FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Prp8
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General Information
Symbol
Dmel\Prp8
Species
D. melanogaster
Name
pre-mRNA processing factor 8
Annotation Symbol
CG8877
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033688
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
pre-mRNA processing factor 8 (Prp8) is an essential gene that encodes the largest and most highly conserved splicing factor. It is a core component of the U5 snRNP, with a key function in pre-mRNA processing catalyzed by the spliceosome. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
48E3-48E4
Sequence location
Recombination map
2-66
RefSeq locus
NT_033778 REGION:12154258..12162998
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
enables RNA binding
inferred from electronic annotation with InterPro:IPR019582
(InterPro Project Members, 2004-)
contributes_to second spliceosomal transesterification activity
inferred from biological aspect of ancestor with PANTHER:PTN000124558
(GO Reference Genome Project, 2011-)
enables snRNA binding
inferred from sequence or structural similarity with SGD:S000001208
(Gene Ontology Curators, 2002-)
enables U5 snRNA binding
inferred from electronic annotation with InterPro:IPR019581
(InterPro Project Members, 2004-)
enables U6 snRNA binding
inferred from electronic annotation with InterPro:IPR019580
(InterPro Project Members, 2004-)
NOT enables metal-dependent deubiquitinase activity
inferred from sequence or structural similarity with UniProtKB:Q6P2Q9
(Gene Ontology Curators, 2002-)
inferred from key residues
(GO curators, 2012-)
NOT enables peptidase activity
inferred from key residues
(GO curators, 2012-)
inferred from sequence or structural similarity with UniProtKB:Q6P2Q9
(Gene Ontology Curators, 2002-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in mRNA splicing, via spliceosome
inferred from mutant phenotype
(Monedero Cobeta et al., 2018, Claudius et al., 2014, Andersen and Tapon, 2008)
involved_in ventral cord development
inferred from high throughput mutant phenotype
(Bivik et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mRNA cis splicing, via spliceosome
inferred from biological aspect of ancestor with PANTHER:PTN000124558
(GO Reference Genome Project, 2011-)
involved_in mRNA splicing, via spliceosome
inferred by curator from GO:0071011,GO:0071013
(Herold et al., 2009)
inferred from sequence or structural similarity with SGD:S000001208
(Mount and Salz, 2000)
inferred from electronic annotation with InterPro:IPR012591, InterPro:IPR012592, InterPro:IPR027652
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR027652
(InterPro Project Members, 2004-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
located_in cytoplasm
inferred from direct assay
(Claudius et al., 2014)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
part_of small nuclear ribonucleoprotein complex
inferred from physical interaction with FLYBASE:CG12320; FB:FBgn0038590
(Claudius et al., 2014)
inferred from physical interaction with FLYBASE:CG4849; FB:FBgn0039566
(Claudius et al., 2014)
inferred from physical interaction with FLYBASE:Brr2; FB:FBgn0263599
(Claudius et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from biological aspect of ancestor with PANTHER:PTN000124558
(GO Reference Genome Project, 2011-)
part_of spliceosomal complex
inferred from electronic annotation with InterPro:IPR027652
(InterPro Project Members, 2004-)
part_of U5 snRNP
inferred from biological aspect of ancestor with PANTHER:PTN000124558
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with SGD:S000001208
(Mount and Salz, 2000)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
pre-mRNA processing factor 8 (Prp8) is an essential gene that encodes the largest and most highly conserved splicing factor. It is a core component of the U5 snRNP, with a key function in pre-mRNA processing catalyzed by the spliceosome. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -
The U5 small nuclear ribonucleoprotein particle (U5 snRNP) contains U5 RNA and assembles with U4-U6 snRNP to form the U4-U6.U5 tri-snRNP. U5 snRNA interacts with the 5' and 3' exons. (Adapted from PMID:21441581).
U4-U6-U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -
U4/U6.U5 tri-snRNP is assembled from U5 and U4/U6 snRNPs. The complex contains U4 and U6 snRNAs base-paired with each other and U6 snRNA. This complex is recruited to the pre-catalytic splicing intermediate, complex B. (Adapted from PMID:21441581).
SPLICEOSOME COMPLEX B -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. After the assembly of complex A on pre-mRNA, the U4-U6 and U5 snRNPs are recruited as a preassembled tri-snRNP to form complex B. U5 snRNP binds exons at the 5' site. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX C -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex B undergoes a number of structural rearrangements and U4 and U1 snRNPs dissociate to generate complex C, the catalytic spliceosome. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX P -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex P, the post-spliceosomal complex, is formed after the catalytic removal of the intron by complex C. Complex P contains the lariat intron and spliced exons. (Adapted from PMID:24452469 and PMID:23118483).
M67 NON-PEPTIDASE HOMOLOGS -
M67 non-peptidase homologs are similar in amino acid sequence to JAMM deubiquitinases (M67 metallopeptidases) but lack one or more of the expected catalytic residues or zinc-binding sites. They may act as scaffold proteins or as ubiquitin-binding modules within complexes. (Adapted from FBrf0239469 and PMID:17559875.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Prp8 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A1Z8U0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Prp8-RA
FBtr0088016
NM_136891
7442
2396
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Prp8-PA
FBpp0087124
279.6
2396
9.19
A1Z8U0
NP_610735
AAF58573
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Prp8 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.64

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
located_in cytoplasm
inferred from direct assay
(Claudius et al., 2014)
part_of precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
part_of small nuclear ribonucleoprotein complex
inferred from physical interaction with FLYBASE:CG12320; FB:FBgn0038590
(Claudius et al., 2014)
inferred from physical interaction with FLYBASE:CG4849; FB:FBgn0039566
(Claudius et al., 2014)
inferred from physical interaction with FLYBASE:Brr2; FB:FBgn0263599
(Claudius et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Prp8 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Prp8
Transgenic constructs containing regulatory region of Prp8
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2R)BSC40
(Coelho et al., 2005)
Gene not disrupted in
Df(2R)CB21
(Coelho et al., 2005)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4insc-Mz1407
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4pnr-MD237
lethal - all die before end of larval stage (with Prp82e1)
lethal - all die before end of larval stage (with Prp82e2)
lethal - all die before end of pupal stage, with Scer\GAL4dpp.PU
lethal - all die before end of pupal stage | heat sensitive, with Scer\GAL4dpp.PU
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
male sterile, with Scer\GAL4VP16.bam
Other Phenotypes
Allele
abnormal neuroanatomy
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal size | third instar larval stage, with Scer\GAL4Cg.PA
decreased body size | larval stage (with Prp82e1)
decreased body size | larval stage (with Prp82e2)
increased cell death, with Scer\GAL4dpp.PU
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during larval stage (with Prp82e1)
some die during larval stage (with Prp82e2)
some die during pupal stage, with Scer\GAL4dpp.PU
some die during pupal stage | heat sensitive, with Scer\GAL4dpp.PU
visible, with Scer\GAL4bbg-C96
visible, with Scer\GAL4dpp.PU
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
anterior crossvein, with Scer\GAL4dpp.PU
apterous-expressing neuron of the lateral cluster of the thorax | ectopic
apterous-expressing neuron of the lateral cluster of the thorax Ap4
embryonic/larval fat body | third instar larval stage, with Scer\GAL4Cg.PA
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
first posterior wing cell, with Scer\GAL4dpp.PU
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
larval somatic muscle cell, with Scer\GAL4Mef2.PR
mesonotum, with Scer\GAL4pnr-MD237
mitochondrion | third instar larval stage, with Scer\GAL4Cg.PA
prothoracic gland | larval stage, with Scer\GAL4phtm.PO
sarcomere, with Scer\GAL4Mef2.PR
scutellar bristle, with Scer\GAL4dpp.PU
spermatogonium, with Scer\GAL4VP16.bam
spermatozoon, with Scer\GAL4VP16.bam
wing, with Scer\GAL4bbg-C96
wing disc, with Scer\GAL4dpp.PU
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\PRPF8
13 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Prpf8
14 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Prpf8
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\prpf8
11 of 13
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\prpf8
14 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\prp-8
14 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP006885
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\AT4G38780
13 of 13
Yes
Yes
Atha\SUS2
13 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PRP8
13 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\spp42
12 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Prp8. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 9 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
PRPF8; pre-mRNA processing factor 8
model of  retinitis pigmentosa 13
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Prp8GD6578
exacerbates  Machado-Joseph disease
modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
(Voßfeldt et al., 2012)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PRPF8; pre-mRNA processing factor 8
13 of 14
607300
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Prp8 - Brr2
anti tag coimmunoprecipitation, anti tag western blot, experimental knowledge based
(Claudius et al., 2014, Guruharsha et al., 2011)
Prp8 - Bx42
experimental knowledge based
(Guruharsha et al., 2011)
Prp8 - CG12320
anti tag coimmunoprecipitation, anti tag western blot
(Claudius et al., 2014)
Prp8 - CG14641
experimental knowledge based
(Guruharsha et al., 2011)
Prp8 - CG1965
experimental knowledge based
(Guruharsha et al., 2011)
Prp8 - CG3436
experimental knowledge based
(Guruharsha et al., 2011)
Prp8 - CG4849
experimental knowledge based, anti tag coimmunoprecipitation, anti tag western blot
(Claudius et al., 2014, Guruharsha et al., 2011)
Prp8 - CG6015
experimental knowledge based
(Guruharsha et al., 2011)
Prp8 - CG6674
experimental knowledge based
(Guruharsha et al., 2011)
Prp8 - CG9667
experimental knowledge based
(Guruharsha et al., 2011)
Prp8 - Mfap1
anti bait coimmunoprecipitation, peptide massfingerprinting
(Andersen and Tapon, 2008)
Prp8 - Prp38
anti bait coimmunoprecipitation, peptide massfingerprinting
(Andersen and Tapon, 2008)
Prp8 - Pten
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Prp8 - S6kII
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Prp8 - SmD3
anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry
(Erkelenz et al., 2021)
Prp8 - Wdr92
experimental knowledge based
(Guruharsha et al., 2011)
Prp8 - crn
experimental knowledge based
(Guruharsha et al., 2011)
Prp8 - ecd
anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot, peptide massfingerprinting, experimental knowledge based
(Erkelenz et al., 2021, Claudius et al., 2014, Guruharsha et al., 2011)
Prp8 - fand
experimental knowledge based
(Guruharsha et al., 2011)
Prp8 - foxo
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Prp8 - gig
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Prp8 - l(1)10Bb
experimental knowledge based
(Guruharsha et al., 2011)
Summary of Genetic Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
aos
enhanceable
Prp8
(Coelho et al., 2005)
Pi3K92E
enhanceable
Prp8
(Coelho et al., 2005)
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-66
Cytogenetic map
48E3-48E4
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
48E3-48E4
Limits computationally determined from genome sequence between P{lacW}jebk05644 and P{PZ}SmD302833
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

2-66

(FlyBase, 2016)

2-67.4

(Comeron et al., 2012)

2-

(Coelho et al., 2005)
Left of (cM)
(Coelho et al., 2005)
Right of (cM)
(Coelho et al., 2005)
Notes
Stocks and Reagents
Stocks (12)
Genomic Clones (23)
cDNA Clones (54)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Erkelenz et al., 2021, Stanković et al., 2020)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        Identification: as a complementation group whose members dominantly modify the small wing phenotype caused by expression of Pi3K92ED954A.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096. 2 alleles of prp8 have been recovered.

        (Coelho et al., 2005)

        Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.

        (Nybakken et al., 2005)
        Relationship to Other Genes
        Source for database merge of
        Additional comments

        snoRNA:Prp8-a is encoded in an intron of Prp8.

        (Graveley et al., 2011)

        The mir-988 microRNA is derived from an intron of Prp8.

        (Kawamura et al., 2008)
        Nomenclature History
        Source for database identify of

        Source for identity of: prp8 CG8877

        (Coelho et al., 2005)
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (7)
        Reported As
        Symbol Synonym
        A1Z8U0
        (Clague et al., 2013)
        CG8877
        (National Institute of Genetics Fly Stocks, 2022-, Páhi et al., 2022, Wu et al., 2016, Lin et al., 2015, Claudius et al., 2014, Tsou et al., 2012, Voßfeldt et al., 2012, Zhang et al., 2012, Lee et al., 2010, Ni et al., 2010.12.1, Herold et al., 2009, Andersen and Tapon, 2008, Holloway et al., 2008, Coelho et al., 2005, Nybakken et al., 2005, Giot et al., 2003, Lai et al., 2003, Ramet et al., 2002, Mount and Salz, 2000)
        E-2e
        (Coelho et al., 2005)
        Prp8
        (Lee et al., 2024, Zhao et al., 2024, Páhi et al., 2022, Repton et al., 2022, Kao et al., 2021, Sureka and Mishra, 2021, Chen et al., 2019, Gao et al., 2019, Lehmann et al., 2019, Zhou et al., 2019, Gene Disruption Project members, 2018-, Monedero Cobeta et al., 2018, Transgenic RNAi Project members, 2017-, David-Morrison et al., 2016, Garcia et al., 2016, Bivik et al., 2015, Kwong et al., 2015, Ashton-Beaucage et al., 2014, Lu et al., 2014, Kwon et al., 2013, Neumüller et al., 2013, Tsou et al., 2012, Voßfeldt et al., 2012, Zhang et al., 2012, Friedman et al., 2011, Graveley et al., 2011, Dekanty et al., 2010, Somma et al., 2008)
        prp8
        (Stanković et al., 2024, Badmos et al., 2021, Stanković et al., 2020, Shakhmantsir et al., 2018, Sharma et al., 2017, Wu et al., 2016, Chen et al., 2014, Claudius et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Graveley et al., 2011, Neumüller et al., 2011, Herold et al., 2009, Andersen and Tapon, 2008, Holloway et al., 2008, Kawamura et al., 2008, Lecuyer et al., 2007)
        Name Synonyms
        Prp8
        (Somma et al., 2008)
        U5 small nuclear ribonucleoprotein-specific factor
        (Lee et al., 2010)
        pre-mRNA processing factor 8
        prp8
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          External Crossreferences and Linkouts ( 47 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (93)