FlyBase Gene Report: Dmel\IA-2

General Information

Symbol

Dmel\IA-2

Species

D. melanogaster

Name

IA-2 protein tyrosine phosphatase

Annotation Symbol

CG31795

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031294

Gene Model Status

Current

Stock Availability

23 publicly available

Gene Summary

IA-2 protein tyrosine phosphatase (IA-2) encodes a protein involved in gut development and insulin-like peptide secretion. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

ia2

Key Links

Genomic Location

Cytogenetic map

21E3-21E3

Sequence location

2L:1,008,378..1,048,053 [-]

Recombination map

2-1.5

RefSeq locus

NT_033779 REGION:1008378..1048053

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

NOT enables phosphatase activity

inferred from key residues

(Hatzihristidis et al., 2015)

NOT enables protein tyrosine phosphatase activity

inferred from key residues

(Hatzihristidis et al., 2015)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in digestive tract development

inferred from mutant phenotype

(Kim et al., 2008)

involved_in regulation of secretion

inferred from mutant phenotype

(Kim et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of secretion

inferred from biological aspect of ancestor with PANTHER:PTN000439769

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in secretory granule

inferred from biological aspect of ancestor with PANTHER:PTN000439769

(GO Reference Genome Project, 2011-)

located_in secretory granule

inferred from electronic annotation with InterPro:IPR033522

(InterPro Project Members, 2004-)

is_active_in synapse

inferred from biological aspect of ancestor with PANTHER:PTN000439769

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PSEUDOPHOSPHATASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

IA-2 protein tyrosine phosphatase (IA-2) encodes a protein involved in gut development and insulin-like peptide secretion. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

PSEUDOPHOSPHATASES -: Pseudophosphatases are proteins that are evolutionary related to phosphatases but lack relevant catalytic activity. Proposed functions of pseudophosphatases include: (i) being part of scaffolding signaling complexes; (ii) acting as 'antiphosphatases' that protect specific substrates from other active phosphatases; and (iii) working as functional inhibitors of their substrate. (Adapted from FBrf0227974.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\IA-2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPV8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

IA-2-RC

FBtr0301416

NM_134718

6722

1319

IA-2-RD

FBtr0301417

NM_164401

9821

1306

IA-2-RE

FBtr0332270

NM_001272922

6648

1318

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

IA-2-PC

FBpp0290630

146.9

1319

6.34

FBpp0290631

145.6

1306

6.34

FBpp0304559

147.1

1318

6.34

M9PAZ4

NP_001259851

AGB92388

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\IA-2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.70

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

epithelial cell

• cytoplasm | apical

Comment: clustered apical distribution

(Lecuyer et al., 2007)

epithelium

• cytoplasm | apical

(Lecuyer et al., 2007)

embryonic stage 12 -- 15

larval neuron | subset of presumptive embryonic/larval central nervous system

(Cai et al., 2001)

first instar larval stage

larval brain

(Kim et al., 2008)

embryonic/larval midgut

(Kim et al., 2008)

third instar larval stage

larval brain

(Kim et al., 2008)

embryonic/larval midgut

(Kim et al., 2008)

adult stage

adult brain

(Kim et al., 2008)

adult midgut

(Kim et al., 2008)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage -- adult stage

organism

(Kim et al., 2008)

Additional Descriptive Data

IA-2 transcript is observed in a subset of neurons flanking the ventral ventral cord midline, and in a subset of neurons in the cephalic lobe,beginning at embryonic stage 12.

(Cai et al., 2001)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: PBac{566.P.SVS-1}IA-2^CPTI100013

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult lateral horn

(Knowles-Barley, 2011.8.24)

medulla

(Knowles-Barley, 2011.8.24)

adult mushroom body

(Knowles-Barley, 2011.8.24)

adult protocerebrum

(Knowles-Barley, 2011.8.24)

fan-shaped body

(Knowles-Barley, 2011.8.24)

adult antennal lobe

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\IA-2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\IA-2

View exonic expression by tissue for Dmel\IA-2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33277/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031294

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031294

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031294

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31795

Flygut - An atlas of the Drosophila adult midgut

FBgn0031294

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\IA-2

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of IA-2

Transgenic constructs containing regulatory region of IA-2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel6003

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^Kr.PU

IA-2^RNAi.UAS

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

IA-2^GD537

viable, with Scer\GAL4^Mef2.PR

IA-2^GD537

viable, with Scer\GAL4^pnr-MD237

IA-2^GD537

viable, with Scer\GAL4^tin.CΔ4

IA-2^GD537

Other Phenotypes

Allele

increased cell number | larval stage, with Scer\GAL4^repo.PU

IA-2^UAS.cHa

some die during pupal stage, with Scer\GAL4^Kr.PU

IA-2^RNAi.UAS

Phenotype manifest in

Allele

larval ventral nerve cord, with Scer\GAL4^repo.PU

IA-2^UAS.cHa

pupal abdomen, with Scer\GAL4^Kr.PU

IA-2^RNAi.UAS

pupal cuticle, with Scer\GAL4^Kr.PU

IA-2^RNAi.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (37)

Hsap\PTPRN2

11 of 14

Yes

Hsap\PTPRN

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (27)

Rnor\Ptprn2

11 of 14

Yes

Rnor\Ptprn

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (27)

Mmus\Ptprn2

11 of 14

Yes

Mmus\Ptprn

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (10)

Xtro\ptprn

7 of 13

Yes

Xtro\ptprn2

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (31)

Drer\ptprn2

11 of 14

Yes

Drer\ptprna

11 of 14

Yes

Drer\ptprnb

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ptpn18

1 of 14

Drer\ptpn22

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ptprsa

1 of 14

Drer\ptprt

1 of 14

Drer\ptprz1a

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (64)

Cele\ida-1

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\Y22D7AR.7

1 of 14

Yes

Cele\Y39B6A.30

1 of 14

Cele\Y48G1C.5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (13)

Agam\AgaP_AGAP008127

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PTP1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:IA-2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (14)

Lar

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

csw

2 of 13

Ptp36E

2 of 13

Ptpmeg

2 of 13

CG42327

1 of 13

Pez

1 of 13

Ptp99A

1 of 13

PTP-ER

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PTPRN2; protein tyrosine phosphatase receptor type N2

11 of 14

601698

PTPRN; protein tyrosine phosphatase receptor type N

11 of 14

601773

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

IA-2

suppressible

Hex-C

(Kim et al., 2008)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

kon

suppressible

IA-2

(Harrison et al., 2021)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59531

DroID - A comprehensive database of gene and protein interactions.

FBgn0031294

MIST (protein-protein) - An integrated Molecular Interaction Database

33277

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-1.5

Cytogenetic map

21E3-21E3

Sequence location

2L:1,008,378..1,048,053 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21E3-21E3

Limits computationally determined from genome sequence between P{lacW}l(2)k09610^k09610&P{lacW}S^k09538a and P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-1.5

(FlyBase, 2016)

2-1.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (23)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

81920

w^*; PBac{U6:3-IA-2.gRNA}VK00027

24255

w¹¹¹⁸; Mi{ET1}IA-2^MB05302

44099

y¹ v¹; P{TRiP.HMS02819}attP40

Kyoto

123650

w¹¹¹⁸; P{RS3}IA-2^CB-5483-3

125014

w¹¹¹⁸; P{RS5}IA-2^5-HA-1023

115077

w¹¹¹⁸; PBac{566.P.SVS-1}IA-2^CPTI100013

203335

y¹ w^67c23; P{GSV6}IA-2^GS11438/SM1

NIG-Fly

11344R-3

P{NIG.11344R}3

11344R-4

P{NIG.11344R}4

HMS02819

y¹ v¹; P{TRiP.HMS02819}attP40/CyO

VDRC

v110595

P{KK108555}VIE-260B

v7560

w¹¹¹⁸; P{GD537}v7560

More stocks available...

Genomic Clones (26)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (41)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031294

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031294

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

S2R+-IA2-KO

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: ia2 CG11344

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: ia2 anon-WO0153538.69

(FlyBase, 1996-)

Additional comments

Annotations CG11344 and CG4355 merged as CG31795 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for identity of ia2 CG4355 was sequence comparison ( date:010307 ).

(FlyBase, 1996-)

Source for merge of ia2 anon-WO0153538.69 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: ia2 CG4355

(FlyBase, 1996-)

Source for identity of: IA-2 ia2

(Cai et al., 2001)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG11344

CG31795

(National Institute of Genetics Fly Stocks, 2022-, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Kim et al., 2008)

CG4355

IA-2

(Voutyraki et al., 2023, Kawakami et al., 2022, Baker et al., 2021, McLaughlin et al., 2021, Xie et al., 2021, Hung et al., 2020, Zhao et al., 2020, Gene Disruption Project members, 2018-, Liu et al., 2017, Transgenic RNAi Project members, 2017-, Hatzihristidis et al., 2015, Morgante et al., 2015, Morozova et al., 2015, Yu et al., 2015, Cai et al., 2001)

IA2

(Lund et al., 2021, Chapman et al., 2020, Hope et al., 2019, Luhur et al., 2019, Andersen et al., 2004)

R-PTPX/1A2

(Morrison et al., 2000)

anon-WO0153538.69

ia-2

(Harrison et al., 2021)

ia2

(Titlow et al., 2023, Cao et al., 2014, Chatterjee et al., 2014, Webber et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Murray et al., 2012, Sorge et al., 2012, Abruzzi et al., 2011, Knowles-Barley et al., 2010, Kim et al., 2008, Lecuyer et al., 2007, Gauthier and Hewes, 2006, Liebl and Featherstone, 2005, Liu et al., 2005, Yang et al., 2004)

Name Synonyms

IA-2 ortholog

IA-2 protein tyrosine phosphatase

Ia2

(Khanna et al., 2010)

ia2

Secondary FlyBase IDs

FBgn0031297
FBgn0045882
FBgn0051795

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33277

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPV8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPV8

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33277/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031294

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031294

FlyMine - An integrated database for Drosophila genomics

FBgn0031294

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31795

MARRVEL_MODEL - MARRVEL (model organism gene)

33277

Linkouts

BioGRID - A database of protein and genetic interactions.

59531

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031294

DroID - A comprehensive database of gene and protein interactions.

FBgn0031294

DRSC - Results frm RNAi screens

FBgn0031294

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031294

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031294

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31795

Flygut - An atlas of the Drosophila adult midgut

FBgn0031294

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0031294

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012616

MIST (protein-protein) - An integrated Molecular Interaction Database

33277

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

References (85)

The following external sites may use different assemblies or annotations than FlyBase.

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