beta3, β3, AP-3β, apl6
Gene model reviewed during 5.40
Gene model reviewed during 5.45
Gene model reviewed during 5.52
5.4, 5.2 (northern blot)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rb using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\rb in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: rb beta3
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
rb mutations lead to a decreased number and altered size of pigment granules in various cell types in and adjacent to the retina. rb mutants also show defective behaviour in alternating pattern fixation in Buridan's paradigm.
The rb gene product is part of the AP-3 adaptor complexs, which is critical for pigment granule formation.
Lesions in rb reduce or eliminate pigmentation in the eyes and ocelli and block pigmentation of the fat body and tubules: rb is required for normal pigmentation of all four tissues.
Pteridines (neodrosopterin, drosopterin, isodrosopterin, aurodrosopterin, 6-acetyl-dihydrohomopterin, sepiapterin, dihydrobiopterin, biopterin, pterin and isoxanthopterin) have been quantified in single and double mutants.
It is likely that this gene is required for the normal transport of eye-pigment precursors.
Bridges, 18th Oct. 1914.