Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
3.162 (longest cDNA)
None of the polypeptides share 100% sequence identity.
602 (aa); 66 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Amph using the Feature Mapper tool.
Amph protein is distributed in a polarized fashion in clusters of migrating border follicle cells, being present at high levels in the trailing border cells.
Amph protein is first detected in cellularizing embryos at the sites of developing cell membranes. Later, Amph is localized to epithelial tissues and the embryonic foregut and hindgut. In third instar larvae, Amph protein is cytoplasmic, and found in epithelial cells and somatic muscles. In the later, Amph is localized to the postsynaptic membrane of neuromuscular junctions.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Amph in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The structure of the Amph BAR domain has been solved: It is a crescent-shaped dimer that binds preferentially to highly curved negatively charged membranes.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
Area matching Drosophila EST AA540348.
Amph is involved in the structural organisation of the membrane-bound compartments of the excitation-contraction coupling machinery of muscles, but not in synaptic vesicle endocytosis.