Reference Report

Reference
Citation	Badenhorst, P., Finch, J.T., Travers, A.A. (2002). Tramtrack co-operates to prevent inappropriate neural development in Drosophila. Mech. Dev. 117(1-2): 87--101. (Export to RIS)
FlyBase ID	FBrf0152198
Publication Type	Research paper
PubMed ID	12204250
PubMed Abstract	Each sensory organ of the Drosophila peripheral nervous system is derived from a single sensory organ precursor cell (SOP). These originate in territories defined by expression of the proneural genes of the Achaete-Scute complex (AS-C). Formation of ectopic sensilla outside these regions is prevented by transcriptional repression of proneural genes. We demonstrate that the BTB/POZ-domain transcriptional repressor Tramtrack (Ttk) co-operates in this repression. Ttk is expressed ubiquitously, except in proneural clusters and SOPs. Ttk over-expression represses proneural genes and sensilla formation. Loss of Ttk enhances bristle-promoting mutants. Using neural repression as an assay, we dissected functional domains of Ttk, confirming the importance of the bric-à-brac-tramtrack-broad complex (BTB) motif. We show that the Ttk BTB domain is a protein-protein interaction motif mediating tetramer formation.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (1)
	Df(3R)awd-KRB
Alleles (29)
	ac^Hw-1 ac^Hw-49c CtBP^87De-10 emc^E12 emc^ip15 h⁴¹ sc¹ sc^ase-1 Scer\GAL4^Bx-MS1096 ttk¹ ttk^1e11 ttk^{69.286-ZFS.Scer\UAS} ttk^{69.BTB.Scer\UAS} ttk^{69.BTB-R113.Scer\UAS} ttk^{69.BTB-ZF.Scer\UAS} ttk^{69.BTB-ZFS.Scer\UAS} ttk^{69.D32A.B.Scer\UAS} ttk^{69.D32N.Scer\UAS} ttk^69.hs ttk^{69.K46E.Scer\UAS} ttk^{69.R113.Scer\UAS} ttk^{69.S35A.Scer\UAS} ttk^69.Scer\UAS ttk^{69.ΔBTB.Scer\UAS} ttk^{69.ΔSA.Scer\UAS} ttk⁰⁰²¹⁹ ttk^p88.Scer\UAS ttk^rM730 ttk^unspecified
Constructs (15)
	P{hs69-ttk} P{UAS-ttk.69.286-ZFS} P{UAS-ttk.69.B} P{UAS-ttk.69.BTB} P{UAS-ttk.69.BTB-R113} P{UAS-ttk.69.BTB-ZF} P{UAS-ttk.69.BTB-ZFS} P{UAS-ttk.69.D32A.B} P{UAS-ttk.69.D32N} P{UAS-ttk.69.K46E} P{UAS-ttk.69.R113} P{UAS-ttk.69.S35A} P{UAS-ttk.69.ΔBTB} P{UAS-ttk.69.ΔSA} P{UAS-ttk.p88}
Genes (8)
	ac ase CtBP emc h sc Scer\GAL4 ttk
Insertions (1)
	P{GawB}Bx^MS1096