FlyBase Gene Report: Dmel\Pfdn2

General Information

Symbol

Dmel\Pfdn2

Species

D. melanogaster

Name

Prefoldin 2

Annotation Symbol

CG6302

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010741

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). (UniProt, Q9VTE5)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

l(3)01239, l(3)j9B4

Key Links

Genomic Location

Cytogenetic map

68A4-68A4

Sequence location

3L:11,073,292..11,074,388 [-]

Recombination map

3-34

RefSeq locus

NT_037436 REGION:11073292..11074388

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse JBrowse2 (beta)

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein-macromolecule adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000329566

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in establishment or maintenance of neuroblast polarity

inferred from mutant phenotype

(Zhang et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein folding

inferred from biological aspect of ancestor with PANTHER:PTN000329566

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002777, InterPro:IPR027235

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of prefoldin complex

inferred from direct assay

(Zhang et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of prefoldin complex

inferred from electronic annotation with InterPro:IPR002777, InterPro:IPR027235

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000329566

(GO Reference Genome Project, 2011-)

Gene Group / Complex (FlyBase)

PREFOLDIN COMPLEX

PREFOLDIN HOLDASES

Protein Family (UniProt)

Belongs to the prefoldin subunit beta family. (Q9VTE5)

Protein Signatures (InterPro)

Summaries

Gene Group / Complex (FlyBase)

PREFOLDIN COMPLEX -: The prefoldin complex is a heterohexameric co-chaperone involved in the folding of proteins such as tubulin and actin. It binds the cytosolic chaperonin containing TCP-1 (CCT) complex and and transfers target proteins to it. (Adapted from FBrf0231608 and PMID:29427249).
PREFOLDIN HOLDASES -: Prefoldins are holdases that bind unfolded polypeptides and maintain them in a folding-competent state. The canonical eukaryotic prefoldins form a heterohexameric complex that binds actin and tubulin co-translationally and delivers them to the chaperonin containing TCP-1 (CCT) complex. (Adapted from FBrf0231608 and PMID:29427249.)

Protein Function (UniProtKB)

(UniProt, Q9VTE5)

Summary (Interactive Fly)

a subunit of abmolecular chaperone complex - regulates tubulin function in mitosis - regulates neuroblast polarity in larval brains

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pfdn2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VTE5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pfdn2-RA

FBtr0076238

NM_168438

819

143

Pfdn2-RB

FBtr0332708

NM_001274767

993

143

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Pfdn2-PA

FBpp0075967

16.2

143

5.35

FBpp0304954

16.2

143

5.35

Q9VTE5

NP_001261696

AGB94390

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

143 aa isoforms: Pfdn2-PA, Pfdn2-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

(UniProt, Q9VTE5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pfdn2 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.06

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

intermediate neuronal progenitor | subset

(Zhang et al., 2016)

larval neuroblast | subset

(Zhang et al., 2016)

ganglion mother cell | subset

(Zhang et al., 2016)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval brain | restricted

(Zhang et al., 2016)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of prefoldin complex

inferred from direct assay

(Zhang et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pfdn2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pfdn2

View exonic expression by tissue for Dmel\Pfdn2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

46121/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010741

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010741

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010741

Flygut - An atlas of the Drosophila adult midgut

FBgn0010741

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pfdn2

Transgenic constructs containing regulatory region of Pfdn2

Aberrations (Deficiencies and Duplications) ( 14 )

Inferred from experimentation ( 14 )

Gene not disrupted in

Df(3L)h76

(Zhang et al., 2003, Makunin et al., 2002)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

Pfdn2^GD13510

lethal | recessive

lethal - all die before end of P-stage

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Pfdn2^GD13510

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Pfdn2^GD13510

viable, with Scer\GAL4^Mef2.PR

Pfdn2^GD13510

viable, with Scer\GAL4^tin.CΔ4

Pfdn2^GD13510

Sterility

Allele

female sterile

Pfdn2^j9B4

Other Phenotypes

Allele

abnormal flight, with Scer\GAL4^sr-md710

Pfdn2^NIG.6302R

abnormal mitotic cell cycle | third instar larval stage (with Df(3L)BSC457)

Pfdn2⁰¹²³⁹

abnormal neuroanatomy | third instar larval stage

Pfdn2^Δ10

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^insc-Mz1407

Pfdn2^GD13510

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

Pfdn2^GD13510

abnormal neuroanatomy | third instar larval stage (with Df(3L)BSC457)

Pfdn2⁰¹²³⁹

abnormal neuroanatomy | third instar larval stage (with Pfdn2⁰¹²³⁹)

Pfdn2^Δ10

abnormal neuroanatomy | third instar larval stage (with Pfdn2^Δ10)

Pfdn2⁰¹²³⁹

increased cell number | third instar larval stage

Pfdn2^Δ10

increased cell number | third instar larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

Pfdn2^GD13510

increased cell number | third instar larval stage (with Pfdn2⁰¹²³⁹)

Pfdn2^Δ10

increased cell number | third instar larval stage (with Pfdn2^Δ10)

Pfdn2⁰¹²³⁹

increased occurrence of cell division | third instar larval stage (with Pfdn2^Δ10)

Pfdn2^Δ17

increased occurrence of cell division | third instar larval stage (with Pfdn2^Δ17)

Pfdn2^Δ10

some die during pupal stage, with Scer\GAL4^pnr-MD237

Pfdn2^GD13510

visible, with Scer\GAL4^pnr-MD237

Pfdn2^GD13510

Phenotype manifest in

Allele

centrosome | third instar larval stage

Pfdn2^Δ10

larval brain | larval stage, with Scer\GAL4^insc-Mz1407

Pfdn2^GD13510

mitotic spindle | third instar larval stage

Pfdn2^Δ10

mitotic spindle | third instar larval stage (with Df(3L)BSC457)

Pfdn2⁰¹²³⁹

neuroblast | increased number | third instar larval stage

neuroblast | increased number | third instar larval stage (with Df(3L)BSC457)

Pfdn2⁰¹²³⁹

neuroblast | increased number | third instar larval stage (with Pfdn2⁰¹²³⁹)

Pfdn2^Δ10

neuroblast | increased number | third instar larval stage (with Pfdn2^Δ10)

Pfdn2⁰¹²³⁹

neuroblast | somatic clone | increased number | third instar larval stage

neuroblast | third instar larval stage

Pfdn2^Δ10

oocyte | germline clone

Pfdn2^j9B4

ovariole | germline clone

Pfdn2^j9B4

spindle microtubule | third instar larval stage

Pfdn2^Δ10

trichogen cell, with Scer\GAL4^pnr-MD237

Pfdn2^GD13510

type II neuroblast | increased number | third instar larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

Pfdn2^GD13510

type I neuroblast | increased number | third instar larval stage, with Scer\GAL4^insc-Mz1407

Pfdn2^GD13510

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\PFDN2

14 of 14

Yes

Hsap\PFDN6

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Pfdn2

14 of 14

Yes

Rnor\Pfdn6

1 of 14

Mus musculus (laboratory mouse) (2)

Mmus\Pfdn2

13 of 14

Yes

Mmus\Pfdn6

1 of 14

Xenopus tropicalis (Western clawed frog) (2)

Xtro\pfdn2

11 of 13

Yes

Xtro\pfdn6

1 of 13

Danio rerio (Zebrafish) (2)

Drer\pfdn2

14 of 14

Yes

Drer\pfdn6

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\pfd-2

12 of 14

Yes

Cele\pfd-6

1 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP006070

12 of 12

Yes

Agam\AgaP_AGAP012235

1 of 12

Arabidopsis thaliana (thale-cress) (2)

Atha\PDF2

13 of 13

Yes

Atha\PFD6

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\GIM4

12 of 13

Yes

Scer\YKE2

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPAC227.10

11 of 12

Yes

Spom\SPAC3A11.13

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Pfdn2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

Pfdn6

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PFDN2; prefoldin subunit 2

14 of 14

613466

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Pfdn2 - CG10252

experimental knowledge based

(Guruharsha et al., 2011)

Pfdn2 - Lst8

anti tag coimmunoprecipitation, peptide massfingerprinting

(Glatter et al., 2011)

Pfdn2 - Met

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Pfdn2 - Pfdn1

experimental knowledge based

(Guruharsha et al., 2011)

Pfdn2 - Pfdn4

experimental knowledge based

(Guruharsha et al., 2011)

Pfdn2 - Pfdn5

anti tag coimmunoprecipitation, anti tag western blot, experimental knowledge based

(Zhang et al., 2016, Guruharsha et al., 2011)

Pfdn2 - Pfdn6

experimental knowledge based

(Guruharsha et al., 2011)

Pfdn2 - bin

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Pfdn2 - mdlc

experimental knowledge based

(Guruharsha et al., 2011)

Pfdn2 - mgr

experimental knowledge based, anti tag coimmunoprecipitation, anti tag western blot

(Zhang et al., 2016, Guruharsha et al., 2011)

Pfdn2 - mst

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Palumbo et al., 2015)

Pfdn2 - βTub56D

anti tag coimmunoprecipitation, anti tag western blot

(Zhang et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Pfdn2

suppressible

aPKC

(Zhang et al., 2016)

Pfdn2

enhanceable

mgr

(Zhang et al., 2016)

Pfdn2

suppressible

par-6

(Zhang et al., 2016)

Pfdn2

enhanceable

pins

(Zhang et al., 2016)

pins|Pfdn2

suppressible

αTub84B

(Zhang et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

mgr

enhanceable

Pfdn2

(Zhang et al., 2016)

pins

suppressible

Pfdn2

(Zhang et al., 2016)

External Data

Subunit Structure (UniProtKB)

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

(UniProt, Q9VTE5 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010741

MIST (genetic) - An integrated Molecular Interaction Database

46121

MIST (protein-protein) - An integrated Molecular Interaction Database

46121

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-34

Cytogenetic map

68A4-68A4

Sequence location

3L:11,073,292..11,074,388 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

68A4-68A4

Limits computationally determined from genome sequence between P{PZ}klu⁰⁹⁰³⁶ and P{PZ}l(3)01239⁰¹²³⁹&P{lacW}l(3)01239^j9B4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

68A4-68A5

(determined by in situ hybridisation)

(Spradling et al., 1999, Perrimon et al., 1996)

68A4-68A5

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-34

(FlyBase, 2016)

3-28.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

61843

y¹ v¹; P{TRiP.HMJ23331}attP40

12082

y¹ w^*; P{lacW}Pfdn2^j9B4/TM3, Sb¹

63459

w¹¹¹⁸; PBac{IT.GAL4}Pfdn2^0640-G4/TM6B, Tb¹

11526

P{PZ}Pfdn2⁰¹²³⁹ ry⁵⁰⁶/TM6B, ry^CB Tb¹ ca¹

19918

y¹ w^67c23; P{EPgy2}Pfdn2^EY06124/TM3, Sb¹ Ser¹

NIG-Fly

6302R-2

P{NIG.6302R}2

HMJ23331

y¹ v¹; P{TRiP.HMJ23331}attP40/CyO

VDRC

v28794

w¹¹¹⁸; P{GD13510}v28794/TM3

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (151)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD39331

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010741

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010741

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Zhang et al., 2016)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(w^hs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. l(3)01239 is required for germ cell viability or early oogenesis.

(Perrimon et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: l(3)01239 l(3)j9B4

(Spradling et al., 1999)

Source for merge of: l(3)01239 CG6302

(Makunin et al., 2002)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Pfdn2 l(3)01239

(Zhang et al., 2016)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG6302

(Zhang et al., 2016, Hosono et al., 2015, Tiwari et al., 2015, White-Grindley et al., 2014, Glatter et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009, Gandhi et al., 2007, Stroschein-Stevenson et al., 2006, Zhang et al., 2003, Makunin et al., 2002)

P01239

(Makunin et al., 2002)

Pfdn2

(Scharenbrock et al., 2024, Deolankar et al., 2022, Zhang et al., 2016)

l(3)01239

(Zur Lage et al., 2018, Clandinin and Owens, 2016-, Spratford and Kumar, 2015, Tiwari et al., 2015, White-Grindley et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Siddiqui et al., 2012, Guruharsha et al., 2011, Wasbrough et al., 2010, Christensen et al., 2009.2.28, Christensen et al., 2009.6.15, Christensen et al., 2008.4.15, Muraro and Moffat, 2006)

l(3)j9B4

(Perrimon et al., 1996, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

pfdn2

(Zhang et al., 2016)

Name Synonyms

Prefoldin 2

(Palumbo et al., 2015)

Prefoldin β-like subunit

(Zhang et al., 2016)

lethal (3) 01239

Secondary FlyBase IDs

FBgn0011417
FBgn0036123

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

46121

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VTE5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VTE5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PF40

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VTE5

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

46121/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010741

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010741

FlyMine - An integrated database for Drosophila genomics

FBgn0010741

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6302

MARRVEL_MODEL - MARRVEL (model organism gene)

46121

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010741

DroID - A comprehensive database of gene and protein interactions.

FBgn0010741

DRSC - Results frm RNAi screens

FBgn0010741

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010741

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

DMEL:FBGN0010741

Flygut - An atlas of the Drosophila adult midgut

FBgn0010741

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000359

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

46121

MIST (protein-protein) - An integrated Molecular Interaction Database

46121

References (55)

The following external sites may use different assemblies or annotations than FlyBase.

-0.06

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