Gene Group: MEDIATOR COMPLEXES

General Information

Name

MEDIATOR COMPLEXES

Species

D. melanogaster

Symbol

MEDC

FlyBase ID

FBgg0001867

Date last reviewed

2023-11-07

Number of members

Description

The Mediator (MED) complex serves as a hub for transcriptional signaling events, bridging transcriptional activators and repressors. This large multi-protein complex has a central core conserved from yeast to humans. The core is composed of three modules: head, middle, and tail. A separate module, a Cdk8 kinase module called the CKM complex. (Adapted from FBrf0226415 and FBrf0191850).

Notes on Group

Source Material

The MEDIATOR COMPLEXES Gene Group has been compiled using the following publication(s): Homem et al., 2014, Marr et al., 2014, Loncle et al., 2007, Bourbon et al., 2004, Gu et al., 2002, Park et al., 2001, Park et al., 2001, and Boube et al., 2000 .

Key Gene Ontology (GO) terms

Molecular Function

transcription coregulator activity

Biological Process

regulation of transcription by RNA polymerase II

Cellular Component

nuclear protein-containing complex

Related Gene Groups

Component group(s)

CKM COMPLEX

MEDIATOR CORE COMPLEX

Members (30)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

CKM COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cdk8

Cyclin-dependent kinase 8

(Loncle et al., 2007)

CycC

Cyclin C

Cln3, DmcycC

(Loncle et al., 2007)

kto

kohtalo

Med12, psg14, Trap230, dTRAP230

(Loncle et al., 2007)

skd

skuld

Med13, pap, bli, blind spot, flytrap

(Loncle et al., 2007)

MEDIATOR CORE COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

intersex

Med29

(Homem et al., 2014, Bourbon et al., 2004)

MED1

Mediator complex subunit 1

Trap220, dTRAP220

(Homem et al., 2014, Bourbon et al., 2004, Park et al., 2001, Park et al., 2001, Boube et al., 2000)

MED4

Mediator complex subunit 4

Trap36, dp34

(Homem et al., 2014, Bourbon et al., 2004, Gu et al., 2002, Park et al., 2001, Park et al., 2001, Boube et al., 2000)

MED6

Mediator complex subunit 6

dMED6

(Homem et al., 2014, Bourbon et al., 2004, Gu et al., 2002, Park et al., 2001, Park et al., 2001, Boube et al., 2000)

MED7

Mediator complex subunit 7

dMED7

(Homem et al., 2014, Bourbon et al., 2004, Park et al., 2001, Park et al., 2001, Boube et al., 2000)

MED8

Mediator complex subunit 8

Arc32, dARC32

(Homem et al., 2014, Bourbon et al., 2004, Boube et al., 2000)

MED9

Mediator complex subunit 9

(Homem et al., 2014, Bourbon et al., 2004)

MED10

Mediator complex subunit 10

Nut2, dMED10

(Homem et al., 2014, Bourbon et al., 2004, Park et al., 2001, Park et al., 2001, Boube et al., 2000)

MED11

Mediator complex subunit 11

Med21

(Homem et al., 2014, Bourbon et al., 2004, Gu et al., 2002)

MED14

Mediator complex subunit 14

Trap170

(Homem et al., 2014, Marr et al., 2014, Bourbon et al., 2004, Park et al., 2001, Boube et al., 2000)

MED15

Mediator complex subunit 15

Arc105, dARC105

(Homem et al., 2014, Bourbon et al., 2004, Park et al., 2001, Boube et al., 2000)

MED16

Mediator complex subunit 16

Trap95, dTRAP95

(Homem et al., 2014, Bourbon et al., 2004, Park et al., 2001, Boube et al., 2000)

MED17

Mediator complex subunit 17

Trap80, l(3)s2956, dTRAP80

(Homem et al., 2014, Marr et al., 2014, Bourbon et al., 2004, Gu et al., 2002, Park et al., 2001, Park et al., 2001, Boube et al., 2000)

MED18

Mediator complex subunit 18

EG:63B12.13, p28/CG14802, dp28b

(Homem et al., 2014, Bourbon et al., 2004, Gu et al., 2002, Park et al., 2001)

MED19

Mediator complex subunit 19

(Homem et al., 2014, Bourbon et al., 2004)

MED20

Mediator complex subunit 20

Trfp, l(2)28DE, Tmr, lethal(2)28DE, Transcription mediator-related

(Homem et al., 2014, Bourbon et al., 2004, Gu et al., 2002, Park et al., 2001, Park et al., 2001, Boube et al., 2000)

MED21