FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\fz3
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General Information
Symbol
Dmel\fz3
Species
D. melanogaster
Name
frizzled 3
Annotation Symbol
CG16785
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027343
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Summary
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles. (UniProt, O77438)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Dfz3, EG:34F3.6 , Dfrizzled-3

Key Links
Genomic Location
Cytogenetic map
1C4-1C4
Sequence location
Recombination map
1-0
RefSeq locus
NC_004354 REGION:769945..784222
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables Wnt-protein binding
inferred from physical interaction with FLYBASE:Wnt2; FB:FBgn0004360
(Wu and Nusse, 2002)
inferred from physical interaction with FLYBASE:wg; FB:FBgn0284084
(Wu and Nusse, 2002)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables nucleic acid binding
inferred from electronic annotation with InterPro:IPR035979
(InterPro Project Members, 2004-)
enables RNA binding
inferred from electronic annotation with InterPro:IPR000504
(InterPro Project Members, 2004-)
enables transmembrane signaling receptor activity
inferred from electronic annotation with InterPro:IPR017981
(InterPro Project Members, 2004-)
enables Wnt-protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in establishment or maintenance of cell polarity
inferred from mutant phenotype
(Sato et al., 1999)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in canonical Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(GO Reference Genome Project, 2011-)
involved_in cell surface receptor signaling pathway
inferred from electronic annotation with InterPro:IPR000539, InterPro:IPR017981
(InterPro Project Members, 2004-)
involved_in non-canonical Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN002259328
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from electronic annotation with InterPro:IPR000539, InterPro:IPR017981
(InterPro Project Members, 2004-)
non-traceable author statement
(Sato et al., 1999)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor Fz/Smo family. (O77438)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
FRIZZLED-TYPE RECEPTORS -
The frizzled gene family belong to Class F GPCRs. Frizzled GPCRs are characterized by a large N-terminal extracellular domain containing a cysteine-rich ligand-binding domain. The frizzled genes were first identified in Drosophila. Frizzled proteins are receptors for secreted Wnt proteins, as well as other ligands, and also play a critical role in the regulation of cell polarity. Frizzleds function in three distinct signaling pathways - the planar cell polarity pathway, the canonical Wnt/β-catenin pathway, and the Wnt/calcium pathway. (Adapted from FBrf0222139).
Protein Function (UniProtKB)
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
(UniProt, O77438)
Summary (Interactive Fly)

transmembrane - 7 pass - frizzled family - antagonizes wingless signal

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\fz3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O77438)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
fz3-RA
FBtr0070138
NM_080296
2249
581
fz3-RB
FBtr0112928
NM_001103389
2304
646
fz3-RC
FBtr0345511
NM_001297831
3250
581
Additional Transcript Data and Comments
Reported size (kB)

2.1 (longest cDNA)

(Sivasankaran et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
fz3-PA
FBpp0070133
63.4
581
8.06
X2JC46
NP_525035
AAF45547
fz3-PB
FBpp0111841
71.4
646
7.86
A8JUT5
NP_001096859
ABW09320
fz3-PC
FBpp0311620
63.4
581
8.06
X2JC46
NP_001284760
AHN59231
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

581 aa isoforms: fz3-PA, fz3-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

581 (aa)

(Sivasankaran et al., 2000)
Comments
External Data
Domain

The FZ domain is involved in binding with Wnt ligands.

(UniProt, O77438)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fz3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.03

Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
leg disc | restricted
(Sivasankaran et al., 2000)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
ventral ectoderm | segmentally repeated | striped
(Sato et al., 1999)
embryonic stage 11 -- 12
embryonic brain
(Sato et al., 1999)
proventriculus inclusive primordium
(Sato et al., 1999)
anal pad primordium
(Sato et al., 1999)
Malpighian tubule primordium
(Sato et al., 1999)
embryonic stage 12
parasegment 8 of visceral trunk mesoderm
(Sato et al., 1999)
third instar larval stage
wing disc | restricted
(Sivasankaran et al., 2000)
eye-antennal disc | restricted
(Sivasankaran et al., 2000)
early third instar larval stage
leg disc | restricted

Comment: within ~6 cell diameters both dorsal and ventral of wg signaling

(Sato et al., 1999)
late third instar larval stage
wing hinge primordium
(Sato et al., 1999)
mesothoracic tergum primordium
(Sato et al., 1999)
wing pouch | faint
(Sato et al., 1999)
photoreceptor cell R7
(Sato et al., 1999)
photoreceptor cell R8
(Sato et al., 1999)
eye disc | restricted

Comment: within several cell diameters of wg expression

(Sato et al., 1999)
antennal disc | restricted
(Sato et al., 1999)
dorsal-ventral compartment boundary of the wing disc
(Sato et al., 1999)
leg disc ventral compartment
(Sato et al., 1999)
Additional Descriptive Data

Expression of fz3 transcript can be first detected at embryonic stage 9.

(Sato et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\fz3 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of fz3
Transgenic constructs containing regulatory region of fz3
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (25)
Hsap\FZD9
5 of 14
Yes
Yes
Hsap\FZD10
5 of 14
Yes
Yes
Hsap\FZD1
4 of 14
No
No
Hsap\FZD2
4 of 14
No
No
Hsap\FZD3
4 of 14
No
No
Hsap\FZD5
4 of 14
No
No
Hsap\FZD7
4 of 14
No
No
3  
Hsap\FZD8
4 of 14
No
No
Hsap\FRZB
3 of 14
No
No
Hsap\FZD4
3 of 14
No
No
Hsap\FZD6
3 of 14
No
No
Hsap\SFRP1
3 of 14
No
Yes
Hsap\SFRP2
3 of 14
No
Yes
Hsap\SFRP4
3 of 14
No
No
Hsap\SFRP5
3 of 14
No
Yes
Hsap\SMO
3 of 14
No
No
Hsap\CORIN
2 of 14
No
No
Hsap\MFRP
2 of 14
No
Yes
Hsap\ADGRB1
1 of 14
No
No
Hsap\ADGRB2
1 of 14
No
No
Hsap\ADGRG4
1 of 14
No
No
Hsap\ADGRL3
1 of 14
No
No
Hsap\COL18A1
1 of 14
No
No
Hsap\CPZ
1 of 14
No
No
Hsap\NTN4
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (20)
Rnor\Fzd9
5 of 14
Yes
Yes
Rnor\Fzd1
4 of 14
No
No
Rnor\Fzd2
4 of 14
No
No
Rnor\Fzd3
4 of 14
No
No
Rnor\Fzd7
4 of 14
No
No
Rnor\Fzd8
4 of 14
No
No
Rnor\Frzb
3 of 14
No
No
Rnor\Fzd4
3 of 14
No
No
Rnor\Fzd5
3 of 14
No
No
Rnor\Fzd6
3 of 14
No
No
Rnor\Sfrp1
3 of 14
No
Yes
Rnor\Sfrp2
3 of 14
No
Yes
Rnor\Sfrp5
3 of 14
No
Yes
Rnor\Smo
3 of 14
No
No
Rnor\Corin
2 of 14
No
No
Rnor\Sfrp4
2 of 14
No
No
Rnor\Adgrb2
1 of 14
No
No
Rnor\Adgrl3
1 of 14
No
No
Rnor\Fzd10
1 of 14
No
Yes
Rnor\Mfrp
1 of 14
No
No
Mus musculus (laboratory mouse) (20)
Mmus\Fzd9
5 of 14
Yes
Yes
Mmus\Fzd10
5 of 14
Yes
Yes
Mmus\Fzd1
4 of 14
No
No
Mmus\Fzd2
4 of 14
No
No
Mmus\Fzd3
4 of 14
No
No
Mmus\Fzd8
4 of 14
No
No
Mmus\Frzb
3 of 14
No
No
Mmus\Fzd4
3 of 14
No
No
Mmus\Fzd5
3 of 14
No
No
Mmus\Fzd6
3 of 14
No
No
Mmus\Fzd7
3 of 14
No
No
Mmus\Sfrp1
3 of 14
No
Yes
1  
Mmus\Sfrp2
3 of 14
No
Yes
Mmus\Sfrp4
3 of 14
No
No
Mmus\Sfrp5
3 of 14
No
Yes
Mmus\Smo
3 of 14
No
No
Mmus\Adgrb2
1 of 14
No
No
Mmus\Adgrl3
1 of 14
No
No
Mmus\Corin
1 of 14
No
No
Mmus\Mfrp
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (33)
Xtro\fzd9
3 of 13
Yes
Yes
Xtro\fzd3
2 of 13
No
No
Xtro\fzd4
2 of 13
No
No
Xtro\fzd5
2 of 13
No
No
Xtro\fzd6
2 of 13
No
No
Xtro\fzd7
2 of 13
No
No
Xtro\corin
1 of 13
No
No
Xtro\cpz
1 of 13
No
No
Xtro\cradd.1
1 of 13
No
Yes
Xtro\frzb2
1 of 13
No
Yes
Xtro\frzb
1 of 13
No
No
Xtro\fzd2
1 of 13
No
No
Xtro\fzd8
1 of 13
No
No
Xtro\fzd10
1 of 13
No
No
Xtro\galnt6.3
1 of 13
No
Yes
Xtro\hsdl2
1 of 13
No
No
Xtro\lman1
1 of 13
No
No
Xtro\LOC100494394
1 of 13
No
No
Xtro\MGC108497
1 of 13
No
Yes
Xtro\ntn1
1 of 13
No
No
Xtro\ntn4
1 of 13
No
No
Xtro\pdgfb
1 of 13
No
No
Xtro\pik3r3
1 of 13
No
No
Xtro\ppp1r9b
1 of 13
No
No
Xtro\sfrp2
1 of 13
No
Yes
Xtro\sfrp5
1 of 13
No
Yes
Xtro\smim12
1 of 13
No
No
Xtro\smo
1 of 13
No
No
Xtro\spi1
1 of 13
No
Yes
Xtro\stk17a
1 of 13
No
No
Xtro\stoml2
1 of 13
No
No
Xtro\szl
1 of 13
No
Yes
Xtro\tlx1
1 of 13
No
No
Danio rerio (Zebrafish) (28)
Drer\fzd9b
5 of 14
Yes
Yes
Drer\fzd10
5 of 14
Yes
Yes
Drer\fzd2
4 of 14
No
No
Drer\fzd3a
4 of 14
No
No
Drer\fzd3b
4 of 14
No
No
Drer\fzd5
4 of 14
No
No
Drer\fzd7a
4 of 14
No
No
Drer\fzd7b
4 of 14
No
No
Drer\fzd8a
4 of 14
No
No
Drer\fzd8b
4 of 14
No
No
Drer\fzd9a
4 of 14
No
Yes
Drer\frzb
3 of 14
No
Yes
Drer\fzd1
3 of 14
No
No
Drer\sfrp1a
3 of 14
No
Yes
Drer\sfrp1b
3 of 14
No
Yes
Drer\sfrp2
3 of 14
No
Yes
Drer\sfrp5
3 of 14
No
Yes
Drer\smo
3 of 14
No
No
Drer\col18a1a
2 of 14
No
No
Drer\fzd4
2 of 14
No
No
Drer\fzd6
2 of 14
No
No
Drer\LOC101884738
2 of 14
No
Yes
Drer\szl
2 of 14
No
Yes
Drer\adgrb3
1 of 14
No
Yes
Drer\adgrl4
1 of 14
No
No
Drer\corin
1 of 14
No
No
Drer\mfrp
1 of 14
No
No
Drer\sfrp2l
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\lin-17
3 of 14
Yes
Yes
Cele\mom-5
3 of 14
Yes
No
Cele\cfz-2
2 of 14
No
No
Cele\mig-1
2 of 14
No
No
Cele\sfrp-1
2 of 14
No
Yes
Cele\unc-6
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\GPRFZ3
12 of 12
Yes
Yes
Agam\GPRFZ2
3 of 12
No
No
Agam\GPRFZ4
3 of 12
No
No
Agam\AgaP_AGAP000303
2 of 12
No
No
Agam\AgaP_AGAP011379
2 of 12
No
No
Agam\GPRSMO
2 of 12
No
No
Agam\SCRASP2
2 of 12
No
No
Agam\GPRFZ1A
1 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:fz3. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
fz2
5 of 13
fz4
5 of 13
fz
5 of 13
smo
5 of 13
Corin
2 of 13
CG1632
1 of 13
mthl15
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FZD9; frizzled class receptor 9
    5 of 14
    601766
        FZD10; frizzled class receptor 10
        5 of 14
        606147
            FZD1; frizzled class receptor 1
            4 of 14
            603408
                FZD2; frizzled class receptor 2
                4 of 14
                600667
                FZD3; frizzled class receptor 3
                4 of 14
                606143
                    FZD5; frizzled class receptor 5
                    4 of 14
                    601723
                      FZD7; frizzled class receptor 7
                      4 of 14
                      603410
                           
                          FZD8; frizzled class receptor 8
                          4 of 14
                          606146
                              FRZB; frizzled related protein
                              3 of 14
                              605083
                                FZD4; frizzled class receptor 4
                                3 of 14
                                604579
                                FZD6; frizzled class receptor 6
                                3 of 14
                                603409
                                SFRP1; secreted frizzled related protein 1
                                3 of 14
                                604156
                                    SFRP2; secreted frizzled related protein 2
                                    3 of 14
                                    604157
                                        SFRP4; secreted frizzled related protein 4
                                        3 of 14
                                        606570
                                          SFRP5; secreted frizzled related protein 5
                                          3 of 14
                                          604158
                                              SMO; smoothened, frizzled class receptor
                                              3 of 14
                                              601500
                                                Functional Complementation Data
                                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                Interactions
                                                Summary of Physical Interactions
                                                Summary of Genetic Interactions
                                                Interaction Browsers
                                                View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                Please look at the allele data for full details of the genetic interactions
                                                Starting gene(s)
                                                Interaction type
                                                Interacting gene(s)
                                                Reference
                                                Starting gene(s)
                                                Interaction type
                                                Interacting gene(s)
                                                Reference
                                                ap
                                                suppressible
                                                fz3|wg
                                                (Sato et al., 1999)
                                                Ser
                                                enhanceable
                                                fz3
                                                (Sivasankaran et al., 2000)
                                                wg
                                                suppressible
                                                fz3
                                                (Sato et al., 1999)
                                                External Data
                                                Linkouts
                                                BioGRID - A database of protein and genetic interactions.
                                                DroID - A comprehensive database of gene and protein interactions.
                                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                                Pathways
                                                Signaling Pathways (FlyBase)
                                                Metabolic Pathways
                                                FlyBase
                                                External Links
                                                External Data
                                                Linkouts
                                                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                                Class of Gene
                                                Genomic Location and Detailed Mapping Data
                                                Chromosome (arm)
                                                X
                                                Recombination map
                                                1-0
                                                Cytogenetic map
                                                1C4-1C4
                                                Sequence location
                                                FlyBase Computed Cytological Location
                                                Cytogenetic map
                                                Evidence for location
                                                1C4-1C4
                                                Limits computationally determined from genome sequence between P{EP}sdkEP369 and P{EP}EP1600&P{EP}EP1498
                                                Experimentally Determined Cytological Location
                                                Cytogenetic map
                                                Notes
                                                References
                                                1C-1C
                                                (Sivasankaran, 1999.10.15)
                                                1C1-1C1
                                                (Sato et al., 1999)
                                                Experimentally Determined Recombination Data
                                                Location

                                                1-0

                                                (FlyBase, 2016)

                                                1-0.0

                                                (Comeron et al., 2012)
                                                Left of (cM)
                                                Right of (cM)
                                                Notes
                                                Stocks and Reagents
                                                Stocks (20)
                                                Genomic Clones (12)
                                                 

                                                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                cDNA Clones (10)
                                                 

                                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                cDNA clones, fully sequenced
                                                BDGP DGC clones
                                                Other clones
                                                  Drosophila Genomics Resource Center cDNA clones

                                                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                  cDNA Clones, End Sequenced (ESTs)
                                                  BDGP DGC clones
                                                  Other clones
                                                  RNAi and Array Information
                                                  Linkouts
                                                  DRSC - Results frm RNAi screens
                                                  Antibody Information
                                                  Laboratory Generated Antibodies
                                                   
                                                  Commercially Available Antibodies
                                                   
                                                  Cell Line Information
                                                  Publicly Available Cell Lines
                                                   
                                                    Other Stable Cell Lines
                                                     
                                                      Other Comments

                                                      Molecular null mutants are perfectly viable and show no phenotype.

                                                      (Sivasankaran et al., 2000)

                                                      fz3 expression is positively regulated by wg signaling. Overall orientation not stated: anon-1Ca- fz3+

                                                      (Sato et al., 1999)

                                                      fz3 may serve as an attenuator of wg signaling.

                                                      (Sato et al., 1999)
                                                      Relationship to Other Genes
                                                      Source for database merge of

                                                      Source for merge of: fz3 EG:34F3.6

                                                      (FlyBase, 1996-)
                                                      Additional comments

                                                      Source for merge of fz3 EG:34F3.6 was sequence comparison ( date:000202 ).

                                                      (FlyBase, 1996-)
                                                      Nomenclature History
                                                      Source for database identify of

                                                      Source for identity of: fz3 CG16785

                                                      (Lai, 1999.11)
                                                      Nomenclature comments
                                                      Etymology
                                                      Synonyms and Secondary IDs (14)
                                                      Reported As
                                                      Symbol Synonym
                                                      CG16785
                                                      (Jayakumar et al., 2016, Schertel et al., 2013, Chen et al., 2012, Hadar et al., 2012, Zhang et al., 2011, Ni et al., 2010.12.1, Zhang et al., 2010, Perkins et al., 2009, Khokhar et al., 2008, Quinones-Coello, 2007, Benos, 2000.12.13)
                                                      DFz3
                                                      (Mosimann et al., 2006, Schweizer and Varmus, 2003, Wu and Nusse, 2002)
                                                      Dfz3
                                                      (Klebes et al., 2005, Chen et al., 2004, Huang and Klein, 2004, Jones, 2000, Sato et al., 2000, Sivasankaran et al., 2000, Sato et al., 1999)
                                                      Dm Fz3
                                                      (Konikoff et al., 2010)
                                                      EG:34F3.6
                                                      (Benos et al., 2001, Benos, 2000.12.13)
                                                      Fz3
                                                      (Nair and Baker, 2024, Boumard and Bardin, 2021, Kizhedathu et al., 2020, Melamed and Kalderon, 2020, Johansson et al., 2019, Martins et al., 2017, Alexandre et al., 2014, Pancratov et al., 2013, Regnard et al., 2011)
                                                      dFz3
                                                      (Kennell and Cadigan, 2008)
                                                      dfz3
                                                      (Mohan et al., 2010, Taniue et al., 2010, Li et al., 2004)
                                                      fz3
                                                      (Liu et al., 2024, Sun et al., 2024, Corthals et al., 2023, Akiyama et al., 2022, Chen et al., 2022, Schlichting et al., 2022, Everetts et al., 2021, Liu et al., 2021, Ewen-Campen et al., 2020, Mo et al., 2020, Waghmare et al., 2020, Meltzer et al., 2019, Tian et al., 2019, Tsai and Galko, 2019, Franz et al., 2017, Tian et al., 2017, Jenny and Basler, 2016, Sarov et al., 2016, Tian et al., 2016, Hall and Verheyen, 2015, Menuz et al., 2014, Reim et al., 2014, Schilling et al., 2014, Schertel et al., 2013, Shen et al., 2013, Southall et al., 2013, Wang et al., 2013, Hadar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Legent et al., 2012, Cherbas et al., 2011, Olson et al., 2011, Toku et al., 2011, Piddini and Vincent, 2009, Song et al., 2009, Chang et al., 2008, Kennell et al., 2008, Khokhar et al., 2008, Quinones-Coello, 2007, Zeitlinger et al., 2007, Srahna et al., 2006, Pickeral et al., 2000)
                                                      Name Synonyms
                                                      Dfrizzled-3
                                                      (Adachi-Yamada and O'Connor, 2002, Sato et al., 1999, Saigo, 1998.10.12)
                                                      Frizzled 3
                                                      (Niehrs, 2012, Davis et al., 2011)
                                                      dFrizzled3
                                                      (Valenta et al., 2011)
                                                      frizzled 3
                                                      (Tian et al., 2016, Dunne et al., 2014, Mohan et al., 2010, Song et al., 2009, Khokhar et al., 2008, Sato et al., 1999)
                                                      frizzled3
                                                      (Waghmare and Page-McCaw, 2018, Davis et al., 2011, Olson et al., 2011)
                                                      Secondary FlyBase IDs
                                                      • FBgn0025619
                                                      Datasets (0)
                                                      Study focus (0)
                                                      Experimental Role
                                                      Project
                                                      Project Type
                                                      Title
                                                      Study result (0)
                                                      Result
                                                      Result Type
                                                      Title
                                                      External Crossreferences and Linkouts ( 58 )
                                                      Sequence Crossreferences
                                                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                      Other crossreferences
                                                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                      FlyMine - An integrated database for Drosophila genomics
                                                      InterPro - A database of protein families, domains and functional sites
                                                      KEGG Genes - Molecular building blocks of life in the genomic space.
                                                      MARRVEL_MODEL - MARRVEL (model organism gene)
                                                      Linkouts
                                                      BioGRID - A database of protein and genetic interactions.
                                                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                      DroID - A comprehensive database of gene and protein interactions.
                                                      DRSC - Results frm RNAi screens
                                                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                      Flygut - An atlas of the Drosophila adult midgut
                                                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                                      References (134)