amo, Almost there, Polycystic kidney disease gene-2, Dmpkd2, TRPP2
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pkd2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Pkd2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Haploinsufficient locus (not associated with strong haplolethality or haplosterility).
Pkd2 mutant sperm remain capable of reverse motility but fail to display hyperactivation.
Localisation of Pkd2 at the distal end of the sperm tail is essential for proper function.
Mutation causes male sterility. Normal amounts of motile sperm are produced by mutant males and transferred to females, but few sperm are stored.
Pkd2 is required for directional sperm movement inside the female reproductive tract and male fertility.
Named "Pkd2" after the human ortholog.