FlyBase Gene Report: Dmel\cato

General Information

Symbol

Dmel\cato

Species

D. melanogaster

Name

cousin of atonal

Annotation Symbol

CG7760

Feature Type

protein_coding_gene

FlyBase ID

FBgn0024249

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

cousin of atonal (cato) encodes a transcription factor involved in the development of the sensory nervous system. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

53A4-53A4

Sequence location

2R:16,277,685..16,278,396 [-]

Recombination map

2-79

RefSeq locus

NT_033778 REGION:16277685..16278396

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN001060907

(GO Reference Genome Project, 2011-)

enables E-box binding

inferred from biological aspect of ancestor with PANTHER:PTN000446010

(GO Reference Genome Project, 2011-)

enables protein dimerization activity

inferred from electronic annotation with InterPro:IPR011598, InterPro:IPR036638

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in sensory organ development

inferred from mutant phenotype

(zur Lage and Jarman, 2010)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in axon development

inferred from biological aspect of ancestor with PANTHER:PTN000446010

(GO Reference Genome Project, 2011-)

involved_in neuron fate commitment

inferred from biological aspect of ancestor with PANTHER:PTN002711780

(GO Reference Genome Project, 2011-)

involved_in positive regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000446010

(GO Reference Genome Project, 2011-)

involved_in sensory organ development

traceable author statement

(Skaer et al., 2002)

inferred from biological aspect of ancestor with PANTHER:PTN000446010

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000446010

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

cousin of atonal (cato) encodes a transcription factor involved in the development of the sensory nervous system. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -: Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).

Summary (Interactive Fly)

bHLH transcription factor required for sensory neuron morphology - plays roles in sense organ precursor maintenance and/or identity, and in controlling the number of cell divisions in the neuronal branch of the lineage arising from these precursors

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\cato for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q0IGT4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

cato-RA

FBtr0087183

NM_057996

712

189

Additional Transcript Data and Comments

Reported size (kB)

0.8 (northern blot)

(Goulding et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

cato-PA

FBpp0086327

20.6

189

4.80

Q0IGT4

NP_477344

AAF58026

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

189 (aa)

(Goulding et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cato using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cato_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 10

C1 chordotonal organ precursor cell

(Goulding et al., 2000)

embryonic stage 10 -- 11

chordotonal organ precursor cell

(Goulding et al., 2000)

embryonic stage 10 -- 13

presumptive embryonic/larval peripheral nervous system

(Goulding et al., 2000)

embryonic stage 11 -- 12

antennal primordium

(Fisher et al., 2012)

Bolwig organ primordium

Comment: reported as larval eye primordium

(Fisher et al., 2012)

dorsal sensory complex primordium

(Fisher et al., 2012)

posterior pharyngeal sense organ primordium

(Fisher et al., 2012)

labial sensory complex primordium

(Fisher et al., 2012)

labral sensory complex primordium

(Fisher et al., 2012)

maxillary sensory complex primordium

(Fisher et al., 2012)

ventral sensory complex anlage

(Fisher et al., 2012)

embryonic stage 11 -- 13

sensory mother cell

(Goulding et al., 2000)

external sensory organ precursor cell

(Goulding et al., 2000)

embryonic stage 13 -- 16

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

ventral sensory complex primordium

(Fisher et al., 2012)

larval stage

sensory mother cell

(Goulding et al., 2000)

peripheral nervous system

(Goulding et al., 2000)

imaginal disc

(Goulding et al., 2000)

Additional Descriptive Data

cato transcripts are expressed specifically in the developing PNS during neurogenesis. Expression is first observed at embryonic stage 10-11 in the chordotonal SOPs. Expression continues in many or all SOPs through stages 11 and 12 and is switched off by the end of stage 13. The timing of expression varies between different SOP subtypes. In larval imaginal discs, cato epxression is again restricted to the PNS and is confined to the SOPs and their progeny.

(Goulding et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\cato in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\cato

View exonic expression by tissue for Dmel\cato

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024249

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36813/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0024249

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024249

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0024249

Flygut - An atlas of the Drosophila adult midgut

FBgn0024249

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of cato

Transgenic constructs containing regulatory region of cato

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2R)Exel6063

(Ryder, 2004.4.26)

Df(2R)Jp7

(Goulding et al., 2000)

Df(2R)Jp8

(Goulding et al., 2000)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal | male limited, with Scer\GAL4^Bx-MS1096

cato^{UAS.ORF.GW.Tag:HA}

partially lethal | male limited | cold sensitive, with Scer\GAL4^Bx-MS1096

cato^{UAS.ORF.GW.Tag:HA}

partially lethal - majority die, with Scer\GAL4^phtm.PO

cato^KK103853

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cato^GD4281

viable, with Scer\GAL4^Mef2.PR

cato^GD4281

viable, with Scer\GAL4^pnr-MD237

cato^GD4281

viable, with Scer\GAL4^tin.CΔ4

cato^GD4281

Other Phenotypes

Allele

abnormal neuroanatomy | embryonic stage

abnormal neuroanatomy | embryonic stage (with Df(2R)Jp7)

cato⁵¹³

visible | female limited, with Scer\GAL4^Bx-MS1096

cato^{UAS.ORF.GW.Tag:HA}

visible | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

cato^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

abdominal lch1 neuron | increased number

cato⁵³⁶

abdominal lch1 neuron | increased number (with Df(2R)Jp7)

cato⁵¹³

chordotonal neuron | increased number

chordotonal organ, with Scer\GAL4^h-1J3

cato^UAS.cGa

chordotonal organ | ectopic, with Scer\GAL4^h-1J3

cato^UAS.cGa

chordotonal organ | ectopic, with Scer\GAL4^sca-109-68

cato^UAS.cGa

macrochaeta, with Scer\GAL4^sca-109-68

cato^UAS.cGa

macrochaeta | ectopic, with Scer\GAL4^sca-109-68

cato^UAS.cGa

scolopidium, with Scer\GAL4^sca-109-68

cato^UAS.cGa

wing, with Scer\GAL4^Bx-MS1096

cato^{UAS.ORF.GW.Tag:HA}

wing | cold sensitive, with Scer\GAL4^Bx-MS1096

cato^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (55)

Hsap\ATOH1

4 of 14

Yes

Hsap\ATOH7

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (52)

Rnor\Atoh1

4 of 14

Yes

Rnor\Atoh7

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (55)

Mmus\Atoh1

4 of 14

Yes

Mmus\Atoh7

4 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (35)

Xtro\atoh7

3 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\neurod4

1 of 13

Yes

Xtro\neurod6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (53)

Drer\atoh1a

5 of 14

Yes

Drer\atoh7

5 of 14

Yes

4 of 14

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-196c10.13

1 of 14

Drer\si:ch211-246m6.4

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (21)

Cele\lin-32

8 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (25)

Agam\AgaP_AGAP007822

5 of 12

Yes

4 of 12

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP013335

1 of 12

Agam\AgaP_AGAP013406

1 of 12

Arabidopsis thaliana (thale-cress) (5)

Atha\bHLH38

1 of 13

Yes

Atha\bHLH39

1 of 13

Yes

Atha\BHLH100

1 of 13

Yes

Atha\BHLH101

1 of 13

Yes

Atha\UNE10

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:cato. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (25)

amos

5 of 13

ato

5 of 13

3 of 13

crp

2 of 13

dimm

2 of 13

net

2 of 13

Oli

2 of 13

tap

2 of 13

1 of 13

ase

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

nau

1 of 13

sage

1 of 13

soul

1 of 13

twi

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

ATOH1; atonal bHLH transcription factor 1

model of autosomal dominant nonsyndromic deafness 89

IEA

(FlyBase, 2019-)

ATOH7; atonal bHLH transcription factor 7

model of persistent hyperplastic primary vitreous

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATOH1; atonal bHLH transcription factor 1

4 of 14

601461

DEAFNESS, AUTOSOMAL DOMINANT 89; DFNA89

autosomal dominant nonsyndromic deafness 89

ATOH7; atonal bHLH transcription factor 7

4 of 14

609875

PERSISTENT HYPERPLASTIC PRIMARY VITREOUS, AUTOSOMAL RECESSIVE; PHPVAR

persistent hyperplastic primary vitreous

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

cato - CG33695

two hybrid array

(Shokri et al., 2019)

cato - Rel

two hybrid array

(Shokri et al., 2019)

cato - bun

two hybrid array

(Shokri et al., 2019)

cato - sr

two hybrid array

(Shokri et al., 2019)

cato - trabl

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cato

suppressible

CycA

(zur Lage and Jarman, 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62531

DroID - A comprehensive database of gene and protein interactions.

FBgn0024249

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-79

Cytogenetic map

53A4-53A4

Sequence location

2R:16,277,685..16,278,396 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

53A4-53A4

Limits computationally determined from genome sequence between P{lacW}Lis-1^k11702&P{EP}CG8443^EP969 and P{lacW}l(2)k07824^k07824&P{lacW}veg^k03402

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

53A3-53A5

(determined by in situ hybridisation)

(Goulding et al., 2000)

53A3-53A5

(Goulding, 1999.3.15)

53A-53A

(determined by in situ hybridisation)

(Jarman, 1998.3.18)

Experimentally Determined Recombination Data

Location

2-79

(FlyBase, 2016)

2-81.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

59985

w¹¹¹⁸; PBac{cato-GFP.FPTB}VK00033

26317

y¹ v¹; P{TRiP.JF02090}attP2

79929

y¹ sc^* v¹ sev²¹; P{TOE.GS02208}attP40

FlyORF

F004501

M{UAS-cato.ORF-CC}ZH-21F

F000077

M{UAS-cato.ORF.3xHA.GW}ZH-86Fb

VDRC

v101564

P{KK103853}VIE-260B

v37611

w¹¹¹⁸; P{GD4281}v37611

v341558

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00636}attP40/CyO-GFP

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0024249

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0024249

Antibody Information

Laboratory Generated Antibodies

polyclonal

(zur Lage and Jarman, 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

cato is involved in sensory neuron morphology.

(Goulding et al., 2000)

cato is identified degenerate PCR which contain bHLH domains with closest similarity to ato. RNA is seen in sense organ precursor cells (SOPs) and their daughters.

(Goulding and Jarman, 1998)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Name Synonyms

Drosophila atonal homologue

(Goulding and Jarman, 1998)

cousin of atonal

(Urbach et al., 2016, zur Lage and Jarman, 2010, Lage and Jarman, 2008, Jarman, 1998.3.18)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36813

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q0IGT4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q0IGT4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024249

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36813/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0024249

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0024249

FlyMine - An integrated database for Drosophila genomics

FBgn0024249

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7760

MARRVEL_MODEL - MARRVEL (model organism gene)

36813

Linkouts

BioGRID - A database of protein and genetic interactions.

62531

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0024249

DroID - A comprehensive database of gene and protein interactions.

FBgn0024249

DRSC - Results frm RNAi screens

FBgn0024249

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cato_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024249

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0024249

Flygut - An atlas of the Drosophila adult midgut

FBgn0024249

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (56)

The following external sites may use different assemblies or annotations than FlyBase.

NA

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