FlyBase Allele Report: Dmel\Su(H)[2]

When expression is driven using Scer\GAL4^da.PU, Su(H)^{Scer\UAS.T:Avic\GFP,T:SV5\V5} rescues viability of Su(H)²/Su(H)⁸, although adult flies have some wing and eye defects (reminiscent of reduced N function).

(Reynolds and Bray, 2014.4.15)

In Su(H)² homozygous embryos, the early steps of proventricular development including the formation of the ball-like evagination at the ectoderm/endoderm boundary occur normally. However, at stage 14, the anterior boundary cells of the keyhole region fail to invaginate into the endodermal cell layer, but arrest anteriorly and do not move inwards until the final stages of embryonic development (16 and 17). In addition, the posterior boundary cells of the endodermal component of the proventriculus rim collapses in these animals.

(Fuss et al., 2004)

Mutant embryos show normal boundary cell differentiation in the hindgut.

(Takashima et al., 2002)

Wing primordium is established but does not grow. Lateral inhibition fails in the notum, causing an excess of neural precursors.

(Klein et al., 2000)

In Su(H)⁸/Su(H)² mutant wing discs, each proneural cluster is enlarged as compared to wild-type.

(Brennan et al., 1999)

Homozygous clones in the anterior ventral compartment of the leg result in fusion between the distal femur and proximal tibia, and cells in the clone fail to form joint tissue.

(de Celis et al., 1998)

Dorsal mitotic clones in the wing encompassing the LII and LII veins cause an autonomous thickening of dorsal LIII but does not affect vein differentiation in the ventral surface. Ventral clone covering LII results in the differentiation of a thicker LII.

(de Celis et al., 1997)

Dorsal, ventral and dorsoventral clones that extend to the wing margin produce extensive scalloping.

(de Celis et al., 1996)

Clones in the thorax produce patches of naked cuticle, due to the differentiation of the ectopic SOPs into neurons. Clones in the wing that reach the wing margin show a loss of margin and blade tissue due to the requirement for N at the D/V boundary. Wing veins also appear thicker.

(de Celis et al., 1996)

Homozygous embryos derived from germ-line clones exhibit a strong neurogenic cuticular phenotype and fail to hatch. The number of neuroblasts and sensory precursors that segregate from the ventral and dorsolateral neuroectoderm, respectively, is greatly increased. This leads to hypertrophy of the CNS and PNS and failure of ventral and head cuticle to develop. No defect is seen in the nervous system when rescued by wild type paternal copy of Su(H). Heterozygous embryos derived from germ-line clones survive to adulthood.

(Lecourtois and Schweisguth, 1995)

Lethality during the first day of pupal development. Supernumerary cells stained in mutant imaginal discs have adopted a sensory organ precursor (SOP) fate instead of the epidermal fate they would normally express. The excess SOPs arise from the proneural clusters of potential precursor cels that appear in the imaginal discs during the development of wild type bristles. The wing pouch region of the wing imaginal disc and the retinal field of the eye-antennal imaginal disc are dramatically reduced. Identical phenotype is seen when transheterozygous with Df(2L)TE35BC-24, Su(H)¹, Su(H)⁸ or Su(H)^IB115.

(Schweisguth and Posakony, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(H)[+]/Su(H)² is an enhancer of visible | adult stage phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

NOT Enhancer of

Statement

Reference

Su(H)[+]/Su(H)² is a non-enhancer of visible phenotype of Scer\GAL4^pnr-MD237, fred^RNAi.UAS

(Chandra et al., 2003)

Su(H)⁸/Su(H)² is a non-enhancer of visible phenotype of N^{ECNΔ10-12.UAS}, Scer\GAL4^ptc-559.1

(Brennan et al., 1999)

Suppressor of

Statement

Reference

Su(H)[+]/Su(H)² is a suppressor | partially of visible | heat sensitive phenotype of Dcr-2^UAS.cDa, Eogt^GD5084, Scer\GAL4^en.PU

(Müller et al., 2013)

NOT Suppressor of

Statement

Reference

Su(H)[+]/Su(H)² is a non-suppressor of visible phenotype of Scer\GAL4^pnr-MD237, fred^RNAi.UAS

(Chandra et al., 2003)

Su(H)⁸/Su(H)² is a non-suppressor of visible phenotype of N^{ECNΔ10-12.UAS}, Scer\GAL4^ptc-559.1

(Brennan et al., 1999)

Other

Statement

Reference

Su(H)², sno^71e3 has lethal | pupal stage phenotype

(Majumdar et al., 1997)

Su(H)[+]/Su(H)², sno^71e3 has lethal | pupal stage phenotype

(Majumdar et al., 1997)

Phenotype Manifest In

Suppressed by

Statement

Reference

Su(H)⁸/Su(H)² has proneural cluster phenotype, suppressible by Scer\GAL4^klu-G410/E(spl)m8-HLH^UAS.cNa

(Klein et al., 2000)

Su(H)⁸/Su(H)² has proneural cluster phenotype, suppressible by E(spl)m7-HLH^UAS.cdCa/Scer\GAL4^klu-G410

(Klein et al., 2000)

Su(H)⁸/Su(H)² has wing phenotype, suppressible by Scer\GAL4^ptc-559.1/vg^UAS.cKa

(Klein and Martinez Arias, 1998)

Su(H)⁸/Su(H)² has wing phenotype, suppressible by Scer\GAL4^dpp.blk1/vg^UAS.cKa

(Klein and Martinez Arias, 1998)

NOT suppressed by

Statement

Reference

Su(H)⁸/Su(H)² has wing disc phenotype, non-suppressible by Delta^UAS.cHa/Scer\GAL4^dpp.blk1

(Klein et al., 2000)

Su(H)⁸/Su(H)² has wing disc phenotype, non-suppressible by Scer\GAL4^klu-G410/E(spl)m8-HLH^UAS.cNa

(Klein et al., 2000)

Su(H)⁸/Su(H)² has wing disc phenotype, non-suppressible by H^E31

(Klein et al., 2000)

Su(H)⁸/Su(H)² has wing disc phenotype, non-suppressible by E(spl)m7-HLH^UAS.cdCa/Scer\GAL4^klu-G410

(Klein et al., 2000)

Su(H)⁸/Su(H)² has wing disc phenotype, non-suppressible by N^int.SH.UAS/Scer\GAL4^dpp.blk1

(Klein et al., 2000)

Su(H)⁸/Su(H)² has wing disc phenotype, non-suppressible by Scer\GAL4^dpp.blk1/Ser^UAS.cSa/vg^UAS.cKa

(Klein et al., 2000)

Su(H)⁸/Su(H)² has wing phenotype, non-suppressible by wg^UAS.cGa/Scer\GAL4^dpp.blk1

(Klein and Martinez Arias, 1998)

Enhancer of

Statement

Reference

Su(H)[+]/Su(H)² is an enhancer of notal microchaeta | adult stage phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

Su(H)[+]/Su(H)² is an enhancer of tormogen cell | adult stage phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

Su(H)[+]/Su(H)² is an enhancer of trichogen cell | adult stage | ectopic phenotype of Scer\GAL4^sca-109-68, ham^UAS.cMa

(Endo et al., 2011)

Su(H)[+]/Su(H)² is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, fred^RNAi.UAS

(Chandra et al., 2003)

Su(H)² is an enhancer of wing vein phenotype of N^Ax-E2

(Rollins et al., 1999)

Su(H)[+]/Su(H)² is an enhancer of wing phenotype of N^nd-1

(Royet et al., 1998)

Su(H)[+]/Su(H)² is an enhancer of wing vein phenotype of N^nd-1

(Royet et al., 1998)

Su(H)² is an enhancer of phenotype of Delta^9P

(Fortini and Artavanis-Tsakonas, 1994)

NOT Enhancer of

Statement

Reference

Su(H)² is a non-enhancer of larval intersegmental nerve | heat sensitive phenotype of N^l1N-ts1

(Crowner et al., 2003)

Su(H)² is a non-enhancer of phenotype of N^Ax-M1

(Brennan et al., 1999)

Su(H)² is a non-enhancer of phenotype of N^Ax-59d

(Brennan et al., 1999)

Su(H)² is a non-enhancer of phenotype of N^l1N-B

(Brennan et al., 1999)

Suppressor of

Statement

Reference

Su(H)[+]/Su(H)² is a suppressor | partially of wing blade posterior compartment | heat sensitive phenotype of Dcr-2^UAS.cDa, Eogt^GD5084, Scer\GAL4^en.PU

(Müller et al., 2013)

NOT Suppressor of

Statement

Reference

Su(H)² is a non-suppressor of larval intersegmental nerve | heat sensitive phenotype of N^l1N-ts1

(Crowner et al., 2003)

Su(H)² is a non-suppressor of phenotype of N^Ax-M1

(Brennan et al., 1999)

Su(H)² is a non-suppressor of phenotype of N^l1N-B

(Brennan et al., 1999)

Su(H)² is a non-suppressor of phenotype of N^Ax-59d

(Brennan et al., 1999)

Other

Statement

Reference

Sox15^4AA, Su(H)⁸/Su(H)², Su(H)^RC-ΔASE has tormogen cell phenotype

(Miller et al., 2009)

Scer\GAL4^dpp.blk1, Su(H)², vg^UAS.cKa has wing phenotype

(Klein and Martinez Arias, 1998)

Scer\GAL4^ptc-559.1, Su(H)², vg^UAS.cKa has wing phenotype

(Klein and Martinez Arias, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The wing blistering phenotype seen in the posterior compartment of wings in flies expressing Eogt^GD5084 under the control of Scer\GAL4^en.PU in the presence of Dcr-2^Scer\UAS.cDa is dominantly partially suppressed if the flies are also heterozygous for Su(H)².

(Müller et al., 2013)

Su(H)² Sox15^4AA/Su(H)⁸ Sox15^4AA; Su(H)^RC-ΔASE mutants show a more dramatic socket differentiation defect than either single mutant. Most of the double mutant bristles have a convex (rather than concave) socket-shaft cuticular interface. Dome of these bulbous socket structures extend one or more small cuticular projections, while others extend one or two distinctly shaft-like structures.

(Miller et al., 2009)

The addition of Su(H)²/+ to fred^{dsRNA.Scer\UAS}, Scer\GAL4^pnr-MD237 animals has no detectable effect on the fred^{dsRNA.Scer\UAS} phenotype. However when Su(H)²/+ is added to fred^{dsRNA.Scer\UAS} driven by Scer\GAL4^GMR.PF, an enhancement of the rough eye phenotype is seen.

(Chandra et al., 2003)

The neurogenic phenotype, but not the wing development phenotype, of Su(H)²/Su(H)⁸ is strongly suppressed by either HLHm7^{Scer\UAS.cdCa} or E(spl)^Scer\UAS.cNa driven by Scer\GAL4^klu-G410. The wing development phenotype of Su(H)²/Su(H)⁸ is not suppressed by either N^{int.SH.Scer\UAS} or Dl^Scer\UAS.cHa, or Ser^Scer\UAS.cSa in combination with vg^Scer\UAS.cKa, driven by Scer\GAL4^dpp.blk1. The wing development phenotype of Su(H)²/Su(H)⁸ is also not suppressed by H^E31.

(Klein et al., 2000)

Su(H)² has no effect on the wing disc proneural cluster phenotypes seen in N^Ax-59d or N^Ax-M1, or the lack of phenotype seen in N^l1N-B discs. The addition of Su(H)²/Su(H)⁸ has no effect on the wing disc proneural cluster phenotype seen in N^{ECNΔ10-12.Scer\UAS}/Scer\GAL4^ptc-559.1 discs.

(Brennan et al., 1999)

Scer\GAL4^dpp.blk1-mediated or Scer\GAL4^ptc-559.1-mediated expression of vg^Scer\UAS.cKa substantially rescues the wing blade phenotype. Scer\GAL4^dpp.blk1-mediated expression of wg^Scer\UAS.cGa does not rescue loss of wing tissue.

(Klein and Martinez Arias, 1998)

Loss of a single copy of Su(H) in sno^71e3 flies causes pupal lethality at 23^oC and at 20^oC some pupae eclose and exhibit severe wing margin defects.

(Majumdar et al., 1997)

Abruptex wing phenotype of N^Ax-E2 dominantly enhanced by Su(H)².

(Fortini and Artavanis-Tsakonas, 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Su(H)^226.1

(Rollins et al., 1999)

Rescued by

Su(H)⁸/Su(H)² is rescued by Su(H)^{UAS.GFP,Tag:V5}/Scer\GAL4^da.PU

(Reynolds and Bray, 2014.4.15)

Su(H)⁸/Su(H)² is rescued by Su(H)^+t6.0

(Schweisguth and Posakony, 1992)

Partially rescued by

Su(H)⁸/Su(H)² is partially rescued by Scer\GAL4^klu-G410/Su(H)^UAS.cKa

(Klein et al., 2000)

Su(H)⁸/Su(H)² is partially rescued by Scer\GAL4^dpp.blk1/Su(H)^UAS.cKa

(Klein et al., 2000)

Comments

When expression is driven using Scer\GAL4^da.PU, Su(H)^{Scer\UAS.T:Avic\GFP,T:SV5\V5} rescues viability of Su(H)²/Su(H)⁸.

(Reynolds and Bray, 2014.4.15)

When expression of Su(H)^Scer\UAS.cKa is driven by Scer\GAL4^dpp.blk1 in a Su(H)²/Su(H)⁸ mutant the wing pouch size defect is rescued. When expression of Su(H)^Scer\UAS.cKa is driven by Scer\GAL4^klu-G410 in a Su(H)²/Su(H)⁸ mutant the neurogenesis and wing pouch size defects are rescued.

(Klein et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

30477

pr¹ cn¹ Su(H)²/CyO

Kyoto

101289

Adh^F Su(H)² / In(2L)Cy In(2R)Cy, Duox^Cy Bl¹ cn²

Notes on Origin

Discoverer

Ashburner.

Isolated from: Greece population.

(Furukawa et al., 1992, Ashburner, 1982)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

AR9

(Wurmbach et al., 1999, Furukawa et al., 1992)

Su(H)²

(Zhu et al., 2017, Müller et al., 2013, Tsuda et al., 2006)

Su(H)^A9

(Gomez-Lamarca et al., 2018)

Su(H)^AR9

(Gomez-Lamarca et al., 2018, Endo et al., 2011, Miller et al., 2009, Koelzer and Klein, 2006, Fuss et al., 2004, Chandra et al., 2003, Crowner et al., 2003, Koelzer and Klein, 2003, Lebestky et al., 2003, Johannes and Preiss, 2002, Rebeiz et al., 2002, Rohrbaugh et al., 2002, Furriols and Bray, 2001, Cooper et al., 2000, Klein et al., 2000, Lai et al., 2000, Nagel et al., 2000, Brennan et al., 1999, Maier et al., 1999, Nellesen et al., 1999, Bachmann and Knust, 1998, de Celis et al., 1998, Klein and Martinez Arias, 1998, Klein and Martinez Arias, 1998, Lecourtois and Schweisguth, 1998, Royet et al., 1998, de Celis et al., 1997, Eastman et al., 1997, de Celis et al., 1996, de Celis et al., 1996, Gho et al., 1996, Neumann and Cohen, 1996, Bailey and Posakony, 1995, Diaz-Benjumea and Cohen, 1995, Lecourtois and Schweisguth, 1995, Fortini and Artavanis-Tsakonas, 1994, Schweisguth and Posakony, 1992)

Su(H)^Ar9

(Majumdar et al., 1997)

Su(H)Ar9

(Reynolds and Bray, 2014.4.15)

l(2)br7^AR9

(Ashburner, 1982, Woodruff and Ashburner, 1979)

Name Synonyms

Secondary FlyBase IDs

References (51)

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