FlyBase Gene Report: Dmel\Ykt6

General Information

Symbol

Dmel\Ykt6

Species

D. melanogaster

Name

YKT6 v-SNARE

Annotation Symbol

CG1515

Feature Type

protein_coding_gene

FlyBase ID

FBgn0260858

Gene Model Status

Current

Stock Availability

16 publicly available

Enzyme Name (EC)

protein S-acyltransferase (2.3.1.225)

Gene Summary

YKT6 v-SNARE (Ykt6) encodes an R-SNARE localized to the Golgi apparatus and endosomes/lysosomes, to regulate the bi-directional transport between the endoplasmic reticulum and the Golgi apparatus. Ykt6 can form a prefusion SNARE complex with Syx17 and Snap29, to promote the fusion of autophagosomes with lysosomes. Through interaction with Syx13 and Snap29, it also mediates the fusion of Lamp1 carriers and secretory granules. [Date last reviewed: 2024-04-04] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(1)G0155

Key Links

Genomic Location

Cytogenetic map

7C3-7C3

Sequence location

X:7,920,409..7,921,966 [+]

Recombination map

1-21

RefSeq locus

NC_004354 REGION:7920409..7921966

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables protein-cysteine S-palmitoyltransferase activity

inferred from sequence or structural similarity with UniProtKB:O15498

(Rossi et al., 2004)

enables SNAP receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000473886

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity

(Littleton, 2000)

inferred from sequence or structural similarity with UniProtKB:O15498

(Rossi et al., 2004)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in endoplasmic reticulum to Golgi vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN000473886

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:O15498

(Rossi et al., 2004)

involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

inferred from sequence or structural similarity with UniProtKB:O15498

(Rossi et al., 2004)

involved_in vesicle-mediated transport

inferred from sequence or structural similarity

(Littleton, 2000)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

located_in endosome

inferred from sequence or structural similarity with UniProtKB:O15498

(Rossi et al., 2004)

is_active_in Golgi apparatus

inferred from biological aspect of ancestor with PANTHER:PTN000473886

(GO Reference Genome Project, 2011-)

located_in Golgi apparatus

inferred from sequence or structural similarity with UniProtKB:O15498

(Rossi et al., 2004)

part_of SNARE complex

inferred from sequence or structural similarity with UniProtKB:O15498

(Rossi et al., 2004)

located_in transport vesicle

inferred from sequence or structural similarity

(Littleton, 2000)

Gene Group (FlyBase)

R-SNAREs

PALMITOYLTRANSFERASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein-cysteine S-palmitoyltransferase activity

L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl- [protein] + CoA (2.3.1.225)

RHEA 36683:

Summaries

Gene Snapshot

Gene Group (FlyBase)

R-SNAREs -: R-SNAREs are members of the SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptor) family that mediate vesicle-fusion. SNAREs are cytoplasmic, membrane-anchored proteins that contain a 60 amino acid SNARE domain. Three Q-SNAREs domains from the target membrane and one R-SNARE domain from the vesicle interact to form a four-helix bundle that pulls the two membranes in close proximity and promotes fusion. After fusion, the complexes are dissembled by NSF (N-ethylmaleimide-sensitive factor) and SNAPs (Soluble NSF Attachment Proteins). R-SNAREs are named from their contribution of a conserved arginine (R) residue to the helix bundle. (Adapted from PMID:15893389 and FBrf0216182).
PALMITOYLTRANSFERASES -: Palmitoyltransferases catalyze the post-translational addition of a palmitate moiety to a cysteine residue through a covalent thioester bond. (Adapted from FBrf0210485).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ykt6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W3M8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ykt6-RA

FBtr0071093

NM_132195

1469

199

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ykt6-PA

FBpp0071049

22.4

199

8.07

Q9W3M8

NP_572423

AAF46294

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ykt6 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ykt6_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.04

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ykt6 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ykt6

View exonic expression by tissue for Dmel\Ykt6

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31706/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0260858

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026664

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0260858

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1515

Flygut - An atlas of the Drosophila adult midgut

FBgn0260858

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 24 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ykt6

Transgenic constructs containing regulatory region of Ykt6

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 15 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Ykt6^{CR70461-KO-kG4})

lethal (with Ykt6^G808)

lethal (with Ykt6^L162Q)

lethal | recessive

Ykt6^G0155

lethal - all die before end of larval stage

Ykt6^G0155

lethal - all die before end of P-stage

Ykt6^L162Q

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Ykt6^GD8927

lethal - all die during first instar larval stage

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ykt6^GD8927

viable, with Scer\GAL4^Mef2.PR

Ykt6^GD8927

viable, with Scer\GAL4^tin.CΔ4

Ykt6^GD8927

Sterility

Allele

female sterile germline-dependent | germline clone

Ykt6^C

Other Phenotypes

Allele

abnormal cell migration | germline clone | oogenesis

Ykt6^C

decreased cell number | larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

Ykt6^HMJ21032

decreased rate of adult locomotory behavior, with Ykt6^L162Q

Ykt6^Y186C.GR

decreased rate of adult locomotory behavior, with Ykt6^Y186C.GR

Ykt6^L162Q

decreased size | germline clone | oogenesis

Ykt6^C

increased cell death | adult stage, with Ykt6^L162Q

Ykt6^Y186C.GR

increased cell death | adult stage, with Ykt6^Y186C.GR

Ykt6^L162Q

majority die during P-stage

Ykt6^L162Q

short lived, with Ykt6^L162Q

Ykt6^Y186C.GR

short lived, with Ykt6^Y186C.GR

Ykt6^L162Q

some die during larval stage

Ykt6^G0155

some die during pupal stage, with Scer\GAL4^pnr-MD237

Ykt6^GD8927

visible | adult stage | somatic clone

Ykt6^C

visible | oogenesis | somatic clone

Ykt6^C

Phenotype manifest in

Allele

adult brain, with Ykt6^L162Q

Ykt6^Y186C.GR

adult brain, with Ykt6^Y186C.GR

Ykt6^L162Q

adult thoracic mechanosensory chaeta | increased number | somatic clone

Ykt6^C

centripetal follicle cell | germline clone

Ykt6^C

cytoplasmic vesicle | decreased number | germline clone | oogenesis

Ykt6^C

dorsal appendage | decreased number | germline clone

Ykt6^C

dorsal appendage | germline clone

Ykt6^C

egg | germline clone

Ykt6^C

egg chamber | germline clone

Ykt6^C

eye | somatic clone

Ykt6^C

filamentous actin | germline clone | oogenesis

Ykt6^C

Golgi apparatus | germline clone | oogenesis

Ykt6^C

late endosome | germline clone | oogenesis

Ykt6^C

lysosome | germline clone | oogenesis

Ykt6^C

nucleus | germline clone | increased number

Ykt6^C

nurse cell | germline clone

Ykt6^C

oocyte | decreased number | germline clone

Ykt6^C

oocyte | germline clone

Ykt6^C

ring canal | germline clone

Ykt6^C

type II neuroblast | decreased number | larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

Ykt6^HMJ21032

yolk granule | decreased number | germline clone

Ykt6^C

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (11)

Hsap\YKT6

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (11)

Rnor\Ykt6

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Mus musculus (laboratory mouse) (12)

Mmus\Ykt6

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (9)

Xtro\ykt6

11 of 13

Yes

Xtro\camk2g

1 of 13

Xtro\cpne3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (14)

Drer\ykt6

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch73-234b20.5

1 of 14

Drer\vamp4

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\ykt-6

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP000392

12 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (20)

Atha\ATYKT62

12 of 13

Yes

Atha\YKT61

12 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Atha\AT4G10170

1 of 13

Yes

Atha\AT4G27840

1 of 13

Yes

Atha\AT5G52990

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\YKT6

13 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\ykt6

12 of 12

Yes

Spom\sec22

2 of 12

Spom\syb1

2 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ykt6. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

nSyb

3 of 13

Sec22

3 of 13

Syb

3 of 13

Vamp7

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

neurological disorder with or without progressive infantile liver disease

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 5 )

Allele

Disease

Evidence

References

Ykt6^{CR70461-KO-kG4}

model of syndromic intellectual disability

CEA

(Ma et al., 2024)

CEC with Ykt6^L162Q

(Ma et al., 2024)

CEC with Ykt6^G808

(Ma et al., 2024)

Ykt6^G808

model of syndromic intellectual disability

CEA

(Ma et al., 2024)

CEC with Ykt6^L162Q

(Ma et al., 2024)

CEC with Ykt6^{CR70461-KO-kG4}

(Ma et al., 2024)

Ykt6^L162Q

model of syndromic intellectual disability

CEA

(Ma et al., 2024)

CEC with Ykt6^G808

(Ma et al., 2024)

CEC with Ykt6^{CR70461-KO-kG4}

(Ma et al., 2024)

CEA with Ykt6^Y186C.GR

(Ma et al., 2024)

Ykt6^Y186C.GR

model of syndromic intellectual disability

CEA with Ykt6^L162Q

(Ma et al., 2024)

Ykt6^Y65C.GR

model of syndromic intellectual disability

CEA

(Ma et al., 2024)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

YKT6; YKT6 vesicular SNARE protein

14 of 14

606209

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ykt6 - Bet1

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Gos28

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Hsap\APOL1

anti tag coimmunoprecipitation, anti tag western blot

(Lee et al., 2023)

Ykt6 - Membrin

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Nsf2

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Sec20

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Sec22

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Slh

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Snap24

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Snap25

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Snap29

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Syb

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Syx13

pull down, molecular weight estimation by staining, experimental knowledge based

(Szenci et al., 2024, Guruharsha et al., 2011)

Ykt6 - Syx17

pull down, molecular weight estimation by staining, anti tag coimmunoprecipitation, anti tag western blot, western blot

(Takáts et al., 2018)

Ykt6 - Syx18

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Syx1A

experimental knowledge based, anti tag coimmunoprecipitation, Identification by mass spectrometry

(Gordon et al., 2017, Guruharsha et al., 2011)

Ykt6 - Syx5

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Syx7

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Syx8

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Use1

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Vamp7

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - Vti1a

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - car

pull down, western blot

(Takáts et al., 2018)

Ykt6 - dor

pull down, western blot

(Takáts et al., 2018)

Ykt6 - koko

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - αSnap

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - γSnap1

experimental knowledge based

(Guruharsha et al., 2011)

Ykt6 - γSnap2

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dref

enhanceable

Ykt6

(Ida et al., 2009)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0260858

MIST (protein-protein) - An integrated Molecular Interaction Database

31706

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-21

Cytogenetic map

7C3-7C3

Sequence location

X:7,920,409..7,921,966 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7C3-7C3

Limits computationally determined from genome sequence between P{EP}EP1209 and P{EP}CG10777^EP1347&P{EP}CG10777^EP1363

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

7C4-7C5

(determined by in situ hybridisation)

(Peter et al., 2002)

7C-7C

(determined by in situ hybridisation)

(Schäfer et al., 1999.3.29)

Experimentally Determined Recombination Data

Location

1-21

(FlyBase, 2016)

1-22.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

11858

w^67c23 P{lacW}Ykt6^G0155/FM7c

50937

y¹ v¹; P{TRiP.HMJ21032}attP40

605770

y¹ w^*; PBac{UAS-Ykt6.B}VK00037

26602

w^* P{EP}Ykt6^G808/FM6, w^*

605769

y¹ w^*; PBac{UAS-Ykt6.EGFP}VK00033

605771

y¹ w^*; PBac{UAS-Ykt6.HA.B}VK00037

FlyORF

F003046

M{UAS-Ykt6.ORF.3xHA.GW}ZH-86Fb

NIG-Fly

1515R-1

P{NIG.1515R}1

HMJ21032

y¹ v¹; P{TRiP.HMJ21032}attP40/CyO

VDRC

v105648

P{KK101343}VIE-260B

v19329

w¹¹¹⁸; P{GD8927}v19329/CyO

v342927

P{hsFLP}1, y1 w1118; P{HD_CFD02295}attP40/CyO-GFP

More stocks available...

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (30)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD34211

Other clones

DPiM_LD34211

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0260858

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0260858

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Takáts et al., 2018)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against l(1)G0155 that is transfected into S2 treated with Listeria monocytogenes reveals l(1)G0155 to be involved in Listeria monocytogenes entry and vacuolar escape.

(Cheng et al., 2005)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: l(1)G0155 CG1515

(Peter et al., 2002)

Source for merge of: Ykt6 l(1)G0155

(Dorer et al., 2006)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Named "Ykt6" after the S. cerevisiae ortholog.

(FlyBase, 2009-)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG1515

(Yu et al., 2024, Aradska et al., 2015, Hosono et al., 2015, Peltan et al., 2012, Ni et al., 2010.12.1, Ida et al., 2009, Keleman et al., 2009.8.5, Haussmann et al., 2008, Dorer et al., 2006, Cheng et al., 2005, Filippini et al., 2001, Bock, 2000.10.26)

YKT6

(Gordon et al., 2017, Peltan et al., 2012, Dorer et al., 2006)

Ykt6p

(Littleton, 2000)

cg1515

(Gupta et al., 2014)

dYkt6

(Ma et al., 2024)

l(1)G0155

(Japanese National Institute of Genetics, 2012.5.21, Ida et al., 2009)

Name Synonyms

YKT6 ortholog

YKT6 v-SNARE

(Graves et al., 2020)

lethal (1) G0155

Secondary FlyBase IDs

FBgn0044802
FBgn0026664
FBgn0029978

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31706

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W3M8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W3M8

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W3M8

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31706/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0260858

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0260858

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1515

MARRVEL_MODEL - MARRVEL (model organism gene)

31706

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0260858

DroID - A comprehensive database of gene and protein interactions.

FBgn0260858

DRSC - Results frm RNAi screens

FBgn0260858

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ykt6_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026664

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0260858

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1515

Flygut - An atlas of the Drosophila adult midgut

FBgn0260858

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0260858

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013212

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

31706

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (78)

The following external sites may use different assemblies or annotations than FlyBase.

-1.04

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