FlyBase Gene Report: Dmel\Dgk

General Information

Symbol

Dmel\Dgk

Species

D. melanogaster

Name

Diacyl glycerol kinase

Annotation Symbol

CG34361

Feature Type

protein_coding_gene

FlyBase ID

FBgn0085390

Gene Model Status

Current

Stock Availability

36 publicly available

Enzyme Name (EC)

diacylglycerol kinase (ATP) (2.7.1.107)

Gene Summary

Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity (By similarity). May have a role in the development of the embryonic nervous system and the function of the adult nervous system and muscle; regulating signal transduction in neurons. (UniProt, Q01583)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

43E18-43F1

Sequence location

2R:7,834,812..7,885,982 [-]

Recombination map

2-57

RefSeq locus

NT_033778 REGION:7834812..7885982

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables ATP-dependent diacylglycerol kinase activity

inferred from direct assay

(Inoue et al., 1992)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP-dependent diacylglycerol kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN007499105

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000756, InterPro:IPR037607

(InterPro Project Members, 2004-)

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR002048

(InterPro Project Members, 2004-)

enables kinase activity

inferred from electronic annotation with InterPro:IPR001206

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in diacylglycerol metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000135281

(GO Reference Genome Project, 2011-)

involved_in intracellular signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN007499105

(GO Reference Genome Project, 2011-)

involved_in phosphatidic acid biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000135281

(GO Reference Genome Project, 2011-)

involved_in phospholipase C-activating G protein-coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000756

(InterPro Project Members, 2004-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR037607

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000883263

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

DIACYLGLYCEROL KINASES

Protein Family (UniProt)

Belongs to the eukaryotic diacylglycerol kinase family. (Q01583)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATP-dependent diacylglycerol kinase activity

a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+) (2.7.1.107)

RHEA 10272:

Summaries

Gene Group (FlyBase)

DIACYLGLYCEROL KINASES -: Diacylglycerol kinases catalyze the phosphorylation of diacylglycerol to form phosphatidic acid. (Adapted from FBrf0161471).

Protein Function (UniProtKB)

(UniProt, Q01583)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dgk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q01583)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.39

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 6.02

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dgk-RE

FBtr0112580

NM_001103749

4450

1211

Dgk-RF

FBtr0112581

NM_001103750

4238

1108

Dgk-RG

FBtr0112579

NM_078930

3152

791

Dgk-RH

FBtr0308589

NM_165568

6282

1230

Dgk-RI

FBtr0308590

NM_206053

2923

747

Dgk-RJ

FBtr0330238

NM_001273863

4214

1139

Dgk-RK

FBtr0346954

NM_001316408

4214

1100

Additional Transcript Data and Comments

Reported size (kB)

6, 3.5 (northern blot)

(Masai et al., 1992)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dgk-PE

FBpp0111492

133.0

1211

8.01

FBpp0111493

122.6

1108

7.95

NP_001097220

ABV53720

Dgk-PG

FBpp0111491

87.3

791

8.28

NP_523654

AAF59180

Dgk-PH

FBpp0300813

134.7

1230

8.04

NP_724619

AAM68870

Dgk-PI

FBpp0300814

82.5

747

8.21

NP_995775

AAS64897

Dgk-PJ

FBpp0303271

125.9

1139

7.76

FBpp0312418

121.6

1100

7.89

A0A126GUN0

NP_001303337

ALI30167

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

796 (aa)

(Koelle et al., 1992)

791 (aa)

(Masai et al., 1992)

Comments

The Drosophila and porcine enzymes are homologous

over a 430aa region that comprises the catalytic domain of the porcine

DGK. The region of homology in the Drosophila protein is split into two

clusters of 194aa and 236aa that are widely separated. The ORF size

predicted from the cDNA and from the genomic sequence differ by 5 aa. The

shorter protein is predicted by the cDNA.

(Koelle et al., 1992)

The Drosophila and porcine enzymes are homologous over a 430aa region that comprises the catalytic domain of the porcine DGK. The region of homology in the Drosophila protein is split into two clusters of 194aa and 236aa that are widely separated. The ORF size predicted from the cDNA and from the genomic sequence differ by 5 aa. The shorter protein is predicted by the cDNA.

(Masai et al., 1992)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dgk using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dgk_1
Dgk_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.16

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

Bolwig organ

(Masai et al., 1992)

ventral midline of embryo

(Masai et al., 1992)

adult stage

adult brain cell body rind

(Masai et al., 1992)

mesothoracic tergotrochanter muscle cell

(Masai et al., 1992)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

larval VUM neuron

(Masai et al., 1992)

presumptive embryonic/larval central nervous system | restricted

(Masai et al., 1992)

embryonic stage 4 -- 6

hindgut anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 11 -- 12

Malpighian tubule primordium

(Fisher et al., 2012)

Malpighian tubule tip cell primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

(Fisher et al., 2012)

adult stage

indirect flight muscle cell

(Masai et al., 1992)

retina

(Masai et al., 1992)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dgk in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dgk

View exonic expression by tissue for Dmel\Dgk

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0085390

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35738/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085390

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085390

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085390

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18654

Flygut - An atlas of the Drosophila adult midgut

FBgn0085390

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Dgk

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dgk

Transgenic constructs containing regulatory region of Dgk

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

Dgk^GD6575

lethal | pupal stage, with Scer\GAL4^pnr-MD237

Dgk^GD6575

viable

Dgk^f03609

Sterility

Allele

fertile

Dgk^f03609

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (38)

Hsap\DGKB

13 of 14

Yes

Hsap\DGKG

12 of 14

Yes

Hsap\DGKA

11 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (19)

Rnor\Dgkb

13 of 14

Yes

Rnor\Dgkg

12 of 14

Yes

Rnor\Dgka

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (22)

Mmus\Dgkb

13 of 14

Yes

Mmus\Dgkg

12 of 14

Yes

Mmus\Dgka

10 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\dgkb

8 of 13

Yes

Xtro\dgka

7 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (23)

Drer\dgkb

13 of 14

Yes

Drer\dgkaa

11 of 14

Yes

Drer\LOC567728

11 of 14

Yes

Drer\dgkab

9 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (25)

Cele\dgk-3

14 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\rsf-1

1 of 14

Yes

Cele\tpa-1

1 of 14

Cele\unc-13

1 of 14

Anopheles gambiae (African malaria mosquito) (21)

Agam\AgaP_AGAP006762

12 of 12

Yes

4 of 12

3 of 12

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (19)

Atha\DGK1

6 of 13

Yes

Atha\DGK2

5 of 13

Atha\DGK3

3 of 13

Yes

Atha\DGK4

3 of 13

Yes

Atha\DGK5

3 of 13

Yes

Atha\DGK6

3 of 13

Yes

Atha\DGK7

3 of 13

Yes

Atha\LCBK2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CNB1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cam1

1 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\yegS

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dgk. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (27)

6 of 13

6 of 13

5 of 13

4 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

elm

1 of 13

gek

1 of 13

Nox

1 of 13

Pkc98E

1 of 13

Pkcδ

1 of 13

PKD

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Vav

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

insulin pathway effects, DGK-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

Dgk^GD6575

model of glucose metabolism disease

CEA

(Trinh et al., 2019)

Dgk^JF03396

model of glucose metabolism disease

CEA

(Trinh et al., 2019)

Dgk^{G509D.UAS.RF.Tag:V5}

model of glucose metabolism disease

CEA

(Trinh et al., 2019)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DGKB; diacylglycerol kinase beta

13 of 14

604070

DGKG; diacylglycerol kinase gamma

12 of 14

DIACYLGLYCEROL KINASE, GAMMA, 90-KD; DGKG

DGKA; diacylglycerol kinase alpha

11 of 14

DIACYLGLYCEROL KINASE, ALPHA, 80-KD; DGKA

DGKE; diacylglycerol kinase epsilon

3 of 14

601440

NEPHROTIC SYNDROME, TYPE 7; NPHS7

nephrotic syndrome type 7

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ctdnep1

suppressible

Dgk

(Jacquemyn et al., 2021)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0085390

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Effects of PIP2 hydrolysis

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-57

Cytogenetic map

43E18-43F1

Sequence location

2R:7,834,812..7,885,982 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

43E18-43F1

Limits computationally determined from genome sequence between P{EP}CanB2^EP774 and P{lacW}lin19^k01207&P{lacW}rnh1^k07624;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

43E6-43E7

(determined by in situ hybridisation)

(Harden et al., 1993)

Experimentally Determined Recombination Data

Location

2-57

(FlyBase, 2016)

2-57.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (36)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

49939

w¹¹¹⁸; P{GMR36G02-GAL4}attP2

49940

w¹¹¹⁸; P{GMR36G04-GAL4}attP2

601198

w¹¹¹⁸; P{R36G02-p65.AD}JK73A

601464

w¹¹¹⁸; P{R36E12-p65.AD}attP2

54140

w¹¹¹⁸; P{GMR36G04-lexA}attP40

68768

w¹¹¹⁸; P{R36G02-GAL4.DBD}attP2

68891

w¹¹¹⁸; P{R36G04-GAL4.DBD}attP2

Korea

15985

P{GMR39E10-lexA}JK22C

15992

P{GMR39E10-lexA}JK73A

11724

P{EP}Dgk^G19542

VDRC

v105753

P{KK109158}VIE-260B

v38239

w¹¹¹⁸; P{GD6575}v38239

More stocks available...

Genomic Clones (38)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (31)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT10182

Other clones

DPiM_AT10182

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0085390

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085390

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

A membrane-associated diacylglycerol kinase (which may be the rdgA gene product) has been partially purified from Drosophila heads and characterised.

(Inoue et al., 1992)

Dgk gene product is expressed predominantly in the embryonic CNS and adult nervous system and muscle.

(Masai et al., 1992)

Dgk has been cloned and its structure and expression pattern characterized.

(Masai et al., 1992)

Dgk has been isolated and characterised.

(Harden et al., 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: Dgk CG12820

(FlyBase Genome Annotators, 2007)

Source for merge of: Dgk CG18654

(FlyBase, 1996-)

Additional comments

Annotations CG18654 and CG12820 merged as CG34361 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Source for merge of Dgk CG18654 was sequence comparison ( date:001104 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Dgk CG1535

(Gabrielian, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG12820

CG1535

CG18654

(Pawar et al., 2011, Morrison et al., 2000)

CG34361

(National Institute of Genetics Fly Stocks, 2022-, Cockcroft and Raghu, 2016, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2007)

DAGK

(Jacquemyn et al., 2021)

DGK

(Jacquemyn et al., 2021, Lehmann, 2021)

DGKb

(Morrison et al., 2000)

Dgk

(Chapman et al., 2020, Myat et al., 2019, Trinh et al., 2019, Weigelt et al., 2019, Li-Kroeger et al., 2018, Palmer et al., 2018, Peiris et al., 2018, Cockcroft and Raghu, 2016, Gene Disruption Project members, 2016-, Ashwal-Fluss et al., 2014, Mizrak et al., 2012, Jungreis et al., 2011, Wasbrough et al., 2010)

dDGK

dgk

(McElwain et al., 2011, Stagg et al., 2011)

Name Synonyms

CG12820

Diacyl glycerol kinase

Diacylglycerol kinase

(McElwain et al., 2011)

diacylglycerol kinase

(Johnson and Stolzing, 2019)

Secondary FlyBase IDs

FBgn0042192
FBgn0004568
FBgn0033230

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

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External Crossreferences and Linkouts ( 73 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35738

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q01583

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q01583

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q01583

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0085390

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35738/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085390

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085390

FlyMine - An integrated database for Drosophila genomics

FBgn0085390

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34361

MARRVEL_MODEL - MARRVEL (model organism gene)

35738

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0085390

DroID - A comprehensive database of gene and protein interactions.

FBgn0085390

DRSC - Results frm RNAi screens

FBgn0085390

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dgk_1
Dgk_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085390

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0085390

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18654

Flygut - An atlas of the Drosophila adult midgut

FBgn0085390

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0085390

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033574

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Effects of PIP2 hydrolysis

References (69)

The following external sites may use different assemblies or annotations than FlyBase.

4.16

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