FlyBase Allele Report: Dmel\fz[23]

General Information

Symbol

Dmel\fz²³

Species

D. melanogaster

Name

FlyBase ID

FBal0004939

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

Also Known As

fz^R52

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Bhanot et al., 1999)

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Amino acid replacement: W500term.

(Povelones et al., 2005, Jones et al., 1996)

There may be a second mutation in the non-translated sequences.

(Jones et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:14,367,034..14,367,034 [+]

Nucleotide change:

G14367034A

Reported nucleotide change:

G?A

Amino acid change:

W500term | fz-PA; W500term | fz-PC

Reported amino acid change:

W500term

Comment:

TGG to TGA nonsense mutation at amino acid 500.

(Povelones et al., 2005, Jones et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity

(Tree et al., 2002)

abnormal neuroanatomy (with fz³⁰)

(Gombos et al., 2015)

abnormal planar polarity

(Axelrod, 2001)

abnormal planar polarity (with fz²¹)

(Wu et al., 2004)

abnormal planar polarity | adult stage (with fz¹⁹)

(Ripp et al., 2018)

abnormal planar polarity | adult stage (with fz²¹)

(Ripp et al., 2018)

abnormal planar polarity | cell non-autonomous | recessive | somatic clone

(Chae et al., 1999)

abnormal planar polarity | cell non-autonomous | somatic clone

(Lee and Adler, 2002, Adler et al., 2000)

abnormal planar polarity | P-stage (with fz³⁰)

(Besson et al., 2015)

abnormal planar polarity | somatic clone

(Wu and Mlodzik, 2008)

lethal

(Ripp et al., 2018)

male fertile (with fz²¹)

(Steinhauer et al., 2019)

viable (with fz¹⁹)

(Ripp et al., 2018)

viable (with fz²¹)

(Ripp et al., 2018)

visible

visible (with fz³⁰)

(Povelones et al., 2005)

Phenotype Manifest In

border follicle cell (with fz¹⁵)

(Bastock and Strutt, 2007)

embryonic neuroblast

(Bhat, 1998)

external sensory organ precursor cell I | P-stage (with fz³⁰)

(Besson et al., 2015)

eye (with fz²¹)

(Wu et al., 2004)

larval RP2 motor neuron

(Bhat, 1998)

macrochaeta & adult thorax

mushroom body medial lobe (with fz³⁰)

(Gombos et al., 2015)

wing

(Jones et al., 1996)

wing | cell non-autonomous | somatic clone

(Adler et al., 2000)

wing blade dorsal compartment (with fz²¹)

(Doyle et al., 2008)

wing blade dorsal compartment | somatic clone (with fz¹⁵)

(Doyle et al., 2008)

wing cell | P-stage | cell non-autonomous | somatic clone

(Classen et al., 2005)

wing cell | P-stage | somatic clone

(Classen et al., 2005)

wing hair

(Tree et al., 2002)

wing hair (with fz²¹)

(Wu et al., 2008, Wu et al., 2004)

wing hair | cell non-autonomous | somatic clone

(Lee and Adler, 2002)

wing hair | increased number (with fz³⁰)

(Povelones et al., 2005)

wing hair | somatic clone

(Wu and Mlodzik, 2008, Chae et al., 1999)

Detailed Description

Statement

Reference

In fz²¹/fz²³ testes the number of normal individualization complexes (ICs), abnormal ICs and waste bags is similar to controls.

(Steinhauer et al., 2019)

Approximately 15% of fz³⁰/fz²³ mutant mushroom bodies exhibit medial lobe fusion phenotypes.

(Gombos et al., 2015)

The directional preferences of growing microtubules in fz³⁰/fz²³ wing cells is not significantly different from that seen in wild type at 24 hours after puparium formation.

(Harumoto et al., 2010)

In contrast to wild-types, no clear wing membrane ridge orientation is apparent in either the anterior or posterior region of the wing of fz²³/fz²¹ mutants.

fz²³/fz¹⁵ mutant clones in the wing non-autonomously disrupt wing membrane ridges.

(Doyle et al., 2008)

fz²³ mutant clones non-autonomously reorient the wing hairs of neighbouring wild type cells.

(Wu and Mlodzik, 2008)

Border cell clusters from fz²¹/fz²³ mutants show an average of 38.4 actin protrusions, reduced compared to the average of 94.8 in wild-type clusters.

(Bastock and Strutt, 2007)

The hexagonal packing of intervein cells, which usually occurs between wing development stage P2B (when the first morphological signs of veins appear (FBrf0005070), and the middle of P2C (before hair formation (FBrf0005070)) is severely disrupted in fz²³/fz²³ somatic clones. Hexagonal packing of intervein cells is also partially disrupted over a distance of several cell diameters from these clones.

(Classen et al., 2005)

fz²³ has a moderate multiple wing hair phenotype in combination with fz³⁰.

(Povelones et al., 2005)

Mutant clones in the wing show domineering non-autonomy: cells distal to the clone, as well as within the clone, show alteration of polarity of wing hairs.

(Lee and Adler, 2002)

Mutant animals have a mutant planar cell polarity phenotype.

(Axelrod, 2001)

Homozygous fz²³ clones in the wing exhibit a non-symmetrical domineering non-autonomy. The polarity defects seen are biased in that cells medial to the clone are more likely to be affected.

(Adler et al., 2000)

Shows domineering non-autonomy of wing hair polarity phenotype in clones in the wing.

(Chae et al., 1999)

Embryos lacking maternal and zygotic fz function (derived from a cross between fz³⁰/fz²³ males and females) are missing the RP2/sib lineage in 1-3 hemisegments in 15% of cases. Row 6 neuroblasts are infrequently missing in a partially penetrant manner. Embryos lacking maternal and zygotic fz function (derived from a cross between fz¹/fz²³ males and females) are missing the RP2/sib lineage in 1-2 hemisegments in 11% of cases.

(Bhat, 1998)

Non-autonomous phenotype in wing clones. Strong fz phenotype.

(Jones et al., 1996)

Moderate thoracic bristle phenotype; moderate wing-hair disorientation.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fz²³ has abnormal planar polarity | cell non-autonomous | somatic clone phenotype, enhanceable by pk^D

(Adler et al., 2000)

NOT Enhanced by

Statement

Reference

fz²³/fz¹⁹ has viable phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has viable phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz²¹ has viable phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz²¹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz²¹ has viable phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz²¹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³ has lethal phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³ has lethal phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

Suppressed by

Statement

Reference

fz²³/fz²¹ has abnormal planar polarity phenotype, suppressible by fz::fz2^1-1-2S.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has abnormal planar polarity phenotype, suppressible by fz::fz2^1-2-1.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has abnormal planar polarity phenotype, suppressible by fz::fz2^1-1-2.tub.W

(Wu et al., 2004)

fz²³ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, suppressible by dsh¹

(Lee and Adler, 2002)

fz²³ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, suppressible by mwh¹

(Lee and Adler, 2002)

NOT suppressed by

Statement

Reference

fz²³/fz¹⁹ has viable phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has viable phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz²¹ has viable phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz²¹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz²¹ has viable phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz²¹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³ has lethal phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³ has lethal phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz²¹ has abnormal planar polarity | somatic clone phenotype, non-suppressible by fz::fz2^{2-1-1.tub.Tag:MYC}

(Wu and Mlodzik, 2008)

fz²³ has abnormal planar polarity | somatic clone phenotype, non-suppressible by Vang^A3

(Wu and Mlodzik, 2008)

fz²³/fz²¹ has abnormal planar polarity phenotype, non-suppressible by fz::fz2^1-2-2.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has abnormal planar polarity phenotype, non-suppressible by fz::fz2^2-1-1.tub.W

(Wu et al., 2004)

fz²³ has abnormal planar polarity | somatic clone | cell autonomous phenotype, non-suppressible by dsh¹

(Lee and Adler, 2002)

fz²³ has abnormal planar polarity | somatic clone | cell autonomous phenotype, non-suppressible by mwh¹

(Lee and Adler, 2002)

fz²³ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, non-suppressible by dsh¹

(Lee and Adler, 2002)

fz²³ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, non-suppressible by mwh¹

(Lee and Adler, 2002)

fz²³ has abnormal cell polarity phenotype, non-suppressible by dsh^hs.PA

(Tree et al., 2002)

Enhancer of

Statement

Reference

fz²³ is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

NOT Enhancer of

Statement

Reference

fz²³/fz¹⁹ is a non-enhancer of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz²³/fz[+] is a non-enhancer of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz²³/fz[+] is a non-enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

fz²³/fz[+] is a non-enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

fz²³ is a non-enhancer of abnormal cell polarity phenotype of pk^pk.sev

(Jenny et al., 2003)

Suppressor of

Statement

Reference

fz²³/fz[+] is a suppressor | partially of abnormal planar polarity phenotype of Egfr^t1/Egfr^f11

(Weber et al., 2008)

fz²³/fz[+] is a suppressor of abnormal planar polarity | dominant phenotype of Egfr^f24

(Weber et al., 2008)

fz²³ is a suppressor of abnormal planar polarity | somatic clone phenotype of Vang^A3

(Wu and Mlodzik, 2008)

fz²³ is a suppressor of abnormal cell polarity phenotype of dsh^hs.PA

(Tree et al., 2002)

NOT Suppressor of

Statement

Reference

fz²³/fz¹⁹ is a non-suppressor of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz²³/fz[+] is a non-suppressor of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz²³/fz[+] is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

fz²³/fz[+] is a non-suppressor of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

fz²³ is a non-suppressor of abnormal cell polarity phenotype of pk^pk.sev

(Jenny et al., 2003)

Other

Statement

Reference

fz2^e3/Df(3L)fz2, fz²³/fz^GL31 has lethal phenotype

(Povelones et al., 2005)

fz2^e4/Df(3L)fz2, fz²³/fz^GL31 has lethal phenotype

(Povelones et al., 2005)

fz2^e5/Df(3L)fz2, fz²³/fz^GL31 has lethal phenotype

(Povelones et al., 2005)

fz2^e6/Df(3L)fz2, fz²³/fz^GL31 has lethal phenotype

(Povelones et al., 2005)

fz2^e1/Df(3L)fz2, fz²³/fz^GL31 has lethal phenotype

(Povelones et al., 2005)

fz2^e2/Df(3L)fz2, fz²³/fz^GL31 has lethal phenotype

(Povelones et al., 2005)

fz²³, pk¹ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype

(Adler et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

fz²³ has wing | cell non-autonomous | somatic clone phenotype, enhanceable by pk^D

(Adler et al., 2000)

Suppressed by

Statement

Reference

fz²³/fz²¹ has eye phenotype, suppressible by fz::fz2^1-1-2.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has eye phenotype, suppressible by fz::fz2^1-1-2S.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has eye phenotype, suppressible by fz::fz2^1-2-1.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has wing hair phenotype, suppressible by fz::fz2^1-1-2.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has wing hair phenotype, suppressible by fz::fz2^1-1-2S.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has wing hair phenotype, suppressible by fz::fz2^1-2-1.tub.W

(Wu et al., 2004)

fz²³ has wing hair | somatic clone | cell non-autonomous phenotype, suppressible by dsh¹

(Lee and Adler, 2002)

fz²³ has wing hair | somatic clone | cell non-autonomous phenotype, suppressible by mwh¹

(Lee and Adler, 2002)

fz²³/Df(3L)fz-D21, Df(3L)fz2 has embryonic/first instar larval cuticle phenotype, suppressible by fz::fz2^{fz2CRD.UAS.Tag:MYC}/Scer\GAL4^da.G32

(Rulifson et al., 2000)

fz²³/Df(3L)fz-D21, Df(3L)fz2 has embryonic/first instar larval cuticle phenotype, suppressible by fz::fz2^{fzCRD.UAS.Tag:MYC}/Scer\GAL4^da.G32

(Rulifson et al., 2000)

fz²³ has wing hair | somatic clone phenotype, suppressible by stan³

(Chae et al., 1999)

fz²³ has phenotype, suppressible by Vang^A3

(Taylor et al., 1998)

NOT suppressed by

Statement

Reference

fz²³/fz²¹ has wing hair | somatic clone phenotype, non-suppressible by fz::fz2^{2-1-1.tub.Tag:MYC}

(Wu and Mlodzik, 2008)

fz²³ has wing hair | somatic clone phenotype, non-suppressible by Vang^A3

(Wu and Mlodzik, 2008)

fz²³/fz²¹ has eye phenotype, non-suppressible by fz::fz2^1-2-2.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has eye phenotype, non-suppressible by fz::fz2^2-1-1.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has wing hair phenotype, non-suppressible by fz::fz2^1-2-2.tub.W

(Wu et al., 2004)

fz²³/fz²¹ has wing hair phenotype, non-suppressible by fz::fz2^2-1-1.tub.W

(Wu et al., 2004)

fz²³ has wing hair | somatic clone | cell autonomous phenotype, non-suppressible by dsh¹

(Lee and Adler, 2002)

fz²³ has wing hair | somatic clone | cell autonomous phenotype, non-suppressible by mwh¹

(Lee and Adler, 2002)

fz²³ has wing hair | somatic clone | cell non-autonomous phenotype, non-suppressible by dsh¹

(Lee and Adler, 2002)

fz²³ has wing hair | somatic clone | cell non-autonomous phenotype, non-suppressible by mwh¹

(Lee and Adler, 2002)

fz²³ has wing hair phenotype, non-suppressible by dsh^hs.PA

(Tree et al., 2002)

Enhancer of

Statement

Reference

fz²³ is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

fz²³/fz³⁰ is an enhancer of wing hair phenotype of fy²/fy⁶

(Lee and Adler, 2002)

fz²³ is an enhancer of phenotype of Vang^Tbs42

(Taylor et al., 1998)

fz²³ is an enhancer of phenotype of Vang^A3

(Taylor et al., 1998)

NOT Enhancer of

Statement

Reference

fz²³/fz[+] is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

fz²³/fz[+] is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

fz²³ is a non-enhancer of ommatidium phenotype of pk^pk.sev

(Jenny et al., 2003)

Suppressor of

Statement

Reference

fz²³/fz[+] is a suppressor | partially of ommatidium phenotype of Egfr^t1/Egfr^f11

(Weber et al., 2008)

fz²³/fz[+] is a suppressor of ommatidium phenotype of Egfr^f24

(Weber et al., 2008)

fz²³ is a suppressor of wing hair | somatic clone phenotype of Vang^A3

(Wu and Mlodzik, 2008)

fz²³ is a suppressor of wing hair phenotype of dsh^hs.PA

(Tree et al., 2002)

NOT Suppressor of

Statement

Reference

fz²³/fz[+] is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

fz²³/fz[+] is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

fz²³ is a non-suppressor of ommatidium phenotype of pk^pk.sev

(Jenny et al., 2003)

Other

Statement

Reference

fz2^e2, fz²³/fz^GL31 has embryonic/first instar larval cuticle | maternal effect phenotype

(Povelones et al., 2005)

fz²³, pk¹ has wing | somatic clone | cell non-autonomous phenotype

(Adler et al., 2000)

fz²³/Df(3L)fz-D21, Df(3L)fz2 has embryonic/first instar larval cuticle phenotype

(Rulifson et al., 2000)

Df(3L)fz2, fz²³ has larval RP2 motor neuron phenotype

(Bhanot et al., 1999)

Df(3L)fz2, fz²³ has dorsal vessel wall cell phenotype

(Bhanot et al., 1999)

Df(3L)fz2, fz²³ has embryonic midgut constriction phenotype

(Bhanot et al., 1999)

Df(3L)N2-27, fz²³ has larval RP2 motor neuron phenotype

(Bhat, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The planar cell polarity defects seen in Egfr^f11/Egfr^t1 eyes are partially suppressed by fz²³/+.

The frequency of rotation defects in the ommatidia of Egfr^f24/+ flies is reduced to 12% or 18% respectively if they are also carrying fz²³/+.

(Weber et al., 2008)

As is seen with fz²³ clones alone, fz²³ Vang^A3 double mutant clones non-autonomously reorient the wing hairs of neighbouring wild type cells so that they point towards the clone.

Expression of fz::fz2^{2-1-1.tub.T:Hsap\MYC} fails to rescue the non-autonomous effects of fz²³/fz²¹ mutant clones on the orientation of the wing hairs of neighbouring wild type cells.

(Wu and Mlodzik, 2008)

A fz²³/+ background does not affect the Scer\GAL4^hs.2sev>shg^{dCR3h.Scer\UAS.T:Avic\GFP-rs} ommatidial phenotype.

(Mirkovic and Mlodzik, 2006)

Embryos that lack zygotic fz and fz2 function which are derived from fz²³/fz^GL31 fz2^e2 females mated to fz^GL31 fz2^e2/+ males are modestly shortened and have mild patterning defects in the cuticle.

(Povelones et al., 2005)

When a wing clone is doubly mutant for fz²³ and mwh¹ or dsh¹, domineering nonautonomy of polarity defect of fz²³ is unaffected. When a wing clone is doubly mutant for fz²³ and mwh¹ (or dsh¹) in a genetic background deficient for mwh (or dsh¹), domineering nonautonomy of polarity defect of fz²³ is suppressed, though polarity defect within the clone is not.

(Lee and Adler, 2002)

The addition of dsh^hs.PA to fz²³ animals has no effect on the fz²³ wing hair polarity phenotype.

(Tree et al., 2002)

Parp^GMR.PU shows no genetic interaction with fz²³/+.

(Uchida et al., 2002)

fz²³ homozygous clones in pk¹ wings, exhibit domineering cell non-autonomy where the direction of the non-autonomy is no longer distal. For these clones the domineering cell autonomy is in the same direction as local hair polarity. fz²⁵ clones in a pk^D background show significantly stronger domineering non-autonomy than in a wild-type background. They almost always show proximal domineering non-autonomy. That is cells proximal, but not distal to the clone show abnormal polarity. Thus the direction of the domineering non-autonomy is the same as local hair polarity.

(Adler et al., 2000)

Df(3L)fz-D21 Df(3L)fz2 embryos derived from fz²³/Df(3L)fz-D21 Df(3L)fz2 females show a "denticle lawn" cuticle phenotype which is suppressed by expression of fz::fz2^{fz2CRD.Scer\UAS.T:Hsap\MYC} or fz::fz2^{fzCRD.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^da.G32.

(Rulifson et al., 2000)

Double mutants with Df(3L)fz2 show variable segmentation defects ranging from a few extra denticles in the posterior part of some segments to complete replacement of naked cuticle with denticles. This phenotype is reminiscent of that for wg loss of function. The expression of arm^ΔN.Scer\UAS driven by Scer\GAL4^da.G32 completely overrides this phenotype, causing naked cuticle. Double mutants with Df(3L)fz2 show a reduction of RP2 neurons, though 26% of embryos retain RP2 neurons in 1-3 hemisegments. In double mutants of fz²¹ or fz²³ with Df(3L)fz2 cardiac precursors are missing. Double mutants of fz²¹ or fz²³ with Df(3L)fz2 lack the normal number of midgut constrictions. Overexpression of wg^Scer\UAS.cLb by Scer\GAL4^da.G32 has no effect on the cuticle phenotype of double mutants of fz²¹ or fz²³ with Df(3L)fz2.

(Bhanot et al., 1999)

The domineering non-autonomy of fz²³ clones is suppressed by stan³.

(Chae et al., 1999)

All fz²³/fz²³; Df(3L)N2-27 double mutant embryos show RP2/sib lineage defects, with 10-13 hemisegments per embryo being affected.

(Bhat, 1998)

Acts as a dominant enhancer of the dominant wing basal cell 1 phenotype of Vang^Tbs42 and Vang^A3. Vang^A3 suppresses the domineering nonautonomy of fz²³ clones.

(Taylor et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

fz²³ is rescued by fz^tub.Tag:MYC

(Wu and Mlodzik, 2008)

fz²³ is rescued by fz^{ΔSWRNF.tub.Tag:MYC}

(Wu and Mlodzik, 2008)

fz²³/fz²¹ is rescued by fz^tub.Tag:MYC

(Wu et al., 2008)

fz²³/fz²¹ is rescued by fz^{565Stop.tub.Tag:MYC}

(Wu et al., 2008)

fz²³/fz²¹ is rescued by fz^1-1-1.tub.W

(Wu et al., 2004)

fz²³ is rescued by Scer\GAL4^da.G32/fz^UAS.cAa

(Bhanot et al., 1999)

Not rescued by

fz²³/fz²¹ is not rescued by fz^{ΔCRD.tub.Tag:MYC}

(Wu and Mlodzik, 2008)

fz²³/fz²¹ is not rescued by fz^{ΔSWRNF.tub.Tag:MYC}

(Wu et al., 2008)

fz²³/fz²¹ is not rescued by fz^{ΔSKT.tub.Tag:MYC}

(Wu et al., 2008)

fz²³/fz²¹ is not rescued by fz^{M469R.tub.Tag:MYC}

(Wu et al., 2008)

Comments

Expression of fz^{ΔSWRNF.tub.T:Hsap\MYC} rescues the non-autonomous effects of fz²³ mutant clones on the orientation of the wing hairs of neighbouring wild-type cells.

Expression of fz^{tub.T:Hsap\MYC} rescues the non-autonomous effects of fz²³ mutant clones on the orientation of the wing hairs of neighbouring cells.

Expression of fz^{ΔCRD.tub.T:Hsap\MYC} fails to rescue the non-autonomous effects of fz²³/fz²¹ mutant clones on the orientation of the wing hairs of neighbouring wild type cells. 92.3% of clones have surrounding wild type cells pointing towards the clone.

(Wu and Mlodzik, 2008)

Expression of fz^{tub.T:Hsap\MYC} rescues the wing hair phenotype seen in fz²¹/fz²³ mutants.

Expression of fz^{ΔSWRNF.tub.T:Hsap\MYC} fails to rescue the wing hair phenotype seen in fz²¹/fz²³ mutants.

Expression of fz^{ΔSKT.tub.T:Hsap\MYC} fails to rescue the wing hair phenotype seen in fz²¹/fz²³ mutants.

Expression of fz^{M469R.tub.T:Hsap\MYC} fails to rescue the wing hair phenotype seen in fz²¹/fz²³ mutants.

Expression of fz^{565Stop.tub.T:Hsap\MYC} rescues the wing hair phenotype seen in fz²¹/fz²³ mutants.

(Wu et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Adler.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

(Weber et al., 2012)

FzR52

(Weiner et al., 2020)

R52

(Weber et al., 2012)

fz²³

(Gombos et al., 2015, Bastock and Strutt, 2007)

fz^R52

(Weiner et al., 2025, Sanchez Bosch et al., 2024, Song et al., 2023, Cho et al., 2022, Cho et al., 2020, Steinhauer et al., 2019, Thuveson et al., 2019, Ripp et al., 2018, Ahmad et al., 2016, Besson et al., 2015, Cho et al., 2015, Linnemannstöns et al., 2014, Merkel et al., 2014, Matsubara et al., 2011, Mirkovic et al., 2011, Doyle et al., 2008, Weber et al., 2008, Wu and Mlodzik, 2008, Wu et al., 2008, Bhat, 2007, Tyler et al., 2007, Mirkovic and Mlodzik, 2006, Amonlirdviman et al., 2005, Classen et al., 2005, Djiane et al., 2005, Jenny et al., 2005, Povelones et al., 2005, Das et al., 2004, Wu et al., 2004, Jenny et al., 2003, Ma et al., 2003, Lee and Adler, 2002, Tree et al., 2002, Uchida et al., 2002, Axelrod, 2001, Shimada et al., 2001, Adler et al., 2000, Rulifson et al., 2000, Bhanot et al., 1999, Chae et al., 1999, Muller et al., 1999, Usui et al., 1999, Adler et al., 1998, Bhat, 1998, Taylor et al., 1998, Jones et al., 1996, Adler et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (54)

Report Sections

Open Close