FlyBase Gene Report: Dmel\NSD

General Information

Symbol

Dmel\NSD

Species

D. melanogaster

Name

Nuclear receptor binding SET domain protein

Annotation Symbol

CG4976

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039559

Gene Model Status

Current

Stock Availability

8 publicly available

Enzyme Name (EC)

[histone H3]-lysine(36) N-dimethyltransferase (2.1.1.357)

Gene Summary

Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity). (UniProt, Q8MT36)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

Mes-4, dMes-4

Key Links

Genomic Location

Cytogenetic map

98B6-98B6

Sequence location

3R:27,932,982..27,937,853 [-]

Recombination map

3-94

RefSeq locus

NT_033777 REGION:27932982..27937853

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables chromatin DNA binding

inferred from direct assay

(Alekseyenko et al., 2014)

enables histone H3K36 dimethyltransferase activity

inferred from mutant phenotype

(Won et al., 2023)

enables transcription coactivator activity

inferred from direct assay

(Won et al., 2023)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables histone H3K36 methyltransferase activity

inferred from biological aspect of ancestor with PANTHER:PTN002739645

(GO Reference Genome Project, 2011-)

enables histone methyltransferase activity

inferred from electronic annotation with InterPro:IPR006560

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with WB:WBGene00003222

(Gene Ontology Curators, 2002-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in positive regulation of canonical NF-kappaB signal transduction

inferred from direct assay

(Won et al., 2023)

involved_in positive regulation of transcription by RNA polymerase II

inferred from direct assay

(Won et al., 2023)

involved_in transposable element silencing by heterochromatin formation

inferred from mutant phenotype

(Lindehell et al., 2023)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in chromatin remodeling

inferred by curator from GO:0003713

(Won et al., 2023)

involved_in germ-line sex determination

inferred from sequence or structural similarity with UniProtKB:Q9NH52

(Gene Ontology Curators, 2002-)

involved_in regulation of DNA-templated transcription

inferred from biological aspect of ancestor with PANTHER:PTN002739645

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in heterochromatin

inferred from direct assay

(Won et al., 2023)

located_in pericentric heterochromatin

inferred from direct assay

(Alekseyenko et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in chromatin

inferred from biological aspect of ancestor with PANTHER:PTN002739645

(GO Reference Genome Project, 2011-)

is_active_in nuclear chromosome

inferred from sequence or structural similarity with UniProtKB:Q9NH52

(Gene Ontology Curators, 2002-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002739645

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from electronic annotation with InterPro:IPR006560

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

SET DOMAIN LYSINE METHYLTRANSFERASES

Pathway (FlyBase)

POSITIVE REGULATORS OF IMD SIGNALING PATHWAY

Protein Family (UniProt)

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (Q8MT36)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

histone methyltransferase activity
histone H3K36 dimethyltransferase activity

L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)- dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+) (2.1.1.357)

RHEA 60308:

Summaries

Gene Group (FlyBase)

SET DOMAIN LYSINE METHYLTRANSFERASES -: SET domain lysine methyltransferases (KMTs) catalyze the addition of methyl groups to lysine residues. SET domain KMTs possess a domain that was original characterized in the D.mel KMTs Su(var)3-9, E(z) and trx. (Adapted from FBrf0216343).

Pathway (FlyBase)

POSITIVE REGULATORS OF IMD SIGNALING PATHWAY -: Positive regulators of the immune deficiency (Imd) pathway result in the increased activity of the NFκB-like transcription factor Rel in the nucleus. (Adapted from FBrf0224587 and FBrf0238555.)

Protein Function (UniProtKB)

Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity).

(UniProt, Q8MT36)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\NSD for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8MT36)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

NSD-RA

FBtr0085267

NM_170360

4589

1427

NSD-RB

FBtr0335014

NM_001276100

4577

1423

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

NSD-PA

FBpp0084636

159.0

1427

7.68

FBpp0307022

158.5

1423

7.62

A0A0B4KHR6

NP_001263029

AGB96409

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NSD using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Mes-4_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.25

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in heterochromatin

inferred from direct assay

(Won et al., 2023)

located_in pericentric heterochromatin

inferred from direct assay

(Alekseyenko et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\NSD in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\NSD

View exonic expression by tissue for Dmel\NSD

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039559

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43351/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039559

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039559

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039559

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4976

Flygut - An atlas of the Drosophila adult midgut

FBgn0039559

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\NSD

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of NSD

Transgenic constructs containing regulatory region of NSD

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(3R)ED6277

(Metzendorf and Lind, 2010)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

NSD^ds46

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

NSD^GD4401

viable, with Scer\GAL4^Mef2.PR

NSD^GD4401

viable, with Scer\GAL4^pnr-MD237

NSD^GD4401

viable, with Scer\GAL4^tin.CΔ4

NSD^GD4401

Sterility

Allele

fertile

NSD^ds46

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (30)

Hsap\NSD1

11 of 14

Yes

Hsap\NSD2

11 of 14

Yes

Hsap\NSD3

11 of 14

Yes

Hsap\ASH1L

2 of 14

Hsap\SETD2

2 of 14

Hsap\DNMT3A

1 of 14

Yes

Hsap\DNMT3B

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\UHRF2

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (24)

Rnor\Nsd1

11 of 14

Yes

Rnor\Nsd2

11 of 14

Yes

Rnor\Nsd3

10 of 14

Yes

Rnor\Ash1l

2 of 14

Rnor\Setd2

2 of 14

Rnor\Dnmt3a

1 of 14

Yes

Rnor\Dnmt3b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (25)

Mmus\Nsd1

11 of 14

Yes

Mmus\Nsd2

11 of 14

Yes

Mmus\Nsd3

11 of 14

Yes

Mmus\Setd2

2 of 14

Mmus\Ash1l

1 of 14

Mmus\Dnmt3a

1 of 14

Yes

Mmus\Dnmt3b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (20)

Xtro\nsd3

8 of 13

Yes

Xtro\nsd1

7 of 13

Yes

Xtro\nsd2

5 of 13

Yes

Xtro\setd2

2 of 13

Xtro\ash1l

1 of 13

Xtro\dnmt3a

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (32)

Drer\nsd3

11 of 14

Yes

Drer\nsd1b

10 of 14

Yes

Drer\nsd2

10 of 14

Yes

Drer\nsd1a

9 of 14

Yes

Drer\ash1l

2 of 14

Drer\setd2

2 of 14

Drer\dnmt3aa

1 of 14

Yes

Drer\dnmt3ab

1 of 14

Yes

Drer\dnmt3ba

1 of 14

Drer\dnmt3bb.1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\suv39h1a

1 of 14

Drer\suv39h1b

1 of 14

Drer\uhrf1

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (21)

Cele\mes-4

4 of 14

Yes

Cele\met-1

2 of 14

Cele\set-8

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (11)

Agam\AgaP_AGAP004656

11 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (45)

Atha\SDG4

5 of 13

Yes

Atha\ASHH1

3 of 13

Atha\ASHH3

3 of 13

Yes

Atha\ASHH4

3 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Atha\AT3G48187

1 of 13

Atha\AT3G51120

1 of 13

Atha\AT5G02950

1 of 13

Yes

Atha\AT5G27650

1 of 13

Yes

Atha\AT5G40340

1 of 13

Yes

Atha\AT5G47150

1 of 13

Yes

Atha\AT5G47160

1 of 13

Yes

Atha\AT5G63700

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\VIM3

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\SET2

3 of 13

Yes

Scer\SET1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\set2

3 of 12

Yes

Spom\clr4

1 of 12

Spom\set1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:NSD. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (11)

4 of 13

2 of 13

1 of 13

1 of 13

G9a

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

trr

1 of 13

trx

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

NSD^EY01950

model of syndrome

CEA

(Quintero-Rivera et al., 2021)

NSD^DP00238

model of syndrome

CEA

(Kim et al., 2020)

NSD^CRISPR

model of Sotos syndrome 1

CEA

(Choi et al., 2021)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

NSD1; nuclear receptor binding SET domain protein 1

model of Sotos syndrome 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

NSD^EY01950

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

model of syndrome

is ameliorated by InR^UAS.Exel

(Quintero-Rivera et al., 2021)

NSD^DP00238

model of syndrome

is ameliorated by Diap1^UAS.cHa

(Kim et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NSD1; nuclear receptor binding SET domain protein 1

11 of 14

606681

SOTOS SYNDROME; SOTOS

Sotos syndrome 1

NSD2; nuclear receptor binding SET domain protein 2

11 of 14

602952

RAUCH-STEINDL SYNDROME; RAUST

NSD3; nuclear receptor binding SET domain protein 3

11 of 14

607083

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

NSD - BEAF-32

affinity chromatography technology, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot, two hybrid

(Lhoumaud et al., 2014)

NSD - Su(var)205

anti tag coimmunoprecipitation, peptide massfingerprinting

(Alekseyenko et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68232

DroID - A comprehensive database of gene and protein interactions.

FBgn0039559

MIST (protein-protein) - An integrated Molecular Interaction Database

43351

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF IMD SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-94

Cytogenetic map

98B6-98B6

Sequence location

3R:27,932,982..27,937,853 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

98B6-98B6

Limits computationally determined from genome sequence between P{PZ}btz^rL203 and P{PZ}l(3)06487⁰⁶⁴⁸⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-94

(FlyBase, 2016)

3-92.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

15384

y¹ w^67c23; P{EPgy2}NSD^EY01950

85431

w¹¹¹⁸; P{XP}NSD^d03569/TM6B, Tb¹

22044

y¹ w^67c23; P{Mae-UAS.6.11}NSD^DP00238

83481

y¹ sc^* v¹ sev²¹; P{TKO.GS04163}attP40

34033

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01004}attP2

Kyoto

103639

w^*; P{GawB}NSD^NP0527 / TM3, Ser¹

VDRC

v10836

w¹¹¹⁸; P{GD4401}v10836

v10837

w¹¹¹⁸; P{GD4401}v10837/TM3

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (63)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE61305

Other clones

FI01019

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039559

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039559

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lhoumaud et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Gene expression is increased in response to the presence of two copies of Scer\GAL4^hs.PB.

(Liu and Lehmann, 2008)

One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

(Inlow and Restifo, 2004)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Mes-4 CG4976

(Ketel, 2002.3.18)

Source for identity of: NSD Mes-4

(FlyBase, 2009-)

Nomenclature comments

Renamed from 'Mes-4' to 'NSD' because: i) the 'Mes-4' symbol was too easily confused with the unrelated gene 'Mes4' (FBgn0034726); ii) the original 'Mes-4' symbol was assigned based only on an ADRC abstract (FBrf0145882); iii) FBrf0201596 and FBrf0178951 say that this gene shows homology to human and mouse NSD1, WHSC1 (aka NSD2) and WHSC1-L (NSD3); iv) FBrf0225639 uses 'NSD' as a synonym of 'Mes-4'.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG4976

(Erez et al., 2021, Ni et al., 2010.12.1, Bell et al., 2007, Bienz, 2006, Egger et al., 2002, Anholt and Mackay, 2001, Mount, 2001.8.14, den Dunnen, 2000.4.1)

MES-4

(Alekseyenko et al., 2014, Alekseyenko et al., 2014)

Mes-4

(Quintero-Rivera et al., 2021, Gulati et al., 2020, Olson et al., 2019, Kwon et al., 2013, Vagin et al., 2013, Vaque et al., 2013, Rodriguez et al., 2012, Du et al., 2011, Metzendorf and Lind, 2010, Liu and Lehmann, 2008, Yokoyama et al., 2007, Bienz, 2006)

NSD

(Jayakrishnan et al., 2025, Jayakrishnan et al., 2024, Ko et al., 2024, Owings and Chow, 2024, Ding et al., 2022, Bilder et al., 2021, Chaouch and Lasko, 2021, Choi et al., 2021, Lindehell et al., 2021, Quintero-Rivera et al., 2021, Feuillette et al., 2020, Kim et al., 2020, Meyer-Nava et al., 2020, Dorafshan et al., 2019, Sang Cho et al., 2019, Jeong et al., 2018, Kim et al., 2018)

dMES-4

(Saha et al., 2020, Wang et al., 2005, Ketel et al., 2003)

dMes-4

(Lhoumaud et al., 2014, Bell et al., 2007, Ketel et al., 2002)

Name Synonyms

Mes-4

Nuclear receptor binding SET domain protein

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 50 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43351

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8MT36

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8MT36

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KHR6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8MT36

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039559

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43351/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039559

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039559

FlyMine - An integrated database for Drosophila genomics

FBgn0039559

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4976

MARRVEL_MODEL - MARRVEL (model organism gene)

43351

Linkouts

BioGRID - A database of protein and genetic interactions.

68232

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039559

DroID - A comprehensive database of gene and protein interactions.

FBgn0039559

DRSC - Results frm RNAi screens

FBgn0039559

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Mes-4_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039559

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039559

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4976

Flygut - An atlas of the Drosophila adult midgut

FBgn0039559

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012700

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

43351

References (77)

The following external sites may use different assemblies or annotations than FlyBase.

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