 2010, Doheny et al., 2008, Cayirlioglu et al., 2003, Adams et al., 2000)

l(2)49Fd

(Hao et al., 1995, Lasko and Pardue, 1988)

l(2)vr6

lat

(Neuert et al., 2017, Kwong et al., 2015, Ostrowski et al., 2015, Van Bortle et al., 2015, Liang et al., 2014, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Neumüller et al., 2011, Cook and Cook, 2010.5.7, Müller et al., 2010, Müller et al., 2010, Seugnet et al., 2009, Doheny et al., 2008, Christensen and Cook, 2007.3.22, FlyBase Genome Annotators, 2007, van Swinderen, 2007, Brown and Feder, 2005)

latheo

(Kwong et al., 2015)

orc3

(Doheny et al., 2008)

vr-6

(Duronio et al., 1998)

vr6

(Renn et al., 1998, Boynton and Tully, 1992)

Name Synonyms

Latheo

(Hua and Orr-Weaver, 2017)

Origin recognition complex subunit 3

(Doheny et al., 2008, Pak et al., 1997)

latheo

(Seugnet et al., 2009, Doheny et al., 2008, Guo and Zhong, 2006, Wang et al., 2006, Ehlers, 2005, Dubnau et al., 2003)

Secondary FlyBase IDs

FBgn0002075
FBgn0004955
FBgn0023182

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 68 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36454

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7K2L1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7K2L1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36454/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0005654

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0005654

FlyMine - An integrated database for Drosophila genomics

FBgn0005654

FlyBase CV Report -

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4088

MARRVEL_MODEL - MARRVEL (model organism gene)

36454

PDB - An information portal to biological macromolecular structures

Linkouts

BioGRID - A database of protein and genetic interactions.

62217

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0005654

DroID - A comprehensive database of gene and protein interactions.

FBgn0005654

DRSC - Results frm RNAi screens

FBgn0005654

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lat_1
lat_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0005654

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0005654

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4088

Flygut - An atlas of the Drosophila adult midgut

FBgn0005654

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0005654

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013076

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

36454

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (144)

The following external sites may use different assemblies or annotations than FlyBase.

4.19

Report Sections