Human Disease Model Report: prostate cancer, E-cadherin-related

General Information

Name

prostate cancer, E-cadherin-related

FlyBase ID

FBhh0000457

Disease Ontology Term

prostate cancer

Parent Disease

prostate cancer

OMIM

Overview

This model of prostate cancer is based on the observation that the Drosophila adult male accessory gland acts as a functional homolog of the mammalian prostate. It was hypothesized that normal cell growth and migration of secondary cells in the accessory gland may be regulated by Drosophila orthologs of known regulators of human prostate cancer progression. A number of the genes in this category are highly expressed in the male accessory gland; for several these, including shg, knockdown via RNAi was shown to result in changes in the number or migration of the secondary cells. (FBrf0226167)

Cadherins are a diverse group of transmembrane receptors which mediate cell-cell adhesion and cell movement. Dmel\shg is one of multiple cadherins in flies; there are also many cadherins in human. A low-scoring ortholog of Dmel\shg, human CDH1, has been implicated in susceptibility to prostate cancer (MIM:192090).

Amorphic mutations of Dmel\shg result in embryonic lethality. For assessment of function in the accessory gland, RNAi-mediated knockdown of shg was controlled by using a temperature-sensitive driver and targeting newly eclosed, newly mated males. Knockdown of shg results in an increase in secondary cell migration in the accessory gland; the phenotype is variable with incomplete penetrance. Physical and genetic interactions of Dmel\shg have been characterized; see below and in the gene report for shg.

[updated Dec. 2016 by FlyBase; FBrf0222196]

Disease Summary Information

Parent Disease Summary: prostate cancer

Symptoms and phenotype

Prostate cancer is the most common cancer in American men and is usually very slowly progressive; it is diagnosed in an estimated 80% of men who reach age 80 (http://www.webmd.com/prostate-cancer; 2016.12.20).

(FlyBase Curators, 2013-)

Specific Disease Summary: prostate cancer, E-cadherin-related

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Genetics

Cellular phenotype and pathology

Molecular information

The cadherin ("calcium-dependent adhesion") superfamily represents a diverse group of transmembrane receptors which mediate cell-cell adhesion and cell movement. (FBrf0146675)

(FlyBase Curators, 2013-)

See 'Gene Family: Cadherins' (http://www.genenames.org/cgi-bin/genefamilies/set/16) and 'Gene Family: Type II classical cadherins (CDH)' (http://www.genenames.org/cgi-bin/genefamilies/set/1186).

(FlyBase Curators, 2013-)

External links

COSMIC gene: CDH20
Gene2Function (human gene): CDH20
Gene Cards: CDH20
MedlinePlus (condition): prostate cancer
MedlinePlus (gene): CDH20
KEGG Disease Pathways: Prostate cancer
MARRVEL (human gene): CDH20
NCBI (Entrez) gene: CDH20; cadherin 20

Disease synonyms

Related Diseases

Related human health report(s)

prostate cancer

Related Specific Diseases

OMIM phenotypic series

Disease

Associated Human gene(s)

Drosophila model

Human transgene in Drosophila

Ortholog Information

Human gene(s) in FlyBase

Human gene (HGNC)

Symbol / Name

CDH20; cadherin 20

D. melanogaster ortholog (based on DIOPT)

Dmel\shg

(DIOPT, 2013-)

Comments on ortholog(s)

Many to many (not all listed).

Other mammalian ortholog(s) used

D. melanogaster Gene Information (1)

Dmel\shg

Gene Snapshot

shotgun (shg) encodes E-cadherin, a cell adhesion molecule that plays a critical role in mediating intercellular interactions and maintaining tissue integrity. [Date last reviewed: 2026-01-29]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Low-scoring ortholog of human type II cadherin CDH20 (most closely related) and multiple others (many Drosophila to many human), including CDH1. Dmel\shg shares 19% identity and 29% similarity with human CDH20.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Other Genes Used: Viral, Bacterial, Synthetic (0)

Summary of Physical Interactions (23 groups)

shg

protein-protein

Interacting group

Assay

References

shg

bead aggregation assay, fluorescence microscopy, inferred by author, atomic force microscopy, transmission electron microscopy, light microscopy

(Oda et al., 2025, Nishiguchi and Oda, 2021, Nishiguchi et al., 2016, Lovegrove et al., 2006)

shg - α-Cat

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot

(Desai et al., 2013, Iwai et al., 1997, Oda et al., 1994)

shg - arm

anti bait coimmunoprecipitation, molecular weight estimation by staining, anti tag coimmunoprecipitation, western blot, two hybrid, fluorescent resonance energy transfer, fluorescence microscopy, pull down, autoradiography

(Röper et al., 2018, Chen et al., 2017, Houssin et al., 2015, Hamada-Kawaguchi et al., 2014, Huang et al., 2011, Bahri et al., 2010, Sawyer et al., 2009, Liu et al., 2008, Stevens et al., 2008, Takahashi et al., 2005, Myster et al., 2003, Dumstrei et al., 2002, Cox et al., 1999, Loureiro and Peifer, 1998, Iwai et al., 1997, Orsulic and Peifer, 1996, Pai et al., 1996, Oda et al., 1994)

shg - baz

anti bait coimmunoprecipitation, western blot, nuclear magnetic resonance

(Renschler et al., 2018, Bulgakova et al., 2013, Harris and Peifer, 2005)

shg - cno

pull down, molecular weight estimation by staining

(Sawyer et al., 2009)

shg - Egfr

anti bait coimmunoprecipitation, western blot

(Dumstrei et al., 2002)

shg - Hakai

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Kaido et al., 2009)

shg - Inx2

anti bait coimmunoprecipitation, western blot, two hybrid

(Bauer et al., 2004)

shg - Inx3

anti tag coimmunoprecipitation, western blot

(Giuliani et al., 2013)

shg - lqfR

anti tag coimmunoprecipitation, western blot

(Lee and Fischer, 2012)

shg - mib2

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot

(Trivedi et al., 2022)

shg - Mmp1

enzymatic study, molecular weight estimation by staining

(Jia et al., 2014)

shg - Mmp2

enzymatic study, molecular weight estimation by staining

(Jia et al., 2014)

shg - Myo10A

pull down, autoradiography, two hybrid, anti bait coimmunoprecipitation, western blot

(Liu et al., 2008)

shg - Myo31DF

anti tag coimmunoprecipitation, western blot

(Petzoldt et al., 2012)

shg - N

anti bait coimmunoprecipitation, western blot

(Sasaki et al., 2007)

shg - p120ctn

pull down, autoradiography, two hybrid, anti tag coimmunoprecipitation, western blot

(Liu et al., 2008, Myster et al., 2003)

shg - Src42A

anti bait coimmunoprecipitation, western blot

(Takahashi et al., 2005)

shg - Stat92E

anti tag coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy

(Mallart et al., 2022)

shg - wrapper

anti bait coimmunoprecipitation, western blot

(Slováková and Carmena, 2011)

RNA-protein

Interacting group

Assay

References

shg - aub

iclip, partial RNA sequence identification

(Ma et al., 2017)

shg - Fmr1

anti bait coimmunoprecipitation, quantitative reverse transcription pcr, clip-seq

(Buddika et al., 2021)

shg - Hrb98DE

nucleic acid uv cross-linking assay, tag visualisation, anti bait coimmunoprecipitation, quantitative reverse transcription pcr, reverse transcription pcr, electrophoretic mobility shift assay

(Ji and Tulin, 2016, Ji and Tulin, 2012)

Alleles Reported to Model Human Disease (Disease Ontology) (10 alleles)

shg

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

shg^UAS.cSa

model of cancer

CEA

(Shen et al., 2014)