RpI135, DmRP135, RNA polymerase I, Rpl135
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Polr1B using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Polr1B in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene in combination with dsRNA against gig results in suppression of the final average cell size, with it being closer to the control average cell size, rather than the average cell size resulting from knockdown of the candidate gene alone.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
Based on biochemical evidence, it has been shown that RpI135 encodes the second largest subunit of RNA polymerase I, and not the equivalent subunit of RNA polymerase III, as previously reported (FBrf0050568).
Isolated as a clone having weak homology to the 150kD subunit of yeast RNA polymerase II.
Named 'Polr1B' after the human ortholog.