FlyBase Gene Report: Dmel\APP-BP1

General Information

Symbol

Dmel\APP-BP1

Species

D. melanogaster

Name

β-Amyloid precursor protein binding protein 1

Annotation Symbol

CG7828

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261112

Gene Model Status

Current

Stock Availability

6 publicly available

Enzyme Name (EC)

E1 NEDD8-activating enzyme (6.2.1.64)

Gene Summary

Regulatory subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Appl and APP-BP1 interact antagonistically during development. (UniProt, Q9VTE9)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dAPP-BP1, APPBP1

Key Links

Genomic Location

Cytogenetic map

68A6-68A6

Sequence location

3L:11,098,412..11,100,578 [+]

Recombination map

3-34

RefSeq locus

NT_037436 REGION:11098412..11100578

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables amyloid-beta binding

inferred from physical interaction with UniProtKB:P14599

(Kim et al., 2007)

contributes_to NEDD8 activating enzyme activity

inferred from direct assay

(Du et al., 2011)

enables protein binding

inferred from physical interaction with FLYBASE:Appl; FB:FBgn0000108

(Kim et al., 2007)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

contributes_to NEDD8 activating enzyme activity

inferred from sequence or structural similarity with UniProtKB:Q13564

(Kim et al., 2007)

inferred from sequence or structural similarity with UniProtKB:Q13564

(Gene Ontology Curators, 2002-)

enables NEDD8 activating enzyme activity

inferred from electronic annotation with InterPro:IPR030667

(InterPro Project Members, 2004-)

enables protein heterodimerization activity

inferred from sequence or structural similarity with UniProtKB:Q13564

(Gene Ontology Curators, 2002-)

enables ubiquitin-like modifier activating enzyme activity

inferred from electronic annotation with InterPro:IPR035985

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in protein neddylation

inferred from direct assay

(Du et al., 2011)

inferred from mutant phenotype

(Kim et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein neddylation

inferred from electronic annotation with InterPro:IPR030667

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:Q13564

(Kim et al., 2007)

inferred from sequence or structural similarity with UniProtKB:Q13564

(Gene Ontology Curators, 2002-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of NAE1-UBA3 complex

inferred from physical interaction with FLYBASE:Uba3; FB:FBgn0263697

(Du et al., 2011)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

NEDD8 ACTIVATING ENZYMES

Protein Family (UniProt)

Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (Q9VTE9)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

NEDD8 activating enzyme activity

ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L- cysteine (6.2.1.64)

Summaries

Gene Group (FlyBase)

NEDD8 ACTIVATING ENZYMES -: NEDD8 activating enzymes are 'canonical' E1 enzymes that act as heterodimers to activate the ubiquitin-like protein NEDD8 for subsequent steps along the NEDD8 conjugation cascade. They perform three distinct chemical reactions: first, they bind ATP, magnesium and NEDD8 to catalyze formation of a high-energy acyl adenylate intermediate with subsequent release of pyrophosphate; second, an E1 catalytic cysteine attacks the NEDD8-adenylate to catalyze formation of a high-energy thioester bond between the E1 and NEDD8 and release of the AMP product; finally, the E1-NEDD8 catalyzes transthioesterification to an E2 to form a high energy thioester-linked E2-NEDD8 product. (Adapted from PMID:28234446.)

Protein Function (UniProtKB)

(UniProt, Q9VTE9)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\APP-BP1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VTE9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

APP-BP1-RA

FBtr0076208

NM_140178

1867

524

APP-BP1-RB

FBtr0331179

NM_001274770

1650

524

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

APP-BP1-PA

FBpp0075938

58.7

524

4.99

FBpp0303606

58.7

524

4.99

Q9VTE9

NP_001261699

AGB94393

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

524 aa isoforms: APP-BP1-PA, APP-BP1-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Heterodimer of Uba3 and APP-BP1. The complex binds Nedd8 and UbcE2M. Interacts with Appl (via the intracellular domain, ICD).

(UniProt, Q9VTE9)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\APP-BP1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.84

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Kim et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of NAE1-UBA3 complex

inferred from physical interaction with FLYBASE:Uba3; FB:FBgn0263697

(Du et al., 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\APP-BP1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\APP-BP1

View exonic expression by tissue for Dmel\APP-BP1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261112

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39244/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261112

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036127

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261112

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7828

Flygut - An atlas of the Drosophila adult midgut

FBgn0261112

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of APP-BP1

Transgenic constructs containing regulatory region of APP-BP1

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage

APP-BP1^Ex62

partially lethal - majority die, with Scer\GAL4^pnr-MD237

APP-BP1^GD1303

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

APP-BP1^GD1303

viable, with Scer\GAL4^Mef2.PR

APP-BP1^GD1303

viable, with Scer\GAL4^tin.CΔ4

APP-BP1^GD1303

Other Phenotypes

Allele

increased cell death

APP-BP1^Ex62

increased cell death | somatic clone

APP-BP1^Ex62

short lived

APP-BP1^LP67

some die during pupal stage, with Scer\GAL4^pnr-MD237

APP-BP1^GD1303

some die during third instar larval stage

APP-BP1^Ex62

visible, with Scer\GAL4^ap-md544

APP-BP1^UAS.cKa

visible, with Scer\GAL4^how-24B

APP-BP1^UAS.cKa

visible, with Scer\GAL4^pnr-MD237

APP-BP1^GD1303

Phenotype manifest in

Allele

eye | somatic clone

APP-BP1^Ex183

eye disc

APP-BP1^Ex62

eye disc | somatic clone

APP-BP1^Ex62

imaginal disc

APP-BP1^Ex62

imaginal disc (with Df(3L)lxd6)

APP-BP1^Ex62

scutellar bristle, with Scer\GAL4^ap-md544

APP-BP1^UAS.cKa

scutellum, with Scer\GAL4^ap-md544

APP-BP1^UAS.cKa

trichogen cell, with Scer\GAL4^pnr-MD237

APP-BP1^GD1303

wing, with Scer\GAL4^how-24B

APP-BP1^UAS.cKa

wing disc | somatic clone

APP-BP1^Ex62

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (10)

Hsap\NAE1

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (11)

Rnor\Nae1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (11)

Mmus\Nae1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\nae1

11 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (8)

Drer\nae1

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\ula-1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP005544

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (14)

Atha\AXL

13 of 13

Yes

Atha\AXR1

13 of 13

Yes

Atha\AT3G25880

4 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (9)

Scer\ULA1

8 of 13

Yes

4 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Scer\TCD2

1 of 13

Schizosaccharomyces pombe (Fission yeast) (7)

Spom\uba5

11 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Escherichia coli (enterobacterium) (2)

Ecol\moeB

3 of 11

Yes

Ecol\thiF

3 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:APP-BP1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (8)

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

APP-BP1^UAS.cKa

ameliorates Parkinson's disease

modeled by Pink1^RNAi.UAS.cWa

(Choo et al., 2012)

modeled by Pink1^RNAi.UAS.cYa

(Choo et al., 2012)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NAE1; NEDD8 activating enzyme E1 subunit 1

14 of 14

603385

NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND ISCHIOPUBIC HYPOPLASIA; NEDFIH

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

APP-BP1 - Appl

pull down, autoradiography

(Kim et al., 2007)

APP-BP1 - Uba3

anti tag coimmunoprecipitation, anti tag western blot

(Du et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Kim et al., 2007)

enhanceable

(Kim et al., 2007)

suppressible

(Choo et al., 2012)

External Data

Subunit Structure (UniProtKB)

Heterodimer of Uba3 and APP-BP1. The complex binds Nedd8 and UbcE2M. Interacts with Appl (via the intracellular domain, ICD).

(UniProt, Q9VTE9 )

Linkouts

BioGRID - A database of protein and genetic interactions.

64618

DroID - A comprehensive database of gene and protein interactions.

FBgn0261112

MIST (genetic) - An integrated Molecular Interaction Database

39244

MIST (protein-protein) - An integrated Molecular Interaction Database

39244

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

protein NEDDylation

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neddylation

Class of Gene

gene

(Kim et al., 2007)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-34

Cytogenetic map

68A6-68A6

Sequence location

3L:11,098,412..11,100,578 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

68A6-68A6

Limits computationally determined from genome sequence between P{PZ}l(3)01239⁰¹²³⁹&P{lacW}l(3)01239^j9B4 and P{PZ}CycA⁰²⁴⁶¹&P{PZ}CycA⁰³⁹⁴⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-34

(FlyBase, 2016)

3-28.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

21968

w¹¹¹⁸; P{EPg}APP-BP1^HP32137

15426

y¹ w^67c23; P{EPgy2}APP-BP1^EY02617

NIG-Fly

7828R-2

P{NIG.7828R}2

HMJ23864

y¹ v¹; P{TRiP.HMJ23864}attP40/CyO

VDRC

v330354

P{VSH330354}attP40

v7728

w¹¹¹⁸; P{GD1303}v7728

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (22)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT09990

Other clones

FI06139

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261112

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261112

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kim et al., 2007)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

APP-BP1 hinders tissue development, causes apoptosis in imaginal disc cells, and blocks the NEDD8 conjugation pathway.

(Kim et al., 2007)

S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on degradation of dup and geminin genes.

(Higa et al., 2003)

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: APP-BP1 CG7828

(Kim et al., 2007)

Source for merge of: CG7828 anon-WO0140519.225

(FlyBase, 1996-)

Additional comments

Source for merge of CG7828 anon-WO0140519.225 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

APP

(Moyer et al., 2021)

APP-BP1

(Hagen et al., 2021, Lin et al., 2020, Bouleau and Tricoire, 2015, Chang et al., 2013, Choo et al., 2012, Chan et al., 2008, Kim et al., 2007)

APPBP1

(Du et al., 2011, Higa et al., 2003)

CG7828

(National Institute of Genetics Fly Stocks, 2023-, Meadows, 2017.1.11, Hosono et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Yano et al., 2012, Kim et al., 2007)

anon-WO0140519.225

dAPP-BP1

(Kim, 2012.1.10, Kim et al., 2010, Kim et al., 2007, Kim et al., 2007)

dAPPBP1

(Du et al., 2011)

Name Synonyms

CG7828

β-Amyloid precursor protein binding protein 1

(Shafer, 2025)

Secondary FlyBase IDs

FBgn0086218
FBgn0036127
FBgn0063280
FBgn0046307
FBgn0044646

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39244

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VTE9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VTE9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PEU5

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VTE9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261112

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39244/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261112

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261112

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7828

MARRVEL_MODEL - MARRVEL (model organism gene)

39244

Linkouts

BioGRID - A database of protein and genetic interactions.

64618

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261112

DroID - A comprehensive database of gene and protein interactions.

FBgn0261112

DRSC - Results frm RNAi screens

FBgn0261112

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036127

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261112

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

protein NEDDylation

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7828

Flygut - An atlas of the Drosophila adult midgut

FBgn0261112

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261112

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003419

MIST (genetic) - An integrated Molecular Interaction Database

39244

MIST (protein-protein) - An integrated Molecular Interaction Database

39244

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neddylation

References (47)

The following external sites may use different assemblies or annotations than FlyBase.

4.84

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