FB2025_05 , released December 11, 2025
Gene: Dmel\Spc105R
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General Information
Symbol
Dmel\Spc105R
Species
D. melanogaster
Name
Spc105-related
Annotation Symbol
CG11451
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037025
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
Spc105-related (Spc105R) encodes an essential component of the kinetochore, to which it is recruited by binding to the Mis12 kinetochore complex. The products of Spc105R and Mis12 recruit the Ndc80 complex, which provides the major microtubule binding activity of the kinetochore. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Spc105, KNL1

Key Links
Genomic Location
Cytogenetic map
77E6-77E8
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:20800410..20806853
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in attachment of spindle microtubules to kinetochore
inferred from mutant phenotype
(Radford et al., 2015)
involved_in kinetochore assembly
inferred from mutant phenotype
(Radford et al., 2015, Schittenhelm et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of outer kinetochore
inferred from direct assay
(Schittenhelm et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Snapshot
    Spc105-related (Spc105R) encodes an essential component of the kinetochore, to which it is recruited by binding to the Mis12 kinetochore complex. The products of Spc105R and Mis12 recruit the Ndc80 complex, which provides the major microtubule binding activity of the kinetochore. [Date last reviewed: 2019-03-14]
    Gene Group (FlyBase)
    KNL1 SUBUNIT -
    In many other organisms, the kinetochore Knl1 complex is a heterodimer of KNL1/Spc105 and ZWINT. In Drosophila, only the KNL1/Spc105 subunit is present. (Adapted from FBrf0231098.)
    Gene Model and Products
    Number of Transcripts
    2
    Number of Unique Polypeptides
    2

    Please see the JBrowse view of Dmel\Spc105R for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure
    Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9PIC9)

    If you don't see a structure in the viewer, refresh your browser.
    Model Confidence:
    • Very high (pLDDT > 90)
    • Confident (90 > pLDDT > 70)
    • Low (70 > pLDDT > 50)
    • Very low (pLDDT < 50)

    AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

    Experimentally Determined Structures
    Crossreferences
    Comments on Gene Model

    Gene model reviewed during 5.43

    Low-frequency RNA-Seq exon junction(s) not annotated.

    Gene model reviewed during 5.45

    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    Spc105R-RA
    FBtr0078255
    NM_141002
    6083
    1959
    Spc105R-RB
    FBtr0321284
    NM_001275194
    6134
    1960
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    UniProt
    RefSeq ID
    GenBank
    Spc105R-PA
    FBpp0077913
    223.1
    1959
    5.73
    Q9VPB2
    NP_649259
    AAF51643
    Spc105R-PB
    FBpp0302830
    223.2
    1960
    5.88
    M9PIC9
    NP_001262123
    AGB94816
    Polypeptides with Identical Sequences

    None of the polypeptides share 100% sequence identity.

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Spc105R using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Testis-specificity index

    The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

    -0.10

    Transcript Expression
    in situ
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    embryonic stage 1 -- 3
    organism

    Comment: maternally deposited

    (Fisher et al., 2012)
    embryonic stage 4 -- 6
    organism | ubiquitous
    (Fisher et al., 2012)
    embryonic stage 9 -- 10
    antennal primordium

    Comment: reported as procephalic ectoderm primordium

    (Fisher et al., 2012)
    central brain primordium

    Comment: reported as procephalic ectoderm primordium

    (Fisher et al., 2012)
    visual primordium

    Comment: reported as procephalic ectoderm primordium

    (Fisher et al., 2012)
    dorsal head epidermis primordium

    Comment: reported as procephalic ectoderm primordium

    (Fisher et al., 2012)
    lateral head epidermis primordium

    Comment: reported as procephalic ectoderm primordium

    (Fisher et al., 2012)
    ventral head epidermis primordium

    Comment: reported as procephalic ectoderm primordium

    (Fisher et al., 2012)
    ventral ectoderm
    (Fisher et al., 2012)
    ventral nerve cord primordium
    (Fisher et al., 2012)
    embryonic stage 11 -- 12
    antennal primordium

    Comment: reported as procephalon primordium

    (Fisher et al., 2012)
    central brain primordium

    Comment: reported as procephalon primordium

    (Fisher et al., 2012)
    dorsal head epidermis primordium

    Comment: reported as procephalon primordium

    (Fisher et al., 2012)
    lateral head epidermis primordium

    Comment: reported as procephalon primordium

    (Fisher et al., 2012)
    ventral head epidermis primordium

    Comment: reported as procephalon primordium

    (Fisher et al., 2012)
    visual primordium

    Comment: reported as procephalon primordium

    (Fisher et al., 2012)
    procephalic glioblast
    (Fisher et al., 2012)
    procephalic neuroblast
    (Fisher et al., 2012)
    ventral nerve cord primordium
    (Fisher et al., 2012)
    embryonic stage 13 -- 16
    embryonic brain
    (Fisher et al., 2012)
    larval ventral nerve cord
    (Fisher et al., 2012)
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    mass spectroscopy
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    day 5 of adulthood | male -- day 7 of adulthood | male
    spermatozoon
    (Wasbrough et al., 2010)
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    part_of outer kinetochore
    inferred from direct assay
    (Schittenhelm et al., 2009)
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    JBrowse - Visual display of RNA-Seq signals

    View Dmel\Spc105R in JBrowse
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Images
    FlyExpress - Embryonic expression images (BDGP data)
    • Stages(s) 1-3
    • Stages(s) 4-6
    • Stages(s) 11-12
    • Stages(s) 13-16
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 5 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 32 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Spc105R
    Transgenic constructs containing regulatory region of Spc105R
    Aberrations (Deficiencies and Duplications) ( 1 )
    Inferred from experimentation ( 1 )
    Gene disrupted in
    Df(3L)ri-XT1
    (Unhavaithaya et al., 2013)
    Inferred from location ( 3 )
    Variants
    Variant Molecular Consequences
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    lethal, with Scer\GAL4insc-Mz1407
    lethal, with Scer\GAL4αTub84B.PL
    lethal (with Df(3L)ri-XT1)
    lethal | recessive
    lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
    lethal - all die during pharate adult stage, with Scer\GAL4ey-OK107
    viable, with Scer\GAL4unspecified, Spc105RGL00392
    viable, with Scer\GAL4unspecified, Spc105RΔKI.UASp.RR
    viable, with Scer\GAL4unspecified, Spc105RΔMELT.UASp.RR
    Sterility
    Allele
    female sterile, with Scer\GAL4unspecified
    female sterile, with Scer\GAL4unspecified, Spc105RA-4A.UASp.RR
    female sterile, with Scer\GAL4unspecified, Spc105RB-4A.UASp.RR
    female sterile, with Scer\GAL4unspecified, Spc105RC.UASp.RR
    female sterile, with Scer\GAL4unspecified, Spc105RGL00392
    female sterile, with Scer\GAL4unspecified, Spc105RRIDF.UASp.RR
    female sterile, with Scer\GAL4unspecified, Spc105RΔM.UASp.RR
    female sterile, with Scer\GAL4unspecified, Spc105RΔMELT.UASp.RR
    female sterile, with Scer\GAL4unspecified, Spc105RΔMELT-KI.UASp.RR
    female sterile, with Scer\GAL4unspecified, Spc105RΔN.UASp.RR
    female sterile, with Scer\GAL4VP16.mat.αTub67C
    female sterile, with Scer\GAL4VP16.nanos.UTR
    Other Phenotypes
    Allele
    abnormal meiotic cell cycle | oogenesis, with Scer\GAL4unspecified
    abnormal meiotic cell cycle | oogenesis, with Scer\GAL4unspecified, Spc105RC.UASp.RR
    abnormal meiotic cell cycle | oogenesis, with Scer\GAL4unspecified, Spc105RGL00392
    abnormal meiotic cell cycle | oogenesis, with Scer\GAL4unspecified, Spc105RΔM.UASp.RR
    abnormal meiotic cell cycle | oogenesis, with Scer\GAL4unspecified, Spc105RΔMELT-KI.UASp.RR
    abnormal meiotic cell cycle | oogenesis, with Scer\GAL4unspecified, Spc105RΔN.UASp.RR
    abnormal mitotic cell cycle
    abnormal mitotic cell cycle (with Df(3L)ri-XT1)
    abnormal mitotic cell cycle (with Spc105R1)
    abnormal mitotic cell cycle (with Spc105RP01511LE)
    abnormal neuroanatomy | embryonic stage (with Df(3L)ri-XT1)
    abnormal neuroanatomy | embryonic stage | recessive
    abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
    abnormal neuroanatomy | pharate adult stage P15, with Scer\GAL4ey-OK107
    some die during pupal stage, with Scer\GAL4pnr-MD237
    visible, with Scer\GAL4Bx-MS1096
    Phenotype manifest in
    Allele
    brain | pharate adult stage P15, with Scer\GAL4ey-OK107
    chromosome, centromeric region | oogenesis, with Scer\GAL4unspecified
    chromosome, centromeric region | oogenesis, with Scer\GAL4unspecified, Spc105RA-4A.UASp.RR
    chromosome, centromeric region | oogenesis, with Scer\GAL4unspecified, Spc105RB-4A.UASp.RR
    chromosome, centromeric region | oogenesis, with Scer\GAL4unspecified, Spc105RGL00392
    chromosome, centromeric region | oogenesis, with Scer\GAL4unspecified, Spc105RRIAF.UASp.RR
    chromosome, centromeric region | oogenesis, with Scer\GAL4unspecified, Spc105RRIDF.UASp.RR
    chromosome, centromeric region | oogenesis, with Scer\GAL4unspecified, Spc105RΔN.UASp.RR
    chromosome, with Scer\GAL4VP16.mat.αTub67C
    ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
    head | pharate adult stage P15, with Scer\GAL4ey-OK107
    karyosome, with Scer\GAL4VP16.mat.αTub67C
    karyosome | oogenesis, with Scer\GAL4unspecified, Spc105RC.UASp.RR
    karyosome | oogenesis, with Scer\GAL4unspecified, Spc105RGL00392
    karyosome | oogenesis, with Scer\GAL4unspecified, Spc105RRIAF.UASp.RR
    karyosome | oogenesis, with Scer\GAL4unspecified, Spc105RRIDF.UASp.RR
    karyosome | oogenesis, with Scer\GAL4unspecified, Spc105RΔN.UASp.RR
    kinetochore, with Scer\GAL4VP16.mat.αTub67C
    kinetochore microtubule, with Scer\GAL4VP16.mat.αTub67C
    larval central nervous system | embryonic stage
    larval central nervous system | embryonic stage (with Df(3L)ri-XT1)
    larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
    nucleus
    nucleus (with Df(3L)ri-XT1)
    oocyte, with Scer\GAL4unspecified
    oocyte, with Scer\GAL4unspecified, Spc105RA-4A.UASp.RR
    oocyte, with Scer\GAL4unspecified, Spc105RB-4A.UASp.RR
    oocyte, with Scer\GAL4unspecified, Spc105RC.UASp.RR
    oocyte, with Scer\GAL4unspecified, Spc105RGL00392
    oocyte, with Scer\GAL4unspecified, Spc105RRIAF.UASp.RR
    oocyte, with Scer\GAL4unspecified, Spc105RRIDF.UASp.RR
    oocyte, with Scer\GAL4unspecified, Spc105RΔM.UASp.RR
    oocyte, with Scer\GAL4unspecified, Spc105RΔMELT-KI.UASp.RR
    oocyte, with Scer\GAL4unspecified, Spc105RΔN.UASp.RR
    oocyte, with Scer\GAL4VP16.mat.αTub67C
    spindle, with Scer\GAL4VP16.mat.αTub67C
    spindle | oogenesis, with Scer\GAL4unspecified
    spindle | oogenesis, with Scer\GAL4unspecified, Spc105RC.UASp.RR
    spindle | oogenesis, with Scer\GAL4unspecified, Spc105RGL00392
    spindle midzone, with Scer\GAL4VP16.mat.αTub67C
    wing, with Scer\GAL4Bx-MS1096
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Human Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Homo sapiens (Human) (0)
    Model Organism Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Rattus norvegicus (Norway rat) (0)
    Mus musculus (laboratory mouse) (0)
    Xenopus tropicalis (Western clawed frog) (0)
    Danio rerio (Zebrafish) (0)
    Caenorhabditis elegans (Nematode, roundworm) (0)
    Anopheles gambiae (African malaria mosquito) (0)
    Arabidopsis thaliana (thale-cress) (0)
    Saccharomyces cerevisiae (Brewer's yeast) (1)
    Scer\NUM1
    1 of 13
    Yes
    Yes
    Schizosaccharomyces pombe (Fission yeast) (0)
    Escherichia coli (enterobacterium) (0)
    Other Organism Orthologs (via OrthoDB)
    Data provided directly from OrthoDB:Spc105R. Refer to their site for version information.
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v9.1)
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 2 )
      Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Spc105R - Bub1
      two hybrid
      (Schittenhelm et al., 2009)
      Spc105R - Bub3
      pull down, anti tag western blot
      (Audett et al., 2022)
      Spc105R - CG8478
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014)
      Spc105R - Cenp-C
      anti tag coimmunoprecipitation, peptide massfingerprinting, molecular sieving, cosedimentation, molecular weight estimation by staining
      (Liu et al., 2016, Lipinszki et al., 2015, Przewloka et al., 2011)
      Spc105R - Kmn1
      molecular sieving, cosedimentation, molecular weight estimation by staining, two hybrid
      (Liu et al., 2016, Schittenhelm et al., 2009)
      Spc105R - Mis12
      molecular sieving, cosedimentation, molecular weight estimation by staining, anti tag coimmunoprecipitation, peptide massfingerprinting
      (Liu et al., 2016, Przewloka et al., 2007)
      Spc105R - Ndc80
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Przewloka et al., 2007)
      Spc105R - Nnf1a
      molecular sieving, cosedimentation, molecular weight estimation by staining, anti tag coimmunoprecipitation, peptide massfingerprinting
      (Liu et al., 2016, Przewloka et al., 2007)
      Spc105R - Nnf1b
      molecular sieving, cosedimentation, molecular weight estimation by staining
      (Liu et al., 2016)
      Spc105R - Nuf2
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Przewloka et al., 2007)
      Spc105R - Spc25
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Przewloka et al., 2007)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Spc105R
      suppressible
      Ndc80
      (Joshi et al., 2024)
      Spc105R
      suppressible
      Spc105R::Dwil\Spc105R
      (Schittenhelm et al., 2009)
      Spc105R
      enhanceable
      sub
      (Radford et al., 2015)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      cmet
      suppressible
      Spc105R
      (Radford et al., 2015)
      Klp61F
      suppressible
      Spc105R
      (Radford et al., 2017)
      mei-P22
      suppressible
      Spc105R|Ndc80
      (Joshi et al., 2024)
      mei-P22
      suppressible
      Spc105R
      (Joshi et al., 2024)
      thr
      enhanceable
      Spc105R
      (Schittenhelm et al., 2009)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map
      3-47
      Cytogenetic map
      77E6-77E8
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      77E6-77E8
      Limits computationally determined from genome sequence between P{EP}trblEP3519 and P{EP}fngEP3082&P{lacW}skdL7062
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-47

      (FlyBase, 2016)

      3-43.7

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (18)
      Genomic Clones (21)
      cDNA Clones (39)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        monoclonal

        (Joshi et al., 2024)

        polyclonal

        (Przewloka et al., 2011)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

            (Goshima et al., 2007)

            RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

            (Boutros et al., 2004)
            Relationship to Other Genes
            Source for database merge of
            Additional comments
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (13)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 29 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (78)